ARHL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARHL2_HUMAN
• UniProt AC: Q9NX46
• Protein Name: Poly(ADP-ribose) glycohydrolase ARH3
• Gene Name: ADPRHL2
• Organism: Homo sapiens (Human).
• Sequence Length: 363
• Subcellular Localization: Cytoplasm . Mitochondrion matrix . Nucleus .
• Protein Description: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria..
• Protein Sequence: MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHDTVDLTSVLRHVQSLEPDPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGVVTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQLTHASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDARELGMEERPYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNSLQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVFQKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	Succinylation	HRFAQEYKKDPDRGY HHHHHHHHHCCCCCC	50.36	23954790
125	Acetylation	AGVVTVFKKLLNPKC CCHHHHHHHHHCHHH	37.87	25038526
131	Acetylation	FKKLLNPKCRDVFEP HHHHHCHHHHHCCHH	40.61	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARHL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARHL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARHL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IMDH2_HUMAN	IMPDH2	physical	26344197
PCID2_HUMAN	PCID2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.