dbPTM

DDX3Y_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DDX3Y_HUMAN
UniProt AC	O15523
Protein Name	ATP-dependent RNA helicase DDX3Y
Gene Name	DDX3Y
Organism	Homo sapiens (Human).
Sequence Length	660
Subcellular Localization	Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.
Protein Description	Probable ATP-dependent RNA helicase. May play a role in spermatogenesis..
Protein Sequence	MSHVVVKNDPELDQQLANLDLNSEKQSGGASTASKGRYIPPHLRNREASKGFHDKDSSGWSCSKDKDAYSSFGSRDSRGKPGYFSERGSGSRGRFDDRGRSDYDGIGNRERPGFGRFERSGHSRWCDKSVEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGSNCPPHIENFSDIDMGEIIMGNIELTRYTRPTPVQKHAIPIIKGKRDLMACAQTGSGKTAAFLLPILSQIYTDGPGEALKAVKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEDLDKRSFLLDILGATGSDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNEKNMNITKDLLDLLVEAKQEVPSWLENMAYEHHYKGGSRGRSKSNRFSGGFGARDYRQSSGSSSSGFGASRGSSSRSGGGGYGNSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSHVVVKND ------CCCEEECCC	25.62	-
23	Phosphorylation	LANLDLNSEKQSGGA HHCCCCCCCCCCCCC	54.17	30622161
25	Ubiquitination	NLDLNSEKQSGGAST CCCCCCCCCCCCCCC	49.97	-
34	Phosphorylation	SGGASTASKGRYIPP CCCCCCCCCCCCCCH	35.41	22210691
38	Phosphorylation	STASKGRYIPPHLRN CCCCCCCCCCHHHCC	26.84	22210691
49	Phosphorylation	HLRNREASKGFHDKD HHCCCHHHCCCCCCC	28.67	20068231
55	Acetylation	ASKGFHDKDSSGWSC HHCCCCCCCCCCCCC	51.44	-
66	Malonylation	GWSCSKDKDAYSSFG CCCCCCCHHHHHCCC	48.25	26320211
66	Methylation	GWSCSKDKDAYSSFG CCCCCCCHHHHHCCC	48.25	-
66	Ubiquitination	GWSCSKDKDAYSSFG CCCCCCCHHHHHCCC	48.25	-
69	Phosphorylation	CSKDKDAYSSFGSRD CCCCHHHHHCCCCCC	18.25	25159151
70	Phosphorylation	SKDKDAYSSFGSRDS CCCHHHHHCCCCCCC	22.40	27273156
71	Phosphorylation	KDKDAYSSFGSRDSR CCHHHHHCCCCCCCC	22.43	23401153
74	Phosphorylation	DAYSSFGSRDSRGKP HHHHCCCCCCCCCCC	30.79	23401153
75	Methylation	AYSSFGSRDSRGKPG HHHCCCCCCCCCCCC	46.43	-
77	Phosphorylation	SSFGSRDSRGKPGYF HCCCCCCCCCCCCCC	41.65	29083192
78	Methylation	SFGSRDSRGKPGYFS CCCCCCCCCCCCCCC	62.54	-
85	Phosphorylation	RGKPGYFSERGSGSR CCCCCCCCCCCCCCC	20.21	23401153
87	Methylation	KPGYFSERGSGSRGR CCCCCCCCCCCCCCC	43.30	-
89	Phosphorylation	GYFSERGSGSRGRFD CCCCCCCCCCCCCCC	39.55	24961811
98	Methylation	SRGRFDDRGRSDYDG CCCCCCCCCCCCCCC	44.24	-
100	Methylation	GRFDDRGRSDYDGIG CCCCCCCCCCCCCCC	27.52	-
101	Phosphorylation	RFDDRGRSDYDGIGN CCCCCCCCCCCCCCC	43.26	23401153
103	Phosphorylation	DDRGRSDYDGIGNRE CCCCCCCCCCCCCCC	19.81	21609022
109	Methylation	DYDGIGNRERPGFGR CCCCCCCCCCCCCCC	35.77	-
129	Phosphorylation	HSRWCDKSVEDDWSK CCCCCCCCCCCCCCC	19.93	-
135	Phosphorylation	KSVEDDWSKPLPPSE CCCCCCCCCCCCHHH	31.24	24719451
150	Phosphorylation	RLEQELFSGGNTGIN HHHHHHHCCCCCCCC	59.42	21815630
154	Phosphorylation	ELFSGGNTGINFEKY HHHCCCCCCCCCCCC	42.59	20873877
161	Phosphorylation	TGINFEKYDDIPVEA CCCCCCCCCCCCCCC	16.20	-
181	Phosphorylation	PPHIENFSDIDMGEI CCCCCCCCCCCCCHH	45.28	-
198	Phosphorylation	GNIELTRYTRPTPVQ EEEEEEEECCCCCCH	11.23	28152594
199	Phosphorylation	NIELTRYTRPTPVQK EEEEEEECCCCCCHH	27.21	21406692
202	Phosphorylation	LTRYTRPTPVQKHAI EEEECCCCCCHHCCC	32.57	28152594
203	Ubiquitination	TRYTRPTPVQKHAIP EEECCCCCCHHCCCC	29.26	-
206	Ubiquitination	TRPTPVQKHAIPIIK CCCCCCHHCCCCEEC	34.93	21890473
206	Ubiquitination	TRPTPVQKHAIPIIK CCCCCCHHCCCCEEC	34.93	21890473
213	Ubiquitination	KHAIPIIKGKRDLMA HCCCCEECCCHHHHH	60.13	-
221	Glutathionylation	GKRDLMACAQTGSGK CCHHHHHHCCCCCCH	1.47	22555962
224	Phosphorylation	DLMACAQTGSGKTAA HHHHHCCCCCCHHHH	18.13	20873877
226	Phosphorylation	MACAQTGSGKTAAFL HHHCCCCCCHHHHHH	40.27	20873877
229	Phosphorylation	AQTGSGKTAAFLLPI CCCCCCHHHHHHHHH	27.09	-
247	Ubiquitination	IYTDGPGEALKAVKE HHCCCCCHHHHHHHH	54.70	21890473
250	Ubiquitination	DGPGEALKAVKENGR CCCCHHHHHHHHHCC	59.17	21890473
258	Phosphorylation	AVKENGRYGRRKQYP HHHHHCCCCCCCCCC	19.18	-
259	Ubiquitination	VKENGRYGRRKQYPI HHHHCCCCCCCCCCC	22.89	-
262	Ubiquitination	NGRYGRRKQYPISLV HCCCCCCCCCCCEEE	53.47	21890473
262	Ubiquitination	NGRYGRRKQYPISLV HCCCCCCCCCCCEEE	53.47	21890473
264	Phosphorylation	RYGRRKQYPISLVLA CCCCCCCCCCEEEEC	12.93	20090780
267	Phosphorylation	RRKQYPISLVLAPTR CCCCCCCEEEECCCH	14.12	28152594
281	Phosphorylation	RELAVQIYEEARKFS HHHHHHHHHHHHHCC	7.22	28152594
288	Phosphorylation	YEEARKFSYRSRVRP HHHHHHCCHHHCCCC	23.75	24144214
289	Phosphorylation	EEARKFSYRSRVRPC HHHHHCCHHHCCCCE	18.75	24144214
291	Phosphorylation	ARKFSYRSRVRPCVV HHHCCHHHCCCCEEE	27.22	24144214
296	Glutathionylation	YRSRVRPCVVYGGAD HHHCCCCEEEECCCC	1.96	22555962
299	Phosphorylation	RVRPCVVYGGADIGQ CCCCEEEECCCCHHH	6.88	28152594
313	Methylation	QQIRDLERGCHLLVA HHHHHHHCCCEEEEE	61.41	-
315	S-nitrosocysteine	IRDLERGCHLLVATP HHHHHCCCEEEEECC	2.27	-
315	Glutathionylation	IRDLERGCHLLVATP HHHHHCCCEEEEECC	2.27	22555962
315	S-nitrosylation	IRDLERGCHLLVATP HHHHHCCCEEEEECC	2.27	19483679
315	S-palmitoylation	IRDLERGCHLLVATP HHHHHCCCEEEEECC	2.27	26865113
321	Phosphorylation	GCHLLVATPGRLVDM CCEEEEECCCHHHHH	20.85	25159151
330	Ubiquitination	GRLVDMMERGKIGLD CHHHHHHHCCCCCHH	52.20	-
333	Ubiquitination	VDMMERGKIGLDFCK HHHHHCCCCCHHHHH	39.56	21890473
337	Ubiquitination	ERGKIGLDFCKYLVL HCCCCCHHHHHHHHC	41.50	-
339	Glutathionylation	GKIGLDFCKYLVLDE CCCCHHHHHHHHCCH	2.57	22555962
340	Ubiquitination	KIGLDFCKYLVLDEA CCCHHHHHHHHCCHH	41.43	-
341	Phosphorylation	IGLDFCKYLVLDEAD CCHHHHHHHHCCHHH	11.83	28152594
360	Methylation	MGFEPQIRRIVEQDT CCCHHHHHHHHHHCC	19.61	-
368	Ubiquitination	RIVEQDTMPPKGVRH HHHHHCCCCCCCCCE	7.81	-
371	Ubiquitination	EQDTMPPKGVRHTMM HHCCCCCCCCCEEEE	65.25	-
380	Phosphorylation	VRHTMMFSATFPKEI CCEEEEEECCCCHHH	14.43	28450419
382	Phosphorylation	HTMMFSATFPKEIQM EEEEEECCCCHHHHH	38.99	28450419
408	Phosphorylation	LAVGRVGSTSENITQ HHCCCCCCCCCCCCE	26.38	25159151
409	Phosphorylation	AVGRVGSTSENITQK HCCCCCCCCCCCCEE	33.85	28450419
410	Phosphorylation	VGRVGSTSENITQKV CCCCCCCCCCCCEEE	30.28	28450419
414	Phosphorylation	GSTSENITQKVVWVE CCCCCCCCEEEEEEC	33.64	30108239
436	Phosphorylation	LLDILGATGSDSLTL HHHHHCCCCCCEEEE	35.11	-
438	Phosphorylation	DILGATGSDSLTLVF HHHCCCCCCEEEEEE	21.48	-
440	Phosphorylation	LGATGSDSLTLVFVE HCCCCCCEEEEEEEE	25.58	-
447	Ubiquitination	SLTLVFVETKKGADS EEEEEEEEECCCCCC	43.37	-
450	Ubiquitination	LVFVETKKGADSLED EEEEEECCCCCCHHH	67.75	-
454	Phosphorylation	ETKKGADSLEDFLYH EECCCCCCHHHHHHC	32.88	28450419
460	Phosphorylation	DSLEDFLYHEGYACT CCHHHHHHCCCCCCC	9.60	20090780
464	Phosphorylation	DFLYHEGYACTSIHG HHHHCCCCCCCCCCC	8.77	30108239
467	Phosphorylation	YHEGYACTSIHGDRS HCCCCCCCCCCCCCC	23.65	20873877
468	Phosphorylation	HEGYACTSIHGDRSQ CCCCCCCCCCCCCCH	16.69	20873877
486	Ubiquitination	EEALHQFRSGKSPIL HHHHHHHHCCCCCHH	37.62	-
487	Phosphorylation	EALHQFRSGKSPILV HHHHHHHCCCCCHHH	52.43	30108239
489	Ubiquitination	LHQFRSGKSPILVAT HHHHHCCCCCHHHHH	55.06	-
490	Phosphorylation	HQFRSGKSPILVATA HHHHCCCCCHHHHHH	22.24	30108239
496	Phosphorylation	KSPILVATAVAARGL CCCHHHHHHHHHCCC	17.74	28857561
518	Phosphorylation	VINFDLPSDIEEYVH EEECCCCCCHHHHHH	59.52	28450419
541	Phosphorylation	GNLGLATSFFNEKNM CCCHHCHHHHCCCCC	23.41	28857561
543	Ubiquitination	LGLATSFFNEKNMNI CHHCHHHHCCCCCCC	13.30	-
546	Ubiquitination	ATSFFNEKNMNITKD CHHHHCCCCCCCCHH	63.70	21890473
549	Ubiquitination	FFNEKNMNITKDLLD HHCCCCCCCCHHHHH	48.44	-
552	Ubiquitination	EKNMNITKDLLDLLV CCCCCCCHHHHHHHH	42.45	21890473
567	Phosphorylation	EAKQEVPSWLENMAY HHHHHCCHHHHHHHH	49.85	20873877
574	Phosphorylation	SWLENMAYEHHYKGG HHHHHHHHHCCCCCC	12.67	29978859
578	Phosphorylation	NMAYEHHYKGGSRGR HHHHHCCCCCCCCCC	17.15	28796482
588	Phosphorylation	GSRGRSKSNRFSGGF CCCCCCCCCCCCCCC	34.19	23403867
590	Methylation	RGRSKSNRFSGGFGA CCCCCCCCCCCCCCC	33.91	-
592	Phosphorylation	RSKSNRFSGGFGARD CCCCCCCCCCCCCCC	34.47	29255136
598	Methylation	FSGGFGARDYRQSSG CCCCCCCCCCCCCCC	41.70	-
600	Phosphorylation	GGFGARDYRQSSGSS CCCCCCCCCCCCCCC	12.66	22210691
603	Phosphorylation	GARDYRQSSGSSSSG CCCCCCCCCCCCCCC	27.89	23312004
604	Phosphorylation	ARDYRQSSGSSSSGF CCCCCCCCCCCCCCC	34.06	20164059
606	Phosphorylation	DYRQSSGSSSSGFGA CCCCCCCCCCCCCCC	29.06	28857561
607	Phosphorylation	YRQSSGSSSSGFGAS CCCCCCCCCCCCCCC	31.86	28857561
608	Phosphorylation	RQSSGSSSSGFGASR CCCCCCCCCCCCCCC	35.86	25278378
609	Phosphorylation	QSSGSSSSGFGASRG CCCCCCCCCCCCCCC	39.84	22210691
614	Phosphorylation	SSSGFGASRGSSSRS CCCCCCCCCCCCCCC	37.24	25278378
615	Methylation	SSGFGASRGSSSRSG CCCCCCCCCCCCCCC	48.78	-
629	Phosphorylation	GGGGYGNSRGFGGGG CCCCCCCCCCCCCCC	29.44	25367160
630	Methylation	GGGYGNSRGFGGGGY CCCCCCCCCCCCCCC	48.75	-
637	Phosphorylation	RGFGGGGYGGFYNSD CCCCCCCCCCCCCCC	19.83	-
643	Phosphorylation	GYGGFYNSDGYGGNY CCCCCCCCCCCCCCC	22.49	28348404
646	Phosphorylation	GFYNSDGYGGNYNSQ CCCCCCCCCCCCCCC	27.18	24719451
650	Phosphorylation	SDGYGGNYNSQGVDW CCCCCCCCCCCCCCC	21.33	27251275
652	Phosphorylation	GYGGNYNSQGVDWWG CCCCCCCCCCCCCCC	20.25	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
592	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DDX3Y_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DDX3Y_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CCNB2_HUMAN	CCNB2	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DDX3Y_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-592, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-321, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-69, AND MASSSPECTROMETRY.	15592455 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-69, AND MASSSPECTROMETRY.	15144186 [Abstract]