COPRS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPRS_HUMAN
• UniProt AC: Q9NQ92
• Protein Name: Coordinator of PRMT5 and differentiation stimulator
• Gene Name: COPRS
• Organism: Homo sapiens (Human).
• Sequence Length: 184
• Subcellular Localization: Nucleus .
• Protein Description: Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity)..
• Protein Sequence: MDLQAAGAQAQGAAEPSRGPPLPSARGAPPSPEAGFATADHSSQERETEKAMDRLARGTQSIPNDSPARGEGTHSEEEGFAMDEEDSDGELNTWELSEGTNCPPKEQPGDLFNEDWDSELKADQGNPYDADDIQESISQELKPWVCCAPQGDMIYDPSWHHPPPLIPYYSKMVFETGQFDDAED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDLQAAGA -------CCHHHHHH		22814378
17	Phosphorylation	AQGAAEPSRGPPLPS HCCCCCCCCCCCCCC		26074081
18	Methylation	QGAAEPSRGPPLPSA CCCCCCCCCCCCCCC		-
24	Phosphorylation	SRGPPLPSARGAPPS CCCCCCCCCCCCCCC		26074081
26	Methylation	GPPLPSARGAPPSPE CCCCCCCCCCCCCCC		-
31	Phosphorylation	SARGAPPSPEAGFAT CCCCCCCCCCCCCCC		28176443
38	Phosphorylation	SPEAGFATADHSSQE CCCCCCCCCCCCHHH		26074081
42	Phosphorylation	GFATADHSSQERETE CCCCCCCCHHHHHHH		28176443
43	Phosphorylation	FATADHSSQERETEK CCCCCCCHHHHHHHH		26074081
48	Phosphorylation	HSSQERETEKAMDRL CCHHHHHHHHHHHHH		26074081
57	Methylation	KAMDRLARGTQSIPN HHHHHHHHCCCCCCC		-
59	Phosphorylation	MDRLARGTQSIPNDS HHHHHHCCCCCCCCC		29255136
61	Phosphorylation	RLARGTQSIPNDSPA HHHHCCCCCCCCCCC		29255136
66	Phosphorylation	TQSIPNDSPARGEGT CCCCCCCCCCCCCCC		29255136
73	Phosphorylation	SPARGEGTHSEEEGF CCCCCCCCCCCCCCC		26074081
75	Phosphorylation	ARGEGTHSEEEGFAM CCCCCCCCCCCCCCC		30576142
87	Phosphorylation	FAMDEEDSDGELNTW CCCCCCCCCCCEEEE		30576142
93	Phosphorylation	DSDGELNTWELSEGT CCCCCEEEEEECCCC		30576142
97	Phosphorylation	ELNTWELSEGTNCPP CEEEEEECCCCCCCC		30576142
100	Phosphorylation	TWELSEGTNCPPKEQ EEEECCCCCCCCCCC		30576142
128	Phosphorylation	KADQGNPYDADDIQE CCCCCCCCCHHHHHH		-
138	Phosphorylation	DDIQESISQELKPWV HHHHHHHHHHHCCCE		25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPRS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPRS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPRS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RUNX1_HUMAN	RUNX1	physical	22193545
ANM5_HUMAN	PRMT5	physical	22193545
PEBB_HUMAN	CBFB	physical	22193545
ANM5_HUMAN	PRMT5	physical	18404153
H31T_HUMAN	HIST3H3	physical	18404153

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.