dbPTM

KAP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KAP3_HUMAN
UniProt AC	P31323
Protein Name	cAMP-dependent protein kinase type II-beta regulatory subunit
Gene Name	PRKAR2B
Organism	Homo sapiens (Human).
Sequence Length	418
Subcellular Localization	Cytoplasm . Cell membrane . Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
Protein Description	Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase..
Protein Sequence	MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSIEIPAGL ------CCCCCCCCH	29.00	24043423
10	Phosphorylation	IEIPAGLTELLQGFT CCCCCCHHHHHCCCC	24.54	24043423
17	Phosphorylation	TELLQGFTVEVLRHQ HHHHCCCCEEHHHCC	23.68	24043423
69	Phosphorylation	GAAAGGGTPSKGVNF CHHCCCCCCCCCCCC	27.88	19664994
71	Phosphorylation	AAGGGTPSKGVNFAE HCCCCCCCCCCCCCC	41.71	30266825
83	Phosphorylation	FAEEPMQSDSEDGEE CCCCCCCCCCCCCCC	36.53	30266825
85	Phosphorylation	EEPMQSDSEDGEEEE CCCCCCCCCCCCCHH	42.72	30266825
110	Phosphorylation	APVINRFTRRASVCA HHHHHHHHHHHHHHH	18.93	26074081
114	Phosphorylation	NRFTRRASVCAEAYN HHHHHHHHHHHHHHC	18.87	29255136
120	Phosphorylation	ASVCAEAYNPDEEED HHHHHHHHCCCCCCC	20.80	22617229
131	Phosphorylation	EEEDDAESRIIHPKT CCCCCHHHCCCCCCC	30.42	23403867
137	Ubiquitination	ESRIIHPKTDDQRNR HHCCCCCCCHHHHHH	50.88	-
149	Glutathionylation	RNRLQEACKDILLFK HHHHHHHHHHHHHHC	3.91	22555962
150	Ubiquitination	NRLQEACKDILLFKN HHHHHHHHHHHHHCC	55.65	-
202	Phosphorylation	DRGTFDIYVKCDGVG ECCEEEEEEEECCCC	8.83	28064214
220	Phosphorylation	GNYDNRGSFGELALM CCCCCCCCHHHHHHH	27.17	27499020
227	Sulfoxidation	SFGELALMYNTPRAA CHHHHHHHCCCCCCE	1.70	30846556
228	Phosphorylation	FGELALMYNTPRAAT HHHHHHHCCCCCCEE	19.41	20068231
230	Phosphorylation	ELALMYNTPRAATIT HHHHHCCCCCCEEEE	9.18	21082442
357	Phosphorylation	FGELALVTNKPRAAS EEEEEEECCCCCCCH	38.07	-
359	Ubiquitination	ELALVTNKPRAASAH EEEEECCCCCCCHHH	26.89	21890473
364	Phosphorylation	TNKPRAASAHAIGTV CCCCCCCHHHHHHHH	21.43	28348404
372	Ubiquitination	AHAIGTVKCLAMDVQ HHHHHHHHHHHCCHH	24.30	-
417	Phosphorylation	NMDIVEPTA------ CCCCCCCCC------	31.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
114	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
114	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
114	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
114	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
114	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	PJA2	O43164	PMID:21423175

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KAP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KAP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNAI3_HUMAN	GNAI3	physical	22186894
TAF12_HUMAN	TAF12	physical	25416956
AKA7A_HUMAN	AKAP7	physical	25416956
AKA7G_HUMAN	AKAP7	physical	25416956
AKAP1_HUMAN	AKAP1	physical	26186194
AKA11_HUMAN	AKAP11	physical	26186194
KAP2_HUMAN	PRKAR2A	physical	26186194
AKAP9_HUMAN	AKAP9	physical	26186194
AKP13_HUMAN	AKAP13	physical	26186194
MYOME_HUMAN	PDE4DIP	physical	26186194
CK5P2_HUMAN	CDK5RAP2	physical	26186194
KAPCA_HUMAN	PRKACA	physical	26186194
KAPCG_HUMAN	PRKACG	physical	26186194
KAPCB_HUMAN	PRKACB	physical	26186194
AKAP2_HUMAN	AKAP2	physical	26186194
MTAP2_HUMAN	MAP2	physical	26186194
AKA7A_HUMAN	AKAP7	physical	26186194
AKA7G_HUMAN	AKAP7	physical	26186194
ZG16B_HUMAN	ZG16B	physical	26186194
AKAP5_HUMAN	AKAP5	physical	26186194
PRKX_HUMAN	PRKX	physical	26186194
CRBG3_HUMAN	CRYBG3	physical	26186194
KAP1_HUMAN	PRKAR1B	physical	26186194
NAA25_HUMAN	NAA25	physical	26186194
VAPB_HUMAN	VAPB	physical	26186194
KC1D_HUMAN	CSNK1D	physical	26496610
DC1I2_HUMAN	DYNC1I2	physical	26496610
PCM1_HUMAN	PCM1	physical	26496610
KAPCB_HUMAN	PRKACB	physical	26496610
KAP2_HUMAN	PRKAR2A	physical	26496610
SURF4_HUMAN	SURF4	physical	26496610
VAV2_HUMAN	VAV2	physical	26496610
OFD1_HUMAN	OFD1	physical	26496610
MYOME_HUMAN	PDE4DIP	physical	26496610
CE170_HUMAN	CEP170	physical	26496610
SC16A_HUMAN	SEC16A	physical	26496610
AKAP9_HUMAN	AKAP9	physical	26496610
CP131_HUMAN	CEP131	physical	26496610
CEP68_HUMAN	CEP68	physical	26496610
HBP1_HUMAN	HBP1	physical	26496610
BABA1_HUMAN	BABAM1	physical	26496610
CSN7A_HUMAN	COPS7A	physical	26496610
CEP72_HUMAN	CEP72	physical	26496610
CK5P2_HUMAN	CDK5RAP2	physical	26496610
MIB1_HUMAN	MIB1	physical	26496610
CCD77_HUMAN	CCDC77	physical	26496610
KAPCA_HUMAN	PRKACA	physical	26496610
KAPCA_HUMAN	PRKACA	physical	21795691
AKP13_HUMAN	AKAP13	physical	28514442
PRKX_HUMAN	PRKX	physical	28514442
CRBG3_HUMAN	CRYBG3	physical	28514442
AKAP1_HUMAN	AKAP1	physical	28514442
MYOME_HUMAN	PDE4DIP	physical	28514442
AKA7A_HUMAN	AKAP7	physical	28514442
AKA7G_HUMAN	AKAP7	physical	28514442
AKAP9_HUMAN	AKAP9	physical	28514442
AKAP5_HUMAN	AKAP5	physical	28514442
AKAP2_HUMAN	AKAP2	physical	28514442
MTAP2_HUMAN	MAP2	physical	28514442
AKA11_HUMAN	AKAP11	physical	28514442
KAPCA_HUMAN	PRKACA	physical	28514442
KAP2_HUMAN	PRKAR2A	physical	28514442
CK5P2_HUMAN	CDK5RAP2	physical	28514442
KAP1_HUMAN	PRKAR1B	physical	28514442
ZG16B_HUMAN	ZG16B	physical	28514442
NAA25_HUMAN	NAA25	physical	28514442
KAP0_HUMAN	PRKAR1A	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KAP3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-85 AND SER-114,AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83 AND SER-85, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, AND MASSSPECTROMETRY.	18318008 [Abstract]
"Phosphoproteomic analysis of synaptosomes from human cerebralcortex."; DeGiorgis J.A., Jaffe H., Moreira J.E., Carlotti C.G. Jr., Leite J.P.,Pant H.C., Dosemeci A.; J. Proteome Res. 4:306-315(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, AND MASSSPECTROMETRY.	15822905 [Abstract]