| UniProt ID | PRKX_HUMAN | |
|---|---|---|
| UniProt AC | P51817 | |
| Protein Name | cAMP-dependent protein kinase catalytic subunit PRKX | |
| Gene Name | PRKX | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 358 | |
| Subcellular Localization | Cytoplasm. Nucleus. cAMP induces nuclear translocation. | |
| Protein Description | Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.. | |
| Protein Sequence | MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MEAPGLAQ -------CCCCHHHH | 10.01 | 22814378 | |
| 33 | Phosphorylation | GAPALCPSPEALSPE CCCCCCCCCCCCCCC | 34.08 | 28348404 | |
| 38 | Phosphorylation | CPSPEALSPEPPVYS CCCCCCCCCCCCEEC | 33.98 | 28348404 | |
| 70 | Phosphorylation | VHLVKEKTAKHFFAL EEEEEHHCHHHEEEE | 41.87 | 28258704 | |
| 174 | Ubiquitination | EIVYRDLKPENILLD CCEECCCCHHHEEEC | 55.35 | - | |
| 195 | Ubiquitination | LTDFGFAKKLVDRTW ECCCHHHHHHCCCCH | 44.36 | - | |
| 201 | Phosphorylation | AKKLVDRTWTLCGTP HHHHCCCCHHCCCCH | 20.52 | 25159151 | |
| 203 | Phosphorylation | KLVDRTWTLCGTPEY HHCCCCHHCCCCHHH | 16.14 | 25159151 | |
| 207 | Phosphorylation | RTWTLCGTPEYLAPE CCHHCCCCHHHHCHH | 16.38 | 25022875 | |
| 210 | Phosphorylation | TLCGTPEYLAPEVIQ HCCCCHHHHCHHHHH | 14.90 | 23403867 | |
| 218 | Phosphorylation | LAPEVIQSKGHGRAV HCHHHHHCCCCCCHH | 29.49 | 23403867 | |
| 305 | Phosphorylation | KHHRWFRSVDWEAVP CCCHHHHCCCHHHCC | 18.24 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRKX_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRKX_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRKX_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KAP0_HUMAN | PRKAR1A | physical | 10026146 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
