TSYL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSYL1_HUMAN
• UniProt AC: Q9H0U9
• Protein Name: Testis-specific Y-encoded-like protein 1
• Gene Name: TSPYL1
• Organism: Homo sapiens (Human).
• Sequence Length: 437
• Subcellular Localization: Nucleus, nucleolus .
• Protein Sequence: MSGLDGVKRTTPLQTHSIIISDQVPSDQDAHQYLRLRDQSEATQVMAEPGEGGSETVALPPPPPSEEGGVPQDAAGRGGTPQIRVVGGRGHVAIKAGQEEGQPPAEGLAAASVVMAADRSLKKGVQGGEKALEICGAQRSASELTAGAEAEAEEVKTGKCATVSAAVAERESAEVVKEGLAEKEVMEEQMEVEEQPPEGEEIEVAEEDRLEEEAREEEGPWPLHEALRMDPLEAIQLELDTVNAQADRAFQQLEHKFGRMRRHYLERRNYIIQNIPGFWMTAFRNHPQLSAMIRGQDAEMLRYITNLEVKELRHPRTGCKFKFFFRRNPYFRNKLIVKEYEVRSSGRVVSLSTPIIWRRGHEPQSFIRRNQDLICSFFTWFSDHSLPESDKIAEIIKEDLWPNPLQYYLLREGVRRARRRPLREPVEIPRPFGFQSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	GLDGVKRTTPLQTHS CCCCCCCCCCCCEEE	27.35	28857561
11	Phosphorylation	LDGVKRTTPLQTHSI CCCCCCCCCCCEEEE	26.49	28985074
15	Phosphorylation	KRTTPLQTHSIIISD CCCCCCCEEEEEEEC	25.85	23312004
17	Phosphorylation	TTPLQTHSIIISDQV CCCCCEEEEEEECCC	20.90	23312004
21	Phosphorylation	QTHSIIISDQVPSDQ CEEEEEEECCCCCCC	16.16	27251275
26	Phosphorylation	IISDQVPSDQDAHQY EEECCCCCCCCHHHH	49.39	22496350
33	Phosphorylation	SDQDAHQYLRLRDQS CCCCHHHHHHHHCHH	5.50	27251275
80	Phosphorylation	DAAGRGGTPQIRVVG CCCCCCCCCCEEEEC	18.16	29496963
95	Sumoylation	GRGHVAIKAGQEEGQ CCCEEEECCCCCCCC	36.41	-
112	Phosphorylation	AEGLAAASVVMAADR CCHHHHHHHHHHHHH	15.54	25954137
120	Phosphorylation	VVMAADRSLKKGVQG HHHHHHHHHHHCCCC	45.12	25954137
123	Acetylation	AADRSLKKGVQGGEK HHHHHHHHCCCCHHH	70.39	25953088
130	Acetylation	KGVQGGEKALEICGA HCCCCHHHHHHHHCC	62.64	25953088
130	Ubiquitination	KGVQGGEKALEICGA HCCCCHHHHHHHHCC	62.64	32015554
140	Phosphorylation	EICGAQRSASELTAG HHHCCCCCHHHHCCC	24.86	29978859
142	Phosphorylation	CGAQRSASELTAGAE HCCCCCHHHHCCCCH	34.09	29978859
145	Phosphorylation	QRSASELTAGAEAEA CCCHHHHCCCCHHHH	20.99	28985074
156	Sumoylation	EAEAEEVKTGKCATV HHHHHHHHCCCCCHH	55.64	-
156	Sumoylation	EAEAEEVKTGKCATV HHHHHHHHCCCCCHH	55.64	28112733
156	Ubiquitination	EAEAEEVKTGKCATV HHHHHHHHCCCCCHH	55.64	32015554
157	Phosphorylation	AEAEEVKTGKCATVS HHHHHHHCCCCCHHH	47.23	23312004
159	Ubiquitination	AEEVKTGKCATVSAA HHHHHCCCCCHHHHH	26.40	32015554
164	Phosphorylation	TGKCATVSAAVAERE CCCCCHHHHHHHHHH	13.22	28176443
177	Ubiquitination	RESAEVVKEGLAEKE HHHHHHHHHHHHHHH	51.76	29967540
256	Ubiquitination	AFQQLEHKFGRMRRH HHHHHHHHHHHHHHH	39.89	23000965
257	Ubiquitination	FQQLEHKFGRMRRHY HHHHHHHHHHHHHHH	8.94	21890473
262	Dimethylation	HKFGRMRRHYLERRN HHHHHHHHHHHHHCC	17.29	-
262	Methylation	HKFGRMRRHYLERRN HHHHHHHHHHHHHCC	17.29	30763395
270	Phosphorylation	HYLERRNYIIQNIPG HHHHHCCCEECCCCC	9.51	19835603
310	Ubiquitination	YITNLEVKELRHPRT HHHHCCHHHCCCCCC	41.47	21963094
311	Ubiquitination	ITNLEVKELRHPRTG HHHCCHHHCCCCCCC	57.10	21890473
322	Ubiquitination	PRTGCKFKFFFRRNP CCCCCEEEEEECCCH	27.10	-
322	Sumoylation	PRTGCKFKFFFRRNP CCCCCEEEEEECCCH	27.10	-
322	Sumoylation	PRTGCKFKFFFRRNP CCCCCEEEEEECCCH	27.10	-
334	Ubiquitination	RNPYFRNKLIVKEYE CCHHHCCCEEEEEEE	35.02	22817900
338	Ubiquitination	FRNKLIVKEYEVRSS HCCCEEEEEEEECCC	47.81	21963094
340	Phosphorylation	NKLIVKEYEVRSSGR CCEEEEEEEECCCCC	17.63	29496907
382	Phosphorylation	CSFFTWFSDHSLPES HHHHHHHCCCCCCCH	26.44	-
397	Ubiquitination	DKIAEIIKEDLWPNP HHHHHHHHHCCCCCH	51.33	33845483
436	Phosphorylation	PRPFGFQSG------ CCCCCCCCC------	44.18	29214152

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSYL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSYL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSYL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HAP1_HUMAN	HAP1	physical	16169070
A4_HUMAN	APP	physical	21832049
NP1L3_HUMAN	NAP1L3	physical	28514442
TSYL2_HUMAN	TSPYL2	physical	28514442
LCA5_HUMAN	LCA5	physical	28514442
PCM1_HUMAN	PCM1	physical	28514442
SI1L2_HUMAN	SIPA1L2	physical	28514442
OSBL3_HUMAN	OSBPL3	physical	28514442
SPAG5_HUMAN	SPAG5	physical	28514442
SNX6_HUMAN	SNX6	physical	28514442
ZN687_HUMAN	ZNF687	physical	28514442
DDX24_HUMAN	DDX24	physical	28514442
AMER1_HUMAN	AMER1	physical	28514442
EVI5L_HUMAN	EVI5L	physical	28514442
PKCB1_HUMAN	ZMYND8	physical	28514442
MRS2_HUMAN	MRS2	physical	28514442
TSYL4_HUMAN	TSPYL4	physical	28514442
GPC3_HUMAN	GPC3	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442
FA83H_HUMAN	FAM83H	physical	28514442
K0232_HUMAN	KIAA0232	physical	28514442
AKA11_HUMAN	AKAP11	physical	28514442
RICTR_HUMAN	RICTOR	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 608800: Sudden infant death with dysgenesis of the testes syndrome (SIDDT)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.