dbPTM

RU2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RU2A_HUMAN
UniProt AC	P09661
Protein Name	U2 small nuclear ribonucleoprotein A'
Gene Name	SNRPA1
Organism	Homo sapiens (Human).
Sequence Length	255
Subcellular Localization	Nucleus .
Protein Description	Involved in pre-mRNA splicing as component of the spliceosome. [PubMed: 11991638]
Protein Sequence	MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEAEKMFKGKRGAQLAKDIARRSKTFNPGAGLPTDKKKGGPSPGDVEAIKNAIANASTLAEVERLKGLLQSGQIPGRERRSGPTDDGEEEMEEDTVTNGS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MVKLTAELIEQA ---CCHHHHHHHHHH	16.62	-
15	Phosphorylation	LIEQAAQYTNAVRDR HHHHHHHHHHHHCCH	9.38	28796482
16	Phosphorylation	IEQAAQYTNAVRDRE HHHHHHHHHHHCCHH	12.48	28796482
27	Methylation	RDRELDLRGYKIPVI CCHHCCCCCCCCCEE	46.17	115917373
30	Ubiquitination	ELDLRGYKIPVIENL HCCCCCCCCCEEECC	43.27	29967540
56	2-Hydroxyisobutyrylation	FSDNEIRKLDGFPLL CCHHHHHHCCCCHHH	57.50	-
56	Ubiquitination	FSDNEIRKLDGFPLL CCHHHHHHCCCCHHH	57.50	33845483
67	Ubiquitination	FPLLRRLKTLLVNNN CHHHHHHHHHHHCCC	35.00	24816145
67	2-Hydroxyisobutyrylation	FPLLRRLKTLLVNNN CHHHHHHHHHHHCCC	35.00	-
68	O-linked_Glycosylation	PLLRRLKTLLVNNNR HHHHHHHHHHHCCCC	29.89	28510447
114	Phosphorylation	DPLASLKSLTYLSIL CHHHHCCCCHHHHHH	31.10	28152594
116	Phosphorylation	LASLKSLTYLSILRN HHHCCCCHHHHHHCC	29.52	28152594
117	Phosphorylation	ASLKSLTYLSILRNP HHCCCCHHHHHHCCC	12.07	28152594
119	Phosphorylation	LKSLTYLSILRNPVT CCCCHHHHHHCCCCC	14.79	28152594
126	Phosphorylation	SILRNPVTNKKHYRL HHHCCCCCCCCEEEE	42.45	20068231
128	2-Hydroxyisobutyrylation	LRNPVTNKKHYRLYV HCCCCCCCCEEEEEE	31.40	-
131	Phosphorylation	PVTNKKHYRLYVIYK CCCCCCEEEEEEEEE	15.93	-
134	Phosphorylation	NKKHYRLYVIYKVPQ CCCEEEEEEEEECCC	3.93	28152594
137	Phosphorylation	HYRLYVIYKVPQVRV EEEEEEEEECCCEEE	8.90	28152594
138	Acetylation	YRLYVIYKVPQVRVL EEEEEEEECCCEEEE	35.99	25953088
138	Ubiquitination	YRLYVIYKVPQVRVL EEEEEEEECCCEEEE	35.99	-
149	Acetylation	VRVLDFQKVKLKERQ EEEECCEEECHHHHH	41.13	26051181
149	Methylation	VRVLDFQKVKLKERQ EEEECCEEECHHHHH	41.13	-
149	Ubiquitination	VRVLDFQKVKLKERQ EEEECCEEECHHHHH	41.13	33845483
151	Ubiquitination	VLDFQKVKLKERQEA EECCEEECHHHHHHH	61.96	-
160	Acetylation	KERQEAEKMFKGKRG HHHHHHHHHHCCHHH	57.60	23749302
160	Ubiquitination	KERQEAEKMFKGKRG HHHHHHHHHHCCHHH	57.60	32015554
160	2-Hydroxyisobutyrylation	KERQEAEKMFKGKRG HHHHHHHHHHCCHHH	57.60	-
163	Ubiquitination	QEAEKMFKGKRGAQL HHHHHHHCCHHHHHH	61.08	24816145
172	Malonylation	KRGAQLAKDIARRSK HHHHHHHHHHHHHCC	59.25	26320211
172	Ubiquitination	KRGAQLAKDIARRSK HHHHHHHHHHHHHCC	59.25	33845483
172	Sumoylation	KRGAQLAKDIARRSK HHHHHHHHHHHHHCC	59.25	28112733
172	Methylation	KRGAQLAKDIARRSK HHHHHHHHHHHHHCC	59.25	23644510
172	Acetylation	KRGAQLAKDIARRSK HHHHHHHHHHHHHCC	59.25	19608861
178	Phosphorylation	AKDIARRSKTFNPGA HHHHHHHCCCCCCCC	30.41	30266825
179	Ubiquitination	KDIARRSKTFNPGAG HHHHHHCCCCCCCCC	56.15	23000965
179	Acetylation	KDIARRSKTFNPGAG HHHHHHCCCCCCCCC	56.15	26051181
180	Phosphorylation	DIARRSKTFNPGAGL HHHHHCCCCCCCCCC	29.86	30266825
189	Phosphorylation	NPGAGLPTDKKKGGP CCCCCCCCCCCCCCC	66.55	24732914
191	Ubiquitination	GAGLPTDKKKGGPSP CCCCCCCCCCCCCCH	59.88	21906983
191	2-Hydroxyisobutyrylation	GAGLPTDKKKGGPSP CCCCCCCCCCCCCCH	59.88	-
191	Acetylation	GAGLPTDKKKGGPSP CCCCCCCCCCCCCCH	59.88	25953088
192	Ubiquitination	AGLPTDKKKGGPSPG CCCCCCCCCCCCCHH	60.50	21906983
193	Ubiquitination	GLPTDKKKGGPSPGD CCCCCCCCCCCCHHH	74.88	21963094
197	Phosphorylation	DKKKGGPSPGDVEAI CCCCCCCCHHHHHHH	44.80	29255136
205	Ubiquitination	PGDVEAIKNAIANAS HHHHHHHHHHHHCCH	47.58	23000965
212	Phosphorylation	KNAIANASTLAEVER HHHHHCCHHHHHHHH	24.62	25627689
213	Phosphorylation	NAIANASTLAEVERL HHHHCCHHHHHHHHH	27.81	21712546
221	Sumoylation	LAEVERLKGLLQSGQ HHHHHHHHHHHHCCC	54.45	28112733
221	Malonylation	LAEVERLKGLLQSGQ HHHHHHHHHHHHCCC	54.45	26320211
221	Ubiquitination	LAEVERLKGLLQSGQ HHHHHHHHHHHHCCC	54.45	23000965
226	Phosphorylation	RLKGLLQSGQIPGRE HHHHHHHCCCCCCCC	32.41	20068231
236	Phosphorylation	IPGRERRSGPTDDGE CCCCCCCCCCCCCCC	56.18	25159151
239	Phosphorylation	RERRSGPTDDGEEEM CCCCCCCCCCCCHHH	50.69	21955146
246	Sulfoxidation	TDDGEEEMEEDTVTN CCCCCHHHHHHCCCC	8.48	21406390
250	Phosphorylation	EEEMEEDTVTNGS-- CHHHHHHCCCCCC--	32.29	27251275
252	Phosphorylation	EMEEDTVTNGS---- HHHHHCCCCCC----	35.63	28450419
255	Phosphorylation	EDTVTNGS------- HHCCCCCC-------	38.83	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RU2A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RU2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RU2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RU2B_HUMAN	SNRPB2	physical	22939629
SF3A1_HUMAN	SF3A1	physical	22939629
SF3A2_HUMAN	SF3A2	physical	22939629
SF3B1_HUMAN	SF3B1	physical	22939629
SF3B3_HUMAN	SF3B3	physical	22939629
U520_HUMAN	SNRNP200	physical	22939629
SMD1_HUMAN	SNRPD1	physical	22939629
SMD2_HUMAN	SNRPD2	physical	22939629
SRSF1_HUMAN	SRSF1	physical	22939629
U5S1_HUMAN	EFTUD2	physical	22939629
SF3B5_HUMAN	SF3B5	physical	22939629
SF3B2_HUMAN	SF3B2	physical	22939629
SF3B4_HUMAN	SF3B4	physical	22939629
SNRPA_HUMAN	SNRPA	physical	22939629
U2AF1_HUMAN	U2AF1	physical	22939629
SRSF7_HUMAN	SRSF7	physical	22939629
SF3A3_HUMAN	SF3A3	physical	22939629
U2AF2_HUMAN	U2AF2	physical	22939629
YBOX1_HUMAN	YBX1	physical	22939629
SFPQ_HUMAN	SFPQ	physical	22939629
SRRM2_HUMAN	SRRM2	physical	22939629
SNUT1_HUMAN	SART1	physical	22939629
TCRG1_HUMAN	TCERG1	physical	22939629
SYF1_HUMAN	XAB2	physical	22939629
SEPT7_HUMAN	SEPT7	physical	22939629
VASN_HUMAN	VASN	physical	22939629
TPR_HUMAN	TPR	physical	22939629
VTNC_HUMAN	VTN	physical	22939629
TR150_HUMAN	THRAP3	physical	22939629
TF3C1_HUMAN	GTF3C1	physical	22939629
STOM_HUMAN	STOM	physical	22939629
SAP_HUMAN	PSAP	physical	22939629
SMRC2_HUMAN	SMARCC2	physical	22939629
TOM22_HUMAN	TOMM22	physical	22939629
UCHL5_HUMAN	UCHL5	physical	22939629
SRP14_HUMAN	SRP14	physical	22939629
S10AG_HUMAN	S100A16	physical	22939629
RUXF_HUMAN	SNRPF	physical	22365833
SNRPA_HUMAN	SNRPA	physical	22365833
RU2B_HUMAN	SNRPB2	physical	22365833
SF3B3_HUMAN	SF3B3	physical	26186194
SF3B1_HUMAN	SF3B1	physical	26186194
TOE1_HUMAN	TOE1	physical	26186194
GEMI5_HUMAN	GEMIN5	physical	26186194
SF3B2_HUMAN	SF3B2	physical	26186194
HTSF1_HUMAN	HTATSF1	physical	26186194
ICE2_HUMAN	ICE2	physical	26186194
RUXG_HUMAN	SNRPG	physical	26186194
C19L2_HUMAN	CWF19L2	physical	26186194
NADAP_HUMAN	SLC4A1AP	physical	26186194
CRNL1_HUMAN	CRNKL1	physical	26186194
C19L1_HUMAN	CWF19L1	physical	26186194
CDC5L_HUMAN	CDC5L	physical	26186194
SF3A1_HUMAN	SF3A1	physical	26186194
SF3A3_HUMAN	SF3A3	physical	26186194
COIL_HUMAN	COIL	physical	26186194
GCFC2_HUMAN	GCFC2	physical	26186194
AQR_HUMAN	AQR	physical	26186194
PKRI1_HUMAN	PRKRIP1	physical	26186194
RU2B_HUMAN	SNRPB2	physical	26186194
PHAX_HUMAN	PHAX	physical	26186194
SNW1_HUMAN	SNW1	physical	26186194
SF3B4_HUMAN	SF3B4	physical	26186194
SMD2_HUMAN	SNRPD2	physical	26186194
PRP17_HUMAN	CDC40	physical	26186194
DGC14_HUMAN	DGCR14	physical	26186194
DDX46_HUMAN	DDX46	physical	26186194
SYF1_HUMAN	XAB2	physical	26186194
TGS1_HUMAN	TGS1	physical	26186194
GPT11_HUMAN	GPATCH11	physical	26186194
CCD12_HUMAN	CCDC12	physical	26186194
SYF2_HUMAN	SYF2	physical	26186194
ICE1_HUMAN	ICE1	physical	26186194
SMD3_HUMAN	SNRPD3	physical	26186194
SPN1_HUMAN	SNUPN	physical	26186194
SMD1_HUMAN	SNRPD1	physical	26186194
RSMN_HUMAN	SNRPN	physical	26186194
RSMB_HUMAN	SNRPB	physical	26186194
SF3A2_HUMAN	SF3A2	physical	26186194
ELL_HUMAN	ELL	physical	26186194
ISY1_HUMAN	ISY1	physical	26186194
SF3B5_HUMAN	SF3B5	physical	26186194
BUD31_HUMAN	BUD31	physical	26186194
PRP17_HUMAN	CDC40	physical	26344197
ISY1_HUMAN	ISY1	physical	26344197
LSM2_HUMAN	LSM2	physical	26344197
RPB4_HUMAN	POLR2D	physical	26344197
PRP19_HUMAN	PRPF19	physical	26344197
PRP31_HUMAN	PRPF31	physical	26344197
PRP8_HUMAN	PRPF8	physical	26344197
SNUT1_HUMAN	SART1	physical	26344197
SF3A3_HUMAN	SF3A3	physical	26344197
SF3B3_HUMAN	SF3B3	physical	26344197
U520_HUMAN	SNRNP200	physical	26344197
SNRPA_HUMAN	SNRPA	physical	26344197
RU2B_HUMAN	SNRPB2	physical	26344197
SMD1_HUMAN	SNRPD1	physical	26344197
RUXF_HUMAN	SNRPF	physical	26344197
LA_HUMAN	SSB	physical	26344197
PKRI1_HUMAN	PRKRIP1	physical	28514442
NADAP_HUMAN	SLC4A1AP	physical	28514442
GEMI5_HUMAN	GEMIN5	physical	28514442
TGS1_HUMAN	TGS1	physical	28514442
TOE1_HUMAN	TOE1	physical	28514442
GPT11_HUMAN	GPATCH11	physical	28514442
RU2B_HUMAN	SNRPB2	physical	28514442
SF3A2_HUMAN	SF3A2	physical	28514442
SPN1_HUMAN	SNUPN	physical	28514442
ICE1_HUMAN	ICE1	physical	28514442
PHAX_HUMAN	PHAX	physical	28514442
HTSF1_HUMAN	HTATSF1	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
SF3A1_HUMAN	SF3A1	physical	28514442
ELL_HUMAN	ELL	physical	28514442
ICE2_HUMAN	ICE2	physical	28514442
C19L2_HUMAN	CWF19L2	physical	28514442
SF3A3_HUMAN	SF3A3	physical	28514442
BUD31_HUMAN	BUD31	physical	28514442
GCFC2_HUMAN	GCFC2	physical	28514442
DGC14_HUMAN	DGCR14	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
SF3B1_HUMAN	SF3B1	physical	28514442
SF3B2_HUMAN	SF3B2	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
SMD2_HUMAN	SNRPD2	physical	28514442
SF3B4_HUMAN	SF3B4	physical	28514442
RSMB_HUMAN	SNRPB	physical	28514442
SNW1_HUMAN	SNW1	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
C19L1_HUMAN	CWF19L1	physical	28514442
SMD1_HUMAN	SNRPD1	physical	28514442
SF3B3_HUMAN	SF3B3	physical	28514442
SF3B5_HUMAN	SF3B5	physical	28514442
RU17_HUMAN	SNRNP70	physical	28514442
PPIE_HUMAN	PPIE	physical	28514442
H14_HUMAN	HIST1H1E	physical	28514442
AQR_HUMAN	AQR	physical	28514442
SMD3_HUMAN	SNRPD3	physical	28514442
ZC3HE_HUMAN	ZC3H14	physical	28514442
ACINU_HUMAN	ACIN1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RU2A_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-172, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178 AND SER-197, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, AND MASSSPECTROMETRY.	18669648 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, AND MASSSPECTROMETRY.	16964243 [Abstract]