dbPTM

TF3C1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TF3C1_HUMAN
UniProt AC	Q12789
Protein Name	General transcription factor 3C polypeptide 1
Gene Name	GTF3C1
Organism	Homo sapiens (Human).
Sequence Length	2109
Subcellular Localization	Nucleus.
Protein Description	Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element..
Protein Sequence	MDALESLLDEVALEGLDGLCLPALWSRLETRVPPFPLPLEPCTQEFLWRALATHPGISFYEEPRERPDLQLQDRYEEIDLETGILESRRDPVALEDVYPIHMILENKDGIQGSCRYFKERKNITNDIRTKSLQPRCTMVEAFDRWGKKLIIVASQAMRYRALIGQEGDPDLKLPDFSYCILERLGRSRWQGELQRDLHTTAFKVDAGKLHYHRKILNKNGLITMQSHVIRLPTGAQQHSILLLLNRFHVDRRSKYDILMEKLSVMLSTRTNHIETLGKLREELGLCERTFKRLYQYMLNAGLAKVVSLRLQEIHPECGPCKTKKGTDVMVRCLKLLKEFKRNDHDDDEDEEVISKTVPPVDIVFERDMLTQTYDLIERRGTKGISQAEIRVAMNVGKLEARMLCRLLQRFKVVKGFMEDEGRQRTTKYISCVFAEESDLSRQYQREKARSELLTTVSLASMQEESLLPEGEDTFLSESDSEEERSSSKRRGRGSQKDTRASANLRPKTQPHHSTPTKGGWKVVNLHPLKKQPPSFPGAAEERACQSLASRDSLLDTSSVSEPNVSFVSHCADSNSGDIAVIEEVRMENPKESSSSLKTGRHSSGQDKPHETYRLLKRRNLIIEAVTNLRLIESLFTIQKMIMDQEKQEGVSTKCCKKSIVRLVRNLSEEGLLRLYRTTVIQDGIKKKVDLVVHPSMDQNDPLVRSAIEQVRFRISNSSTANRVKTSQPPVPQGEAEEDSQGKEGPSGSGDSQLSASSRSESGRMKKSDNKMGITPLRNYHPIVVPGLGRSLGFLPKMPRLRVVHMFLWYLIYGHPASNTVEKPSFISERRTIKQESGRAGVRPSSSGSAWEACSEAPSKGSQDGVTWEAEVELATETVYVDDASWMRYIPPIPVHRDFGFGWALVSDILLCLPLSIFIQIVQVSYKVDNLEEFLNDPLKKHTLIRFLPRPIRQQLLYKRRYIFSVVENLQRLCYMGLLQFGPTEKFQDKDQVFIFLKKNAVIVDTTICDPHYNLARSSRPFERRLYVLNSMQDVENYWFDLQCVCLNTPLGVVRCPRVRKNSSTDQGSDEEGSLQKEQESAMDKHNLERKCAMLEYTTGSREVVDEGLIPGDGLGAAGLDSSFYGHLKRNWIWTSYIINQAKKENTAAENGLTVRLQTFLSKRPMPLSARGNSRLNIWGEARVGSELCAGWEEQFEVDREPSLDRNRRVRGGKSQKRKRLKKDPGKKIKRKKKGEFPGEKSKRLRYHDEADQSALQRMTRLRVTWSMQEDGLLVLCRIASNVLNTKVKGPFVTWQVVRDILHATFEESLDKTSHSVGRRARYIVKNPQAYLNYKVCLAEVYQDKALVGDFMNRRGDYDDPKVCANEFKEFVEKLKEKFSSALRNSNLEIPDTLQELFARYRVLAIGDEKDQTRKEDELNSVDDIHFLVLQNLIQSTLALSDSQMKSYQSFQTFRLYREYKDHVLVKAFMECQKRSLVNRRRVNHTLGPKKNRALPFVPMSYQLSQTYYRIFTWRFPSTICTESFQFLDRMRAAGKLDQPDRFSFKDQDNNEPTNDMVAFSLDGPGGNCVAVLTLFSLGLISVDVRIPEQIIVVDSSMVENEVIKSLGKDGSLEDDEDEEDDLDEGVGGKRRSMEVKPAQASHTNYLLMRGYYSPGIVSTRNLNPNDSIVVNSCQMKFQLRCTPVPARLRPAAAPLEELTMGTSCLPDTFTKLINPQENTCSLEEFVLQLELSGYSPEDLTAALEILEAIIATGCFGIDKEELRRRFSALEKAGGGRTRTFADCIQALLEQHQVLEVGGNTARLVAMGSAWPWLLHSVRLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQLSGQAQPPEGSEDPRGFTESFGAANISQAARERDCESVCFIGRPWRVVDGHLNLPVCKGMMEAMLYHIMTRPGIPESSLLRHYQGVLQPVAVLELLQGLESLGCIRKRWLRKPRPVSLFSTPVVEEVEVPSSLDESPMAFYEPTLDCTLRLGRVFPHEVNWNKWIHL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	LATHPGISFYEEPRE HHHCCCCCCCCCCCC	27.91	28152594
60	Phosphorylation	THPGISFYEEPRERP HCCCCCCCCCCCCCC	16.76	28152594
107	Acetylation	IHMILENKDGIQGSC EEEEEECCCCCCCCH	48.21	26051181
107	Ubiquitination	IHMILENKDGIQGSC EEEEEECCCCCCCCH	48.21	-
121	Ubiquitination	CRYFKERKNITNDIR HHHHHHHCCCCCCHH	54.52	24816145
129	Phosphorylation	NITNDIRTKSLQPRC CCCCCHHCCCCCCCC	25.89	28787133
130	Ubiquitination	ITNDIRTKSLQPRCT CCCCHHCCCCCCCCE	39.04	27667366
172	Ubiquitination	QEGDPDLKLPDFSYC CCCCCCCCCCCCHHH	66.41	21987572
203	Ubiquitination	DLHTTAFKVDAGKLH CCCCEEEEECCCHHH	36.42	29967540
208	Ubiquitination	AFKVDAGKLHYHRKI EEEECCCHHHHHHHH	33.54	33845483
214	Ubiquitination	GKLHYHRKILNKNGL CHHHHHHHHCCCCCC	37.93	23000965
218	Ubiquitination	YHRKILNKNGLITMQ HHHHHCCCCCCEEEE	49.28	23000965
254	Ubiquitination	FHVDRRSKYDILMEK HCCCCHHHHHHHHHH	45.17	21890473
254 (in isoform 3)	Ubiquitination	-	45.17	21890473
263	O-linked_Glycosylation	DILMEKLSVMLSTRT HHHHHHHHHHHHHCC	19.29	30379171
263	Phosphorylation	DILMEKLSVMLSTRT HHHHHHHHHHHHHCC	19.29	22817901
267	Phosphorylation	EKLSVMLSTRTNHIE HHHHHHHHHCCCHHH	9.57	24719451
268	Phosphorylation	KLSVMLSTRTNHIET HHHHHHHHCCCHHHH	37.24	27282143
275	Phosphorylation	TRTNHIETLGKLREE HCCCHHHHHHHHHHH	39.96	27282143
275 (in isoform 2)	Ubiquitination	-	39.96	21890473
278	Acetylation	NHIETLGKLREELGL CHHHHHHHHHHHHCC	47.70	25953088
278	Ubiquitination	NHIETLGKLREELGL CHHHHHHHHHHHHCC	47.70	24816145
294	Phosphorylation	ERTFKRLYQYMLNAG HHHHHHHHHHHHHCC	11.13	-
296	Phosphorylation	TFKRLYQYMLNAGLA HHHHHHHHHHHCCCH	7.04	-
321	Acetylation	HPECGPCKTKKGTDV CCCCCCCCCCCCHHH	67.52	25953088
323	Ubiquitination	ECGPCKTKKGTDVMV CCCCCCCCCCHHHHH	34.40	-
324	Ubiquitination	CGPCKTKKGTDVMVR CCCCCCCCCHHHHHH	72.74	29967540
326	Phosphorylation	PCKTKKGTDVMVRCL CCCCCCCHHHHHHHH	34.01	28555341
337	Ubiquitination	VRCLKLLKEFKRNDH HHHHHHHHHHHHCCC	72.10	-
354	Phosphorylation	DEDEEVISKTVPPVD CCCHHHHHCCCCCCE	27.70	20068231
355	Ubiquitination	EDEEVISKTVPPVDI CCHHHHHCCCCCCEE	42.28	29967540
370	Phosphorylation	VFERDMLTQTYDLIE EEEHHHHHHHHHHHH	16.54	21406692
372	Phosphorylation	ERDMLTQTYDLIERR EHHHHHHHHHHHHHH	17.48	29759185
373	Phosphorylation	RDMLTQTYDLIERRG HHHHHHHHHHHHHHC	10.03	21406692
382	Acetylation	LIERRGTKGISQAEI HHHHHCCCCCCHHHH	58.01	7669951
382	Ubiquitination	LIERRGTKGISQAEI HHHHHCCCCCCHHHH	58.01	33845483
397	Ubiquitination	RVAMNVGKLEARMLC HHHHCCCHHHHHHHH	38.58	21906983
397 (in isoform 3)	Ubiquitination	-	38.58	21890473
414	Ubiquitination	LQRFKVVKGFMEDEG HHHHCHHHCCCCCCC	49.79	21906983
414 (in isoform 3)	Ubiquitination	-	49.79	21890473
418 (in isoform 2)	Ubiquitination	-	51.12	21890473
427	Ubiquitination	EGRQRTTKYISCVFA CCCCCCEEEEEEEEE	39.72	32015554
435 (in isoform 2)	Ubiquitination	-	46.71	21890473
437	Phosphorylation	SCVFAEESDLSRQYQ EEEEECCCHHHHHHH	35.04	28122231
440	Phosphorylation	FAEESDLSRQYQREK EECCCHHHHHHHHHH	23.48	24719451
460	Phosphorylation	LTTVSLASMQEESLL HHHHHHHHHCHHHCC	26.71	26074081
465	Phosphorylation	LASMQEESLLPEGED HHHHCHHHCCCCCCC	34.16	26074081
473	Phosphorylation	LLPEGEDTFLSESDS CCCCCCCCCCCCCCC	23.36	28985074
478	Phosphorylation	EDTFLSESDSEEERS CCCCCCCCCCHHHHH	42.96	24275569
480	Phosphorylation	TFLSESDSEEERSSS CCCCCCCCHHHHHHC	57.07	24275569
496	Acetylation	RRGRGSQKDTRASAN CCCCCCCCCHHHHCC	63.87	7971385
498	Phosphorylation	GRGSQKDTRASANLR CCCCCCCHHHHCCCC	34.86	-
501	Phosphorylation	SQKDTRASANLRPKT CCCCHHHHCCCCCCC	17.88	25159151
507	Ubiquitination	ASANLRPKTQPHHST HHCCCCCCCCCCCCC	54.05	29967540
508	Phosphorylation	SANLRPKTQPHHSTP HCCCCCCCCCCCCCC	50.44	23312004
513	Phosphorylation	PKTQPHHSTPTKGGW CCCCCCCCCCCCCCE	32.80	25849741
514	Phosphorylation	KTQPHHSTPTKGGWK CCCCCCCCCCCCCEE	30.53	23927012
516	Phosphorylation	QPHHSTPTKGGWKVV CCCCCCCCCCCEEEE	42.27	28152594
517	Ubiquitination	PHHSTPTKGGWKVVN CCCCCCCCCCEEEEE	57.54	29967540
521	Ubiquitination	TPTKGGWKVVNLHPL CCCCCCEEEEEEECC	39.31	21890473
521 (in isoform 3)	Ubiquitination	-	39.31	21890473
529	Sumoylation	VVNLHPLKKQPPSFP EEEEECCCCCCCCCC	54.54	28112733
529	Ubiquitination	VVNLHPLKKQPPSFP EEEEECCCCCCCCCC	54.54	33845483
530	Ubiquitination	VNLHPLKKQPPSFPG EEEECCCCCCCCCCC	75.59	29967540
534	Phosphorylation	PLKKQPPSFPGAAEE CCCCCCCCCCCHHHH	51.24	28555341
542 (in isoform 2)	Ubiquitination	-	31.97	21890473
546	Phosphorylation	AEERACQSLASRDSL HHHHHHHHHHCCCCC	26.28	21406692
549	Phosphorylation	RACQSLASRDSLLDT HHHHHHHCCCCCCCC	41.75	21406692
557	Phosphorylation	RDSLLDTSSVSEPNV CCCCCCCCCCCCCCE	28.54	-
560	Phosphorylation	LLDTSSVSEPNVSFV CCCCCCCCCCCEEEE	49.65	-
565	Phosphorylation	SVSEPNVSFVSHCAD CCCCCCEEEEEECCC	26.94	28348404
568	Phosphorylation	EPNVSFVSHCADSNS CCCEEEEEECCCCCC	15.73	28348404
573	Phosphorylation	FVSHCADSNSGDIAV EEEECCCCCCCCEEE	17.86	30576142
575	Phosphorylation	SHCADSNSGDIAVIE EECCCCCCCCEEEEE	41.62	28348404
590	Ubiquitination	EVRMENPKESSSSLK EEECCCCCCCCCCCC	80.13	-
597	Ubiquitination	KESSSSLKTGRHSSG CCCCCCCCCCCCCCC	51.38	24816145
598	Phosphorylation	ESSSSLKTGRHSSGQ CCCCCCCCCCCCCCC	44.75	29449344
602	Phosphorylation	SLKTGRHSSGQDKPH CCCCCCCCCCCCCCH	34.50	28985074
603	Phosphorylation	LKTGRHSSGQDKPHE CCCCCCCCCCCCCHH	34.06	29116813
607	Acetylation	RHSSGQDKPHETYRL CCCCCCCCCHHHHHH	40.15	23749302
607	Ubiquitination	RHSSGQDKPHETYRL CCCCCCCCCHHHHHH	40.15	33845483
607 (in isoform 3)	Ubiquitination	-	40.15	-
611	Phosphorylation	GQDKPHETYRLLKRR CCCCCHHHHHHHHHH	15.77	23312004
612	Phosphorylation	QDKPHETYRLLKRRN CCCCHHHHHHHHHHC	9.04	23312004
626	Phosphorylation	NLIIEAVTNLRLIES CHHHHHHHHHHHHHH	35.27	30266825
639	Ubiquitination	ESLFTIQKMIMDQEK HHHHHHHHHHCCHHH	26.92	-
646	Ubiquitination	KMIMDQEKQEGVSTK HHHCCHHHHCCCCHH	48.28	21906983
646 (in isoform 3)	Ubiquitination	-	48.28	21890473
651	Phosphorylation	QEKQEGVSTKCCKKS HHHHCCCCHHHCHHH	32.76	22617229
652	Phosphorylation	EKQEGVSTKCCKKSI HHHCCCCHHHCHHHH	26.20	22617229
667	Phosphorylation	VRLVRNLSEEGLLRL HHHHHCCCHHHHHHH	36.83	23911959
667 (in isoform 2)	Ubiquitination	-	36.83	21890473
685	Ubiquitination	TVIQDGIKKKVDLVV EEECCCHHHEECEEE	52.66	21906983
685 (in isoform 3)	Ubiquitination	-	52.66	21890473
686	Ubiquitination	VIQDGIKKKVDLVVH EECCCHHHEECEEEC	56.99	-
687	Ubiquitination	IQDGIKKKVDLVVHP ECCCHHHEECEEECC	35.66	29967540
695	Phosphorylation	VDLVVHPSMDQNDPL ECEEECCCCCCCCHH	21.80	27251275
706 (in isoform 2)	Ubiquitination	-	9.97	21890473
715	Phosphorylation	EQVRFRISNSSTANR HHHHHHCCCCCCCCC	26.80	24114839
724	Ubiquitination	SSTANRVKTSQPPVP CCCCCCCCCCCCCCC	38.94	21906983
724 (in isoform 3)	Ubiquitination	-	38.94	21890473
725	Phosphorylation	STANRVKTSQPPVPQ CCCCCCCCCCCCCCC	29.72	23927012
726	Phosphorylation	TANRVKTSQPPVPQG CCCCCCCCCCCCCCC	34.67	23927012
739	Phosphorylation	QGEAEEDSQGKEGPS CCCCCCCCCCCCCCC	44.08	19664994
745 (in isoform 2)	Ubiquitination	-	36.29	21890473
746	Phosphorylation	SQGKEGPSGSGDSQL CCCCCCCCCCCCCCC	57.35	29255136
748	Phosphorylation	GKEGPSGSGDSQLSA CCCCCCCCCCCCCCC	43.71	29255136
751	Phosphorylation	GPSGSGDSQLSASSR CCCCCCCCCCCCCCC	36.22	17525332
754	Phosphorylation	GSGDSQLSASSRSES CCCCCCCCCCCCCCC	20.61	29255136
756	Phosphorylation	GDSQLSASSRSESGR CCCCCCCCCCCCCCC	23.94	29255136
757	Phosphorylation	DSQLSASSRSESGRM CCCCCCCCCCCCCCC	39.27	29255136
759	Phosphorylation	QLSASSRSESGRMKK CCCCCCCCCCCCCCC	37.75	25159151
761	Phosphorylation	SASSRSESGRMKKSD CCCCCCCCCCCCCCC	32.71	23090842
770	Sumoylation	RMKKSDNKMGITPLR CCCCCCCCCCCCCCC	43.42	28112733
770	Ubiquitination	RMKKSDNKMGITPLR CCCCCCCCCCCCCCC	43.42	24816145
774	Phosphorylation	SDNKMGITPLRNYHP CCCCCCCCCCCCCCC	15.56	21712546
779	Phosphorylation	GITPLRNYHPIVVPG CCCCCCCCCCEEECC	11.53	27642862
796	Ubiquitination	RSLGFLPKMPRLRVV CCCCCCCCCCHHHHH	64.78	-
833	Sumoylation	ISERRTIKQESGRAG HHCCCEEEHHHCCCC	47.61	-
833	Sumoylation	ISERRTIKQESGRAG HHCCCEEEHHHCCCC	47.61	28112733
836	Phosphorylation	RRTIKQESGRAGVRP CCEEEHHHCCCCCCC	30.96	30576142
844	Phosphorylation	GRAGVRPSSSGSAWE CCCCCCCCCCCCHHH	26.94	25159151
845	Phosphorylation	RAGVRPSSSGSAWEA CCCCCCCCCCCHHHH	41.21	25159151
846	Phosphorylation	AGVRPSSSGSAWEAC CCCCCCCCCCHHHHH	40.90	25159151
848	Phosphorylation	VRPSSSGSAWEACSE CCCCCCCCHHHHHHC	31.96	21712546
854	Phosphorylation	GSAWEACSEAPSKGS CCHHHHHHCCCCCCC	43.79	30576142
858	Phosphorylation	EACSEAPSKGSQDGV HHHHCCCCCCCCCCC	57.61	30576142
915	Phosphorylation	ILLCLPLSIFIQIVQ HHHHHHHHHHHHHHH	17.32	-
924	Phosphorylation	FIQIVQVSYKVDNLE HHHHHHHHHCCCCHH	11.35	19413330
925	Phosphorylation	IQIVQVSYKVDNLEE HHHHHHHHCCCCHHH	19.04	19413330
939	Ubiquitination	EFLNDPLKKHTLIRF HHHCCHHHHCCHHHH	48.15	29967540
961	Phosphorylation	QLLYKRRYIFSVVEN HHHHHHHHHHHHHHH	15.45	22817900
964	Phosphorylation	YKRRYIFSVVENLQR HHHHHHHHHHHHHHH	18.72	22817900
989	Ubiquitination	PTEKFQDKDQVFIFL CCHHCCCCCCEEEEE	39.00	29967540
1048	Phosphorylation	LQCVCLNTPLGVVRC EEEEECCCCCCEEEC	13.62	26074081
1062	Phosphorylation	CPRVRKNSSTDQGSD CCCCCCCCCCCCCCC	37.34	29255136
1063	Phosphorylation	PRVRKNSSTDQGSDE CCCCCCCCCCCCCCC	45.45	29255136
1064	Phosphorylation	RVRKNSSTDQGSDEE CCCCCCCCCCCCCCC	31.96	22167270
1068	Phosphorylation	NSSTDQGSDEEGSLQ CCCCCCCCCCCCCHH	35.89	19664994
1073	Phosphorylation	QGSDEEGSLQKEQES CCCCCCCCHHHHHHH	30.79	22167270
1080	Phosphorylation	SLQKEQESAMDKHNL CHHHHHHHHHHHHHH	28.70	23403867
1090	Ubiquitination	DKHNLERKCAMLEYT HHHHHHHHHHEEEEC	19.57	29967540
1128	Ubiquitination	SSFYGHLKRNWIWTS HHHCHHHHHHHHHHH	37.70	21906983
1128 (in isoform 3)	Ubiquitination	-	37.70	21890473
1142	Sumoylation	SYIINQAKKENTAAE HHHHHHHHHHCCHHH	51.35	28112733
1143	Ubiquitination	YIINQAKKENTAAEN HHHHHHHHHCCHHHC	60.25	29967540
1146	Phosphorylation	NQAKKENTAAENGLT HHHHHHCCHHHCCCE	28.47	-
1149 (in isoform 2)	Ubiquitination	-	49.74	21890473
1153	O-linked_Glycosylation	TAAENGLTVRLQTFL CHHHCCCEEEHHHHH	12.65	30379171
1158	Phosphorylation	GLTVRLQTFLSKRPM CCEEEHHHHHHCCCC	31.00	20068231
1162	Ubiquitination	RLQTFLSKRPMPLSA EHHHHHHCCCCCCCC	63.77	33845483
1168	Phosphorylation	SKRPMPLSARGNSRL HCCCCCCCCCCCCCC	15.28	24719451
1173	Phosphorylation	PLSARGNSRLNIWGE CCCCCCCCCCCCCCC	40.75	21712546
1202	Phosphorylation	FEVDREPSLDRNRRV CCCCCCCCCCCCCCC	37.84	27690223
1227	Ubiquitination	LKKDPGKKIKRKKKG HCCCCCHHCCCCCCC	60.41	24816145
1240	Ubiquitination	KGEFPGEKSKRLRYH CCCCCCCCHHCCCCC	68.16	24816145
1242	Acetylation	EFPGEKSKRLRYHDE CCCCCCHHCCCCCCH	67.53	21339330
1253	Phosphorylation	YHDEADQSALQRMTR CCCHHCHHHHHHHHH	31.34	29255136
1286	2-Hydroxyisobutyrylation	ASNVLNTKVKGPFVT HHHHCCCCCCCCCHH	40.66	-
1286	Ubiquitination	ASNVLNTKVKGPFVT HHHHCCCCCCCCCHH	40.66	21906983
1286 (in isoform 3)	Ubiquitination	-	40.66	21890473
1288	Ubiquitination	NVLNTKVKGPFVTWQ HHCCCCCCCCCHHHH	63.52	-
1307 (in isoform 2)	Ubiquitination	-	53.03	21890473
1311	Acetylation	TFEESLDKTSHSVGR HHHHHHHCCCCCHHH	58.16	26051181
1311	Ubiquitination	TFEESLDKTSHSVGR HHHHHHHCCCCCHHH	58.16	21906983
1311 (in isoform 3)	Ubiquitination	-	58.16	21890473
1313	Phosphorylation	EESLDKTSHSVGRRA HHHHHCCCCCHHHHH	21.36	24719451
1325	Ubiquitination	RRARYIVKNPQAYLN HHHHHHHCCHHHHHC	54.04	-
1332 (in isoform 2)	Ubiquitination	-	23.15	21890473
1334	Ubiquitination	PQAYLNYKVCLAEVY HHHHHCCCCHHHHHH	25.96	29967540
1341	Phosphorylation	KVCLAEVYQDKALVG CCHHHHHHCCHHHHH	11.51	22461510
1344	Ubiquitination	LAEVYQDKALVGDFM HHHHHCCHHHHHHHH	28.26	32015554
1346	Ubiquitination	EVYQDKALVGDFMNR HHHCCHHHHHHHHHC	5.65	24816145
1361	Ubiquitination	RGDYDDPKVCANEFK CCCCCCHHHHHHHHH	57.87	29967540
1368	Ubiquitination	KVCANEFKEFVEKLK HHHHHHHHHHHHHHH	44.03	29967540
1373	Ubiquitination	EFKEFVEKLKEKFSS HHHHHHHHHHHHHHH	60.60	29967540
1377	Ubiquitination	FVEKLKEKFSSALRN HHHHHHHHHHHHHHC	49.29	29967540
1379	Phosphorylation	EKLKEKFSSALRNSN HHHHHHHHHHHHCCC	26.26	29496963
1380	Phosphorylation	KLKEKFSSALRNSNL HHHHHHHHHHHCCCC	34.16	25278378
1409	Ubiquitination	VLAIGDEKDQTRKED HEECCCCCCCCCCHH	60.93	24816145
1436	Phosphorylation	LQNLIQSTLALSDSQ HHHHHHHHHCCCHHH	10.32	-
1472	Ubiquitination	VKAFMECQKRSLVNR HHHHHHHHHHHHHCC	30.78	24816145
1473	Ubiquitination	KAFMECQKRSLVNRR HHHHHHHHHHHHCCC	56.46	-
1485	Phosphorylation	NRRRVNHTLGPKKNR CCCCCCCCCCCCCCC	28.36	-
1489	Ubiquitination	VNHTLGPKKNRALPF CCCCCCCCCCCCCCC	61.96	29967540
1535	Acetylation	DRMRAAGKLDQPDRF HHHHHCCCCCCCCCC	44.13	25953088
1535	Ubiquitination	DRMRAAGKLDQPDRF HHHHHCCCCCCCCCC	44.13	21906983
1535 (in isoform 3)	Ubiquitination	-	44.13	21890473
1541	Methylation	GKLDQPDRFSFKDQD CCCCCCCCCCCCCCC	35.47	-
1541	Ubiquitination	GKLDQPDRFSFKDQD CCCCCCCCCCCCCCC	35.47	23503661
1543	Phosphorylation	LDQPDRFSFKDQDNN CCCCCCCCCCCCCCC	32.07	29496963
1545	Ubiquitination	QPDRFSFKDQDNNEP CCCCCCCCCCCCCCC	53.97	23503661
1556 (in isoform 2)	Ubiquitination	-	2.25	21890473
1566	Ubiquitination	FSLDGPGGNCVAVLT EECCCCCCCCCHHHH	27.74	21963094
1597	Sulfoxidation	IIVVDSSMVENEVIK EEEEEHHHHHHHHHH	5.19	21406390
1604	Ubiquitination	MVENEVIKSLGKDGS HHHHHHHHHHCCCCC	44.82	23503661
1605	Phosphorylation	VENEVIKSLGKDGSL HHHHHHHHHCCCCCC	31.09	21955146
1608	Ubiquitination	EVIKSLGKDGSLEDD HHHHHHCCCCCCCCC	65.30	21906983
1608 (in isoform 3)	Ubiquitination	-	65.30	21890473
1611	Phosphorylation	KSLGKDGSLEDDEDE HHHCCCCCCCCCCCC	38.42	22167270
1629	Acetylation	LDEGVGGKRRSMEVK CCCCCCCCCCCCCCC	38.41	26051181
1629	Ubiquitination	LDEGVGGKRRSMEVK CCCCCCCCCCCCCCC	38.41	21906983
1629 (in isoform 2)	Ubiquitination	-	38.41	21890473
1629 (in isoform 3)	Ubiquitination	-	38.41	21890473
1632	Phosphorylation	GVGGKRRSMEVKPAQ CCCCCCCCCCCCCCC	24.27	23401153
1636	Ubiquitination	KRRSMEVKPAQASHT CCCCCCCCCCCCCCC	22.71	-
1641	Phosphorylation	EVKPAQASHTNYLLM CCCCCCCCCCCEEEC	20.82	24732914
1643	Phosphorylation	KPAQASHTNYLLMRG CCCCCCCCCEEECCC	24.06	24732914
1645	Phosphorylation	AQASHTNYLLMRGYY CCCCCCCEEECCCCC	11.45	24732914
1650 (in isoform 2)	Ubiquitination	-	16.27	21890473
1651	Phosphorylation	NYLLMRGYYSPGIVS CEEECCCCCCCCEEE	7.15	24732914
1652	Phosphorylation	YLLMRGYYSPGIVST EEECCCCCCCCEEEC	15.94	30266825
1653	Phosphorylation	LLMRGYYSPGIVSTR EECCCCCCCCEEECC	14.25	19664994
1658	Phosphorylation	YYSPGIVSTRNLNPN CCCCCEEECCCCCCC	21.52	30266825
1659	Phosphorylation	YSPGIVSTRNLNPND CCCCEEECCCCCCCC	16.81	30266825
1672	Phosphorylation	NDSIVVNSCQMKFQL CCCEEEECCEEEEEE	8.30	25003641
1676	Ubiquitination	VVNSCQMKFQLRCTP EEECCEEEEEEECCC	12.22	32015554
1704	Glutathionylation	ELTMGTSCLPDTFTK HHCCCCCCCCHHHHH	6.85	22555962
1708	Ubiquitination	GTSCLPDTFTKLINP CCCCCCHHHHHHCCC	31.12	27667366
1767	Phosphorylation	EELRRRFSALEKAGG HHHHHHHHHHHHCCC	30.08	20068231
1771	Ubiquitination	RRFSALEKAGGGRTR HHHHHHHHCCCCCCH	53.86	21906983
1771 (in isoform 3)	Ubiquitination	-	53.86	21890473
1792 (in isoform 2)	Ubiquitination	-	40.98	21890473
1820	Ubiquitination	LLHSVRLKDREDADI HHHHHCCCCCCCCCC	44.14	21906983
1820 (in isoform 3)	Ubiquitination	-	44.14	21890473
1840	O-linked_Glycosylation	QARPLEGSSSEDSPP CCCCCCCCCCCCCCC	22.70	30379171
1840	Phosphorylation	QARPLEGSSSEDSPP CCCCCCCCCCCCCCC	22.70	22167270
1841	Phosphorylation	ARPLEGSSSEDSPPE CCCCCCCCCCCCCCC	48.91	30266825
1841 (in isoform 2)	Ubiquitination	-	48.91	21890473
1842	Phosphorylation	RPLEGSSSEDSPPEG CCCCCCCCCCCCCCC	47.31	30266825
1845	Phosphorylation	EGSSSEDSPPEGQAP CCCCCCCCCCCCCCC	38.00	30266825
1854	Phosphorylation	PEGQAPPSHSPRGTK CCCCCCCCCCCCCCC	35.22	29255136
1856	Phosphorylation	GQAPPSHSPRGTKRR CCCCCCCCCCCCCCC	22.19	29255136
1860	Phosphorylation	PSHSPRGTKRRASWA CCCCCCCCCCCCCCC	23.74	26074081
1865	Phosphorylation	RGTKRRASWASENGE CCCCCCCCCCCCCCC	22.74	29255136
1868	Phosphorylation	KRRASWASENGETDA CCCCCCCCCCCCCCC	25.90	29255136
1873	Phosphorylation	WASENGETDAEGTQM CCCCCCCCCCCCCCC	41.74	29255136
1878	Phosphorylation	GETDAEGTQMTPAKR CCCCCCCCCCCCCCC	13.48	23927012
1881	Phosphorylation	DAEGTQMTPAKRPAL CCCCCCCCCCCCCCC	15.41	23927012
1891	Phosphorylation	KRPALQDSNLAPSLG CCCCCCCCCCCCCCC	22.30	26074081
1896	Phosphorylation	QDSNLAPSLGPGAED CCCCCCCCCCCCCCC	40.11	26074081
1911	Phosphorylation	GAEAQAPSPPPALED CCCCCCCCCCCCHHH	53.72	26074081
1953	Phosphorylation	QAQPPEGSEDPRGFT CCCCCCCCCCCCCCC	36.84	-
1962	Phosphorylation	DPRGFTESFGAANIS CCCCCCHHHCCCHHH	26.39	29214152
1969	Phosphorylation	SFGAANISQAARERD HHCCCHHHHHHHHCC	17.36	28112733
2020	Phosphorylation	RPGIPESSLLRHYQG CCCCCHHHHHHHHCC	29.75	24719451
2105	Ubiquitination	PHEVNWNKWIHL--- CCCCCCCCCCCC---	38.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
667	S	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TF3C1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TF3C1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TOP1_HUMAN	TOP1	physical	9660958
TCP4_HUMAN	SUB1	physical	9660958
TF3C4_HUMAN	GTF3C4	physical	22939629
TF3C2_HUMAN	GTF3C2	physical	22939629
TF3C5_HUMAN	GTF3C5	physical	22939629
TF3C3_HUMAN	GTF3C3	physical	22939629
TF3C6_HUMAN	GTF3C6	physical	22939629
MAGA4_HUMAN	MAGEA4	physical	25416956
ATRAP_HUMAN	AGTRAP	physical	25416956
CKLF5_HUMAN	CMTM5	physical	25416956
MTOR_HUMAN	MTOR	physical	20543138
RPTOR_HUMAN	RPTOR	physical	20543138
TF3C3_HUMAN	GTF3C3	physical	26344197
TF3C5_HUMAN	GTF3C5	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TF3C1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1068; SER-1653; SER-1865AND SER-1868, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-739 AND SER-1068, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-739; THR-774; SER-1062;THR-1064; SER-1611; SER-1632; SER-1653; SER-1856; SER-1865 ANDSER-1868, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1856, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1653, AND MASSSPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-739; SER-751 ANDSER-1969, AND MASS SPECTROMETRY.	17525332 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1653, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1062; SER-1068; SER-1865AND SER-1868, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-739; SER-1068; SER-1653AND SER-1868, AND MASS SPECTROMETRY.	15302935 [Abstract]