S10AG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S10AG_HUMAN
• UniProt AC: Q96FQ6
• Protein Name: Protein S100-A16
• Gene Name: S100A16 {ECO:0000312|HGNC:HGNC:20441}
• Organism: Homo sapiens (Human).
• Sequence Length: 103
• Subcellular Localization: Nucleus, nucleolus . Cytoplasm . Primarily nucleolar. A high intracellular calcium level induces nucleolar exit and nucleocytoplasmic transport, whereas a low intracellular calcium level leads to nuclear translocation and accumulation within specific
• Protein Description: Calcium-binding protein. Binds one calcium ion per monomer. [PubMed: 17030513 Can promote differentiation of adipocytes (in vitro) (By similarity Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity]
• Protein Sequence: MSDCYTELEKAVIVLVENFYKYVSKYSLVKNKISKSSFREMLQKELNHMLSDTGNRKAADKLIQNLDANHDGRISFDEYWTLIGGITGPIAKLIHEQEQQSSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDCYTELE ------CCHHHHHHH	36.07	28355574
5	Phosphorylation	---MSDCYTELEKAV ---CCHHHHHHHHHH	14.29	21955146
6	Phosphorylation	--MSDCYTELEKAVI --CCHHHHHHHHHHH	40.19	23927012
20	Phosphorylation	IVLVENFYKYVSKYS HHHHHHHHHHHHHHH	17.00	-
24	Phosphorylation	ENFYKYVSKYSLVKN HHHHHHHHHHHHHCC	23.84	26356563
25	Malonylation	NFYKYVSKYSLVKNK HHHHHHHHHHHHCCC	28.90	32601280
25	Ubiquitination	NFYKYVSKYSLVKNK HHHHHHHHHHHHCCC	28.90	33845483
25	Acetylation	NFYKYVSKYSLVKNK HHHHHHHHHHHHCCC	28.90	23236377
26	Phosphorylation	FYKYVSKYSLVKNKI HHHHHHHHHHHCCCC	10.34	26356563
27	Phosphorylation	YKYVSKYSLVKNKIS HHHHHHHHHHCCCCC	30.35	26356563
30	Ubiquitination	VSKYSLVKNKISKSS HHHHHHHCCCCCHHH	58.79	33845483
35	Ubiquitination	LVKNKISKSSFREML HHCCCCCHHHHHHHH	54.30	29901268
36	Phosphorylation	VKNKISKSSFREMLQ HCCCCCHHHHHHHHH	28.11	23898821
37	Phosphorylation	KNKISKSSFREMLQK CCCCCHHHHHHHHHH	31.87	28102081
49	Sulfoxidation	LQKELNHMLSDTGNR HHHHHHHHHCHHCCH	3.59	30846556
51	Phosphorylation	KELNHMLSDTGNRKA HHHHHHHCHHCCHHH	26.08	24719451
53	Phosphorylation	LNHMLSDTGNRKAAD HHHHHCHHCCHHHHH	32.74	27251275
57	Ubiquitination	LSDTGNRKAADKLIQ HCHHCCHHHHHHHHH	52.50	21906983
61	Malonylation	GNRKAADKLIQNLDA CCHHHHHHHHHHCCC	42.64	26320211
61	Ubiquitination	GNRKAADKLIQNLDA CCHHHHHHHHHHCCC	42.64	22817900
61	Acetylation	GNRKAADKLIQNLDA CCHHHHHHHHHHCCC	42.64	23236377
79	Phosphorylation	GRISFDEYWTLIGGI CCCCHHHHHHHHCHH	12.92	24719451
81	Phosphorylation	ISFDEYWTLIGGITG CCHHHHHHHHCHHHH	13.95	24719451
101	Phosphorylation	IHEQEQQSSS----- HHHHHHHCCC-----	32.04	22167270
102	Phosphorylation	HEQEQQSSS------ HHHHHHCCC------	35.41	22167270
103	Phosphorylation	EQEQQSSS------- HHHHHCCC-------	49.87	22167270

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S10AG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S10AG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S10AG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
SPHM_HUMAN	SGSH	physical	22939629
SC22B_HUMAN	SEC22B	physical	22939629
TMEM9_HUMAN	TMEM9	physical	22939629
STIM1_HUMAN	STIM1	physical	22939629
TCOF_HUMAN	TCOF1	physical	22939629
VAMP2_HUMAN	VAMP2	physical	22939629
TOIP1_HUMAN	TOR1AIP1	physical	22939629
SUCB1_HUMAN	SUCLA2	physical	22939629
THTR_HUMAN	TST	physical	22939629
VAPB_HUMAN	VAPB	physical	22939629
RL40_HUMAN	UBA52	physical	22939629
STMN1_HUMAN	STMN1	physical	22939629
SUCB2_HUMAN	SUCLG2	physical	22939629
SUCA_HUMAN	SUCLG1	physical	22939629
XRCC1_HUMAN	XRCC1	physical	22939629
THTM_HUMAN	MPST	physical	22939629
UBXN1_HUMAN	UBXN1	physical	22939629
TMEDA_HUMAN	TMED10	physical	22939629
TM177_HUMAN	TMEM177	physical	22939629
SCOT1_HUMAN	OXCT1	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103, AND MASSSPECTROMETRY.
PubMed: 15302935