TBE_HUMAN - dbPTM
TBE_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TBE_HUMAN
UniProt AC Q9UJT0
Protein Name Tubulin epsilon chain
Gene Name TUBE1
Organism Homo sapiens (Human).
Sequence Length 475
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Associated with pericentriolar material.
Protein Description
Protein Sequence MTQSVVVQVGQCGNQIGCCFWDLALREHAAVNQKGIYDEAISSFFRNVDTRVVGDGGSISKGKICSLKARAVLIDMEEGVVNEILQGPLRDVFDTKQLITDISGSGNNWAVGHKVFGSLYQDQILEKFRKSAEHCDCLQCFFIIHSMGGGTGSGLGTFLLKVLEDEFPEVYRFVTSIYPSGEDDVITSPYNSILAMKELNEHADCVLPIDNQSLFDIISKIDLMVNSGKLGTTVKPKSLVTSSSGALKKQHKKPFDAMNNIVANLLLNLTSSARFEGSLNMDLNEISMNLVPFPQLHYLVSSLTPLYTLTDVNIPPRRLDQMFSDAFSKDHQLLRADPKHSLYLACALMVRGNVQISDLRRNIERLKPSLQFVSWNQEGWKTSLCSVPPVGHSHSLLALANNTCVKPTFMELKERFMRLYKKKAHLHHYLQVEGMEESCFTEAVSSLSALIQEYDQLDATKNMPVQDLPRLSIAM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17UbiquitinationGQCGNQIGCCFWDLA
CCCCCCCCHHHHHHH		7.7422817900
19UbiquitinationCGNQIGCCFWDLALR
CCCCCCHHHHHHHHH		3.0522817900
21UbiquitinationNQIGCCFWDLALREH
CCCCHHHHHHHHHHH		5.9422817900
24UbiquitinationGCCFWDLALREHAAV
CHHHHHHHHHHHHHH		11.3327667366
34UbiquitinationEHAAVNQKGIYDEAI
HHHHHHCCCCHHHHH		41.9121906983
37PhosphorylationAVNQKGIYDEAISSF
HHHCCCCHHHHHHHH		19.19-
39UbiquitinationNQKGIYDEAISSFFR
HCCCCHHHHHHHHHH		30.8222817900
43PhosphorylationIYDEAISSFFRNVDT
CHHHHHHHHHHCCCC		23.4524719451
52UbiquitinationFRNVDTRVVGDGGSI
HHCCCCEEECCCCCC		6.4822817900
55UbiquitinationVDTRVVGDGGSISKG
CCCEEECCCCCCCCC		46.8222817900
61UbiquitinationGDGGSISKGKICSLK
CCCCCCCCCCCCEEE		63.6521906983
63UbiquitinationGGSISKGKICSLKAR
CCCCCCCCCCEEEEE		44.2522817900
68UbiquitinationKGKICSLKARAVLID
CCCCCEEEEEEEEEE		21.3827667366
68AcetylationKGKICSLKARAVLID
CCCCCEEEEEEEEEE		21.3825953088
70UbiquitinationKICSLKARAVLIDME
CCCEEEEEEEEEECC		24.5222817900
83UbiquitinationMEEGVVNEILQGPLR
CCCCHHHHHHCCCHH		33.2022817900
86UbiquitinationGVVNEILQGPLRDVF
CHHHHHHCCCHHHCC		58.0622817900
96UbiquitinationLRDVFDTKQLITDIS
HHHCCCHHHHHEECC		44.9721906983
105PhosphorylationLITDISGSGNNWAVG
HHEECCCCCCCCCHH		31.4025332170
114UbiquitinationNNWAVGHKVFGSLYQ
CCCCHHHHHHHHHHH		33.0722817900
127UbiquitinationYQDQILEKFRKSAEH
HHHHHHHHHHHHHHC		47.2022817900
130UbiquitinationQILEKFRKSAEHCDC
HHHHHHHHHHHCCCH		58.0922817900
173UbiquitinationEFPEVYRFVTSIYPS
CCHHHHHHHHCCCCC		3.7327667366
204UbiquitinationKELNEHADCVLPIDN
HHHHHCCCEEEEECC		25.6027667366
229UbiquitinationDLMVNSGKLGTTVKP
HHHHCCCCCCCCCCC		43.49-
229AcetylationDLMVNSGKLGTTVKP
HHHHCCCCCCCCCCC		43.4925953088
235UbiquitinationGKLGTTVKPKSLVTS
CCCCCCCCCHHHCCC		44.64-
241PhosphorylationVKPKSLVTSSSGALK
CCCHHHCCCCCCHHH		28.34-
243PhosphorylationPKSLVTSSSGALKKQ
CHHHCCCCCCHHHHH		24.3525627689
248UbiquitinationTSSSGALKKQHKKPF
CCCCCHHHHHCCCHH		50.2627667366
249UbiquitinationSSSGALKKQHKKPFD
CCCCHHHHHCCCHHH		59.49-
254UbiquitinationLKKQHKKPFDAMNNI
HHHHCCCHHHHHHHH		36.8323503661
264UbiquitinationAMNNIVANLLLNLTS
HHHHHHHHHHHHHHC		21.9623503661
285UbiquitinationSLNMDLNEISMNLVP
CCCCCHHHHHHHCCC		43.6823503661
295UbiquitinationMNLVPFPQLHYLVSS
HHCCCHHHHHHHHHH		41.0523503661
329UbiquitinationMFSDAFSKDHQLLRA
HHHHHCCCCCHHHHC		53.4223503661
339UbiquitinationQLLRADPKHSLYLAC
HHHHCCCCHHHHHHH		46.5023503661
357PhosphorylationVRGNVQISDLRRNIE
HCCCCCHHHHHHHHH		17.3224719451
367UbiquitinationRRNIERLKPSLQFVS
HHHHHHHCCCEEEEE		38.49-
472PhosphorylationVQDLPRLSIAM----
HHHCCCCCCCC----		15.0228555341
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TBE_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TBE_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TBE_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TBD_HUMANTUBD1physical
28514442
CP059_HUMANC16orf59physical
28514442
CN080_HUMANC14orf80physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00570Vinblastine
Regulatory Network of TBE_HUMAN

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Related Literatures of Post-Translational Modification

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