| UniProt ID | SNP47_HUMAN | |
|---|---|---|
| UniProt AC | Q5SQN1 | |
| Protein Name | Synaptosomal-associated protein 47 | |
| Gene Name | SNAP47 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 464 | |
| Subcellular Localization | Endomembrane system. Cytoplasm, perinuclear region. Appears to be exclusively membrane-bound.. | |
| Protein Description | Plays a role in intracellular membrane fusion.. | |
| Protein Sequence | MRAARRGLHCAGAERPRRRGRLWDSSGVPQRQKRPGPWRTQTQEQMSRDVCIHTWPCTYYLEPKRRWVTGQLSLTSLSLRFMTDSTGEILVSFPLSSIVEIKKEASHFIFSSITILEKGHAKHWFSSLRPSRNVVFSIIEHFWRELLLSQPGAVADASVPRTRGEELTGLMAGSQKRLEDTARVLHHQGQQLDSVMRGLDKMESDLEVADRLLTELESPAWWPFSSKLWKTPPETKPREDVSMTSCEPFGKEGILIKIPAVISHRTESHVKPGRLTVLVSGLEIHDSSSLLMHRFEREDVDDIKVHSPYEISIRQRFIGKPDMAYRLISAKMPEVIPILEVQFSKKMELLEDALVLRSARTSSPAEKSCSVWHAASGLMGRTLHREPPAGDQEGTALHLQTSLPALSEADTQELTQILRRMKGLALEAESELERQDEALDGVAAAVDRATLTIDKHNRRMKRLT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 25 | Phosphorylation | RRGRLWDSSGVPQRQ CCCCCCCCCCCCCCC | 19.87 | 24247654 | |
| 62 (in isoform 4) | Ubiquitination | - | 32.43 | 21906983 | |
| 62 (in isoform 3) | Ubiquitination | - | 32.43 | 21906983 | |
| 76 | Phosphorylation | TGQLSLTSLSLRFMT CCCEEEEEEEEEECC | 22.66 | 17081983 | |
| 78 | Phosphorylation | QLSLTSLSLRFMTDS CEEEEEEEEEECCCC | 19.78 | 24719451 | |
| 103 (in isoform 4) | Ubiquitination | - | 65.26 | 21906983 | |
| 103 (in isoform 3) | Ubiquitination | - | 65.26 | 21906983 | |
| 103 | Ubiquitination | SSIVEIKKEASHFIF HHHEEEHHHHHHHEE | 65.26 | - | |
| 106 | Phosphorylation | VEIKKEASHFIFSSI EEEHHHHHHHEEEEE | 21.74 | 23401153 | |
| 127 | Phosphorylation | HAKHWFSSLRPSRNV CHHHHHHHCCCCCHH | 20.94 | 24719451 | |
| 131 | Phosphorylation | WFSSLRPSRNVVFSI HHHHCCCCCHHHHHH | 30.01 | 24719451 | |
| 158 | Phosphorylation | PGAVADASVPRTRGE CCCCCCCCCCCCCHH | 32.95 | 24719451 | |
| 162 | O-linked_Glycosylation | ADASVPRTRGEELTG CCCCCCCCCHHHHCH | 36.64 | 28657654 | |
| 174 | Phosphorylation | LTGLMAGSQKRLEDT HCHHHCCCHHHHHHH | 24.00 | 27251275 | |
| 176 | Ubiquitination | GLMAGSQKRLEDTAR HHHCCCHHHHHHHHH | 61.72 | 21906983 | |
| 176 (in isoform 2) | Ubiquitination | - | 61.72 | 21906983 | |
| 176 (in isoform 1) | Ubiquitination | - | 61.72 | 21906983 | |
| 181 | Phosphorylation | SQKRLEDTARVLHHQ CHHHHHHHHHHHHHH | 13.64 | 23312004 | |
| 194 | Phosphorylation | HQGQQLDSVMRGLDK HHHHHHHHHHHHHHH | 26.80 | 28555341 | |
| 201 | Ubiquitination | SVMRGLDKMESDLEV HHHHHHHHHHHHHHH | 50.00 | 21906983 | |
| 201 (in isoform 1) | Ubiquitination | - | 50.00 | 21906983 | |
| 201 (in isoform 2) | Ubiquitination | - | 50.00 | 21906983 | |
| 204 | Phosphorylation | RGLDKMESDLEVADR HHHHHHHHHHHHHHH | 43.95 | - | |
| 230 | Ubiquitination | PFSSKLWKTPPETKP CCCCCCCCCCCCCCC | 62.68 | - | |
| 231 | Phosphorylation | FSSKLWKTPPETKPR CCCCCCCCCCCCCCC | 32.28 | 29396449 | |
| 251 | Ubiquitination | TSCEPFGKEGILIKI EECCCCCCCCEEEEE | 53.82 | - | |
| 257 | Ubiquitination | GKEGILIKIPAVISH CCCCEEEEECEEEEC | 38.91 | - | |
| 268 | Phosphorylation | VISHRTESHVKPGRL EEECCCCCCCCCCCE | 32.73 | - | |
| 271 | Ubiquitination | HRTESHVKPGRLTVL CCCCCCCCCCCEEEE | 36.01 | - | |
| 304 (in isoform 1) | Ubiquitination | - | 40.67 | 21906983 | |
| 304 (in isoform 2) | Ubiquitination | - | 40.67 | 21906983 | |
| 304 | Ubiquitination | REDVDDIKVHSPYEI CCCCCCCCCCCCEEE | 40.67 | 21906983 | |
| 307 | Phosphorylation | VDDIKVHSPYEISIR CCCCCCCCCEEEEEC | 31.97 | 27251275 | |
| 320 | Ubiquitination | IRQRFIGKPDMAYRL ECHHHCCCCHHHHHH | 32.78 | - | |
| 325 | Phosphorylation | IGKPDMAYRLISAKM CCCCHHHHHHHHCCC | 10.18 | 29496907 | |
| 331 | Ubiquitination | AYRLISAKMPEVIPI HHHHHHCCCCCEEEE | 48.47 | - | |
| 345 (in isoform 2) | Ubiquitination | - | 58.38 | 21906983 | |
| 345 | Ubiquitination | ILEVQFSKKMELLED EEEEECHHHHHHHHH | 58.38 | 2190698 | |
| 345 (in isoform 1) | Ubiquitination | - | 58.38 | 21906983 | |
| 346 | Ubiquitination | LEVQFSKKMELLEDA EEEECHHHHHHHHHH | 36.09 | - | |
| 362 | Phosphorylation | VLRSARTSSPAEKSC HHHHHCCCCCHHHHH | 28.86 | 29396449 | |
| 363 | Phosphorylation | LRSARTSSPAEKSCS HHHHCCCCCHHHHHH | 27.76 | 29396449 | |
| 367 | Ubiquitination | RTSSPAEKSCSVWHA CCCCCHHHHHHHHHH | 59.89 | - | |
| 376 | Phosphorylation | CSVWHAASGLMGRTL HHHHHHHCCCCCCCC | 32.99 | 27251275 | |
| 430 | Phosphorylation | GLALEAESELERQDE HHHHHHHHHHHHHHH | 55.30 | - | |
| 452 | Phosphorylation | AVDRATLTIDKHNRR HHHHHEEEEHHHHHH | 23.83 | 27251275 | |
| 455 | Ubiquitination | RATLTIDKHNRRMKR HHEEEEHHHHHHHHC | 38.64 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SNP47_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SNP47_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SNP47_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KLC3_HUMAN | KLC3 | physical | 25416956 | |
| FAM9B_HUMAN | FAM9B | physical | 25416956 | |
| CE57L_HUMAN | CEP57L1 | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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