ZFY26_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZFY26_HUMAN
• UniProt AC: Q68DK2
• Protein Name: Zinc finger FYVE domain-containing protein 26
• Gene Name: ZFYVE26
• Organism: Homo sapiens (Human).
• Sequence Length: 2539
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.
• Protein Description: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair..
• Protein Sequence: MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVCPNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENILEELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDDGTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLCEELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDHLDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDREFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCIQQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDAVDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPANDSLSSPGAANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYAEDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGPHRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRDGLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGRDRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASCILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPLREVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGIRGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASHTTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGKQTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLLFERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLHASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVACLGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGSLQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDVDDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISDTAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEYELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLFMLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRSDSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKSESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDAVVQDICAQWLLTSHPRGAHGPGSRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MNHPFGKEEAASQK -CCCCCCHHHHHHHH	53.40	-
144	Phosphorylation	DGNPRRESWTPRLSS CCCCCCCCCCCCCCH	34.14	23403867
146	Phosphorylation	NPRRESWTPRLSSEA CCCCCCCCCCCCHHH	14.07	23403867
154 (in isoform 3)	Ubiquitination	-	3.40	21906983
261	Phosphorylation	LREERLLSCLLHKAS CCHHHHHHHHHHHHH	13.81	28842319
266	Ubiquitination	LLSCLLHKASRGLLS HHHHHHHHHHHHHHH	48.29	-
274 (in isoform 2)	Ubiquitination	-	6.31	21906983
291	Phosphorylation	TEKPPRATASGKVSP CCCCCCCCCCCCCCH	23.72	23403867
293	Phosphorylation	KPPRATASGKVSPDH CCCCCCCCCCCCHHH	34.49	29255136
295	Acetylation	PRATASGKVSPDHLD CCCCCCCCCCHHHCC	36.72	11921387
295	Ubiquitination	PRATASGKVSPDHLD CCCCCCCCCCHHHCC	36.72	21906983
295 (in isoform 1)	Ubiquitination	-	36.72	21906983
297	Phosphorylation	ATASGKVSPDHLDPE CCCCCCCCHHHCCHH	28.26	29255136
334	Ubiquitination	CLSNNKHFLEQILVT HHHCCHHHHHHHHHH	9.55	27667366
365	Ubiquitination	LDREFRPLSCLLVLL CCCCCHHHHHHHHHH	5.01	27667366
366	Phosphorylation	DREFRPLSCLLVLLG CCCCHHHHHHHHHHC	12.85	28842319
382	Phosphorylation	THCQSLESAKRLLQT HHHHCHHHHHHHHHH	44.37	28842319
423	Phosphorylation	LEWCIQQSSNPIPKR HHHHHHCCCCCCCHH	18.73	-
424	Phosphorylation	EWCIQQSSNPIPKRD HHHHHCCCCCCCHHH	42.14	-
468	Ubiquitination	DVLKLLQKVPAKDPQ HHHHHHHCCCCCCCC	50.59	29967540
545	Phosphorylation	PANDSLSSPGAANLF CCCCCCCCCCHHHHH	32.42	29507054
609	Phosphorylation	DDDIEGKSPSGLRSP CCCCCCCCCCCCCCC	34.84	25159151
611	Phosphorylation	DIEGKSPSGLRSPSE CCCCCCCCCCCCCCC	58.51	23927012
615	Phosphorylation	KSPSGLRSPSESPQH CCCCCCCCCCCCCCC	37.51	30266825
617	Phosphorylation	PSGLRSPSESPQHIA CCCCCCCCCCCCCCC	52.53	30266825
619	Phosphorylation	GLRSPSESPQHIAHP CCCCCCCCCCCCCCC	33.91	30266825
634	Phosphorylation	ERKSERGSLGVPKTL CCCCCCCCCCCCCCH	28.33	25159151
637	Ubiquitination	SERGSLGVPKTLAYT CCCCCCCCCCCHHCC	5.50	27667366
643	Phosphorylation	GVPKTLAYTMPSHVK CCCCCHHCCCCCCCC	13.49	21945579
644	Phosphorylation	VPKTLAYTMPSHVKA CCCCHHCCCCCCCCC	19.59	21945579
664	Phosphorylation	YPGPHRHSFLDLKHF CCCCCCCCCCCHHHH	27.71	32142685
700	Phosphorylation	QEQLDEISSRSPPEK HHHHHHHHHCCCCCC	20.04	30108239
701	Phosphorylation	EQLDEISSRSPPEKP HHHHHHHHCCCCCCC	42.30	30108239
703	Phosphorylation	LDEISSRSPPEKPKQ HHHHHHCCCCCCCCC	46.91	21712546
707	Ubiquitination	SSRSPPEKPKQESQS HHCCCCCCCCCCCCC	64.39	-
709	Ubiquitination	RSPPEKPKQESQSCS CCCCCCCCCCCCCCC	77.19	-
712	Phosphorylation	PEKPKQESQSCSGSR CCCCCCCCCCCCCCC	25.54	28985074
716	Phosphorylation	KQESQSCSGSRDGLQ CCCCCCCCCCCHHHH	45.08	28985074
744	Phosphorylation	QWRHKVVTSNHRSEE HHHCCCCCCCCCCCC	27.14	-
757	Phosphorylation	EEQPSRRYQPATRHP CCCCCCCCCCCCCCH	20.10	23312004
761	Phosphorylation	SRRYQPATRHPSLRR CCCCCCCCCCHHHHH	35.87	23312004
765	Phosphorylation	QPATRHPSLRRGRRT CCCCCCHHHHHCCCC	28.51	23312004
796	Phosphorylation	ESTSSELSTSTSEGS CCCCCCCCCCCCCCC	19.09	27690223
797	Phosphorylation	STSSELSTSTSEGSL CCCCCCCCCCCCCCH	48.96	27251275
798	Phosphorylation	TSSELSTSTSEGSLS CCCCCCCCCCCCCHH	26.93	27251275
799	Phosphorylation	SSELSTSTSEGSLSA CCCCCCCCCCCCHHC	30.77	27251275
800	Phosphorylation	SELSTSTSEGSLSAM CCCCCCCCCCCHHCC	39.46	23186163
803	Phosphorylation	STSTSEGSLSAMSGR CCCCCCCCHHCCCCC	18.33	27251275
805	Phosphorylation	STSEGSLSAMSGRNE CCCCCCHHCCCCCCH	24.51	27251275
865 (in isoform 2)	Ubiquitination	-	36.07	21906983
873	Phosphorylation	ELMFMERYQEVIQEL CCHHHHHHHHHHHHH	8.84	22817900
886	Ubiquitination	ELAQVEHKIENQNSD HHHHHHHHHHHCCCC	37.90	21906983
886 (in isoform 1)	Ubiquitination	-	37.90	21906983
896	Phosphorylation	NQNSDAGSSTIRRTG HCCCCCCCCCCCCCC	26.48	-
923	Phosphorylation	AAAGMVFYSISDVTD HHCCCCEEEHHHHHH	8.16	-
924	Phosphorylation	AAGMVFYSISDVTDK HCCCCEEEHHHHHHH	12.26	-
929	Phosphorylation	FYSISDVTDKLLNTS EEEHHHHHHHHHCCC	32.19	-
1001	Phosphorylation	TAERRLNSSLERRGR HHHHHHHHHHHHHCC	40.67	23186163
1002	Phosphorylation	AERRLNSSLERRGRR HHHHHHHHHHHHCCC	32.93	23186163
1024 (in isoform 2)	Ubiquitination	-	20.38	21906983
1031 (in isoform 2)	Ubiquitination	-	16.32	21906983
1045	Ubiquitination	LMSASQTKSESVEEK HHCCCCCCCCCHHHH	44.59	21906983
1045 (in isoform 1)	Ubiquitination	-	44.59	21906983
1052	Ubiquitination	KSESVEEKGGGPPRC CCCCHHHHCCCCCCC	49.72	21906983
1052 (in isoform 1)	Ubiquitination	-	49.72	21906983
1105	Phosphorylation	LELPEPRTPPLSSLV HCCCCCCCCCHHHHH	39.72	30266825
1109	Phosphorylation	EPRTPPLSSLVEQAA CCCCCCHHHHHHHHH	27.65	30266825
1110	Phosphorylation	PRTPPLSSLVEQAAQ CCCCCHHHHHHHHHH	44.08	30266825
1136	Ubiquitination	IQTQLLQKNLGKQTP HHHHHHHHCCCCCCC	54.85	29967540
1140	Ubiquitination	LLQKNLGKQTPSGSR HHHHCCCCCCCCCCC	54.91	27667366
1248	Phosphorylation	RQSQQTSSLLTRLGT CCCHHHHHHHHHHHH	30.68	24719451
1255	Phosphorylation	SLLTRLGTLAQLHAS HHHHHHHHHHHHHHH	24.42	27251275
1262	Phosphorylation	TLAQLHASHCLDDLP HHHHHHHHHHHCCCC	12.18	27251275
1271	Phosphorylation	CLDDLPLSTPSSPRT HHCCCCCCCCCCCCC	36.01	21712546
1272	Phosphorylation	LDDLPLSTPSSPRTT HCCCCCCCCCCCCCC	34.57	23898821
1274	Phosphorylation	DLPLSTPSSPRTTEN CCCCCCCCCCCCCCC	53.73	23401153
1275	Phosphorylation	LPLSTPSSPRTTENP CCCCCCCCCCCCCCC	21.43	21712546
1283	Phosphorylation	PRTTENPTLERKPYS CCCCCCCCCCCCCCC	53.48	23898821
1290	Phosphorylation	TLERKPYSSPRDSSL CCCCCCCCCCCCCCC	42.25	17924679
1291	Phosphorylation	LERKPYSSPRDSSLP CCCCCCCCCCCCCCC	20.36	17924679
1295	Phosphorylation	PYSSPRDSSLPALTS CCCCCCCCCCCHHHH	34.75	30576142
1301	Phosphorylation	DSSLPALTSSALAFL CCCCCHHHHHHHHHH	23.81	30576142
1302	Phosphorylation	SSLPALTSSALAFLK CCCCHHHHHHHHHHH	17.92	30576142
1309	Ubiquitination	SSALAFLKSRSKLLA HHHHHHHHHHHHHHH	37.05	-
1313	Ubiquitination	AFLKSRSKLLATVAC HHHHHHHHHHHHHHH	46.54	-
1331	Ubiquitination	SPRLKVSKPSLSWKE CCCCCCCCCCCCHHH	41.43	29967540
1335	Phosphorylation	KVSKPSLSWKELRGR CCCCCCCCHHHHCCC	40.20	27251275
1444	Phosphorylation	GRDVDDLSSIKDAVL CCCHHHHHHHHHHHH	36.69	24719451
1448 (in isoform 2)	Ubiquitination	-	39.99	21906983
1469	Ubiquitination	WQYLFPVKDASLRSR CEEEEECCCHHHHHH	48.06	21906983
1469 (in isoform 1)	Ubiquitination	-	48.06	21906983
1521	Phosphorylation	KLAELQVYQKILGLQ HHHHHHHHHHHHCCC	7.36	-
1583	Ubiquitination	HLISLHQKHLLHLLE HHHHHHHHHHHHHHH	26.02	-
1596	Ubiquitination	LERRDHDKALQLLRR HHCCCHHHHHHHHHC	47.80	-
1719	Phosphorylation	FTMDEVDSLLSRYAE CCHHHHHHHHHHHHH	36.06	24719451
1722	Phosphorylation	DEVDSLLSRYAEKAL HHHHHHHHHHHHHHH	28.65	24719451
1727	Ubiquitination	LLSRYAEKALDFPYP HHHHHHHHHHCCCCC	46.18	-
1740	Phosphorylation	YPQREKRSDSVIHLQ CCCCCCCCCCEEEHH	45.35	29255136
1742	Phosphorylation	QREKRSDSVIHLQEI CCCCCCCCEEEHHHH	24.98	29255136
1758	Phosphorylation	HQAADPETLPRSPSA HHCCCCCCCCCCCCC	47.66	26074081
1762	Phosphorylation	DPETLPRSPSAEFSP CCCCCCCCCCCCCCC	22.67	29255136
1764	Phosphorylation	ETLPRSPSAEFSPAA CCCCCCCCCCCCCCC	41.50	23401153
1768	Phosphorylation	RSPSAEFSPAAPPGI CCCCCCCCCCCCCCC	12.72	29255136
1776	Phosphorylation	PAAPPGISSIHSPSL CCCCCCCCCCCCCCH	29.20	30108239
1777	Phosphorylation	AAPPGISSIHSPSLR CCCCCCCCCCCCCHH	23.54	30108239
1780	Phosphorylation	PGISSIHSPSLRERS CCCCCCCCCCHHHCC	17.95	25159151
1782	Phosphorylation	ISSIHSPSLRERSFP CCCCCCCCHHHCCCC	42.97	23927012
1787	Phosphorylation	SPSLRERSFPPTQPS CCCHHHCCCCCCCCC	37.03	23312004
1791	Phosphorylation	RERSFPPTQPSQEFV HHCCCCCCCCCCCCC	54.04	23312004
1794	Phosphorylation	SFPPTQPSQEFVPPA CCCCCCCCCCCCCCC	32.31	23312004
1802	Phosphorylation	QEFVPPATPPARHQW CCCCCCCCCCCCCCC	35.26	25850435
1882	Ubiquitination	VPEEPSEKPEALDSS CCCCCCCCCCHHCCC	53.12	-
1889	Phosphorylation	KPEALDSSKSESPPY CCCHHCCCCCCCCCC	39.61	25159151
1891	Phosphorylation	EALDSSKSESPPYSF CHHCCCCCCCCCCEE	45.30	27732954
1893	Phosphorylation	LDSSKSESPPYSFVV HCCCCCCCCCCEEEE	37.96	27732954
1896	Phosphorylation	SKSESPPYSFVVRVP CCCCCCCCEEEEEEC	20.37	27642862
1897	Phosphorylation	KSESPPYSFVVRVPK CCCCCCCEEEEEECC	19.83	28122231
1942 (in isoform 2)	Ubiquitination	-	27.91	21906983
1963	Ubiquitination	EHCCRLSKGLTNPEV HHHHHHCCCCCCHHC	63.63	2190698
1963 (in isoform 1)	Ubiquitination	-	63.63	21906983
2062	Phosphorylation	STKTGLDTTGAWHAW ECCCCCCCCCHHHHH	31.97	30622161
2063	Phosphorylation	TKTGLDTTGAWHAWG CCCCCCCCCHHHHHH	25.27	30622161
2213	Ubiquitination	GIFQPSYKSGKLHTL ECCCCCCCCCCCCHH	58.00	29967540
2226	Phosphorylation	TLENLLESIDPTLES HHHHHHHHCCCCHHH	32.06	25332170
2233	Phosphorylation	SIDPTLESWGKYLIA HCCCCHHHHHHHHHH	44.21	25332170
2247	Ubiquitination	AACQHLQKKNYYHIL HHHHHHHHCCHHHHH	49.71	29967540
2416	Acetylation	AARQLVEKEKYSEIQ HHHHHHHHHCHHHHH	52.61	20167786
2418	Ubiquitination	RQLVEKEKYSEIQQL HHHHHHHCHHHHHHH	66.21	29967540
2419	Phosphorylation	QLVEKEKYSEIQQLL HHHHHHCHHHHHHHH	16.78	30622161
2420	Phosphorylation	LVEKEKYSEIQQLLK HHHHHCHHHHHHHHH	39.01	30622161
2452	Ubiquitination	LNCLEAFKRIPPQEL HHHHHHHHCCCHHHH	57.37	29967540
2476	Phosphorylation	DDNKVRAYLICCKLR CCCHHHHHHHHHHHH	5.99	-
2484	Phosphorylation	LICCKLRSAYLIAVK HHHHHHHHCEEEEEC	31.53	29396449

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZFY26_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZFY26_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZFY26_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFP11_HUMAN	TFIP11	physical	25416956
CEP44_HUMAN	CEP44	physical	25416956
USBP1_HUMAN	USHBP1	physical	25416956
PNMA5_HUMAN	PNMA5	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 270700: Spastic paraplegia 15, autosomal recessive (SPG15)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1290 AND SER-1291, ANDMASS SPECTROMETRY.
PubMed: 17924679