dbPTM

TSH3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TSH3_HUMAN	Jmol._Canvas2D (Jmol) "myJmol"[x]
UniProt AC	Q63HK5
Protein Name	Teashirt homolog 3
Gene Name	TSHZ3
Organism	Homo sapiens (Human).
Sequence Length	1081
Subcellular Localization	Nucleus . Cell projection, growth cone. Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus..
Protein Description	Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). [PubMed: 19343227 Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity]
Protein Sequence	MPRRKQQAPRRAAAYVSEELKAAALVDEGLDPEEHTADGEPSAKYMCPEKELARACPSYQNSPAAEFSCHEMDSESHISETSDRMADFESGSIKNEEETKEVTVPLEDTTVSDSLEQMKAVYNNFLSNSYWSNLNLNLHQPSSEKNNGSSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVSQSRMLPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNHETDNNNPKRWSKPRKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVTPVAAKIIPATRKKASLELELPSSPDSTGGTPKATISDTNDALQKNSNPYITPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTAHMMVTGHFIKVTNSAMKKGKPIVETPVTPTITTLLDEKVQSVPLAATTFTSPSNTPASISPKLNVEVKKEVDKEKAVTDEKPKQKDKPGEEEEKCDISSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMFGNSEIVSPTKNQTLVSPPSSQTSPMPKTNFHAMEELVKKVTEKVAKVEEKMKEPDGKLSPPKRATPSPCSSEVGEPIKMEASSDGGFRSQENSPSPPRDGCKDGSPLAEPVENGKELVKPLASSLSGSTAIITDHPPEQPFVNPLSALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPPPLQSKKADHLDRYFYHVNNDQPIDLTKGKSDKGCSLGSVLLSPTSTAPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTSKSSTPSSISEKSDIDGATLEEAEESTPAQKRKGRQSNWNPQHLLILQAQFAASLRQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLSTEQINSQIAQTKSPSEKMVTSSPEEDLGTSYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLYVSELEKQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	GLDPEEHTADGEPSA CCCHHHCCCCCCCCH	29.71	28450419
42	Phosphorylation	HTADGEPSAKYMCPE CCCCCCCCHHHCCCH	32.84	28450419
58	Phosphorylation	ELARACPSYQNSPAA HHHHHCCCCCCCCCC	38.95	30576142
68	Phosphorylation	NSPAAEFSCHEMDSE CCCCCCCCCCCCCCC	13.18	-
74	Phosphorylation	FSCHEMDSESHISET CCCCCCCCCCCCCCC	39.42	30576142
76	Phosphorylation	CHEMDSESHISETSD CCCCCCCCCCCCCHH	30.03	30576142
90	Phosphorylation	DRMADFESGSIKNEE HHHCCCCCCCCCCHH	37.52	29978859
92	Phosphorylation	MADFESGSIKNEEET HCCCCCCCCCCHHHC	39.40	26657352
103	Phosphorylation	EEETKEVTVPLEDTT HHHCCEEEEECCCCC	19.93	19690332
110	Phosphorylation	TVPLEDTTVSDSLEQ EEECCCCCCCHHHHH	30.27	19690332
112	Phosphorylation	PLEDTTVSDSLEQMK ECCCCCCCHHHHHHH	21.27	-
114	Phosphorylation	EDTTVSDSLEQMKAV CCCCCCHHHHHHHHH	26.71	19690332
127	Phosphorylation	AVYNNFLSNSYWSNL HHHHHHHCCHHHHHC	21.42	27251275
129	Phosphorylation	YNNFLSNSYWSNLNL HHHHHCCHHHHHCCE	25.30	27251275
130	Phosphorylation	NNFLSNSYWSNLNLN HHHHCCHHHHHCCEE	19.67	27251275
132	Phosphorylation	FLSNSYWSNLNLNLH HHCCHHHHHCCEEEC	24.17	27251275
142	Phosphorylation	NLNLHQPSSEKNNGS CEEECCCCCCCCCCC	44.55	27251275
143	Phosphorylation	LNLHQPSSEKNNGSS EEECCCCCCCCCCCC	60.31	27251275
151	Phosphorylation	EKNNGSSSSSSSSSS CCCCCCCCCCCCCCC	35.62	-
152	Phosphorylation	KNNGSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
153	Phosphorylation	NNGSSSSSSSSSSSC CCCCCCCCCCCCCCC	35.87	-
154	Phosphorylation	NGSSSSSSSSSSSCG CCCCCCCCCCCCCCC	35.87	-
164	Phosphorylation	SSSCGSGSFDWHQSA CCCCCCCCCHHHHHH	23.02	-
200	Phosphorylation	TVQLYRQSSKLYGSI HHHHHHHCCCHHCHH	22.05	-
201	Phosphorylation	VQLYRQSSKLYGSIF HHHHHHCCCHHCHHH	20.52	-
209	Phosphorylation	KLYGSIFTGASKFRC CHHCHHHCCCCCCCC	30.12	-
213	Ubiquitination	SIFTGASKFRCKDCS HHHCCCCCCCCCCCH	35.97	23000965
217	Ubiquitination	GASKFRCKDCSAAYD CCCCCCCCCCHHHHH	58.47	23000965
255	Phosphorylation	NNNPKRWSKPRKRSL CCCCCCCCCCCHHHH	36.49	22468782
261	Phosphorylation	WSKPRKRSLLEMEGK CCCCCHHHHHHHCCH	40.10	27499020
286	Phosphorylation	YCGHSFESLQDLSVH HCCCCHHHHHHHHHH	29.35	30631047
300	Phosphorylation	HMIKTKHYQKVPLKE HEECCCCCCCCCCCC	16.16	-
302	Ubiquitination	IKTKHYQKVPLKEPV ECCCCCCCCCCCCCC	38.36	-
310	Phosphorylation	VPLKEPVTPVAAKII CCCCCCCCHHHHHHC	23.82	29978859
325	Phosphorylation	PATRKKASLELELPS CCCCCCEEEEEECCC	31.12	27690223
332	Phosphorylation	SLELELPSSPDSTGG EEEEECCCCCCCCCC	68.10	30266825
333	Phosphorylation	LELELPSSPDSTGGT EEEECCCCCCCCCCC	30.68	30266825
336	Phosphorylation	ELPSSPDSTGGTPKA ECCCCCCCCCCCCCC	32.13	30266825
337	Phosphorylation	LPSSPDSTGGTPKAT CCCCCCCCCCCCCCE	47.19	28450419
340	Phosphorylation	SPDSTGGTPKATISD CCCCCCCCCCCEECC	23.98	28450419
421	Acetylation	VTNSAMKKGKPIVET ECHHHHHCCCCCEEC	60.11	11688331
423	Acetylation	NSAMKKGKPIVETPV HHHHHCCCCCEECCC	40.21	11688341
428	Phosphorylation	KGKPIVETPVTPTIT CCCCCEECCCCCCHH	16.50	29978859
431	Phosphorylation	PIVETPVTPTITTLL CCEECCCCCCHHHHC	18.87	29978859
433	Phosphorylation	VETPVTPTITTLLDE EECCCCCCHHHHCCH	22.91	29978859
435	Phosphorylation	TPVTPTITTLLDEKV CCCCCCHHHHCCHHH	17.55	29978859
436	Phosphorylation	PVTPTITTLLDEKVQ CCCCCHHHHCCHHHC	22.82	29978859
444	Phosphorylation	LLDEKVQSVPLAATT HCCHHHCCCCEEEEE	28.79	27251275
450	Phosphorylation	QSVPLAATTFTSPSN CCCCEEEEEECCCCC	19.48	27251275
451	Phosphorylation	SVPLAATTFTSPSNT CCCEEEEEECCCCCC	21.86	27251275
453	Phosphorylation	PLAATTFTSPSNTPA CEEEEEECCCCCCCC	37.32	27732954
454	Phosphorylation	LAATTFTSPSNTPAS EEEEEECCCCCCCCC	23.34	27732954
456	Phosphorylation	ATTFTSPSNTPASIS EEEECCCCCCCCCCC	53.77	24117733
458	Phosphorylation	TFTSPSNTPASISPK EECCCCCCCCCCCCC	25.27	24117733
461	Phosphorylation	SPSNTPASISPKLNV CCCCCCCCCCCCCCC	25.46	28450419
463	Phosphorylation	SNTPASISPKLNVEV CCCCCCCCCCCCCEE	17.31	26657352
481	Phosphorylation	VDKEKAVTDEKPKQK HCHHHCCCCCCCCCC	43.21	29083192
503	Ubiquitination	EKCDISSKYHYLTEN HHCCCHHHEEEECCC	29.29	29967540
508	Phosphorylation	SSKYHYLTENDLEES HHHEEEECCCCCCCC	26.10	24961811
515	Phosphorylation	TENDLEESPKGGLDI CCCCCCCCCCCCHHH	23.65	29978859
570	Phosphorylation	SLGSSGKSTPLKPMF ECCCCCCCCCCCCCC	38.49	27251275
571	Phosphorylation	LGSSGKSTPLKPMFG CCCCCCCCCCCCCCC	35.81	27251275
580	Phosphorylation	LKPMFGNSEIVSPTK CCCCCCCCCCCCCCC	29.13	27732954
584	Phosphorylation	FGNSEIVSPTKNQTL CCCCCCCCCCCCCCE	32.29	28450419
586	Phosphorylation	NSEIVSPTKNQTLVS CCCCCCCCCCCCEEC	34.81	28450419
590	Phosphorylation	VSPTKNQTLVSPPSS CCCCCCCCEECCCCC	38.22	21406692
593	Phosphorylation	TKNQTLVSPPSSQTS CCCCCEECCCCCCCC	33.92	29978859
596	Phosphorylation	QTLVSPPSSQTSPMP CCEECCCCCCCCCCC	38.16	19664995
597	Phosphorylation	TLVSPPSSQTSPMPK CEECCCCCCCCCCCC	43.16	30576142
599	Phosphorylation	VSPPSSQTSPMPKTN ECCCCCCCCCCCCCC	36.42	19664995
600	Phosphorylation	SPPSSQTSPMPKTNF CCCCCCCCCCCCCCH	16.15	19664995
636	Phosphorylation	KEPDGKLSPPKRATP CCCCCCCCCCCCCCC	42.51	27732954
642	Phosphorylation	LSPPKRATPSPCSSE CCCCCCCCCCCCCCC	28.47	27732954
644	Phosphorylation	PPKRATPSPCSSEVG CCCCCCCCCCCCCCC	33.90	27732954
647	Phosphorylation	RATPSPCSSEVGEPI CCCCCCCCCCCCCCC	32.68	27732954
648	Phosphorylation	ATPSPCSSEVGEPIK CCCCCCCCCCCCCCE	42.91	27732954
659	Phosphorylation	EPIKMEASSDGGFRS CCCEEEECCCCCCCC	18.69	27732954
660	Phosphorylation	PIKMEASSDGGFRSQ CCEEEECCCCCCCCC	47.53	27732954
666	Phosphorylation	SSDGGFRSQENSPSP CCCCCCCCCCCCCCC	39.32	27732954
670	Phosphorylation	GFRSQENSPSPPRDG CCCCCCCCCCCCCCC	26.46	23927012
672	Phosphorylation	RSQENSPSPPRDGCK CCCCCCCCCCCCCCC	47.56	20873877
682	Phosphorylation	RDGCKDGSPLAEPVE CCCCCCCCCCCCCCC	27.20	19745106
740	Phosphorylation	LGKAAKPSLPALDPM CCCCCCCCCCCCCHH	46.40	30576142
748	Phosphorylation	LPALDPMSMLFKMSN CCCCCHHHHHHHHHH	20.09	30576142
809	Phosphorylation	SLGSVLLSPTSTAPA CCCCEEECCCCCCCC	23.21	-
811	Phosphorylation	GSVLLSPTSTAPATS CCEEECCCCCCCCCC	35.02	22798277
812	Phosphorylation	SVLLSPTSTAPATSS CEEECCCCCCCCCCC	26.42	22798277
818	Phosphorylation	TSTAPATSSSTVTTA CCCCCCCCCCCEECC	25.13	-
821	Phosphorylation	APATSSSTVTTAKTS CCCCCCCCEECCCHH	24.66	22798277
824	Phosphorylation	TSSSTVTTAKTSAVV CCCCCEECCCHHHEE	23.09	-
827	Phosphorylation	STVTTAKTSAVVSFM CCEECCCHHHEEEEC	21.32	21406692
828	Phosphorylation	TVTTAKTSAVVSFMS CEECCCHHHEEEECC	20.54	21406692
832	Phosphorylation	AKTSAVVSFMSNSPL CCHHHEEEECCCCCC	14.50	21406692
835	Phosphorylation	SAVVSFMSNSPLREN HHEEEECCCCCCHHC	31.95	28450419
837	Phosphorylation	VVSFMSNSPLRENAL EEEECCCCCCHHCHH	20.29	28450419
845	Phosphorylation	PLRENALSDISDMLK CCHHCHHHHHHHHHH	30.41	-
857	Phosphorylation	MLKNLTESHTSKSST HHHHHHHHHCCCCCC	27.16	-
859	Phosphorylation	KNLTESHTSKSSTPS HHHHHHHCCCCCCCC	47.32	-
860	Phosphorylation	NLTESHTSKSSTPSS HHHHHHCCCCCCCCC	25.72	30576142
862	Phosphorylation	TESHTSKSSTPSSIS HHHHCCCCCCCCCHH	38.93	27732954
863	Phosphorylation	ESHTSKSSTPSSISE HHHCCCCCCCCCHHH	48.34	27732954
864	Phosphorylation	SHTSKSSTPSSISEK HHCCCCCCCCCHHHC	33.99	27732954
866	Phosphorylation	TSKSSTPSSISEKSD CCCCCCCCCHHHCCC	40.15	27732954
867	Phosphorylation	SKSSTPSSISEKSDI CCCCCCCCHHHCCCC	31.19	27732954
869	Phosphorylation	SSTPSSISEKSDIDG CCCCCCHHHCCCCCC	40.70	27732954
872	Phosphorylation	PSSISEKSDIDGATL CCCHHHCCCCCCCCH	35.43	27732954
878	Phosphorylation	KSDIDGATLEEAEES CCCCCCCCHHHHHHC	39.99	27732954
928	Phosphorylation	KYIMSDLSPQERMHI CEECCCCCHHHHHCH	29.54	-
947	Phosphorylation	GLSMTTISHWLANVK CCCHHHHHHHHHHHH	13.40	27251275
1007	Phosphorylation	GFRLRDLSKLSTEQI CHHHHHHHHCCHHHH	35.52	-
1010	O-linked_Glycosylation	LRDLSKLSTEQINSQ HHHHHHCCHHHHHHH	33.37	30059200
1010	Phosphorylation	LRDLSKLSTEQINSQ HHHHHHCCHHHHHHH	33.37	28450419
1011	O-linked_Glycosylation	RDLSKLSTEQINSQI HHHHHCCHHHHHHHH	42.20	30059200
1011	Phosphorylation	RDLSKLSTEQINSQI HHHHHCCHHHHHHHH	42.20	28450419
1016	Phosphorylation	LSTEQINSQIAQTKS CCHHHHHHHHHCCCC	25.29	28450419
1021	Phosphorylation	INSQIAQTKSPSEKM HHHHHHCCCCCCHHC	25.19	29978859
1023	Phosphorylation	SQIAQTKSPSEKMVT HHHHCCCCCCHHCCC	36.73	29978859
1025	Phosphorylation	IAQTKSPSEKMVTSS HHCCCCCCHHCCCCC	57.87	29978859
1030	Phosphorylation	SPSEKMVTSSPEEDL CCCHHCCCCCCHHHC	21.71	27732954
1031	Phosphorylation	PSEKMVTSSPEEDLG CCHHCCCCCCHHHCC	32.27	27732954
1032	Phosphorylation	SEKMVTSSPEEDLGT CHHCCCCCCHHHCCC	27.28	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TSH3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TSH3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TSH3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBB1_HUMAN	APBB1	physical	19343227
CEP63_HUMAN	CEP63	physical	25416956
CEP70_HUMAN	CEP70	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
KASH5_HUMAN	CCDC155	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TSH3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-672, AND MASSSPECTROMETRY.	17081983 [Abstract]