MYH3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYH3_HUMAN
• UniProt AC: P11055
• Protein Name: Myosin-3
• Gene Name: MYH3
• Organism: Homo sapiens (Human).
• Sequence Length: 1940
• Subcellular Localization: Cytoplasm, myofibril. Thick filaments of the myofibrils.
• Protein Description: Muscle contraction..
• Protein Sequence: MSSDTEMEVFGIAAPFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYAKGKIKSSQDGKVTVETEDNRTLVVKPEDVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Acetylation	YCFVVDSKEEYAKGK EEEEEECHHHHHCCC	50.53	7710311
78	Phosphorylation	VVKPEDVYAMNPPKF EECHHHHCCCCCCCC	16.68	22461510
104	Phosphorylation	LNEPAVLYNLKDRYT CCCCCHHCCCHHHCC	16.32	25247763
110	Phosphorylation	LYNLKDRYTSWMIYT HCCCHHHCCCEEEEE	18.43	-
130	"N6,N6,N6-trimethyllysine"	CVTVNPYKWLPVYNP EEEECCCCCCCCCCH	43.44	-
130	Methylation	CVTVNPYKWLPVYNP EEEECCCCCCCCCCH	43.44	-
157	Phosphorylation	EAPPHIFSISDNAYQ CCCCCEEECCCCEEE	22.15	25850435
159	Phosphorylation	PPHIFSISDNAYQFM CCCEEECCCCEEEEE	24.50	25850435
163	Phosphorylation	FSISDNAYQFMLTDR EECCCCEEEEEECCC	14.45	25850435
168	Phosphorylation	NAYQFMLTDRENQSI CEEEEEECCCCCCEE	22.63	-
174	Phosphorylation	LTDRENQSILITGES ECCCCCCEEEEECCC	30.83	26437602
181	Phosphorylation	SILITGESGAGKTVN EEEEECCCCCCCCCC	34.98	26437602
242	Phosphorylation	KTVRNDNSSRFGKFI EEECCCCCCCCCEEE	26.25	29514088
243	Phosphorylation	TVRNDNSSRFGKFIR EECCCCCCCCCEEEE	37.57	29514088
247	Acetylation	DNSSRFGKFIRIHFG CCCCCCCEEEEEEEC	34.60	25825284
247	Ubiquitination	DNSSRFGKFIRIHFG CCCCCCCEEEEEEEC	34.60	-
255	Phosphorylation	FIRIHFGTTGKLASA EEEEEECCCCCCCCC	31.28	26437602
256	Phosphorylation	IRIHFGTTGKLASAD EEEEECCCCCCCCCC	32.47	26437602
261	Phosphorylation	GTTGKLASADIETYL CCCCCCCCCCHHHHH	36.59	22673903
266	Phosphorylation	LASADIETYLLEKSR CCCCCHHHHHHHCCE	21.58	22673903
267	Phosphorylation	ASADIETYLLEKSRV CCCCHHHHHHHCCEE	9.12	22817900
271	Ubiquitination	IETYLLEKSRVTFQL HHHHHHHCCEEEEEE	43.46	-
272	Phosphorylation	ETYLLEKSRVTFQLK HHHHHHCCEEEEEEE	23.70	26437602
275	Phosphorylation	LLEKSRVTFQLKAER HHHCCEEEEEEEEEC	12.45	26437602
354	Phosphorylation	KSGLYKLTGAVMHYG CCCHHHHHHHHHHHC	20.95	21712546
360	Phosphorylation	LTGAVMHYGNMKFKQ HHHHHHHHCCCCHHH	7.66	21712546
379	Phosphorylation	EQAEPDGTEVADKTA HHCCCCCCCHHHHHH	34.37	26437602
385	Phosphorylation	GTEVADKTAYLMGLN CCCHHHHHHHHCCCC	22.53	29759185
393	Phosphorylation	AYLMGLNSSDLLKAL HHHCCCCHHHHHHHH	30.21	29759185
394	Phosphorylation	YLMGLNSSDLLKALC HHCCCCHHHHHHHHH	31.07	29759185
411	Phosphorylation	RVKVGNEYVTKGQTV CEEECCEEECCCCCH	19.88	19764811
413	Phosphorylation	KVGNEYVTKGQTVDQ EECCEEECCCCCHHH	28.67	26437602
414	Acetylation	VGNEYVTKGQTVDQV ECCEEECCCCCHHHH	38.69	30584683
417	Phosphorylation	EYVTKGQTVDQVHHA EEECCCCCHHHHHHH	34.42	22468782
429	Phosphorylation	HHAVNALSKSVYEKL HHHHHHHCHHHHHHH	22.07	22468782
450	Phosphorylation	RINQQLDTKLPRQHF HHHHHHCCCCCHHHH	42.97	26437602
503	Acetylation	VLEQEEYKKEGIEWT EECHHHHHHCCCCEE	47.86	30584671
547	Phosphorylation	MFPKATDTSFKNKLY CCCCCCCCHHHHHHH	31.54	24769528
548	Phosphorylation	FPKATDTSFKNKLYD CCCCCCCHHHHHHHH	36.71	24769528
554	Phosphorylation	TSFKNKLYDQHLGKS CHHHHHHHHHCCCCC	18.37	26437602
605	Phosphorylation	NKDPLNETVVGLYQK CCCCCCCHHHHHHHH	21.30	-
610	Phosphorylation	NETVVGLYQKSSNRL CCHHHHHHHHHHHHH	14.15	26437602
643	Phosphorylation	KVAKKKGSSFQTVSA HHHHCCCCCHHHHHH	36.54	26437602
644	Phosphorylation	VAKKKGSSFQTVSAL HHHCCCCCHHHHHHH	30.00	26437602
647	Phosphorylation	KKGSSFQTVSALFRE CCCCCHHHHHHHHHH	17.89	26437602
661	Phosphorylation	ENLNKLMSNLRTTHP HHHHHHHHHHHCCCC	43.05	26437602
679	Phosphorylation	RCIIPNETKTPGAME EEECCCCCCCCCHHH	47.02	26437602
716	Phosphorylation	GFPNRILYGDFKQRY CCCCCEEECCHHHHH	16.57	-
723	Phosphorylation	YGDFKQRYRVLNASA ECCHHHHHHCCCHHH	11.54	-
729	Phosphorylation	RYRVLNASAIPEGQF HHHCCCHHHCCCCCC	26.17	19764811
739	Phosphorylation	PEGQFIDSKKACEKL CCCCCCCCHHHHHHH	31.10	19764811
817	Phosphorylation	ESIFCIQYNIRSFMN HHEEEEEEHHHHHCC	7.82	27067055
832	Acetylation	VKHWPWMKLFFKIKP CCCCHHHHHHHHHHH	37.97	19809373
842	Acetylation	FKIKPLLKSAETEKE HHHHHHHHCHHHHHH	56.13	19809383
852	Phosphorylation	ETEKEMATMKEEFQK HHHHHHHHHHHHHHH	27.71	-
860	Phosphorylation	MKEEFQKTKDELAKS HHHHHHHHHHHHHHH	32.70	-
872	Acetylation	AKSEAKRKELEEKLV HHHHHHHHHHHHHHH	66.98	11920919
924	Phosphorylation	EAKIKEVTERAEDEE HHHHHHHHHHCCCHH	22.35	28787133
938	Phosphorylation	EEINAELTAKKRKLE HHHHHHHHHHHHHHH	28.12	26437602
949	Phosphorylation	RKLEDECSELKKDID HHHHHHHHHHHHCHH	43.87	26437602
952	Acetylation	EDECSELKKDIDDLE HHHHHHHHHCHHHHH	44.33	160691
953	Acetylation	DECSELKKDIDDLEL HHHHHHHHCHHHHHH	72.96	30584689
961	Phosphorylation	DIDDLELTLAKVEKE CHHHHHHHHHHHHHH	18.46	22673903
980	Phosphorylation	ENKVKNLTEELSGLD HHHHHHHHHHHCCHH	36.49	28258704
984	Phosphorylation	KNLTEELSGLDETIA HHHHHHHCCHHHHHH	40.36	-
1020	Phosphorylation	AEEDKVNSLNKTKSK HHHHHHHHHHHHHHH	35.99	26437602
1066	Phosphorylation	DLKLAQESILDLEND HHHHHHHHHHCCCCH	19.17	26437602
1088	Phosphorylation	LKKKDFEYCQLQSKV HHHCCCCHHHHHHHC	5.86	30177828
1100	Phosphorylation	SKVEDEQTLGLQFQK HHCCCCHHHHHHHHH	22.27	26425664
1129	Phosphorylation	EIEAERATRAKTEKQ HHHHHHHHHHHHHHH	37.06	26437602
1133	Phosphorylation	ERATRAKTEKQRSDY HHHHHHHHHHHHHHH	47.64	24719451
1138	Phosphorylation	AKTEKQRSDYARELE HHHHHHHHHHHHHHH	32.26	24719451
1140	Phosphorylation	TEKQRSDYARELEEL HHHHHHHHHHHHHHH	14.59	24719451
1200	Phosphorylation	LRKKHADSVAELGEQ HHHHHCHHHHHHHHH	24.82	19764811
1270	Phosphorylation	KNEEIQRSLSELTTQ CCHHHHHHHHHHHHH	21.63	24719451
1279	Phosphorylation	SELTTQKSRLQTEAG HHHHHHHHHHHHHHH	28.53	24719451
1289	Phosphorylation	QTEAGELSRQLEEKE HHHHHHHHHHHHHHH	17.43	24702127
1300	Phosphorylation	EEKESIVSQLSRSKQ HHHHHHHHHHHHHHH	24.59	22673903
1303	Phosphorylation	ESIVSQLSRSKQAFT HHHHHHHHHHHHHHH	27.20	22673903
1305	Phosphorylation	IVSQLSRSKQAFTQQ HHHHHHHHHHHHHHH	26.24	26434776
1310	Phosphorylation	SRSKQAFTQQTEELK HHHHHHHHHHHHHHH	23.84	26434776
1313	Phosphorylation	KQAFTQQTEELKRQL HHHHHHHHHHHHHHH	22.93	26434776
1336	Phosphorylation	ALAHALQSSRHDCDL HHHHHHHHCHHHHHH	30.14	26437602
1337	Phosphorylation	LAHALQSSRHDCDLL HHHHHHHCHHHHHHH	22.22	22673903
1348	Phosphorylation	CDLLREQYEEEQEGK HHHHHHHHHHHHHHH	22.13	22817900
1367	Phosphorylation	RALSKANSEVAQWRT HHHHHHHHHHHHHHH	38.00	19764811
1374	Phosphorylation	SEVAQWRTKYETDAI HHHHHHHHHHHHHHH	34.71	26437602
1376	Phosphorylation	VAQWRTKYETDAIQR HHHHHHHHHHHHHHH	24.37	19764811
1378	Phosphorylation	QWRTKYETDAIQRTE HHHHHHHHHHHHHHH	27.86	19764811
1384	Phosphorylation	ETDAIQRTEELEEAK HHHHHHHHHHHHHHH	19.89	20068231
1391	Acetylation	TEELEEAKKKLAQRL HHHHHHHHHHHHHHH	54.44	19863031
1392	Acetylation	EELEEAKKKLAQRLQ HHHHHHHHHHHHHHC	61.13	30584677
1393	Acetylation	ELEEAKKKLAQRLQD HHHHHHHHHHHHHCC	48.63	30584695
1414	Phosphorylation	AVNAKCASLEKTKQR HHHHHHHCHHHHHHH	46.67	24719451
1418	Phosphorylation	KCASLEKTKQRLQGE HHHCHHHHHHHHHHH	24.04	24719451
1477	Phosphorylation	ASLKESRSLSTELFK HHHHHHHHHHHHHHH	35.63	19764811
1479	Phosphorylation	LKESRSLSTELFKLK HHHHHHHHHHHHHHH	22.53	19764811
1480	Phosphorylation	KESRSLSTELFKLKN HHHHHHHHHHHHHHH	41.84	19764811
1489	Phosphorylation	LFKLKNAYEEALDQL HHHHHHHHHHHHHHH	24.56	-
1523	Phosphorylation	QIAENGKTIHELEKS HHHHHCCCHHHHHHH	29.03	26437602
1571	Phosphorylation	LELTQVKSEIDRKIA HHHHHHHHHHHHHHH	40.71	26437602
1608	Phosphorylation	ALDAEVRSRNEAIRL HHHHHHHCHHHHHHH	44.63	26437602
1654	Phosphorylation	VQGQLKDTQLHLDDA HCCCHHCCHHHHHHH	31.29	26437602
1692	Phosphorylation	EVEELRATLEQTERA HHHHHHHHHHHHHHH	25.13	26437602
1696	Phosphorylation	LRATLEQTERARKLA HHHHHHHHHHHHHHH	20.33	26437602
1733	Phosphorylation	HTKKKLETDLMQLQS HCCHHHHHHHHHHHH	44.89	18452278
1740	Phosphorylation	TDLMQLQSEVEDASR HHHHHHHHHHHHHHH	52.80	28509920
1746	Phosphorylation	QSEVEDASRDARNAE HHHHHHHHHHHHHHH	42.91	28509920
1761	Phosphorylation	EKAKKAITDAAMMAE HHHHHHHHHHHHHHH	25.17	30576142
1771	Acetylation	AMMAEELKKEQDTSA HHHHHHHHHHHCCHH	58.50	30584701
1776	Phosphorylation	ELKKEQDTSAHLERM HHHHHHCCHHHHHHH	27.75	26437602
1777	Phosphorylation	LKKEQDTSAHLERMK HHHHHCCHHHHHHHH	23.21	26437602
1790	Phosphorylation	MKKNLEQTVKDLQHR HHHHHHHHHHHHHHH	21.83	26437602
1832	Acetylation	FELEGEQKKNTESVK HHCCCCCCCCCCCHH	43.62	19818609
1852	Phosphorylation	ERRVKELTYQSEEDR HHHHHHHHCCCHHHH	22.17	22673903
1853	Phosphorylation	RRVKELTYQSEEDRK HHHHHHHCCCHHHHC	23.75	22673903
1855	Phosphorylation	VKELTYQSEEDRKNV HHHHHCCCHHHHCHH	32.32	22673903
1877	Acetylation	DKLQVKVKSYKRQAE HHHHHHHHHHHHHHH	42.21	129351
1880	Acetylation	QVKVKSYKRQAEEAD HHHHHHHHHHHHHHH	45.16	129355
1895	Phosphorylation	EQANAHLTKFRKAQH HHHHHHHHHHHHHHH	20.47	20068231
1916	Phosphorylation	ERADIAESQVNKLRA HHHHHHHHHHHHHHH	30.33	19764811

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYH3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYH3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYH3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTN2_HUMAN	ACTN2	physical	26344197
TPM2_HUMAN	TPM2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 193700: Arthrogryposis, distal, 2A (DA2A)
• 601680: Arthrogryposis, distal, 2B (DA2B)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.