CIRBP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CIRBP_HUMAN
• UniProt AC: Q14011
• Protein Name: Cold-inducible RNA-binding protein
• Gene Name: CIRBP
• Organism: Homo sapiens (Human).
• Sequence Length: 172
• Subcellular Localization: Nucleus, nucleoplasm . Cytoplasm . Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks.
• Protein Description: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed..
• Protein Sequence: MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGDRGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	KLFVGGLSFDTNEQS CEEECCEECCCCHHH	25.09	27732954
17	Phosphorylation	VGGLSFDTNEQSLEQ ECCEECCCCHHHHHH	38.35	27732954
21	Phosphorylation	SFDTNEQSLEQVFSK ECCCCHHHHHHHHHH	27.91	27732954
27	Phosphorylation	QSLEQVFSKYGQISE HHHHHHHHHHCCEEE	26.55	28122231
29	Phosphorylation	LEQVFSKYGQISEVV HHHHHHHHCCEEEEE	17.05	28152594
31	Ubiquitination	QVFSKYGQISEVVVV HHHHHHCCEEEEEEE	32.70	-
33	Phosphorylation	FSKYGQISEVVVVKD HHHHCCEEEEEEEEC	19.22	28152594
43	Phosphorylation	VVVKDRETQRSRGFG EEEECCCCCHHCCEE	30.12	-
47	Methylation	DRETQRSRGFGFVTF CCCCCHHCCEEEEEE	46.80	-
70	Acetylation	AMMAMNGKSVDGRQI HHHHHCCEECCCCEE	42.15	-
70	Acetylation	AMMAMNGKSVDGRQI HHHHHCCEECCCCEE	42.15	26051181
71	Phosphorylation	MMAMNGKSVDGRQIR HHHHCCEECCCCEEE	27.17	20068231
84	Ubiquitination	IRVDQAGKSSDNRSR EEEECCCCCCCCCCC	50.21	21906983
94	Methylation	DNRSRGYRGGSAGGR CCCCCCCCCCCCCCC	45.91	-
94	Dimethylation	DNRSRGYRGGSAGGR CCCCCCCCCCCCCCC	45.91	-
101	Methylation	RGGSAGGRGFFRGGR CCCCCCCCCCCCCCC	37.52	-
101	Dimethylation	RGGSAGGRGFFRGGR CCCCCCCCCCCCCCC	37.52	-
105	Methylation	AGGRGFFRGGRGRGR CCCCCCCCCCCCCCC	44.38	-
105	Dimethylation	AGGRGFFRGGRGRGR CCCCCCCCCCCCCCC	44.38	-
110 (in isoform 3)	Phosphorylation	-	30.21	21815630
116	Methylation	GRGRGFSRGGGDRGY CCCCCCCCCCCCCCC	45.58	-
121	Methylation	FSRGGGDRGYGGNRF CCCCCCCCCCCCCCC	43.43	-
123	Phosphorylation	RGGGDRGYGGNRFES CCCCCCCCCCCCCCC	23.82	-
127	Methylation	DRGYGGNRFESRSGG CCCCCCCCCCCCCCC	39.73	-
129 (in isoform 2)	Phosphorylation	-	41.84	21815630
130	Phosphorylation	YGGNRFESRSGGYGG CCCCCCCCCCCCCCC	29.09	24670416
131	Methylation	GGNRFESRSGGYGGS CCCCCCCCCCCCCCC	31.93	-
132	Phosphorylation	GNRFESRSGGYGGSR CCCCCCCCCCCCCCC	45.94	21945579
135	Phosphorylation	FESRSGGYGGSRDYY CCCCCCCCCCCCCCC	23.10	21945579
138	Phosphorylation	RSGGYGGSRDYYSSR CCCCCCCCCCCCCCC	20.02	21945579
139	Methylation	SGGYGGSRDYYSSRS CCCCCCCCCCCCCCC	38.94	-
141	Phosphorylation	GYGGSRDYYSSRSQS CCCCCCCCCCCCCCC	12.25	21945579
142	Phosphorylation	YGGSRDYYSSRSQSG CCCCCCCCCCCCCCC	12.40	21945579
143	Phosphorylation	GGSRDYYSSRSQSGG CCCCCCCCCCCCCCC	17.04	21945579
144	Phosphorylation	GSRDYYSSRSQSGGY CCCCCCCCCCCCCCC	21.60	21945579
145	Methylation	SRDYYSSRSQSGGYS CCCCCCCCCCCCCCC	32.54	-
146	Phosphorylation	RDYYSSRSQSGGYSD CCCCCCCCCCCCCCC	30.55	22617229
148	Phosphorylation	YYSSRSQSGGYSDRS CCCCCCCCCCCCCCC	35.12	22617229
151	Phosphorylation	SRSQSGGYSDRSSGG CCCCCCCCCCCCCCC	15.78	28450419
152	Phosphorylation	RSQSGGYSDRSSGGS CCCCCCCCCCCCCCC	29.80	28450419
154	Methylation	QSGGYSDRSSGGSYR CCCCCCCCCCCCCCC	27.12	-
155	Phosphorylation	SGGYSDRSSGGSYRD CCCCCCCCCCCCCCC	38.02	23401153
156	Phosphorylation	GGYSDRSSGGSYRDS CCCCCCCCCCCCCCC	48.33	21712546
159	Phosphorylation	SDRSSGGSYRDSYDS CCCCCCCCCCCCCCC	22.11	23401153
160	Phosphorylation	DRSSGGSYRDSYDSY CCCCCCCCCCCCCCC	23.01	30177828
163	Phosphorylation	SGGSYRDSYDSYATH CCCCCCCCCCCCCCC	23.11	22617229
164	Phosphorylation	GGSYRDSYDSYATHN CCCCCCCCCCCCCCC	17.13	30177828
166	Phosphorylation	SYRDSYDSYATHNE- CCCCCCCCCCCCCC-	14.40	23898821
167	Phosphorylation	YRDSYDSYATHNE-- CCCCCCCCCCCCC--	16.78	27273156
169	Phosphorylation	DSYDSYATHNE---- CCCCCCCCCCC----	19.59	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CIRBP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CIRBP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CIRBP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBMX_HUMAN	RBMX	physical	16189514
A4_HUMAN	APP	physical	21832049
SF01_HUMAN	SF1	physical	22939629
RTN4_HUMAN	RTN4	physical	22939629
CNOT3_HUMAN	CNOT3	physical	22939629
KAP2_HUMAN	PRKAR2A	physical	22939629
LS14A_HUMAN	LSM14A	physical	22939629
TPR_HUMAN	TPR	physical	22939629
FUBP2_HUMAN	KHSRP	physical	22939629
T2FA_HUMAN	GTF2F1	physical	22939629
NUP88_HUMAN	NUP88	physical	22939629
LAP2A_HUMAN	TMPO	physical	22939629
LAP2B_HUMAN	TMPO	physical	22939629
HNRH2_HUMAN	HNRNPH2	physical	22939629
RPAC1_HUMAN	POLR1C	physical	22939629
ROA0_HUMAN	HNRNPA0	physical	22365833
HNRPK_HUMAN	HNRNPK	physical	22365833
KHDR1_HUMAN	KHDRBS1	physical	22365833
IL7RA_HUMAN	IL7R	physical	23151878
SRF_HUMAN	SRF	physical	21988832
HNRPK_HUMAN	HNRNPK	physical	25416956
RBY1A_HUMAN	RBMY1A1	physical	25416956
SNRPA_HUMAN	SNRPA	physical	25416956
RBMX_HUMAN	RBMX	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
RBY1F_HUMAN	RBMY1F	physical	25416956
KHDR2_HUMAN	KHDRBS2	physical	25416956
CCNB2_HUMAN	CCNB2	physical	26344197
NAA20_HUMAN	NAA20	physical	26344197
SYNC_HUMAN	NARS	physical	26344197
HNRPK_HUMAN	HNRNPK	physical	21516116
ANM5_HUMAN	PRMT5	physical	28514442
COPRS_HUMAN	COPRS	physical	28514442
RIOK1_HUMAN	RIOK1	physical	28514442
ANM1_HUMAN	PRMT1	physical	28514442
SYYM_HUMAN	YARS2	physical	28514442
NGRN_HUMAN	NGRN	physical	28514442
PAI2B_HUMAN	PAIP2B	physical	28514442
ANM6_HUMAN	PRMT6	physical	28514442
RM01_HUMAN	MRPL1	physical	28514442
MEP50_HUMAN	WDR77	physical	28514442
MASU1_HUMAN	MALSU1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.