TMEM9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMEM9_HUMAN
• UniProt AC: Q9P0T7
• Protein Name: Transmembrane protein 9
• Gene Name: TMEM9
• Organism: Homo sapiens (Human).
• Sequence Length: 183
• Subcellular Localization: Late endosome membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein .
• Protein Description: May be involved in intracellular transport..
• Protein Sequence: MKLLSLVAVVGCLLVPPAEANKSSEDIRCKCICPPYRNISGHIYNQNVSQKDCNCLHVVEPMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIRKPDAYTEQLHNEEENEDARSMAAAAASLGGPRANTVLERVEGAQQRWKLQVQEQRKTVFDRHKMLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	N-linked_Glycosylation	LVPPAEANKSSEDIR ECCHHHCCCCCCCCC	35.93	UniProtKB CARBOHYD
38	N-linked_Glycosylation	CICPPYRNISGHIYN EECCCCCCCCCCCCC	27.25	UniProtKB CARBOHYD
40	O-linked_Glycosylation	CPPYRNISGHIYNQN CCCCCCCCCCCCCCC	28.06	30059200
47	N-linked_Glycosylation	SGHIYNQNVSQKDCN CCCCCCCCCCHHCCC	31.60	UniProtKB CARBOHYD
55	Ubiquitination	VSQKDCNCLHVVEPM CCHHCCCEEEEEECC	3.32	-
118	Ubiquitination	LVDPLIRKPDAYTEQ HHHHHHCCCCHHHHH	40.01	21906983
122	Phosphorylation	LIRKPDAYTEQLHNE HHCCCCHHHHHHCCH	20.42	28270605
123	Phosphorylation	IRKPDAYTEQLHNEE HCCCCHHHHHHCCHH	20.98	28270605
137	Phosphorylation	EENEDARSMAAAAAS HCCHHHHHHHHHHHH	17.94	29255136
143	Ubiquitination	RSMAAAAASLGGPRA HHHHHHHHHHCCCCH	10.68	-
144	Phosphorylation	SMAAAAASLGGPRAN HHHHHHHHHCCCCHH	23.87	20873877
152	Phosphorylation	LGGPRANTVLERVEG HCCCCHHHHHHHHHH	26.03	28857561
162	Phosphorylation	ERVEGAQQRWKLQVQ HHHHHHHHHHHHHHH	53.30	19651622
165	Ubiquitination	EGAQQRWKLQVQEQR HHHHHHHHHHHHHHH	31.09	-
169	Phosphorylation	QRWKLQVQEQRKTVF HHHHHHHHHHHHHHH	28.30	-
190	Ubiquitination	S-------------- C--------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMEM9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMEM9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMEM9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPS29_HUMAN	VPS29	physical	22939629
VMA21_HUMAN	VMA21	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, AND MASSSPECTROMETRY.
PubMed: 18669648