CAPR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAPR1_HUMAN
• UniProt AC: Q14444
• Protein Name: Caprin-1
• Gene Name: CAPRIN1
• Organism: Homo sapiens (Human).
• Sequence Length: 709
• Subcellular Localization: Cytoplasm, cytosol. Cell projection, dendrite. Associated with RNA granules..
• Protein Description: May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs..
• Protein Sequence: MPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPAVEDQVPEAEPEPAEEYTEQSEVESTEYVNRQFMAETQFTSGEKEQVDEWTVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQADPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQAGTSKPLHSSGINVNAAPFQSMQTVFNMNAPVPPVNEPETLKQQNQYQASYNQSFSSQPHQVEQTELQQEQLQTVVGTYHGSPDQSHQVTGNHQQPPQQNTGFPRSNQPYYNSRGVSRGGSRGARGLMNGYRGPANGFRGGYDGYRPSFSNTPNSGYTQSQFSAPRDYSGYQRDGYQQNFKRGSGQSGPRGAPRGRGGPPRPNRGMPQMNTQQVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MPSATSHSG ------CCCCCCCCC	32.44	21406692
3	Phosphorylation	-----MPSATSHSGS -----CCCCCCCCCC	42.77	23401153
5	Phosphorylation	---MPSATSHSGSGS ---CCCCCCCCCCCC	31.17	21406692
6	Phosphorylation	--MPSATSHSGSGSK --CCCCCCCCCCCCC	18.51	25849741
8	Phosphorylation	MPSATSHSGSGSKSS CCCCCCCCCCCCCCC	34.13	25849741
10	Phosphorylation	SATSHSGSGSKSSGP CCCCCCCCCCCCCCC	42.80	25849741
12	Phosphorylation	TSHSGSGSKSSGPPP CCCCCCCCCCCCCCC	30.94	22496350
14	Phosphorylation	HSGSGSKSSGPPPPS CCCCCCCCCCCCCCC	42.07	23401153
15	Phosphorylation	SGSGSKSSGPPPPSG CCCCCCCCCCCCCCC	60.08	23663014
21	Phosphorylation	SSGPPPPSGSSGSEA CCCCCCCCCCCHHHH	58.02	25159151
23	Phosphorylation	GPPPPSGSSGSEAAA CCCCCCCCCHHHHHC	35.54	25159151
24	Phosphorylation	PPPPSGSSGSEAAAG CCCCCCCCHHHHHCC	50.27	25159151
26	Phosphorylation	PPSGSSGSEAAAGAG CCCCCCHHHHHCCCC	26.47	25159151
39	Phosphorylation	AGAAAPASQHPATGT CCCCCCHHHCCCCCC	28.15	20068231
44	Phosphorylation	PASQHPATGTGAVQT CHHHCCCCCCCHHHH	39.46	20068231
46	Phosphorylation	SQHPATGTGAVQTEA HHCCCCCCCHHHHHH	20.01	20068231
51	Phosphorylation	TGTGAVQTEAMKQIL CCCCHHHHHHHHHHH	21.07	20068231
55	Ubiquitination	AVQTEAMKQILGVID HHHHHHHHHHHHHHH	41.03	29967540
63	2-Hydroxyisobutyrylation	QILGVIDKKLRNLEK HHHHHHHHHHHHHHH	42.45	-
63	Acetylation	QILGVIDKKLRNLEK HHHHHHHHHHHHHHH	42.45	23236377
63	Ubiquitination	QILGVIDKKLRNLEK HHHHHHHHHHHHHHH	42.45	32015554
64	Ubiquitination	ILGVIDKKLRNLEKK HHHHHHHHHHHHHHH	49.26	-
70	Ubiquitination	KKLRNLEKKKGKLDD HHHHHHHHHCCCHHH	64.05	23000965
71	2-Hydroxyisobutyrylation	KLRNLEKKKGKLDDY HHHHHHHHCCCHHHH	58.33	-
71	Ubiquitination	KLRNLEKKKGKLDDY HHHHHHHHCCCHHHH	58.33	23000965
72	Acetylation	LRNLEKKKGKLDDYQ HHHHHHHCCCHHHHH	72.80	25953088
72	Ubiquitination	LRNLEKKKGKLDDYQ HHHHHHHCCCHHHHH	72.80	23000965
74	Acetylation	NLEKKKGKLDDYQER HHHHHCCCHHHHHHH	58.59	23749302
74	Malonylation	NLEKKKGKLDDYQER HHHHHCCCHHHHHHH	58.59	26320211
74	Methylation	NLEKKKGKLDDYQER HHHHHCCCHHHHHHH	58.59	-
74	Ubiquitination	NLEKKKGKLDDYQER HHHHHCCCHHHHHHH	58.59	23000965
74 (in isoform 1)	Ubiquitination	-	58.59	21890473
74 (in isoform 2)	Ubiquitination	-	58.59	21890473
78	Phosphorylation	KKGKLDDYQERMNKG HCCCHHHHHHHHHHH	16.37	28152594
81	Methylation	KLDDYQERMNKGERL CHHHHHHHHHHHCCC	20.60	-
97	Phosphorylation	QDQLDAVSKYQEVTN HHHHHHHHHHHHHHH	27.63	22985185
98	2-Hydroxyisobutyrylation	DQLDAVSKYQEVTNN HHHHHHHHHHHHHHH	44.34	-
98	Acetylation	DQLDAVSKYQEVTNN HHHHHHHHHHHHHHH	44.34	26051181
98	Ubiquitination	DQLDAVSKYQEVTNN HHHHHHHHHHHHHHH	44.34	32015554
99	Phosphorylation	QLDAVSKYQEVTNNL HHHHHHHHHHHHHHH	11.47	28152594
110	Acetylation	TNNLEFAKELQRSFM HHHHHHHHHHHHHHH	65.36	26051181
110	Methylation	TNNLEFAKELQRSFM HHHHHHHHHHHHHHH	65.36	-
110	Ubiquitination	TNNLEFAKELQRSFM HHHHHHHHHHHHHHH	65.36	23000965
110 (in isoform 1)	Ubiquitination	-	65.36	21890473
110 (in isoform 2)	Ubiquitination	-	65.36	21890473
115	Phosphorylation	FAKELQRSFMALSQD HHHHHHHHHHHHHHH	13.35	30266825
117	Sulfoxidation	KELQRSFMALSQDIQ HHHHHHHHHHHHHHH	3.75	21406390
120	Phosphorylation	QRSFMALSQDIQKTI HHHHHHHHHHHHHHH	19.10	30266825
125	Acetylation	ALSQDIQKTIKKTAR HHHHHHHHHHHHHHH	53.18	25953088
125	Malonylation	ALSQDIQKTIKKTAR HHHHHHHHHHHHHHH	53.18	32601280
125	Ubiquitination	ALSQDIQKTIKKTAR HHHHHHHHHHHHHHH	53.18	23000965
125 (in isoform 1)	Ubiquitination	-	53.18	21890473
125 (in isoform 2)	Ubiquitination	-	53.18	21890473
126	Phosphorylation	LSQDIQKTIKKTARR HHHHHHHHHHHHHHH	22.96	-
128	Ubiquitination	QDIQKTIKKTARREQ HHHHHHHHHHHHHHH	49.67	23000965
129	Ubiquitination	DIQKTIKKTARREQL HHHHHHHHHHHHHHH	43.49	23000965
144	Ubiquitination	MREEAEQKRLKTVLE HHHHHHHHHHHHHHH	51.72	24816145
147	Ubiquitination	EAEQKRLKTVLELQY HHHHHHHHHHHHHHH	40.39	-
148	Phosphorylation	AEQKRLKTVLELQYV HHHHHHHHHHHHHHH	34.61	22210691
154	Phosphorylation	KTVLELQYVLDKLGD HHHHHHHHHHHHHCC	18.66	22210691
158	Ubiquitination	ELQYVLDKLGDDEVR HHHHHHHHHCCHHHH	50.65	22817900
158 (in isoform 1)	Ubiquitination	-	50.65	21890473
158 (in isoform 2)	Ubiquitination	-	50.65	21890473
165	Methylation	KLGDDEVRTDLKQGL HHCCHHHHHHHHHCC	22.07	-
169	Ubiquitination	DEVRTDLKQGLNGVP HHHHHHHHHCCCCCC	45.17	32015554
169 (in isoform 2)	Ubiquitination	-	45.17	-
179	Phosphorylation	LNGVPILSEEELSLL CCCCCCCCHHHHHHH	43.62	-
200	Phosphorylation	VDPERDMSLRLNEQY HCCCCCHHHHHHHHH	18.02	28348404
221	Acetylation	LWDLLEGKEKPVCGT HHHHHCCCCCCCCCC	53.87	26051181
221	Ubiquitination	LWDLLEGKEKPVCGT HHHHHCCCCCCCCCC	53.87	29967540
223	Acetylation	DLLEGKEKPVCGTTY HHHCCCCCCCCCCHH	46.35	25953088
223	Ubiquitination	DLLEGKEKPVCGTTY HHHCCCCCCCCCCHH	46.35	27667366
226	S-nitrosocysteine	EGKEKPVCGTTYKVL CCCCCCCCCCHHHHH	5.63	-
226	S-nitrosylation	EGKEKPVCGTTYKVL CCCCCCCCCCHHHHH	5.63	19483679
231	Acetylation	PVCGTTYKVLKEIVE CCCCCHHHHHHHHHH	38.71	26051181
231	Ubiquitination	PVCGTTYKVLKEIVE CCCCCHHHHHHHHHH	38.71	32015554
234	Acetylation	GTTYKVLKEIVERVF CCHHHHHHHHHHHHH	48.67	26822725
234	Ubiquitination	GTTYKVLKEIVERVF CCHHHHHHHHHHHHH	48.67	33845483
264	Phosphorylation	CEEEEAASAPAVEDQ CCHHHHHCCCCHHHC	41.66	30576142
282	Phosphorylation	AEPEPAEEYTEQSEV CCCCCHHHHCCCCCC	60.92	18669648
283	Phosphorylation	EPEPAEEYTEQSEVE CCCCHHHHCCCCCCC	13.69	22817900
287	Phosphorylation	AEEYTEQSEVESTEY HHHHCCCCCCCCCHH	37.06	-
291	Phosphorylation	TEQSEVESTEYVNRQ CCCCCCCCCHHHCHH	31.54	26074081
292	Phosphorylation	EQSEVESTEYVNRQF CCCCCCCCHHHCHHH	20.17	18669648
294	Phosphorylation	SEVESTEYVNRQFMA CCCCCCHHHCHHHHH	11.78	26074081
300	Sulfoxidation	EYVNRQFMAETQFTS HHHCHHHHHEECCCC	2.20	21406390
303	Phosphorylation	NRQFMAETQFTSGEK CHHHHHEECCCCCCC	21.31	22199227
306	Phosphorylation	FMAETQFTSGEKEQV HHHEECCCCCCCCCC	26.46	25850435
307	Phosphorylation	MAETQFTSGEKEQVD HHEECCCCCCCCCCC	46.36	25159151
317	Phosphorylation	KEQVDEWTVETVEVV CCCCCEEEEEEHHHH	13.35	23663014
320	Phosphorylation	VDEWTVETVEVVNSL CCEEEEEEHHHHHHH	20.03	23663014
326	Phosphorylation	ETVEVVNSLQQQPQA EEHHHHHHHHHCCCC	18.88	23663014
335	Phosphorylation	QQQPQAASPSVPEPH HHCCCCCCCCCCCCC	22.26	30278072
337	Phosphorylation	QPQAASPSVPEPHSL CCCCCCCCCCCCCCC	48.05	23663014
343	Phosphorylation	PSVPEPHSLTPVAQA CCCCCCCCCCCHHHC	44.66	23663014
345	Phosphorylation	VPEPHSLTPVAQADP CCCCCCCCCHHHCCH	20.80	21082442
384	O-linked_Glycosylation	MLDFENQTLDPAIVS HHHCCCCCCCHHHHC	44.72	23301498
398	Phosphorylation	SAQPMNPTQNMDMPQ CCCCCCCCCCCCCCC	27.80	-
430	Phosphorylation	VPVQPEATQVPLVSS CCCCCCCCCCCCEEE	28.56	21945579
436	O-linked_Glycosylation	ATQVPLVSSTSEGYT CCCCCCEEECCCCCC	35.26	23301498
436	Phosphorylation	ATQVPLVSSTSEGYT CCCCCCEEECCCCCC	35.26	21945579
437	Phosphorylation	TQVPLVSSTSEGYTA CCCCCEEECCCCCCC	28.59	21945579
438	Phosphorylation	QVPLVSSTSEGYTAS CCCCEEECCCCCCCC	24.24	21945579
439	Phosphorylation	VPLVSSTSEGYTASQ CCCEEECCCCCCCCC	30.85	21945579
442	Phosphorylation	VSSTSEGYTASQPLY EEECCCCCCCCCCCC	8.62	21945579
443	Phosphorylation	SSTSEGYTASQPLYQ EECCCCCCCCCCCCC	30.59	21945579
445	Phosphorylation	TSEGYTASQPLYQPS CCCCCCCCCCCCCCC	25.24	21945579
449	Phosphorylation	YTASQPLYQPSHATE CCCCCCCCCCCCCCC	25.68	21945579
452	Phosphorylation	SQPLYQPSHATEQRP CCCCCCCCCCCCCCC	15.38	21945579
455	Phosphorylation	LYQPSHATEQRPQKE CCCCCCCCCCCCCCC	27.51	21945579
472	O-linked_Glycosylation	DQIQATISLNTDQTT CCEEEEEECCCCCCC	15.94	23301498
475	O-linked_Glycosylation	QATISLNTDQTTASS EEEEECCCCCCCCCC	34.47	23301498
488	O-linked_Glycosylation	SSSLPAASQPQVFQA CCCCCCCCCCCEECC	44.49	23301498
498	Phosphorylation	QVFQAGTSKPLHSSG CEECCCCCCCCCCCC	31.21	24719451
503	Phosphorylation	GTSKPLHSSGINVNA CCCCCCCCCCCCCCC	37.63	28348404
504	Phosphorylation	TSKPLHSSGINVNAA CCCCCCCCCCCCCCC	32.70	28348404
541	Phosphorylation	TLKQQNQYQASYNQS HHHHHHCHHHHHCCC	17.37	22817900
545	Phosphorylation	QNQYQASYNQSFSSQ HHCHHHHHCCCCCCC	21.90	22817900
568	Phosphorylation	LQQEQLQTVVGTYHG HHHHHHHHHHHCCCC	26.25	29496963
572	Phosphorylation	QLQTVVGTYHGSPDQ HHHHHHHCCCCCCCC	10.75	-
573	Phosphorylation	LQTVVGTYHGSPDQS HHHHHHCCCCCCCCC	9.77	-
576	Phosphorylation	VVGTYHGSPDQSHQV HHHCCCCCCCCCCCC	16.40	26074081
580	Phosphorylation	YHGSPDQSHQVTGNH CCCCCCCCCCCCCCC	24.22	26074081
584	Phosphorylation	PDQSHQVTGNHQQPP CCCCCCCCCCCCCCC	26.20	26074081
595	Phosphorylation	QQPPQQNTGFPRSNQ CCCCCCCCCCCCCCC	35.54	26074081
600	Phosphorylation	QNTGFPRSNQPYYNS CCCCCCCCCCCCCCC	39.80	26074081
604	Phosphorylation	FPRSNQPYYNSRGVS CCCCCCCCCCCCCCC	12.91	26074081
608	Dimethylation	NQPYYNSRGVSRGGS CCCCCCCCCCCCCCC	45.99	-
608	Methylation	NQPYYNSRGVSRGGS CCCCCCCCCCCCCCC	45.99	-
611	Phosphorylation	YYNSRGVSRGGSRGA CCCCCCCCCCCCCCH	28.21	17924679
612	Dimethylation	YNSRGVSRGGSRGAR CCCCCCCCCCCCCHH	51.60	-
612	Methylation	YNSRGVSRGGSRGAR CCCCCCCCCCCCCHH	51.60	-
615	Phosphorylation	RGVSRGGSRGARGLM CCCCCCCCCCHHHHC	30.30	17924679
616	Dimethylation	GVSRGGSRGARGLMN CCCCCCCCCHHHHCC	46.17	-
616	Methylation	GVSRGGSRGARGLMN CCCCCCCCCHHHHCC	46.17	-
619	Dimethylation	RGGSRGARGLMNGYR CCCCCCHHHHCCCCC	41.42	-
619	Methylation	RGGSRGARGLMNGYR CCCCCCHHHHCCCCC	41.42	-
626	Methylation	RGLMNGYRGPANGFR HHHCCCCCCCCCCCC	46.12	24129315
633	Dimethylation	RGPANGFRGGYDGYR CCCCCCCCCCCCCCC	38.74	-
633	Methylation	RGPANGFRGGYDGYR CCCCCCCCCCCCCCC	38.74	24129315
636	Phosphorylation	ANGFRGGYDGYRPSF CCCCCCCCCCCCCCC	14.71	28152594
639	Phosphorylation	FRGGYDGYRPSFSNT CCCCCCCCCCCCCCC	19.22	28152594
640	Dimethylation	RGGYDGYRPSFSNTP CCCCCCCCCCCCCCC	26.39	-
640	Methylation	RGGYDGYRPSFSNTP CCCCCCCCCCCCCCC	26.39	24129315
642	Phosphorylation	GYDGYRPSFSNTPNS CCCCCCCCCCCCCCC	32.10	28152594
644	Phosphorylation	DGYRPSFSNTPNSGY CCCCCCCCCCCCCCC	44.10	28152594
646	Phosphorylation	YRPSFSNTPNSGYTQ CCCCCCCCCCCCCCC	23.73	28152594
649	Phosphorylation	SFSNTPNSGYTQSQF CCCCCCCCCCCCCCC	34.09	28450419
651	Phosphorylation	SNTPNSGYTQSQFSA CCCCCCCCCCCCCCC	11.04	26074081
652	Phosphorylation	NTPNSGYTQSQFSAP CCCCCCCCCCCCCCC	25.85	27174698
654	Phosphorylation	PNSGYTQSQFSAPRD CCCCCCCCCCCCCCC	25.95	26074081
657	Phosphorylation	GYTQSQFSAPRDYSG CCCCCCCCCCCCCCC	29.71	26074081
662	Phosphorylation	QFSAPRDYSGYQRDG CCCCCCCCCCCCCCC	12.79	28796482
663	Phosphorylation	FSAPRDYSGYQRDGY CCCCCCCCCCCCCCC	35.00	28796482
665	Phosphorylation	APRDYSGYQRDGYQQ CCCCCCCCCCCCCHH	8.40	28796482
667	Dimethylation	RDYSGYQRDGYQQNF CCCCCCCCCCCHHCC	30.73	-
667	Methylation	RDYSGYQRDGYQQNF CCCCCCCCCCCHHCC	30.73	-
670	Phosphorylation	SGYQRDGYQQNFKRG CCCCCCCCHHCCCCC	15.94	28796482
675	Methylation	DGYQQNFKRGSGQSG CCCHHCCCCCCCCCC	64.50	-
678	Phosphorylation	QQNFKRGSGQSGPRG HHCCCCCCCCCCCCC	37.38	20068231
681	Phosphorylation	FKRGSGQSGPRGAPR CCCCCCCCCCCCCCC	55.05	20068231
690	Methylation	PRGAPRGRGGPPRPN CCCCCCCCCCCCCCC	48.45	-
695	Methylation	RGRGGPPRPNRGMPQ CCCCCCCCCCCCCCC	44.23	-
698	Asymmetric dimethylarginine	GGPPRPNRGMPQMNT CCCCCCCCCCCCCCC	45.53	-
698	Methylation	GGPPRPNRGMPQMNT CCCCCCCCCCCCCCC	45.53	24129315

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAPR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAPR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAPR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
G3BP1_HUMAN	G3BP1	physical	17210633
A4_HUMAN	APP	physical	21832049
CIRBP_HUMAN	CIRBP	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-611 AND SER-615, ANDMASS SPECTROMETRY.
PubMed: 17924679