NAA25_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAA25_HUMAN
• UniProt AC: Q14CX7
• Protein Name: N-alpha-acetyltransferase 25, NatB auxiliary subunit
• Gene Name: NAA25
• Organism: Homo sapiens (Human).
• Sequence Length: 972
• Subcellular Localization: Cytoplasm .
• Protein Description: Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression..
• Protein Sequence: MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQSISAQDENLSKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRGKLGEKLTSEIQSRENKCMAMYKKLSRWPECNALSRRLLLKNSDDWQFYLTYFDSVFRLIEEAWSPPAEGEHSLEGEVHYSAEKAVKFIEDRITEESKSSRHLRGPHLAKLELIRRLRSQGCNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPATQCTKFINQLLGVVPLSTPTEDKLALPADIRALQQHLCVVQLTRLLGLYHTMDKNQKLSVVRELMLRYQHGLEFGKTCLKTELQFSDYYCLLAVHALIDVWRETGDETTVWQALTLLEEGLTHSPSNAQFKLLLVRIYCMLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAESLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLEANISTSLAESIKSMNLRPEEDDIPWEDLRDNRDLNVFFSWDPKDRDVSEEHKKLSLEEETLWLRIRSLTLRLISGLPSLNHPVEPKNSEKTAENGVSSRIDILRLLLQQLEATLETGKRFIEKDIQYPFLGPVPTRMGGFFNSGCSQCQISSFYLVNDIYELDTSGLEDTMEIQERIENSFKSLLDQLKDVFSKCKGDLLEVKDGNLKTHPTLLENLVFFVETISVILWVSSYCESVLRPYKLNLQKKKKKKKETSIIMPPVFTSFQDYVTGLQTLISNVVDHIKGLETHLIALKLEELILEDTSLSPEERKFSKTVQGKVQSSYLHSLLEMGELLKKRLETTKKLKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Methylation	----MATRGHVQDPN ----CCCCCCCCCCC	24.55	115484405
6	Ubiquitination	--MATRGHVQDPNDR --CCCCCCCCCCCCC	15.69	22817900
7	Ubiquitination	-MATRGHVQDPNDRR -CCCCCCCCCCCCCC	8.43	22817900
11	Ubiquitination	RGHVQDPNDRRLRPI CCCCCCCCCCCCCCH	64.81	22817900
19	Phosphorylation	DRRLRPIYDYLDNGN CCCCCCHHHHHCCCC	10.96	28450419
21	Phosphorylation	RLRPIYDYLDNGNNK CCCCHHHHHCCCCCH	10.05	29978859
36	Ubiquitination	MAIQQADKLLKKHKD HHHHHHHHHHHHCCC	59.75	29967540
40	Methylation	QADKLLKKHKDLHCA HHHHHHHHCCCHHHH	56.72	-
47	Ubiquitination	KHKDLHCAKVLKAIG HCCCHHHHHHHHHHC	8.34	23503661
48	Methylation	HKDLHCAKVLKAIGL CCCHHHHHHHHHHCC	54.19	-
50	Ubiquitination	DLHCAKVLKAIGLQR CHHHHHHHHHHCCCC	2.82	21963094
53	Ubiquitination	CAKVLKAIGLQRTGK HHHHHHHHCCCCCCC	5.60	23503661
60	Ubiquitination	IGLQRTGKQEEAFTL HCCCCCCCHHHHHHH	54.65	29967540
72	Ubiquitination	FTLAQEVAALEPTDD HHHHHHHHHCCCCCC	12.94	27667366
83	Ubiquitination	PTDDNSLQALTILYR CCCCCHHHHHHHHHH	33.86	22817900
87	Ubiquitination	NSLQALTILYREMHR CHHHHHHHHHHHHCC	3.11	22817900
102	Phosphorylation	PELVTKLYEAAVKKV HHHHHHHHHHHHHHC	12.70	27642862
105	Ubiquitination	VTKLYEAAVKKVPNS HHHHHHHHHHHCCCC	11.17	24816145
108	Ubiquitination	LYEAAVKKVPNSEEY HHHHHHHHCCCCHHH	57.22	-
112	Phosphorylation	AVKKVPNSEEYHSHL HHHHCCCCHHHHHHH	26.24	23663014
115	Phosphorylation	KVPNSEEYHSHLFMA HCCCCHHHHHHHHHH	12.45	23663014
117	Phosphorylation	PNSEEYHSHLFMAYA CCCHHHHHHHHHHHH	22.45	23663014
123	Phosphorylation	HSHLFMAYARVGEYK HHHHHHHHHCHHCHH	5.33	23663014
131	Ubiquitination	ARVGEYKKMQQAGMA HCHHCHHHHHHHCCH	40.83	29967540
155	Ubiquitination	YYFWSVMSLIMQSIS HHHHHHHHHHHHHHC	16.76	23503661
158	Ubiquitination	WSVMSLIMQSISAQD HHHHHHHHHHHCCCC	2.87	23503661
161	Ubiquitination	MSLIMQSISAQDENL HHHHHHHHCCCCCCC	1.92	23503661
168	Ubiquitination	ISAQDENLSKTMFLP HCCCCCCCCHHCHHH	5.37	27667366
172	Sulfoxidation	DENLSKTMFLPLAER CCCCCHHCHHHHHHH	3.59	21406390
179	Ubiquitination	MFLPLAERMVEKMVK CHHHHHHHHHHHHHH	28.92	22817900
180	Ubiquitination	FLPLAERMVEKMVKE HHHHHHHHHHHHHHH	3.25	27667366
183	Ubiquitination	LAERMVEKMVKEDKI HHHHHHHHHHHHCCC	37.27	23503661
183 (in isoform 2)	Ubiquitination	-	37.27	-
186	Ubiquitination	RMVEKMVKEDKIEAE HHHHHHHHHCCCCHH	57.61	23503661
189	Ubiquitination	EKMVKEDKIEAEAEV HHHHHHCCCCHHHHH	43.46	23503661
191	Ubiquitination	MVKEDKIEAEAEVEL HHHHCCCCHHHHHHH	46.31	21890473
195	Ubiquitination	DKIEAEAEVELYYMI CCCCHHHHHHHHHHH	28.20	22817900
208	Ubiquitination	MILERLGKYQEALDV HHHHHHCHHHHHHHH	48.64	21963094
213	Ubiquitination	LGKYQEALDVIRGKL HCHHHHHHHHHHHHH	5.48	24816145
219	"N6,N6-dimethyllysine"	ALDVIRGKLGEKLTS HHHHHHHHHHHHHHH	43.39	-
219	Methylation	ALDVIRGKLGEKLTS HHHHHHHHHHHHHHH	43.39	23644510
219	Ubiquitination	ALDVIRGKLGEKLTS HHHHHHHHHHHHHHH	43.39	22817900
221	Ubiquitination	DVIRGKLGEKLTSEI HHHHHHHHHHHHHHH	33.22	21890473
222	Ubiquitination	VIRGKLGEKLTSEIQ HHHHHHHHHHHHHHH	56.16	22817900
223	Ubiquitination	IRGKLGEKLTSEIQS HHHHHHHHHHHHHHH	56.09	21906983
223 (in isoform 1)	Ubiquitination	-	56.09	21890473
223 (in isoform 2)	Ubiquitination	-	56.09	21890473
226	Ubiquitination	KLGEKLTSEIQSREN HHHHHHHHHHHHHHH	43.04	22817900
235	Ubiquitination	IQSRENKCMAMYKKL HHHHHHHHHHHHHHH	2.95	22817900
240	Ubiquitination	NKCMAMYKKLSRWPE HHHHHHHHHHHCCHH	33.87	-
241	Ubiquitination	KCMAMYKKLSRWPEC HHHHHHHHHHCCHHH	33.92	24816145
265	Ubiquitination	KNSDDWQFYLTYFDS CCCCCCHHHHHHHHH	4.74	21963094
276	Ubiquitination	YFDSVFRLIEEAWSP HHHHHHHHHHHHCCC	3.82	27667366
287	Ubiquitination	AWSPPAEGEHSLEGE HCCCCCCCCCCCCCE	39.77	22817900
299	Ubiquitination	EGEVHYSAEKAVKFI CCEEEECHHHHHHHH	18.36	21890473
304	Ubiquitination	YSAEKAVKFIEDRIT ECHHHHHHHHHHHHC	45.55	27667366
309	Methylation	AVKFIEDRITEESKS HHHHHHHHHCCCHHH	25.57	115484413
315	Ubiquitination	DRITEESKSSRHLRG HHHCCCHHHCCCCCC	56.59	21906983
315 (in isoform 1)	Ubiquitination	-	56.59	21890473
315 (in isoform 2)	Ubiquitination	-	56.59	21890473
316	Ubiquitination	RITEESKSSRHLRGP HHCCCHHHCCCCCCH	41.71	21963094
327	Ubiquitination	LRGPHLAKLELIRRL CCCHHHHHHHHHHHH	49.18	22817900
327 (in isoform 1)	Ubiquitination	-	49.18	21890473
327 (in isoform 2)	Ubiquitination	-	49.18	21890473
329	Ubiquitination	GPHLAKLELIRRLRS CHHHHHHHHHHHHHH	41.25	21890473
330	Ubiquitination	PHLAKLELIRRLRSQ HHHHHHHHHHHHHHC	5.52	22817900
334	Ubiquitination	KLELIRRLRSQGCND HHHHHHHHHHCCCCC	4.42	22817900
344	Ubiquitination	QGCNDEYKLGDPEEL CCCCCCCCCCCHHHH	43.90	21963094
357	Ubiquitination	ELMFQYFKKFGDKPC HHHHHHHHHHCCCCC	42.11	21906983
357 (in isoform 1)	Ubiquitination	-	42.11	21890473
357 (in isoform 2)	Ubiquitination	-	42.11	21890473
358	Ubiquitination	LMFQYFKKFGDKPCC HHHHHHHHHCCCCCC	44.68	22817900
362	Ubiquitination	YFKKFGDKPCCFTDL HHHHHCCCCCCCCCH	40.09	22817900
373	Ubiquitination	FTDLKVFVDLLPATQ CCCHHHHHHHCCHHH	5.93	21963094
391	Ubiquitination	FINQLLGVVPLSTPT HHHHHHCCCCCCCCC	3.96	21963094
395	Phosphorylation	LLGVVPLSTPTEDKL HHCCCCCCCCCCCCC	26.69	21406692
396	Phosphorylation	LGVVPLSTPTEDKLA HCCCCCCCCCCCCCC	41.74	21406692
396	Ubiquitination	LGVVPLSTPTEDKLA HCCCCCCCCCCCCCC	41.74	22817900
398	Phosphorylation	VVPLSTPTEDKLALP CCCCCCCCCCCCCCC	57.83	21406692
401	Ubiquitination	LSTPTEDKLALPADI CCCCCCCCCCCCHHH	29.45	21906983
401 (in isoform 1)	Ubiquitination	-	29.45	21890473
401 (in isoform 2)	Ubiquitination	-	29.45	21890473
435	Ubiquitination	HTMDKNQKLSVVREL HCCCCCCCHHHHHHH	52.72	29967540
446	Phosphorylation	VRELMLRYQHGLEFG HHHHHHHHHHHHHHC	10.82	29759185
450	Ubiquitination	MLRYQHGLEFGKTCL HHHHHHHHHHCHHHH	4.65	22817900
456	Ubiquitination	GLEFGKTCLKTELQF HHHHCHHHHHHHCCC	4.12	22817900
459	Phosphorylation	FGKTCLKTELQFSDY HCHHHHHHHCCCHHH	29.04	-
464	Phosphorylation	LKTELQFSDYYCLLA HHHHCCCHHHHHHHH	16.25	-
476	Ubiquitination	LLAVHALIDVWRETG HHHHHHHHHHHHHHC	4.10	27667366
544	Phosphorylation	IQHDTIGYLLTRYAE CCHHHHHHHHHHHHH	8.49	-
556	Phosphorylation	YAESLGQYAAASQSC HHHHHHHHHHHHHCC	9.08	-
558	Ubiquitination	ESLGQYAAASQSCNF HHHHHHHHHHHCCCH	11.60	22817900
560	Phosphorylation	LGQYAAASQSCNFAL HHHHHHHHHCCCHHH	20.21	-
564	Ubiquitination	AAASQSCNFALRFFH HHHHHCCCHHHHHHH	30.39	22817900
575	Acetylation	RFFHSNQKDTSEYII HHHHCCCCCCHHHHH	68.19	26051181
575	Malonylation	RFFHSNQKDTSEYII HHHHCCCCCCHHHHH	68.19	26320211
575	Ubiquitination	RFFHSNQKDTSEYII HHHHCCCCCCHHHHH	68.19	-
586	Ubiquitination	EYIIQAYKYGAFEKI HHHHHHHHHCHHHCC	39.98	21906983
586 (in isoform 1)	Ubiquitination	-	39.98	21890473
586 (in isoform 2)	Ubiquitination	-	39.98	21890473
587	Phosphorylation	YIIQAYKYGAFEKIP HHHHHHHHCHHHCCH	10.87	-
588	Ubiquitination	IIQAYKYGAFEKIPE HHHHHHHCHHHCCHH	21.45	27667366
592	Ubiquitination	YKYGAFEKIPEFIAF HHHCHHHCCHHHHHH	58.04	22817900
592 (in isoform 1)	Ubiquitination	-	58.04	21890473
592 (in isoform 2)	Ubiquitination	-	58.04	21890473
606	Ubiquitination	FRNRLNNSLHFAQVR HHHHHHCCCHHHHHH	23.34	21963094
611	Ubiquitination	NNSLHFAQVRTERML HCCCHHHHHHHHHHH	25.04	22817900
618	Ubiquitination	QVRTERMLLDLLLEA HHHHHHHHHHHHHHC	4.16	24816145
628	Phosphorylation	LLLEANISTSLAESI HHHHCCCCHHHHHHH	16.26	-
663	Phosphorylation	RDLNVFFSWDPKDRD CCCEEEEECCCCCCC	21.07	23401153
667	Ubiquitination	VFFSWDPKDRDVSEE EEEECCCCCCCCCHH	64.02	29967540
676	Ubiquitination	RDVSEEHKKLSLEEE CCCCHHHHHCCHHHH	59.70	-
691	Phosphorylation	TLWLRIRSLTLRLIS HHHHHHHHHHHHHHC	24.28	24702127
691	Ubiquitination	TLWLRIRSLTLRLIS HHHHHHHHHHHHHHC	24.28	27667366
693	Phosphorylation	WLRIRSLTLRLISGL HHHHHHHHHHHHCCC	15.87	24702127
714	Ubiquitination	VEPKNSEKTAENGVS CCCCCCHHHHHCCHH	53.51	21963094
719	Ubiquitination	SEKTAENGVSSRIDI CHHHHHCCHHHHHHH	16.52	22817900
737	Phosphorylation	LLQQLEATLETGKRF HHHHHHHHHHHCHHH	18.76	-
742	2-Hydroxyisobutyrylation	EATLETGKRFIEKDI HHHHHHCHHHHHHHC	52.10	-
742	Ubiquitination	EATLETGKRFIEKDI HHHHHHCHHHHHHHC	52.10	21906983
742 (in isoform 1)	Ubiquitination	-	52.10	21890473
742 (in isoform 2)	Ubiquitination	-	52.10	21890473
747	Ubiquitination	TGKRFIEKDIQYPFL HCHHHHHHHCCCCCC	56.14	22817900
747 (in isoform 1)	Ubiquitination	-	56.14	21890473
747 (in isoform 2)	Ubiquitination	-	56.14	21890473
799	Ubiquitination	EDTMEIQERIENSFK CCHHHHHHHHHHHHH	62.38	27667366
803	Ubiquitination	EIQERIENSFKSLLD HHHHHHHHHHHHHHH	50.83	27667366
806	Ubiquitination	ERIENSFKSLLDQLK HHHHHHHHHHHHHHH	39.76	-
813	Ubiquitination	KSLLDQLKDVFSKCK HHHHHHHHHHHHHCC	46.33	-
818	Ubiquitination	QLKDVFSKCKGDLLE HHHHHHHHCCCCEEE	28.62	29967540
820	Ubiquitination	KDVFSKCKGDLLEVK HHHHHHCCCCEEEEE	60.23	29967540
827	Ubiquitination	KGDLLEVKDGNLKTH CCCEEEEECCCCCCC	51.01	27667366
833	Ubiquitination	VKDGNLKTHPTLLEN EECCCCCCCHHHHHH	35.93	24816145
879	Phosphorylation	KKKKKKETSIIMPPV CCCCCCCCCCCCCCC	33.82	23401153
880	Phosphorylation	KKKKKETSIIMPPVF CCCCCCCCCCCCCCC	15.94	23401153
888	Phosphorylation	IIMPPVFTSFQDYVT CCCCCCCCCHHHHHH	28.94	23401153
889	Phosphorylation	IMPPVFTSFQDYVTG CCCCCCCCHHHHHHH	14.94	23401153
893	Phosphorylation	VFTSFQDYVTGLQTL CCCCHHHHHHHHHHH	6.79	23401153
895	Phosphorylation	TSFQDYVTGLQTLIS CCHHHHHHHHHHHHH	26.41	23401153
911	Ubiquitination	VVDHIKGLETHLIAL HHHHHCCHHHHHHHH	6.11	27667366
928	Phosphorylation	EELILEDTSLSPEER HHHHHHCCCCCHHHH	23.38	20068231
929	Phosphorylation	ELILEDTSLSPEERK HHHHHCCCCCHHHHH	38.89	20068231
931	Phosphorylation	ILEDTSLSPEERKFS HHHCCCCCHHHHHCC	29.99	20068231
939	Ubiquitination	PEERKFSKTVQGKVQ HHHHHCCHHHCHHHH	56.71	27667366
941	Ubiquitination	ERKFSKTVQGKVQSS HHHCCHHHCHHHHHH	8.97	24816145
969	Ubiquitination	KRLETTKKLKI---- HHHHHHCCCCC----	53.58	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAA25_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAA25_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAA25_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NAA20_HUMAN	NAA20	physical	22939629
PARP9_HUMAN	PARP9	physical	22939629
NAA20_HUMAN	NAA20	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.