dbPTM

SPAG5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPAG5_HUMAN
UniProt AC	Q96R06
Protein Name	Sperm-associated antigen 5
Gene Name	SPAG5
Organism	Homo sapiens (Human).
Sequence Length	1193
Subcellular Localization	Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Chromosome, centromere, kinetochore . Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytopl
Protein Description	Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. [PubMed: 11724960]
Protein Sequence	MWRVKKLSLSLSPSPQTGKPSMRTPLRELTLQPGALTNSGKRSPACSSLTPSLCKLGLQEGSNNSSPVDFVNNKRTDLSSEHFSHSSKWLETCQHESDEQPLDPIPQISSTPKTSEEAVDPLGNYMVKTIVLVPSPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGDRFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSKESLSSRTEAVREDLVPSESNAFLPSSVLWLSPSTALAADFRVNHVDPEEEIVEHGAMEEREMRFPTHPKESETEDQALVSSVEDILSTCLTPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLRQSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLEFLS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MWRVKKLSLSLSPSP CCCEEEEEEECCCCC	25.45	20068231
10	Phosphorylation	RVKKLSLSLSPSPQT CEEEEEEECCCCCCC	24.35	25159151
12	Phosphorylation	KKLSLSLSPSPQTGK EEEEEECCCCCCCCC	21.69	25159151
14	Phosphorylation	LSLSLSPSPQTGKPS EEEECCCCCCCCCCC	26.68	25159151
17	Phosphorylation	SLSPSPQTGKPSMRT ECCCCCCCCCCCCCC	51.02	20068231
19	Ubiquitination	SPSPQTGKPSMRTPL CCCCCCCCCCCCCCH	36.99	29967540
21	Phosphorylation	SPQTGKPSMRTPLRE CCCCCCCCCCCCHHH	25.12	20068231
24	Phosphorylation	TGKPSMRTPLRELTL CCCCCCCCCHHHEEC	20.31	25159151
30	Phosphorylation	RTPLRELTLQPGALT CCCHHHEECCCCCCC	20.70	29449344
37	Phosphorylation	TLQPGALTNSGKRSP ECCCCCCCCCCCCCC	27.14	30266825
39	Phosphorylation	QPGALTNSGKRSPAC CCCCCCCCCCCCCCH	40.22	30266825
41	Acetylation	GALTNSGKRSPACSS CCCCCCCCCCCCHHH	49.91	25953088
41	Ubiquitination	GALTNSGKRSPACSS CCCCCCCCCCCCHHH	49.91	-
43	Phosphorylation	LTNSGKRSPACSSLT CCCCCCCCCCHHHCC	21.97	30266825
47	Phosphorylation	GKRSPACSSLTPSLC CCCCCCHHHCCHHHH	30.41	30266825
48	Phosphorylation	KRSPACSSLTPSLCK CCCCCHHHCCHHHHH	35.83	29396449
50	Phosphorylation	SPACSSLTPSLCKLG CCCHHHCCHHHHHHC	16.87	25159151
52	Phosphorylation	ACSSLTPSLCKLGLQ CHHHCCHHHHHHCCC	40.96	29396449
55	Ubiquitination	SLTPSLCKLGLQEGS HCCHHHHHHCCCCCC	51.38	29967540
62	Phosphorylation	KLGLQEGSNNSSPVD HHCCCCCCCCCCCCC	31.89	25159151
65	Phosphorylation	LQEGSNNSSPVDFVN CCCCCCCCCCCCHHC	40.02	25159151
66	Phosphorylation	QEGSNNSSPVDFVNN CCCCCCCCCCCHHCC	30.94	25159151
74	Ubiquitination	PVDFVNNKRTDLSSE CCCHHCCCCCCCCHH	52.01	29967540
76	Phosphorylation	DFVNNKRTDLSSEHF CHHCCCCCCCCHHHH	42.79	19691289
79	Phosphorylation	NNKRTDLSSEHFSHS CCCCCCCCHHHHCCC	36.17	25159151
80	Phosphorylation	NKRTDLSSEHFSHSS CCCCCCCHHHHCCCH	42.25	19691289
84	Phosphorylation	DLSSEHFSHSSKWLE CCCHHHHCCCHHHHH	25.11	20860994
86	Phosphorylation	SSEHFSHSSKWLETC CHHHHCCCHHHHHHC	32.20	23403867
87	Phosphorylation	SEHFSHSSKWLETCQ HHHHCCCHHHHHHCC	23.56	23186163
88	Ubiquitination	EHFSHSSKWLETCQH HHHCCCHHHHHHCCC	59.83	29967540
92	Phosphorylation	HSSKWLETCQHESDE CCHHHHHHCCCCCCC	18.46	-
97	Phosphorylation	LETCQHESDEQPLDP HHHCCCCCCCCCCCC	44.30	25159151
109	Phosphorylation	LDPIPQISSTPKTSE CCCCCCCCCCCCCCH	23.94	18691976
110	Phosphorylation	DPIPQISSTPKTSEE CCCCCCCCCCCCCHH	50.81	30576142
111	Phosphorylation	PIPQISSTPKTSEEA CCCCCCCCCCCCHHH	23.24	25159151
113	Ubiquitination	PQISSTPKTSEEAVD CCCCCCCCCCHHHCC	65.85	29967540
114	Phosphorylation	QISSTPKTSEEAVDP CCCCCCCCCHHHCCC	42.44	20860994
115	Phosphorylation	ISSTPKTSEEAVDPL CCCCCCCCHHHCCCC	39.30	19691289
125	Phosphorylation	AVDPLGNYMVKTIVL HCCCCCCCEEEEEEE	11.07	29978859
129	Phosphorylation	LGNYMVKTIVLVPSP CCCCEEEEEEEECCC	12.61	29978859
135	Phosphorylation	KTIVLVPSPLGQQQD EEEEEECCCCCCCHH	25.85	30278072
151	Phosphorylation	IFEARLDTMAETNSI HHHHHHHHHHCCCCC	23.91	19691289
155	Phosphorylation	RLDTMAETNSISLNG HHHHHHCCCCCCCCC	25.40	19691289
157	Phosphorylation	DTMAETNSISLNGPL HHHHCCCCCCCCCCC	22.45	25159151
159	Phosphorylation	MAETNSISLNGPLRT HHCCCCCCCCCCCCC	18.66	25159151
183	Phosphorylation	PCMGDRFSEVAAVSE HHCCCCHHHHHHHCC	31.86	27174698
189	Phosphorylation	FSEVAAVSEKPIFQE HHHHHHHCCCCCCCC	34.87	20873877
191	Ubiquitination	EVAAVSEKPIFQESP HHHHHCCCCCCCCCH	35.59	29967540
197	Phosphorylation	EKPIFQESPSHLLEE CCCCCCCCHHHHCCC	22.40	30576142
199	Phosphorylation	PIFQESPSHLLEESP CCCCCCHHHHCCCCC	35.73	25159151
205	Phosphorylation	PSHLLEESPPNPCSE HHHHCCCCCCCCCCC	35.96	25159151
211	Phosphorylation	ESPPNPCSEQLHCSK CCCCCCCCCHHHCCH	29.63	20873877
217	Phosphorylation	CSEQLHCSKESLSSR CCCHHHCCHHHHHHC	28.80	20873877
220	Phosphorylation	QLHCSKESLSSRTEA HHHCCHHHHHHCHHH	36.97	21815630
222	Phosphorylation	HCSKESLSSRTEAVR HCCHHHHHHCHHHHH	27.36	29449344
223	Phosphorylation	CSKESLSSRTEAVRE CCHHHHHHCHHHHHH	48.81	29449344
225	Phosphorylation	KESLSSRTEAVREDL HHHHHHCHHHHHHHC	30.19	28122231
235	Phosphorylation	VREDLVPSESNAFLP HHHHCCCCCCCCCCC	46.29	28122231
237	Phosphorylation	EDLVPSESNAFLPSS HHCCCCCCCCCCCCC	37.48	28122231
243	Phosphorylation	ESNAFLPSSVLWLSP CCCCCCCCCEEEECH	34.91	28450419
244	Phosphorylation	SNAFLPSSVLWLSPS CCCCCCCCEEEECHH	21.20	28450419
249	Phosphorylation	PSSVLWLSPSTALAA CCCEEEECHHHHHHH	12.77	25159151
251	Phosphorylation	SVLWLSPSTALAADF CEEEECHHHHHHHCC	23.96	28450419
252	Phosphorylation	VLWLSPSTALAADFR EEEECHHHHHHHCCC	29.13	28450419
334	Phosphorylation	DVGRILGSDTESWMS HHHHHCCCCCCCCCC	37.60	25159151
336	Phosphorylation	GRILGSDTESWMSPL HHHCCCCCCCCCCHH	33.35	22199227
338	Phosphorylation	ILGSDTESWMSPLAW HCCCCCCCCCCHHHH	30.12	22199227
341	Phosphorylation	SDTESWMSPLAWLEK CCCCCCCCHHHHHHC	15.54	25159151
352	Phosphorylation	WLEKGVNTSVMLENL HHHCCCCHHHHHHHH	21.94	25159151
353	Phosphorylation	LEKGVNTSVMLENLR HHCCCCHHHHHHHHH	10.58	25159151
362	Phosphorylation	MLENLRQSLSLPSML HHHHHHHHCCCCHHH	17.31	25159151
364	Phosphorylation	ENLRQSLSLPSMLRD HHHHHHCCCCHHHHH	43.40	26055452
367	Phosphorylation	RQSLSLPSMLRDAAI HHHCCCCHHHHHHCC	35.42	22199227
376	Phosphorylation	LRDAAIGTTPFSTCS HHHHCCCCCCCCCCC	25.78	22199227
377	Phosphorylation	RDAAIGTTPFSTCSV HHHCCCCCCCCCCCC	19.68	22199227
380	Phosphorylation	AIGTTPFSTCSVGTW CCCCCCCCCCCCCCE	29.70	28348404
381	Phosphorylation	IGTTPFSTCSVGTWF CCCCCCCCCCCCCEE	14.80	22199227
383	Phosphorylation	TTPFSTCSVGTWFTP CCCCCCCCCCCEECC	24.54	22199227
386	Phosphorylation	FSTCSVGTWFTPSAP CCCCCCCCEECCCCC	18.43	22199227
389	Phosphorylation	CSVGTWFTPSAPQEK CCCCCEECCCCCCCC	14.11	22199227
391	Phosphorylation	VGTWFTPSAPQEKST CCCEECCCCCCCCCC	49.91	22199227
396	Ubiquitination	TPSAPQEKSTNTSQT CCCCCCCCCCCCCCC	58.28	-
397	Phosphorylation	PSAPQEKSTNTSQTG CCCCCCCCCCCCCCC	26.57	25159151
398	Phosphorylation	SAPQEKSTNTSQTGL CCCCCCCCCCCCCCC	54.29	25159151
400	Phosphorylation	PQEKSTNTSQTGLVG CCCCCCCCCCCCCCC	23.46	21712546
401	Phosphorylation	QEKSTNTSQTGLVGT CCCCCCCCCCCCCCC	28.02	17525332
403	Phosphorylation	KSTNTSQTGLVGTKH CCCCCCCCCCCCCCC	32.05	21712546
408	Phosphorylation	SQTGLVGTKHSTSET CCCCCCCCCCCCCHH	20.36	22199227
409	Ubiquitination	QTGLVGTKHSTSETE CCCCCCCCCCCCHHH	29.63	29967540
409	Acetylation	QTGLVGTKHSTSETE CCCCCCCCCCCCHHH	29.63	26051181
411	Phosphorylation	GLVGTKHSTSETEQL CCCCCCCCCCHHHHH	34.87	29214152
412	Phosphorylation	LVGTKHSTSETEQLL CCCCCCCCCHHHHHH	30.24	25159151
413	Phosphorylation	VGTKHSTSETEQLLC CCCCCCCCHHHHHHC	45.60	25159151
440	Phosphorylation	DLEDNLLSSLVILEV CCCHHHHHHHHHHHH	25.45	27732954
441	Phosphorylation	LEDNLLSSLVILEVL CCHHHHHHHHHHHHH	26.99	27732954
449	Phosphorylation	LVILEVLSRQLRDWK HHHHHHHHHHHHHHH	24.13	27732954
456	Ubiquitination	SRQLRDWKSQLAVPH HHHHHHHHHHCCCCC	32.39	29967540
466	Phosphorylation	LAVPHPETQDSSTQT CCCCCCCCCCCCCCC	41.97	28555341
473	Phosphorylation	TQDSSTQTDTSHSGI CCCCCCCCCCCCCCH	41.14	21712546
475	Phosphorylation	DSSTQTDTSHSGITN CCCCCCCCCCCCHHH	31.55	21712546
476	Phosphorylation	SSTQTDTSHSGITNK CCCCCCCCCCCHHHH	20.61	21712546
483	Ubiquitination	SHSGITNKLQHLKES CCCCHHHHHHHHHHH	40.65	22817900
488	Ubiquitination	TNKLQHLKESHEMGQ HHHHHHHHHHHHHHH	55.86	22817900
552	Ubiquitination	CCFDLLKKLRAKLQS HHHHHHHHHHHHHHH	43.08	-
556	Ubiquitination	LLKKLRAKLQSLKAE HHHHHHHHHHHHHHH	40.40	29967540
559	Phosphorylation	KLRAKLQSLKAEREE HHHHHHHHHHHHHHH	42.12	23909892
561	Ubiquitination	RAKLQSLKAEREEAR HHHHHHHHHHHHHHH	54.14	24816145
578	Ubiquitination	EEMALRGKDAAEIVL HHHHHHCCCHHHHHH	37.45	-
614	Ubiquitination	REFRGLLKDAQTQLV HHHHHHHHHHHHHHH	56.94	33845483
647	Phosphorylation	TLQQDWRSMQLDYTT HHHHHHHHCCCCHHH	13.46	29083192
652	Phosphorylation	WRSMQLDYTTWTALL HHHCCCCHHHHHHHH	18.05	29083192
653	Phosphorylation	RSMQLDYTTWTALLS HHCCCCHHHHHHHHH	18.61	29083192
654	Phosphorylation	SMQLDYTTWTALLSR HCCCCHHHHHHHHHH	18.00	29083192
656	Phosphorylation	QLDYTTWTALLSRSR CCCHHHHHHHHHHHH	12.82	29083192
668	Ubiquitination	RSRQLTEKLTVKSQQ HHHHHHHHHCHHHHH	44.19	-
672	Ubiquitination	LTEKLTVKSQQALQE HHHHHCHHHHHHHHH	36.99	32015554
687	Ubiquitination	RDVAIEEKQEVSRVL CCCHHHHHHHHHHHH	38.68	24816145
705	Ubiquitination	SAQLEECKGQTEQLE HHHHHHCCCCCHHHH	58.28	29967540
716	Phosphorylation	EQLELENSRLATDLR HHHHHHHHHHHHHHH	21.21	22210691
720	Phosphorylation	LENSRLATDLRAQLQ HHHHHHHHHHHHHHH	39.91	22210691
753	Ubiquitination	CAQDLAMKDELLCQL HHHHHHHHHHHHHHH	42.30	29967540
779	Ubiquitination	QKEEMALKHMQAELQ HHHHHHHHHHHHHHH	27.74	29967540
794	Ubiquitination	QQQAVLAKEVRDLKE HHHHHHHHHHHHHHH	53.21	29967540
825	Ubiquitination	GQVECQLKTTLEVLR CCCHHHHHHHHHHHH	17.37	29967540
835	Phosphorylation	LEVLRERSLQCENLK HHHHHHHHCCCCCHH	20.31	25159151
842	Ubiquitination	SLQCENLKDTVENLT HCCCCCHHHHHHHHH	64.04	32015554
851	Ubiquitination	TVENLTAKLASTIAD HHHHHHHHHHHHHHH	39.07	29967540
866	Ubiquitination	NQEQDLEKTRQYSQK CHHHHHHHHHHHHHH	57.20	29967540
873	Ubiquitination	KTRQYSQKLGLLTEQ HHHHHHHHHCHHHHH	38.28	-
895	Ubiquitination	LQTKLKEKTEQETLL HHHHHCHHHHHHEEE	56.63	29967540
936	Phosphorylation	VADEEPESTPVPLLG HCCCCCCCCCCCCCC	49.04	27174698
937	Phosphorylation	ADEEPESTPVPLLGS CCCCCCCCCCCCCCC	27.00	18055457
944	Phosphorylation	TPVPLLGSDKSAFTR CCCCCCCCCHHHHHH	41.66	27174698
946	Ubiquitination	VPLLGSDKSAFTRVA CCCCCCCHHHHHHHH	45.43	29967540
947	Phosphorylation	PLLGSDKSAFTRVAS CCCCCCHHHHHHHHH	33.34	27174698
950	Phosphorylation	GSDKSAFTRVASMVS CCCHHHHHHHHHHHC	24.77	26074081
954	Phosphorylation	SAFTRVASMVSLQPA HHHHHHHHHHCCCCC	19.50	26074081
957	Phosphorylation	TRVASMVSLQPAETP HHHHHHHCCCCCCCC	16.79	26074081
963	Phosphorylation	VSLQPAETPGMEESL HCCCCCCCCCCHHHH	27.52	26074081
969	Phosphorylation	ETPGMEESLAEMSIM CCCCCHHHHHHHHHH	21.41	26074081
974	Phosphorylation	EESLAEMSIMTTELQ HHHHHHHHHHHHHHH	10.74	18055457
978	Phosphorylation	AEMSIMTTELQSLCS HHHHHHHHHHHHHHH	19.81	18055457
1001	Ubiquitination	AIRTLQRKICELQAR HHHHHHHHHHHHHHH	38.45	29967540
1021	Ubiquitination	EQHQEVQKAKEADIE HHHHHHHHHHHHCHH	67.60	29967540
1023	Acetylation	HQEVQKAKEADIEKL HHHHHHHHHHCHHHH	61.54	20167786
1023	Ubiquitination	HQEVQKAKEADIEKL HHHHHHHHHHCHHHH	61.54	-
1029	Acetylation	AKEADIEKLNQALCL HHHHCHHHHHHHHHH	53.74	20167786
1029	Ubiquitination	AKEADIEKLNQALCL HHHHCHHHHHHHHHH	53.74	29967540
1039	Ubiquitination	QALCLRYKNEKELQE HHHHHHCCCHHHHHH	52.80	29967540
1042	Ubiquitination	CLRYKNEKELQEVIQ HHHCCCHHHHHHHHH	73.45	29967540
1054	Ubiquitination	VIQQQNEKILEQIDK HHHHHHHHHHHHHHH	61.20	29967540
1061	Ubiquitination	KILEQIDKSGELISL HHHHHHHHCCCEEHH	63.09	29967540
1062	Phosphorylation	ILEQIDKSGELISLR HHHHHHHCCCEEHHH	33.48	23403867
1073	Phosphorylation	ISLREEVTHLTRSLR EHHHHHHHHHHHHHH	17.91	23403867
1076	Phosphorylation	REEVTHLTRSLRRAE HHHHHHHHHHHHHHH	15.59	23403867
1078	Phosphorylation	EVTHLTRSLRRAETE HHHHHHHHHHHHHHH	22.46	-
1121	Ubiquitination	WLSQEVDKLRVMFLE HHCHHHHHHHHHEEE	43.28	-
1156	Ubiquitination	ENLRRSDKELEKLDD HHHHHCHHHHHHHHH	66.50	29967540
1160	Ubiquitination	RSDKELEKLDDIVQH HCHHHHHHHHHHHHH	70.60	29967540
1170	Ubiquitination	DIVQHIYKTLLSIPE HHHHHHHHHHHCHHH	31.90	32015554
1171	Phosphorylation	IVQHIYKTLLSIPEV HHHHHHHHHHCHHHH	18.89	21406692
1174	Phosphorylation	HIYKTLLSIPEVVRG HHHHHHHCHHHHHHH	38.93	21406692
1183	Ubiquitination	PEVVRGCKELQGLLE HHHHHHHHHHHHHHH	65.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
111	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
115	S	Phosphorylation	Kinase	AURA	O14965	PSP
135	S	Phosphorylation	Kinase	CDK1	P06493	PSP
249	S	Phosphorylation	Kinase	CDK1	P06493	PSP
937	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
974	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
978	T	Phosphorylation	Kinase	GSK3B	P49841	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPAG5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPAG5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FBX28_HUMAN	FBXO28	physical	25416956
ORC6_HUMAN	ORC6	physical	25416956
AMOL2_HUMAN	AMOTL2	physical	25416956
CCHCR_HUMAN	CCHCR1	physical	25416956
MIC19_HUMAN	CHCHD3	physical	25416956
CA109_HUMAN	C1orf109	physical	25416956
RBM41_HUMAN	RBM41	physical	25416956
PPL13_HUMAN	LGALS14	physical	25416956
TSH3_HUMAN	TSHZ3	physical	25416956
SH24A_HUMAN	SH2D4A	physical	25416956
TTC23_HUMAN	TTC23	physical	25416956
ZC21C_HUMAN	ZC2HC1C	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
LIGO1_HUMAN	LINGO1	physical	25416956
HAUS1_HUMAN	HAUS1	physical	25416956
SNP47_HUMAN	SNAP47	physical	25416956
ZMAT2_HUMAN	ZMAT2	physical	25416956
CD20B_HUMAN	CDC20B	physical	25416956
ZC3H1_HUMAN	ZFC3H1	physical	25416956
KANL1_HUMAN	KANSL1	physical	25416956
ZFY26_HUMAN	ZFYVE26	physical	21516116
ENKD1_HUMAN	ENKD1	physical	21516116
ZGPAT_HUMAN	ZGPAT	physical	21516116
TRI18_HUMAN	MID1	physical	26748699
TRIM1_HUMAN	MID2	physical	26748699
TBA3C_HUMAN	TUBA3C	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPAG5_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43; THR-50; SER-62;SER-65; SER-66 AND SER-135, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62; SER-65; SER-66;THR-111; SER-135; SER-159; SER-249; SER-341; SER-353 AND THR-403, ANDMASS SPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157; SER-353; SER-362;SER-401 AND THR-403, AND MASS SPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62; SER-66; THR-111;SER-135; SER-249; SER-334; SER-341; SER-353; SER-362; SER-364;THR-377; THR-389; SER-401 AND THR-937, AND MASS SPECTROMETRY.	16565220 [Abstract]