dbPTM

AKA11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AKA11_HUMAN
UniProt AC	Q9UKA4
Protein Name	A-kinase anchor protein 11
Gene Name	AKAP11
Organism	Homo sapiens (Human).
Sequence Length	1901
Subcellular Localization	Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongat
Protein Description	Binds to type II regulatory subunits of protein kinase A and anchors/targets them..
Protein Sequence	MATFRNNHMKTKASVRKSFSEDVFQSVKSLLQSQKELCSVTAEDCLQQDEHANLTEVTFLGFNEETDAAHIQDLAAVSLELPDILNSLHFCSLNENEIICMKNINKPLDISSDPLNQSHPSGMLCVMRVSPTSPRLRIDFIFSLLSKYATGIRYTLDTFLHQKHQLETTDEDDDDTNQSVSSIEDDFVTAFEHLEEEETSKPYNDGMNITVLRSQCDAASQTVTGHHLETHDLKILISSGQQKSLAKPSTSSVNVLGHKELPSVKTSVTTSISEPWTQRSFYRSSNASDKDSDLQKTFFSSSPAYSSESECSSPSPVIFLDEEGYQKSLKAKLELPKIPVMKDDIEDSDSEVSEFFDSFDQFDELEQTLETCLFNKDPVIGKSSQRKGHKHGKSCMNPQKFKFDRPALPANVRKPTPRKPESPYGNLCDAPDSPRPVKASREDSGLFSPIRSSAFSPLGGCTPAECFCQTDIGGDRIHENHDSVYYTYEDYAKSISCEVLGSVLRTHHTNTLSNINSIKHGENKTVTFKHGNLDQKNKSKNKSLMIKDSIQKFAADLVEKSFGSAFKDLQKGVSSCTNALYHLAIKLTSSVLQMAFDELRRQRAFSLKERAISGLANFLVSEALSNALKDLQYVKKQIFTNTVARFAADLAEELVFEGIMEVCQFSYPQTPASPQCGSFDFEDKVVKLYAKDLSESVIQEAFIELSQVDVTFTTKAAVSVSTDNIKYVSAESVVPSTQAVTFSPSFHNQAIMVTKPVQEYKKEYTVQQALFCTSGIVTSIPVPLAGSALLPYHISSTACQAKAHLSSDDSNSNGDSAQVHIATKNREEKAACLRNICLPSEHNPGNQNDFKPTNDDIEMQSSSKLPNDPAIISNFSAAVVHTIVNETLESMTSLEVTKMVDERTDYLTKSLKEKTPPFSHCDQAVLQCSEASSNKDMFADRLSKSIIKHSIDKSKSVIPNIDKNAVYKESLPVSGEESQLTPEKSPKFPDSQNQLTHCSLSAAKDCVPECKVSMVHGSSLETLPSCPAVTGQKSDLKESAKDQPLKKHNLNSTSLEALSFGQENPFPHSHTFSSTALTCVDGLHVEDKQKVRDRNVIPDTPPSTPLVPSRASSEWDIKKLTKKLKGELAKEFAPATPPSTPHNSSVGSLSENEQNTIEKEEFMLKLMRSLSEEVESSESGELPEVDVKSEHSGKKVQFAEALATHILSLATEMAASHLDNKIIQEPKVKNPCLNVQSQRSVSPTFLNPSDENLKTLCNFAGDLAAEVITEAEKIAKVRNCMLFKQKKNSCYADGDEDYKVEEKLDIEAVVHPREVDPFILSLPPSSCMSGLMYKYPSCESVTDEYAGHLIQILKQEGGNSELIMDQYANRLAYRSVKSGLQEAAKTTKVQCNSRMFPVPSSQVKTNKELLMFSNKEHHQEADKKRQSKRNEGYFCKNQTCERTLDPYRNEVSQLYSFSTSLVHSITKDAKEELTASLVGLPKSLTDSCLFEKSGYEEDNECHVTPELPKSLQPSSQNHRFYHSTGSLNGYGCGDNVVQAVEQYAKKVVDDTLELTLGSTVFRVSETTKSADRVTYAEKLSPLTGQACRYCDLKELHNCTGNSSQHFFRQGSLASSKPASNPKFSSRYQKSRIFHLSVPQIHVNLDKKAVLAEKIVAEAIEKAERELSSTSLAADSGIGQEGASFAESLATETMTAAVTNVGHAVSSSKEIEDFQSTESVSSQQMNLSIGDDSTGSWSNLSFEDEHQDESSSFHHLSESNGNSSSWSSLGLEGDLYEDNLSFPTSDSDGPDDKDEEHEDEVEGLGQDGKTLLITNIDMEPCTVDPQLRIILQWLIASEAEVAELYFHDSANKEFMLLSKQLQEKGWKVGDLLQAVLQYYEVMEKASSEERCKSLFDWLLENA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	FRNNHMKTKASVRKS CCCCCCCCCHHHHHH	25.03	24719451
14	Phosphorylation	NHMKTKASVRKSFSE CCCCCCHHHHHHHCH	24.82	101545617
18	Phosphorylation	TKASVRKSFSEDVFQ CCHHHHHHHCHHHHH	24.36	29255136
20	Phosphorylation	ASVRKSFSEDVFQSV HHHHHHHCHHHHHHH	39.72	29255136
26	Phosphorylation	FSEDVFQSVKSLLQS HCHHHHHHHHHHHHH	21.76	23403867
29	Phosphorylation	DVFQSVKSLLQSQKE HHHHHHHHHHHHHHH	31.96	113334215
111	Phosphorylation	INKPLDISSDPLNQS CCCCCCCCCCCCCCC	28.49	28348404
112	Phosphorylation	NKPLDISSDPLNQSH CCCCCCCCCCCCCCC	43.51	28348404
118	Phosphorylation	SSDPLNQSHPSGMLC CCCCCCCCCCCCCEE	35.97	28348404
130	Phosphorylation	MLCVMRVSPTSPRLR CEEEEEECCCCCCHH	16.46	9577369
132	Phosphorylation	CVMRVSPTSPRLRID EEEEECCCCCCHHHH	43.80	26699800
133	Phosphorylation	VMRVSPTSPRLRIDF EEEECCCCCCHHHHH	16.06	26699800
143	Phosphorylation	LRIDFIFSLLSKYAT HHHHHHHHHHHHHHH	24.47	24719451
148	Phosphorylation	IFSLLSKYATGIRYT HHHHHHHHHHHCHHH	13.15	25278378
150	Phosphorylation	SLLSKYATGIRYTLD HHHHHHHHHCHHHHH	30.01	72840651
199	Phosphorylation	EHLEEEETSKPYNDG HHHCHHHCCCCCCCC	45.38	17081983
200	Phosphorylation	HLEEEETSKPYNDGM HHCHHHCCCCCCCCC	34.61	17081983
238	Phosphorylation	HDLKILISSGQQKSL CCEEEEECCCCCCCC	25.60	23898821
239	Phosphorylation	DLKILISSGQQKSLA CEEEEECCCCCCCCC	33.36	25159151
243	Ubiquitination	LISSGQQKSLAKPST EECCCCCCCCCCCCC	39.28	29967540
244	Phosphorylation	ISSGQQKSLAKPSTS ECCCCCCCCCCCCCC	29.26	23186163
249	Phosphorylation	QKSLAKPSTSSVNVL CCCCCCCCCCCEEEC	39.97	29514088
250	Phosphorylation	KSLAKPSTSSVNVLG CCCCCCCCCCEEECC	33.28	108826557
251	Phosphorylation	SLAKPSTSSVNVLGH CCCCCCCCCEEECCC	36.30	29514088
252	Phosphorylation	LAKPSTSSVNVLGHK CCCCCCCCEEECCCC	20.14	28555341
266	Phosphorylation	KELPSVKTSVTTSIS CCCCCCCEEEEECCC	26.69	27251275
267	Phosphorylation	ELPSVKTSVTTSISE CCCCCCEEEEECCCC	16.26	27251275
269	Phosphorylation	PSVKTSVTTSISEPW CCCCEEEEECCCCCC	18.00	27251275
270	Phosphorylation	SVKTSVTTSISEPWT CCCEEEEECCCCCCC	23.16	30108239
271	Phosphorylation	VKTSVTTSISEPWTQ CCEEEEECCCCCCCH	18.10	30108239
273	Phosphorylation	TSVTTSISEPWTQRS EEEEECCCCCCCHHH	37.06	30108239
277	Phosphorylation	TSISEPWTQRSFYRS ECCCCCCCHHHHHCC	25.48	27251275
280	Phosphorylation	SEPWTQRSFYRSSNA CCCCCHHHHHCCCCC	19.47	27080861
282	Phosphorylation	PWTQRSFYRSSNASD CCCHHHHHCCCCCCC	15.72	27080861
284	Phosphorylation	TQRSFYRSSNASDKD CHHHHHCCCCCCCCC	19.30	29978859
285	Phosphorylation	QRSFYRSSNASDKDS HHHHHCCCCCCCCCC	27.67	29978859
288	Phosphorylation	FYRSSNASDKDSDLQ HHCCCCCCCCCCHHH	49.82	25159151
292	Phosphorylation	SNASDKDSDLQKTFF CCCCCCCCHHHHHHH	46.06	29978859
328	Phosphorylation	DEEGYQKSLKAKLEL CCCHHHHHHHHHHCC	21.41	20809049
348	Phosphorylation	MKDDIEDSDSEVSEF CCCCCCCCCHHHHHH	30.19	24275569
350	Phosphorylation	DDIEDSDSEVSEFFD CCCCCCCHHHHHHHH	43.80	24275569
353	Phosphorylation	EDSDSEVSEFFDSFD CCCCHHHHHHHHCCH	25.32	24275569
416	Phosphorylation	PANVRKPTPRKPESP CCCCCCCCCCCCCCC	38.47	28555341
422	Phosphorylation	PTPRKPESPYGNLCD CCCCCCCCCCCCCCC	31.76	25159151
424	Phosphorylation	PRKPESPYGNLCDAP CCCCCCCCCCCCCCC	28.11	30278072
433	Phosphorylation	NLCDAPDSPRPVKAS CCCCCCCCCCCCCCC	23.04	25159151
438	Methylation	PDSPRPVKASREDSG CCCCCCCCCCHHCCC	43.24	-
440	Phosphorylation	SPRPVKASREDSGLF CCCCCCCCHHCCCCC	30.41	23403867
444	Phosphorylation	VKASREDSGLFSPIR CCCCHHCCCCCCCCC	32.42	23401153
448	Phosphorylation	REDSGLFSPIRSSAF HHCCCCCCCCCCCCC	25.18	19664994
452	Phosphorylation	GLFSPIRSSAFSPLG CCCCCCCCCCCCCCC	27.09	25850435
453	Phosphorylation	LFSPIRSSAFSPLGG CCCCCCCCCCCCCCC	24.39	25850435
456	Phosphorylation	PIRSSAFSPLGGCTP CCCCCCCCCCCCCCH	20.94	25159151
462	Phosphorylation	FSPLGGCTPAECFCQ CCCCCCCCHHHHEEE	28.89	25850435
483	Phosphorylation	RIHENHDSVYYTYED CCCCCCCEEEEEHHH	12.41	28796482
485	Phosphorylation	HENHDSVYYTYEDYA CCCCCEEEEEHHHHH	8.27	28796482
486	Phosphorylation	ENHDSVYYTYEDYAK CCCCEEEEEHHHHHH	10.74	28796482
487	Phosphorylation	NHDSVYYTYEDYAKS CCCEEEEEHHHHHHH	11.62	28796482
488	Phosphorylation	HDSVYYTYEDYAKSI CCEEEEEHHHHHHHC	7.23	28796482
491	Phosphorylation	VYYTYEDYAKSISCE EEEEHHHHHHHCHHH	12.18	28796482
502	Phosphorylation	ISCEVLGSVLRTHHT CHHHHHHHHHHHCCC	17.51	25159151
511	Phosphorylation	LRTHHTNTLSNINSI HHHCCCCCCCCCCCC	32.49	28555341
515	Ubiquitination	HTNTLSNINSIKHGE CCCCCCCCCCCCCCC	3.72	21890473
517	Phosphorylation	NTLSNINSIKHGENK CCCCCCCCCCCCCCC	29.26	28555341
519	Ubiquitination	LSNINSIKHGENKTV CCCCCCCCCCCCCEE	45.43	29967540
529	Methylation	ENKTVTFKHGNLDQK CCCEEEEECCCCCCC	41.03	-
543	Phosphorylation	KNKSKNKSLMIKDSI CCCCCCCCCCHHHHH	32.34	28857561
560	Ubiquitination	FAADLVEKSFGSAFK HHHHHHHHHHHHHHH	43.54	21890473
561	O-linked_Glycosylation	AADLVEKSFGSAFKD HHHHHHHHHHHHHHH	22.72	23301498
574	Phosphorylation	KDLQKGVSSCTNALY HHHHHHHHHHHHHHH	28.50	29083192
575	Phosphorylation	DLQKGVSSCTNALYH HHHHHHHHHHHHHHH	23.66	29083192
577	Phosphorylation	QKGVSSCTNALYHLA HHHHHHHHHHHHHHH	26.02	29083192
581	Phosphorylation	SSCTNALYHLAIKLT HHHHHHHHHHHHHHH	7.74	29083192
588	Phosphorylation	YHLAIKLTSSVLQMA HHHHHHHHHHHHHHH	17.60	30619164
589	Phosphorylation	HLAIKLTSSVLQMAF HHHHHHHHHHHHHHH	28.96	30619164
590	Phosphorylation	LAIKLTSSVLQMAFD HHHHHHHHHHHHHHH	22.93	30619164
606	Phosphorylation	LRRQRAFSLKERAIS HHHHHCCCHHHHHHH	37.23	23917254
608	Ubiquitination	RQRAFSLKERAISGL HHHCCCHHHHHHHHH	43.91	33845483
613	Phosphorylation	SLKERAISGLANFLV CHHHHHHHHHHHHHH	27.11	28450419
621	Phosphorylation	GLANFLVSEALSNAL HHHHHHHHHHHHHHH	21.21	46161235
635	Acetylation	LKDLQYVKKQIFTNT HHHHHHHHHHHHHHH	33.74	25953088
673	Phosphorylation	SYPQTPASPQCGSFD CCCCCCCCCCCCCCC	19.39	26657352
713	O-linked_Glycosylation	SQVDVTFTTKAAVSV HHCEEEEEECEEEEE	20.30	23301498
714	O-linked_Glycosylation	QVDVTFTTKAAVSVS HCEEEEEECEEEEEE	17.94	23301498
719	O-linked_Glycosylation	FTTKAAVSVSTDNIK EEECEEEEEECCCEE	12.96	23301498
721	O-linked_Glycosylation	TKAAVSVSTDNIKYV ECEEEEEECCCEEEE	23.65	23301498
721	Phosphorylation	TKAAVSVSTDNIKYV ECEEEEEECCCEEEE	23.65	29514088
722	O-linked_Glycosylation	KAAVSVSTDNIKYVS CEEEEEECCCEEEEE	30.80	23301498
722	Phosphorylation	KAAVSVSTDNIKYVS CEEEEEECCCEEEEE	30.80	29514088
732	O-linked_Glycosylation	IKYVSAESVVPSTQA EEEEEHHHCCCCCCE	28.29	23301498
736	O-linked_Glycosylation	SAESVVPSTQAVTFS EHHHCCCCCCEEEEC	22.88	23301498
737	O-linked_Glycosylation	AESVVPSTQAVTFSP HHHCCCCCCEEEECC	17.93	23301498
741	O-linked_Glycosylation	VPSTQAVTFSPSFHN CCCCCEEEECCCCCC	22.78	23301498
743	O-linked_Glycosylation	STQAVTFSPSFHNQA CCCEEEECCCCCCCE	15.40	23301498
743	Phosphorylation	STQAVTFSPSFHNQA CCCEEEECCCCCCCE	15.40	25627689
745	O-linked_Glycosylation	QAVTFSPSFHNQAIM CEEEECCCCCCCEEE	37.63	23301498
807	Phosphorylation	QAKAHLSSDDSNSNG HHHHHCCCCCCCCCC	52.37	28787133
812	Phosphorylation	LSSDDSNSNGDSAQV CCCCCCCCCCCCEEE	46.25	82900447
853	O-linked_Glycosylation	NQNDFKPTNDDIEMQ CCCCCCCCCCCCHHC	52.44	23301498
873	Phosphorylation	PNDPAIISNFSAAVV CCCHHHHHHCHHHHH	26.21	24144214
876	Phosphorylation	PAIISNFSAAVVHTI HHHHHHCHHHHHHHH	21.40	24144214
882	Phosphorylation	FSAAVVHTIVNETLE CHHHHHHHHHHHHHH	18.27	24144214
887	Phosphorylation	VHTIVNETLESMTSL HHHHHHHHHHHCCHH	30.53	24144214
890	Phosphorylation	IVNETLESMTSLEVT HHHHHHHHCCHHCHH	30.39	24144214
892	Phosphorylation	NETLESMTSLEVTKM HHHHHHCCHHCHHHH	39.16	24144214
893	Phosphorylation	ETLESMTSLEVTKMV HHHHHCCHHCHHHHH	17.56	24719451
897	Phosphorylation	SMTSLEVTKMVDERT HCCHHCHHHHHHHCH	12.21	24144214
909	Ubiquitination	ERTDYLTKSLKEKTP HCHHHHHHHHHHCCC	51.72	29967540
915	Phosphorylation	TKSLKEKTPPFSHCD HHHHHHCCCCCCCCC	36.97	28985074
919	Phosphorylation	KEKTPPFSHCDQAVL HHCCCCCCCCCHHHH	29.04	46161247
945	Phosphorylation	FADRLSKSIIKHSID HHHHHHHHHHHHHHC	26.60	101545649
963	Acetylation	SVIPNIDKNAVYKES CCCCCCCCCCEEECC	42.90	25953088
963	Ubiquitination	SVIPNIDKNAVYKES CCCCCCCCCCEEECC	42.90	29967540
970	Phosphorylation	KNAVYKESLPVSGEE CCCEEECCCCCCCCC	33.55	27732954
974	Phosphorylation	YKESLPVSGEESQLT EECCCCCCCCCHHCC	38.25	30266825
978	Phosphorylation	LPVSGEESQLTPEKS CCCCCCCHHCCCCCC	26.62	30266825
981	Phosphorylation	SGEESQLTPEKSPKF CCCCHHCCCCCCCCC	23.05	30266825
985	Phosphorylation	SQLTPEKSPKFPDSQ HHCCCCCCCCCCCCC	31.49	30266825
991	Phosphorylation	KSPKFPDSQNQLTHC CCCCCCCCCCCCCHH	31.13	27251275
996	Phosphorylation	PDSQNQLTHCSLSAA CCCCCCCCHHCHHHH	15.86	27251275
999	Phosphorylation	QNQLTHCSLSAAKDC CCCCCHHCHHHHHHC	20.11	27251275
1001	Phosphorylation	QLTHCSLSAAKDCVP CCCHHCHHHHHHCCC	15.19	27251275
1013	Phosphorylation	CVPECKVSMVHGSSL CCCCCEEEEECCCCC	10.69	28450419
1018	Phosphorylation	KVSMVHGSSLETLPS EEEEECCCCCCCCCC	19.51	28450419
1019	Phosphorylation	VSMVHGSSLETLPSC EEEECCCCCCCCCCC	34.51	28450419
1022	Phosphorylation	VHGSSLETLPSCPAV ECCCCCCCCCCCCCC	49.62	28450419
1025	Phosphorylation	SSLETLPSCPAVTGQ CCCCCCCCCCCCCCC	35.53	27080861
1059	O-linked_Glycosylation	STSLEALSFGQENPF CCHHHHHHHCCCCCC	34.09	23301498
1100	Phosphorylation	DRNVIPDTPPSTPLV CCCCCCCCCCCCCCC	31.57	29255136
1103	Phosphorylation	VIPDTPPSTPLVPSR CCCCCCCCCCCCCCC	43.81	30266825
1104	Phosphorylation	IPDTPPSTPLVPSRA CCCCCCCCCCCCCCC	26.81	30266825
1109	Phosphorylation	PSTPLVPSRASSEWD CCCCCCCCCCCCCCC	32.76	30266825
1112	Phosphorylation	PLVPSRASSEWDIKK CCCCCCCCCCCCHHH	27.90	24719451
1113	Phosphorylation	LVPSRASSEWDIKKL CCCCCCCCCCCHHHH	41.54	25850435
1136	O-linked_Glycosylation	AKEFAPATPPSTPHN HHHHCCCCCCCCCCC	34.37	23301498
1136	Phosphorylation	AKEFAPATPPSTPHN HHHHCCCCCCCCCCC	34.37	30576142
1139	Phosphorylation	FAPATPPSTPHNSSV HCCCCCCCCCCCCCC	56.63	30576142
1140	Phosphorylation	APATPPSTPHNSSVG CCCCCCCCCCCCCCC	34.05	30576142
1144	O-linked_Glycosylation	PPSTPHNSSVGSLSE CCCCCCCCCCCCCCH	24.30	23301498
1144	Phosphorylation	PPSTPHNSSVGSLSE CCCCCCCCCCCCCCH	24.30	25850435
1145	Phosphorylation	PSTPHNSSVGSLSEN CCCCCCCCCCCCCHH	35.50	25850435
1148	Phosphorylation	PHNSSVGSLSENEQN CCCCCCCCCCHHCCC	26.94	27732954
1150	Phosphorylation	NSSVGSLSENEQNTI CCCCCCCCHHCCCCH	39.82	27732954
1156	Phosphorylation	LSENEQNTIEKEEFM CCHHCCCCHHHHHHH	30.15	27732954
1169	Phosphorylation	FMLKLMRSLSEEVES HHHHHHHHHHHHHHH	23.45	30278072
1171	Phosphorylation	LKLMRSLSEEVESSE HHHHHHHHHHHHHCC	32.72	30278072
1176	Phosphorylation	SLSEEVESSESGELP HHHHHHHHCCCCCCC	44.58	28176443
1177	Phosphorylation	LSEEVESSESGELPE HHHHHHHCCCCCCCC	23.44	30108239
1179	Phosphorylation	EEVESSESGELPEVD HHHHHCCCCCCCCCC	39.24	30108239
1204	Phosphorylation	QFAEALATHILSLAT HHHHHHHHHHHHHHH	15.42	108417763
1237	Phosphorylation	NPCLNVQSQRSVSPT CCCCCCCCCCCCCCC	24.23	26074081
1240	Phosphorylation	LNVQSQRSVSPTFLN CCCCCCCCCCCCCCC	21.22	25159151
1242	Phosphorylation	VQSQRSVSPTFLNPS CCCCCCCCCCCCCCC	21.33	29255136
1244	Phosphorylation	SQRSVSPTFLNPSDE CCCCCCCCCCCCCHH	32.99	23927012
1249	Phosphorylation	SPTFLNPSDENLKTL CCCCCCCCHHHHHHH	57.38	23927012
1255	O-linked_Glycosylation	PSDENLKTLCNFAGD CCHHHHHHHHHHHHH	39.44	23301498
1287	Acetylation	CMLFKQKKNSCYADG CEEEECCCCCCCCCC	52.15	7365665
1289	Phosphorylation	LFKQKKNSCYADGDE EEECCCCCCCCCCCC	19.86	29496963
1291	Phosphorylation	KQKKNSCYADGDEDY ECCCCCCCCCCCCCC	13.93	30108239
1298	Phosphorylation	YADGDEDYKVEEKLD CCCCCCCCCCCEEEC	18.19	30461881
1299	Acetylation	ADGDEDYKVEEKLDI CCCCCCCCCCEEECC	56.33	7365673
1335	Phosphorylation	MSGLMYKYPSCESVT CCCCCCCCCCCCCCC	5.27	30278072
1337	Phosphorylation	GLMYKYPSCESVTDE CCCCCCCCCCCCCHH	27.68	30278072
1340	Phosphorylation	YKYPSCESVTDEYAG CCCCCCCCCCHHHHH	34.34	30278072
1342	Phosphorylation	YPSCESVTDEYAGHL CCCCCCCCHHHHHHH	32.18	22617229
1345	Phosphorylation	CESVTDEYAGHLIQI CCCCCHHHHHHHHHH	22.23	26657352
1360	Phosphorylation	LKQEGGNSELIMDQY HHHCCCCCHHHHHHH	36.73	100646243
1367	Phosphorylation	SELIMDQYANRLAYR CHHHHHHHHHHHHHH	11.11	46161251
1373	Phosphorylation	QYANRLAYRSVKSGL HHHHHHHHHHHHHHH	14.17	22964224
1377	Ubiquitination	RLAYRSVKSGLQEAA HHHHHHHHHHHHHHH	39.80	33845483
1387	Phosphorylation	LQEAAKTTKVQCNSR HHHHHHHCCCCCCCC	28.63	24425749
1388	Ubiquitination	QEAAKTTKVQCNSRM HHHHHHCCCCCCCCE	35.22	29967540
1401	Phosphorylation	RMFPVPSSQVKTNKE CEECCCHHHCCCCHH	32.68	28555341
1452	Phosphorylation	DPYRNEVSQLYSFST CCCHHHHHHHHHHHH	14.32	23663014
1455	Phosphorylation	RNEVSQLYSFSTSLV HHHHHHHHHHHHHHH	10.47	23663014
1456	Phosphorylation	NEVSQLYSFSTSLVH HHHHHHHHHHHHHHH	22.70	23663014
1458	Phosphorylation	VSQLYSFSTSLVHSI HHHHHHHHHHHHHHH	15.90	23663014
1459	Phosphorylation	SQLYSFSTSLVHSIT HHHHHHHHHHHHHHC	24.86	23663014
1460	Phosphorylation	QLYSFSTSLVHSITK HHHHHHHHHHHHHCC	27.48	23663014
1464	Phosphorylation	FSTSLVHSITKDAKE HHHHHHHHHCCCHHH	25.19	23663014
1466	Phosphorylation	TSLVHSITKDAKEEL HHHHHHHCCCHHHHH	26.36	23663014
1470	Ubiquitination	HSITKDAKEELTASL HHHCCCHHHHHHHHH	62.95	29967540
1474	Phosphorylation	KDAKEELTASLVGLP CCHHHHHHHHHHCCC	19.92	29514088
1476	Phosphorylation	AKEELTASLVGLPKS HHHHHHHHHHCCCHH	20.53	30835187
1483	Phosphorylation	SLVGLPKSLTDSCLF HHHCCCHHHCHHCCC	34.26	29691806
1485	Phosphorylation	VGLPKSLTDSCLFEK HCCCHHHCHHCCCCC	32.72	21082442
1487	Phosphorylation	LPKSLTDSCLFEKSG CCHHHCHHCCCCCCC	13.90	25849741
1492	Ubiquitination	TDSCLFEKSGYEEDN CHHCCCCCCCCCCCC	41.67	-
1493	Phosphorylation	DSCLFEKSGYEEDNE HHCCCCCCCCCCCCC	39.13	25849741
1495	Phosphorylation	CLFEKSGYEEDNECH CCCCCCCCCCCCCCC	24.20	28796482
1504	Phosphorylation	EDNECHVTPELPKSL CCCCCCCCCCCCCCC	6.33	54886541
1521	Phosphorylation	SSQNHRFYHSTGSLN CCCCCCEEECCCCCC	8.53	28450419
1523	Phosphorylation	QNHRFYHSTGSLNGY CCCCEEECCCCCCCC	24.08	28450419
1524	O-linked_Glycosylation	NHRFYHSTGSLNGYG CCCEEECCCCCCCCC	19.92	23301498
1524	Phosphorylation	NHRFYHSTGSLNGYG CCCEEECCCCCCCCC	19.92	28450419
1526	O-linked_Glycosylation	RFYHSTGSLNGYGCG CEEECCCCCCCCCCC	20.81	23301498
1526	Phosphorylation	RFYHSTGSLNGYGCG CEEECCCCCCCCCCC	20.81	26657352
1530	Phosphorylation	STGSLNGYGCGDNVV CCCCCCCCCCCHHHH	14.26	28450419
1543	Phosphorylation	VVQAVEQYAKKVVDD HHHHHHHHHHHHCCC	13.59	27080861
1559	Phosphorylation	LELTLGSTVFRVSET HHHCCCCEEEECCCC	23.12	24719451
1569	Phosphorylation	RVSETTKSADRVTYA ECCCCCCCCCCEEEH	33.05	23403867
1574	Phosphorylation	TKSADRVTYAEKLSP CCCCCCEEEHHHHCC	20.22	28450419
1575	Phosphorylation	KSADRVTYAEKLSPL CCCCCEEEHHHHCCC	15.20	28450419
1578	Ubiquitination	DRVTYAEKLSPLTGQ CCEEEHHHHCCCCCC	46.20	29967540
1580	Phosphorylation	VTYAEKLSPLTGQAC EEEHHHHCCCCCCHH	29.00	23401153
1583	Phosphorylation	AEKLSPLTGQACRYC HHHHCCCCCCHHHCC	30.54	23927012
1599	Phosphorylation	LKELHNCTGNSSQHF HHHHHCCCCCCHHHH	44.72	28555341
1602	Phosphorylation	LHNCTGNSSQHFFRQ HHCCCCCCHHHHHHC	32.49	28555341
1611	Phosphorylation	QHFFRQGSLASSKPA HHHHHCCCCCCCCCC	16.66	25849741
1614	Phosphorylation	FRQGSLASSKPASNP HHCCCCCCCCCCCCC	44.16	29396449
1615	Phosphorylation	RQGSLASSKPASNPK HCCCCCCCCCCCCCC	36.73	26657352
1616	Ubiquitination	QGSLASSKPASNPKF CCCCCCCCCCCCCCC	41.95	29967540
1619	Phosphorylation	LASSKPASNPKFSSR CCCCCCCCCCCCCHH	63.29	33259812
1636	Phosphorylation	KSRIFHLSVPQIHVN HHHEEEEECCEEECC	24.15	24247654
1661	Ubiquitination	IVAEAIEKAERELSS HHHHHHHHHHHHHHC	49.81	33845483
1667	Phosphorylation	EKAERELSSTSLAAD HHHHHHHHCCCHHCC	27.15	21955146
1668	Phosphorylation	KAERELSSTSLAADS HHHHHHHCCCHHCCC	34.34	21955146
1669	Phosphorylation	AERELSSTSLAADSG HHHHHHCCCHHCCCC	25.12	21955146
1670	Phosphorylation	ERELSSTSLAADSGI HHHHHCCCHHCCCCC	20.26	21955146
1675	Phosphorylation	STSLAADSGIGQEGA CCCHHCCCCCCHHHH	27.81	21955146
1683	Phosphorylation	GIGQEGASFAESLAT CCCHHHHHHHHHHHH	35.53	21955146
1687	Phosphorylation	EGASFAESLATETMT HHHHHHHHHHHHHHH	21.63	21955146
1690	Phosphorylation	SFAESLATETMTAAV HHHHHHHHHHHHHHH	36.96	21955146
1692	Phosphorylation	AESLATETMTAAVTN HHHHHHHHHHHHHHC	18.57	21955146
1694	Phosphorylation	SLATETMTAAVTNVG HHHHHHHHHHHHCHH	20.91	21955146
1698	Phosphorylation	ETMTAAVTNVGHAVS HHHHHHHHCHHHHHC	21.33	21955146
1705	Phosphorylation	TNVGHAVSSSKEIED HCHHHHHCCCCCCCC	29.67	21955146
1706	Phosphorylation	NVGHAVSSSKEIEDF CHHHHHCCCCCCCCH	38.54	21955146
1707	Phosphorylation	VGHAVSSSKEIEDFQ HHHHHCCCCCCCCHH	27.14	21955146
1737	Phosphorylation	DDSTGSWSNLSFEDE CCCCCCCCCCCCCCC	29.59	21653181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1136	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
1140	T	Phosphorylation	Kinase	GSK3B	P49841	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AKA11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AKA11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAP2_HUMAN	PRKAR2A	physical	12147701
GSK3B_HUMAN	GSK3B	physical	12147701
PP1A_HUMAN	PPP1CA	physical	12147701
PP1B_HUMAN	PPP1CB	physical	12147701
PP1G_HUMAN	PPP1CC	physical	12147701
KAP2_HUMAN	PRKAR2A	physical	8621616
KAP3_HUMAN	PRKAR2B	physical	10864471
KAP0_HUMAN	PRKAR1A	physical	10864471

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AKA11_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-433; SER-448;THR-1100 AND SER-1242, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448; THR-1100; SER-1169;SER-1240 AND SER-1242, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1100 AND SER-1242, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-422; SER-433; SER-448;THR-1100; THR-1104; SER-1337 AND SER-1340, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448; THR-1100; SER-1169AND SER-1242, AND MASS SPECTROMETRY.	18691976 [Abstract]