MAGA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGA4_HUMAN
• UniProt AC: P43358
• Protein Name: Melanoma-associated antigen 4
• Gene Name: MAGEA4
• Organism: Homo sapiens (Human).
• Sequence Length: 317
• Protein Description: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression..
• Protein Sequence: MSSEQKSQHCKPEEGVEAQEEALGLVGAQAPTTEEQEAAVSSSSPLVPGTLEEVPAAESAGPPQSPQGASALPTTISFTCWRQPNEGSSSQEEEGPSTSPDAESLFREALSNKVDELAHFLLRKYRAKELVTKAEMLERVIKNYKRCFPVIFGKASESLKMIFGIDVKEVDPASNTYTLVTCLGLSYDGLLGNNQIFPKTGLLIIVLGTIAMEGDSASEEEIWEELGVMGVYDGREHTVYGEPRKLLTQDWVQENYLEYRQVPGSNPARYEFLWGPRALAETSYVKVLEHVVRVNARVRIAYPSLREAALLEEEEGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	Phosphorylation	WRQPNEGSSSQEEEG ECCCCCCCCCCCCCC	22.19	26503892
89	Phosphorylation	RQPNEGSSSQEEEGP CCCCCCCCCCCCCCC	47.07	26503892
90	Phosphorylation	QPNEGSSSQEEEGPS CCCCCCCCCCCCCCC	43.22	26503892
97	Phosphorylation	SQEEEGPSTSPDAES CCCCCCCCCCCCHHH	52.99	28176443
98	Phosphorylation	QEEEGPSTSPDAESL CCCCCCCCCCCHHHH	47.62	20815410
99	Phosphorylation	EEEGPSTSPDAESLF CCCCCCCCCCHHHHH	25.72	18707149
104	Phosphorylation	STSPDAESLFREALS CCCCCHHHHHHHHHH	34.23	28176443
113	Ubiquitination	FREALSNKVDELAHF HHHHHHHHHHHHHHH	47.92	-
113	Acetylation	FREALSNKVDELAHF HHHHHHHHHHHHHHH	47.92	23236377
128	Ubiquitination	LLRKYRAKELVTKAE HHHHHHHHHHHHHHH	42.45	-
133	Acetylation	RAKELVTKAEMLERV HHHHHHHHHHHHHHH	34.57	23236377
133	Ubiquitination	RAKELVTKAEMLERV HHHHHHHHHHHHHHH	34.57	-
154	Ubiquitination	CFPVIFGKASESLKM HHHHHHCCCCHHHHH	37.68	21906983
160	Ubiquitination	GKASESLKMIFGIDV CCCCHHHHHHHCCCH	38.95	-
245	Ubiquitination	TVYGEPRKLLTQDWV EECCCCHHHCCHHHH	59.57	21906983
256	Phosphorylation	QDWVQENYLEYRQVP HHHHHHCCHHHCCCC	10.52	-
286	Methylation	LAETSYVKVLEHVVR HHCHHHHHHHHHHHH	32.63	21684599
286	Ubiquitination	LAETSYVKVLEHVVR HHCHHHHHHHHHHHH	32.63	21906983
286	Acetylation	LAETSYVKVLEHVVR HHCHHHHHHHHHHHH	32.63	23236377
304	Phosphorylation	RVRIAYPSLREAALL EEEECCHHHHHHHHH	27.64	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAGA4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
QCR7_HUMAN	UQCRB	physical	16189514
TRI69_HUMAN	TRIM69	physical	16189514
TEKT4_HUMAN	TEKT4	physical	16189514
1A02_HUMAN	HLA-A	physical	11502003
1A03_HUMAN	HLA-A	physical	11502003
1A01_HUMAN	HLA-A	physical	11502003
1A26_HUMAN	HLA-A	physical	11502003
PSD10_HUMAN	PSMD10	physical	12525503
A4_HUMAN	APP	physical	21832049
KITH_HUMAN	TK1	physical	25416956
QCR7_HUMAN	UQCRB	physical	25416956
WBP2_HUMAN	WBP2	physical	25416956
AMOL2_HUMAN	AMOTL2	physical	25416956
UBXN6_HUMAN	UBXN6	physical	25416956
BEX2_HUMAN	BEX2	physical	25416956
TIGD5_HUMAN	TIGD5	physical	25416956
TRI69_HUMAN	TRIM69	physical	25416956
TEKT4_HUMAN	TEKT4	physical	25416956
AMOT_HUMAN	AMOT	physical	25416956
QCR7_HUMAN	UQCRB	physical	26186194
IASPP_HUMAN	PPP1R13L	physical	26186194
MAGBG_HUMAN	MAGEB16	physical	26186194
MAGAA_HUMAN	MAGEA10	physical	26186194
MDM1_HUMAN	MDM1	physical	26186194
FXR1_HUMAN	FXR1	physical	26186194
AMOL1_HUMAN	AMOTL1	physical	26186194
AMOT_HUMAN	AMOT	physical	26186194
TIGD5_HUMAN	TIGD5	physical	26186194
IQGA1_HUMAN	IQGAP1	physical	26186194
RAD18_HUMAN	RAD18	physical	26186194
TSYL4_HUMAN	TSPYL4	physical	26186194
RL7L_HUMAN	RPL7L1	physical	26186194
DCAF6_HUMAN	DCAF6	physical	26186194
TSYL1_HUMAN	TSPYL1	physical	26186194
CC85B_HUMAN	CCDC85B	physical	26186194
ZBT17_HUMAN	ZBTB17	physical	14739298
MAGAA_HUMAN	MAGEA10	physical	28514442
TSYL4_HUMAN	TSPYL4	physical	28514442
IASPP_HUMAN	PPP1R13L	physical	28514442
MAGBG_HUMAN	MAGEB16	physical	28514442
MDM1_HUMAN	MDM1	physical	28514442
RAD18_HUMAN	RAD18	physical	28514442
QCR7_HUMAN	UQCRB	physical	28514442
TIGD5_HUMAN	TIGD5	physical	28514442
CC85B_HUMAN	CCDC85B	physical	28514442
AMOL1_HUMAN	AMOTL1	physical	28514442
DCAF6_HUMAN	DCAF6	physical	28514442
FXR1_HUMAN	FXR1	physical	28514442
RL7L_HUMAN	RPL7L1	physical	28514442
IQGA1_HUMAN	IQGAP1	physical	28514442
TSYL1_HUMAN	TSPYL1	physical	28514442
AMOT_HUMAN	AMOT	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.