dbPTM

RL19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RL19_HUMAN
UniProt AC	P84098
Protein Name	60S ribosomal protein L19
Gene Name	RPL19
Organism	Homo sapiens (Human).
Sequence Length	196
Subcellular Localization
Protein Description
Protein Sequence	MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAKKEEIIKTLSKEEETKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSMLRLQKR ------CCHHHHHHH	26.90	29514088
5	Citrullination	---MSMLRLQKRLAS ---CCHHHHHHHHHH	26.82	-
5	Citrullination	---MSMLRLQKRLAS ---CCHHHHHHHHHH	26.82	-
5	Methylation	---MSMLRLQKRLAS ---CCHHHHHHHHHH	26.82	115491861
9	Methylation	SMLRLQKRLASSVLR CHHHHHHHHHHHHHH	23.64	115491851
12	Phosphorylation	RLQKRLASSVLRCGK HHHHHHHHHHHHCCC	26.10	30266825
13	Phosphorylation	LQKRLASSVLRCGKK HHHHHHHHHHHCCCC	21.40	30266825
16	Citrullination	RLASSVLRCGKKKVW HHHHHHHHCCCCEEE	25.61	-
16	Citrullination	RLASSVLRCGKKKVW HHHHHHHHCCCCEEE	25.61	-
20	Ubiquitination	SVLRCGKKKVWLDPN HHHHCCCCEEECCCC	37.53	-
21	Acetylation	VLRCGKKKVWLDPNE HHHCCCCEEECCCCC	41.97	26822725
21	Ubiquitination	VLRCGKKKVWLDPNE HHHCCCCEEECCCCC	41.97	21906983
29	Phosphorylation	VWLDPNETNEIANAN EECCCCCCCHHCCCC	44.80	23663014
37	Phosphorylation	NEIANANSRQQIRKL CHHCCCCHHHHHHHH	29.11	19664994
38	Citrullination	EIANANSRQQIRKLI HHCCCCHHHHHHHHH	32.03	-
38	Citrullination	EIANANSRQQIRKLI HHCCCCHHHHHHHHH	32.03	-
43	Ubiquitination	NSRQQIRKLIKDGLI CHHHHHHHHHHCCCE	57.08	21906983
46	Acetylation	QQIRKLIKDGLIIRK HHHHHHHHCCCEECC	57.06	26051181
46	Ubiquitination	QQIRKLIKDGLIIRK HHHHHHHHCCCEECC	57.06	21890473
53	Ubiquitination	KDGLIIRKPVTVHSR HCCCEECCCCCCCCC	33.17	-
53	Acetylation	KDGLIIRKPVTVHSR HCCCEECCCCCCCCC	33.17	26051181
56	Phosphorylation	LIIRKPVTVHSRARC CEECCCCCCCCCHHH	22.49	-
59	Phosphorylation	RKPVTVHSRARCRKN CCCCCCCCCHHHCCC	24.25	24719451
67	Phosphorylation	RARCRKNTLARRKGR CHHHCCCHHHHHCCC	25.48	-
80	Ubiquitination	GRHMGIGKRKGTANA CCCCCCCCCCCCCCC	49.36	-
80	Acetylation	GRHMGIGKRKGTANA CCCCCCCCCCCCCCC	49.36	23954790
82	Acetylation	HMGIGKRKGTANARM CCCCCCCCCCCCCCC	65.19	7668529
84	Phosphorylation	GIGKRKGTANARMPE CCCCCCCCCCCCCCH	21.55	-
92	2-Hydroxyisobutyrylation	ANARMPEKVTWMRRM CCCCCCHHHHHHHHH	38.81	-
92	Ubiquitination	ANARMPEKVTWMRRM CCCCCCHHHHHHHHH	38.81	21906983
94	Phosphorylation	ARMPEKVTWMRRMRI CCCCHHHHHHHHHHH	25.31	-
117	Methylation	RESKKIDRHMYHSLY HHHCCCCHHHHHHHH	21.68	115491831
119	Sulfoxidation	SKKIDRHMYHSLYLK HCCCCHHHHHHHHHH	3.16	30846556
120	Phosphorylation	KKIDRHMYHSLYLKV CCCCHHHHHHHHHHE	5.11	27642862
122	Phosphorylation	IDRHMYHSLYLKVKG CCHHHHHHHHHHEEC	10.96	28450419
124	Phosphorylation	RHMYHSLYLKVKGNV HHHHHHHHHHEECCH	13.90	27642862
126	Ubiquitination	MYHSLYLKVKGNVFK HHHHHHHHEECCHHC	28.48	-
126	Acetylation	MYHSLYLKVKGNVFK HHHHHHHHEECCHHC	28.48	26051181
128	Ubiquitination	HSLYLKVKGNVFKNK HHHHHHEECCHHCCH	43.08	21906983
128	Acetylation	HSLYLKVKGNVFKNK HHHHHHEECCHHCCH	43.08	26210075
133	Ubiquitination	KVKGNVFKNKRILME HEECCHHCCHHHHHH	58.22	21906983
135	Ubiquitination	KGNVFKNKRILMEHI ECCHHCCHHHHHHHH	41.21	-
139	Sulfoxidation	FKNKRILMEHIHKLK HCCHHHHHHHHHHHH	3.07	30846556
144	Methylation	ILMEHIHKLKADKAR HHHHHHHHHHHHHHH	51.59	72631043
144	Ubiquitination	ILMEHIHKLKADKAR HHHHHHHHHHHHHHH	51.59	21890473
144	2-Hydroxyisobutyrylation	ILMEHIHKLKADKAR HHHHHHHHHHHHHHH	51.59	-
144	Malonylation	ILMEHIHKLKADKAR HHHHHHHHHHHHHHH	51.59	26320211
144	Acetylation	ILMEHIHKLKADKAR HHHHHHHHHHHHHHH	51.59	25953088
146	Ubiquitination	MEHIHKLKADKARKK HHHHHHHHHHHHHHH	60.38	-
152	Ubiquitination	LKADKARKKLLADQA HHHHHHHHHHHHHHH	53.27	21890473
152	Acetylation	LKADKARKKLLADQA HHHHHHHHHHHHHHH	53.27	25953088
153	2-Hydroxyisobutyrylation	KADKARKKLLADQAE HHHHHHHHHHHHHHH	43.08	-
153	Ubiquitination	KADKARKKLLADQAE HHHHHHHHHHHHHHH	43.08	21890473
153	Malonylation	KADKARKKLLADQAE HHHHHHHHHHHHHHH	43.08	26320211
162	Methylation	LADQAEARRSKTKEA HHHHHHHHHHHHHHH	34.60	115491841
164	Phosphorylation	DQAEARRSKTKEARK HHHHHHHHHHHHHHH	38.84	28985074
165	Ubiquitination	QAEARRSKTKEARKR HHHHHHHHHHHHHHH	62.90	-
167	Methylation	EARRSKTKEARKRRE HHHHHHHHHHHHHHH	53.78	116252551
180	Acetylation	REERLQAKKEEIIKT HHHHHHHHHHHHHHH	47.99	23749302
180	Ubiquitination	REERLQAKKEEIIKT HHHHHHHHHHHHHHH	47.99	19608861
181	Sumoylation	EERLQAKKEEIIKTL HHHHHHHHHHHHHHH	64.69	25114211
181	Acetylation	EERLQAKKEEIIKTL HHHHHHHHHHHHHHH	64.69	26051181
181	Ubiquitination	EERLQAKKEEIIKTL HHHHHHHHHHHHHHH	64.69	21890473
186	2-Hydroxyisobutyrylation	AKKEEIIKTLSKEEE HHHHHHHHHHCHHHH	49.42	-
186	Acetylation	AKKEEIIKTLSKEEE HHHHHHHHHHCHHHH	49.42	26051181
186	Ubiquitination	AKKEEIIKTLSKEEE HHHHHHHHHHCHHHH	49.42	21906983
187	Phosphorylation	KKEEIIKTLSKEEET HHHHHHHHHCHHHHH	26.34	27794612
189	Phosphorylation	EEIIKTLSKEEETKK HHHHHHHCHHHHHCC	43.16	23401153
190	Ubiquitination	EIIKTLSKEEETKK- HHHHHHCHHHHHCC-	72.72	1906983
190	Acetylation	EIIKTLSKEEETKK- HHHHHHCHHHHHCC-	72.72	23749302
190	2-Hydroxyisobutyrylation	EIIKTLSKEEETKK- HHHHHHCHHHHHCC-	72.72	-
194	Phosphorylation	TLSKEEETKK----- HHCHHHHHCC-----	47.62	23403867
195	Ubiquitination	LSKEEETKK------ HCHHHHHCC------	60.82	21906983
196	Ubiquitination	SKEEETKK------- CHHHHHCC-------	73.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
12	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
56	T	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RL19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RL19_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL21_HUMAN	RPL21	physical	22939629
RL22_HUMAN	RPL22	physical	22939629
RL23_HUMAN	RPL23	physical	22939629
RL24_HUMAN	RPL24	physical	22939629
RL27A_HUMAN	RPL27A	physical	22939629
RL30_HUMAN	RPL30	physical	22939629
RL31_HUMAN	RPL31	physical	22939629
RL37A_HUMAN	RPL37A	physical	22939629
RL3_HUMAN	RPL3	physical	22939629
RL4_HUMAN	RPL4	physical	22939629
RL5_HUMAN	RPL5	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
RL7A_HUMAN	RPL7A	physical	22939629
RL7_HUMAN	RPL7	physical	22939629
RL9_HUMAN	RPL9	physical	22939629
RS13_HUMAN	RPS13	physical	22939629
RS14_HUMAN	RPS14	physical	22939629
RS15A_HUMAN	RPS15A	physical	22939629
RS16_HUMAN	RPS16	physical	22939629
RS17_HUMAN	RPS17	physical	22939629
RS19_HUMAN	RPS19	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RS25_HUMAN	RPS25	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS5_HUMAN	RPS5	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS7_HUMAN	RPS7	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
RL8_HUMAN	RPL8	physical	22939629
RL23A_HUMAN	RPL23A	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RS11_HUMAN	RPS11	physical	22939629
RS28_HUMAN	RPS28	physical	22939629
RS20_HUMAN	RPS20	physical	22939629
RS12_HUMAN	RPS12	physical	22939629
RLA0_HUMAN	RPLP0	physical	22939629
RL36_HUMAN	RPL36	physical	22939629
RL27_HUMAN	RPL27	physical	22939629
RS9_HUMAN	RPS9	physical	22939629
RL32_HUMAN	RPL32	physical	22939629
RS27A_HUMAN	RPS27A	physical	22939629
RS21_HUMAN	RPS21	physical	22939629
RL1D1_HUMAN	RSL1D1	physical	22939629
SRP14_HUMAN	SRP14	physical	22939629
RS27L_HUMAN	RPS27L	physical	22939629
RRS1_HUMAN	RRS1	physical	22939629
SND1_HUMAN	SND1	physical	22939629
TEBP_HUMAN	PTGES3	physical	22939629
RM12_HUMAN	MRPL12	physical	22939629
HNRPM_HUMAN	HNRNPM	physical	22863883
SYK_HUMAN	KARS	physical	22863883
NMT1_HUMAN	NMT1	physical	22863883
SYQ_HUMAN	QARS	physical	22863883
RL10_HUMAN	RPL10	physical	26344197
RL10A_HUMAN	RPL10A	physical	26344197
RL11_HUMAN	RPL11	physical	26344197
RL12_HUMAN	RPL12	physical	26344197
RL13_HUMAN	RPL13	physical	26344197
RL13A_HUMAN	RPL13A	physical	26344197
RL15_HUMAN	RPL15	physical	26344197
RL17_HUMAN	RPL17	physical	26344197
RL21_HUMAN	RPL21	physical	26344197
RL22_HUMAN	RPL22	physical	26344197
RL23_HUMAN	RPL23	physical	26344197
RL23A_HUMAN	RPL23A	physical	26344197
RL24_HUMAN	RPL24	physical	26344197
RL26_HUMAN	RPL26	physical	26344197
RL27_HUMAN	RPL27	physical	26344197
RL27A_HUMAN	RPL27A	physical	26344197
RL28_HUMAN	RPL28	physical	26344197
RL30_HUMAN	RPL30	physical	26344197
RL31_HUMAN	RPL31	physical	26344197
RL32_HUMAN	RPL32	physical	26344197
RL34_HUMAN	RPL34	physical	26344197
RL35_HUMAN	RPL35	physical	26344197
RL35A_HUMAN	RPL35A	physical	26344197
RL36_HUMAN	RPL36	physical	26344197
RL37A_HUMAN	RPL37A	physical	26344197
RL3L_HUMAN	RPL3L	physical	26344197
RL4_HUMAN	RPL4	physical	26344197
RL5_HUMAN	RPL5	physical	26344197
RL7_HUMAN	RPL7	physical	26344197
RL7A_HUMAN	RPL7A	physical	26344197
RL8_HUMAN	RPL8	physical	26344197
RL9_HUMAN	RPL9	physical	26344197
RLA1_HUMAN	RPLP1	physical	26344197
RLA2_HUMAN	RPLP2	physical	26344197
RS10_HUMAN	RPS10	physical	26344197
RS11_HUMAN	RPS11	physical	26344197
RS12_HUMAN	RPS12	physical	26344197
RS13_HUMAN	RPS13	physical	26344197
RS14_HUMAN	RPS14	physical	26344197
RS15_HUMAN	RPS15	physical	26344197
RS15A_HUMAN	RPS15A	physical	26344197
RS16_HUMAN	RPS16	physical	26344197
RS18_HUMAN	RPS18	physical	26344197
RS2_HUMAN	RPS2	physical	26344197
RS23_HUMAN	RPS23	physical	26344197
RS25_HUMAN	RPS25	physical	26344197
RS26_HUMAN	RPS26	physical	26344197
RS3_HUMAN	RPS3	physical	26344197
RS3A_HUMAN	RPS3A	physical	26344197
RS4X_HUMAN	RPS4X	physical	26344197
RS5_HUMAN	RPS5	physical	26344197
RS6_HUMAN	RPS6	physical	26344197
RS7_HUMAN	RPS7	physical	26344197
RS8_HUMAN	RPS8	physical	26344197
RS9_HUMAN	RPS9	physical	26344197
RSSA_HUMAN	RPSA	physical	26344197
S61A1_HUMAN	SEC61A1	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RL19_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-80, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND THR-187, AND MASSSPECTROMETRY.	18669648 [Abstract]