MRS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MRS2_HUMAN
• UniProt AC: Q9HD23
• Protein Name: Magnesium transporter MRS2 homolog, mitochondrial
• Gene Name: MRS2
• Organism: Homo sapiens (Human).
• Sequence Length: 443
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. [PubMed: 11401429]
• Protein Sequence: MECLRSLPCLLPRAMRLPRRTLCALALDVTSVGPPVAACGRRANLIGRSRAAQLCGPDRLRVAGEVHRFRTSDVSQATLASVAPVFTVTKFDKQGNVTSFERKKTELYQELGLQARDLRFQHVMSITVRNNRIIMRMEYLKAVITPECLLILDYRNLNLEQWLFRELPSQLSGEGQLVTYPLPFEFRAIEALLQYWINTLQGKLSILQPLILETLDALVDPKHSSVDRSKLHILLQNGKSLSELETDIKIFKESILEILDEEELLEELCVSKWSDPQVFEKSSAGIDHAEEMELLLENYYRLADDLSNAARELRVLIDDSQSIIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLMGVAFGMNLESSLEEDHRIFWLITGIMFMGSGLIWRRLLSFLGRQLEAPLPPMMASLPKKTLLADRSMELKNSLRLDGLGSGRSILTNR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MECLRSLPCLLPR --CHHHHHCCCHHHH	24.58	25348772
90	Acetylation	APVFTVTKFDKQGNV CCEEEEEEECCCCCC	47.42	23954790
90	Ubiquitination	APVFTVTKFDKQGNV CCEEEEEEECCCCCC	47.42	-
90 (in isoform 2)	Ubiquitination	-	47.42	-
90	Acetylation	APVFTVTKFDKQGNV CCEEEEEEECCCCCC	47.42	-
93	Ubiquitination	FTVTKFDKQGNVTSF EEEEEECCCCCCCCE	64.34	-
93	Ubiquitination	FTVTKFDKQGNVTSF EEEEEECCCCCCCCE	64.34	-
105	Phosphorylation	TSFERKKTELYQELG CCEEEHHHHHHHHHC	33.97	23879269
108	Phosphorylation	ERKKTELYQELGLQA EEHHHHHHHHHCCHH	8.16	23879269
242	Phosphorylation	LQNGKSLSELETDIK ECCCCCHHHHHHHHH	47.42	-
281	Ubiquitination	SDPQVFEKSSAGIDH CCHHHHCCCCCCCCH	37.94	2190698
281 (in isoform 2)	Ubiquitination	-	37.94	21906983
284	Ubiquitination	QVFEKSSAGIDHAEE HHHCCCCCCCCHHHH	26.50	-
284 (in isoform 1)	Ubiquitination	-	26.50	21906983
365	Phosphorylation	AFGMNLESSLEEDHR HHCCCCHHCCCHHHH	43.31	22210691
366	Phosphorylation	FGMNLESSLEEDHRI HCCCCHHCCCHHHHH	30.35	22210691
410	Phosphorylation	PLPPMMASLPKKTLL CCCHHHHCCCCCCCC	27.58	-
414	Ubiquitination	MMASLPKKTLLADRS HHHCCCCCCCCCCCC	42.33	-
422	Oxidation	TLLADRSMELKNSLR CCCCCCCHHHHHCCC	7.92	17322306
425	Ubiquitination	ADRSMELKNSLRLDG CCCCHHHHHCCCCCC	31.05	-
425	Methylation	ADRSMELKNSLRLDG CCCCHHHHHCCCCCC	31.05	115973285
427	Phosphorylation	RSMELKNSLRLDGLG CCHHHHHCCCCCCCC	17.18	17322306

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MRS2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MRS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MRS2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MRS2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.