AKP13_HUMAN - dbPTM
AKP13_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AKP13_HUMAN
UniProt AC Q12802
Protein Name A-kinase anchor protein 13
Gene Name AKAP13
Organism Homo sapiens (Human).
Sequence Length 2813
Subcellular Localization Cytoplasm, cytosol . Cytoplasm . Cytoplasm, cell cortex . Nucleus . Membrane
Peripheral membrane protein . Colocalizes with the actin cytoskeleton at the cell cortex.
Protein Description Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor. [PubMed: 11546812]
Protein Sequence MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPGHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLTWFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYGDCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPLMMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIVEEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAGEMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAASSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDGLEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDKLCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSDPVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVISDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPLEDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKATLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPPGASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSACEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKAVTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDMELSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVIEQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATGSLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMKQGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSDSDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPNRSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSPFRRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRPPIHRRSFSLEGLTGGAGVGNKPSSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNYCTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationLNPQQAPLYGDCVVT
CCHHHCCCCCCEEEE
9.2827251275
51PhosphorylationCTSTRKVSSDTLETI
HCCCCCCCCCCCCCC
26.0723312004
52PhosphorylationTSTRKVSSDTLETIA
CCCCCCCCCCCCCCC
37.2923312004
54PhosphorylationTRKVSSDTLETIAPG
CCCCCCCCCCCCCCC
28.5723312004
57PhosphorylationVSSDTLETIAPGHDC
CCCCCCCCCCCCCCC
26.0823312004
67PhosphorylationPGHDCCETVKVQLCA
CCCCCCCCEEEEEEC
16.2323312004
122PhosphorylationFTRFLDQSGPPSGDV
HHHHHCCCCCCCCCC
53.5928674151
134UbiquitinationGDVNSLDKKLVLAFR
CCCCHHCHHHHHHHH
53.99-
180PhosphorylationRLGLLRLTWFLLQKP
HHHHHHHHHHHHCCC
14.0346161303
186UbiquitinationLTWFLLQKPGGRGAL
HHHHHHCCCCCCCCE
45.672189047
186 (in isoform 1)Ubiquitination-45.6721890473
186 (in isoform 2)Ubiquitination-45.6721890473
186 (in isoform 4)Ubiquitination-45.6721890473
273PhosphorylationPFPGDGCTGPIFKLM
CCCCCCCCHHHHHHH
52.0746161315
331PhosphorylationPTDPQRLSSSEETES
CCCHHHCCCCCCCCC
33.7230108239
332PhosphorylationTDPQRLSSSEETEST
CCHHHCCCCCCCCCC
46.4930108239
333PhosphorylationDPQRLSSSEETESTQ
CHHHCCCCCCCCCCC
35.7630108239
336PhosphorylationRLSSSEETESTQCCP
HCCCCCCCCCCCCCC
31.0528450419
338PhosphorylationSSSEETESTQCCPGS
CCCCCCCCCCCCCCC
31.0628450419
339PhosphorylationSSEETESTQCCPGSP
CCCCCCCCCCCCCCC
21.2828450419
345O-linked_GlycosylationSTQCCPGSPVAQTES
CCCCCCCCCCCCCCC
11.0129351928
345PhosphorylationSTQCCPGSPVAQTES
CCCCCCCCCCCCCCC
11.0130175587
350PhosphorylationPGSPVAQTESPCDLS
CCCCCCCCCCCCCHH
28.7926657352
352PhosphorylationSPVAQTESPCDLSSI
CCCCCCCCCCCHHHH
33.9328450419
357PhosphorylationTESPCDLSSIVEEEN
CCCCCCHHHHHCHHC
12.5528450419
358PhosphorylationESPCDLSSIVEEENT
CCCCCHHHHHCHHCC
37.6428450419
391PhosphorylationEPAPIVDSGTVSDQD
CCCCCCCCCCCCCHH
26.0123663014
393PhosphorylationAPIVDSGTVSDQDSC
CCCCCCCCCCCHHHH
22.3125159151
395PhosphorylationIVDSGTVSDQDSCLQ
CCCCCCCCCHHHHHH
29.4130278072
399PhosphorylationGTVSDQDSCLQSLPD
CCCCCHHHHHHHCCC
15.8723663014
403PhosphorylationDQDSCLQSLPDCGVK
CHHHHHHHCCCCCCC
28.9926657352
438PhosphorylationGMPTDQESLSSGDAV
CCCCCHHHHCCCCHH
28.11113314805
511PhosphorylationTKERFENSNIGTAGA
HHHHHHCCCCCCCCC
23.7228555341
570PhosphorylationEKTAETETSRSREES
CCCCCCHHHHCHHHH
36.5428555341
586PhosphorylationDAPVDQNSVVIPAAA
CCCCCCCCCEECHHH
16.4825159151
604PhosphorylationISDGLEPYTLLAAGI
CCCCCCHHHHHHHCC
10.7246161327
649PhosphorylationAQSQKGKSSPICSTT
CHHCCCCCCCCCCCC
50.4423401153
650PhosphorylationQSQKGKSSPICSTTG
HHCCCCCCCCCCCCC
23.0523927012
654PhosphorylationGKSSPICSTTGDDKL
CCCCCCCCCCCCCCC
29.7128450419
655PhosphorylationKSSPICSTTGDDKLC
CCCCCCCCCCCCCCC
30.3220068231
656PhosphorylationSSPICSTTGDDKLCA
CCCCCCCCCCCCCCC
23.4863738293
665PhosphorylationDDKLCADSACQQNTV
CCCCCCCCHHHCCCC
16.6625394399
671PhosphorylationDSACQQNTVTSSGDL
CCHHHCCCCCCCHHH
22.3323927012
673PhosphorylationACQQNTVTSSGDLVA
HHHCCCCCCCHHHHH
18.3523927012
674PhosphorylationCQQNTVTSSGDLVAK
HHCCCCCCCHHHHHH
28.1723927012
675PhosphorylationQQNTVTSSGDLVAKL
HCCCCCCCHHHHHHH
27.2828348404
688PhosphorylationKLCDNIVSESESTTA
HHHHHHHCCCCCCCC
31.4468710619
692PhosphorylationNIVSESESTTARQPS
HHHCCCCCCCCCCCC
40.1068710625
693PhosphorylationIVSESESTTARQPSS
HHCCCCCCCCCCCCC
22.0368710631
694PhosphorylationVSESESTTARQPSSQ
HCCCCCCCCCCCCCC
29.1768710637
707PhosphorylationSQDPPDASHCEDPQA
CCCCCCHHHCCCCCC
35.7328555341
7402-HydroxyisobutyrylationPFKVVDNKGQRKDVK
CEEEECCCCCCCCCC
52.54-
753PhosphorylationVKLDKPLTNMLEVVS
CCCCCCCCHHHHHHC
27.4030622161
760PhosphorylationTNMLEVVSHPHPVVP
CHHHHHHCCCCCCCC
36.1530622161
781PhosphorylationVPDQAVISDSTFSLA
CCCCCEEECCCCCCC
20.9328176443
783PhosphorylationDQAVISDSTFSLANS
CCCEEECCCCCCCCC
25.2621955146
784PhosphorylationQAVISDSTFSLANSP
CCEEECCCCCCCCCC
23.4118669648
786PhosphorylationVISDSTFSLANSPGS
EEECCCCCCCCCCCC
27.0263730219
790PhosphorylationSTFSLANSPGSESVT
CCCCCCCCCCCCCCC
25.6528355574
793PhosphorylationSLANSPGSESVTKDD
CCCCCCCCCCCCCCC
30.0430278072
795PhosphorylationANSPGSESVTKDDAL
CCCCCCCCCCCCCHH
36.4623663014
797PhosphorylationSPGSESVTKDDALSF
CCCCCCCCCCCHHHC
37.7321955146
803PhosphorylationVTKDDALSFVPSQKE
CCCCCHHHCCCCCCC
26.3928176443
807PhosphorylationDALSFVPSQKEKGTA
CHHHCCCCCCCCCCC
48.8928176443
813PhosphorylationPSQKEKGTATPELHT
CCCCCCCCCCCCEEE
38.1223927012
815PhosphorylationQKEKGTATPELHTAT
CCCCCCCCCCEEECC
19.6825159151
820PhosphorylationTATPELHTATDYRDG
CCCCCEEECCCCCCC
43.8323927012
822PhosphorylationTPELHTATDYRDGPD
CCCEEECCCCCCCCC
34.4223927012
824PhosphorylationELHTATDYRDGPDGN
CEEECCCCCCCCCCC
13.2727174698
832PhosphorylationRDGPDGNSNEPDTRP
CCCCCCCCCCCCCCC
48.3727174698
848PhosphorylationEDRAVGLSTSSTAAE
HHHCCCCCCHHHHHH
21.9527251275
849PhosphorylationDRAVGLSTSSTAAEL
HHCCCCCCHHHHHHH
31.5727251275
850PhosphorylationRAVGLSTSSTAAELQ
HCCCCCCHHHHHHHH
23.4725627689
851PhosphorylationAVGLSTSSTAAELQH
CCCCCCHHHHHHHHH
23.3525627689
852PhosphorylationVGLSTSSTAAELQHG
CCCCCHHHHHHHHHC
29.6525627689
863PhosphorylationLQHGMGNTSLTGLGG
HHHCCCCCCCCCCCC
21.2725627689
864PhosphorylationQHGMGNTSLTGLGGE
HHCCCCCCCCCCCCC
28.1225159151
866PhosphorylationGMGNTSLTGLGGEHE
CCCCCCCCCCCCCCC
30.0827251275
901PhosphorylationLQSVGKATLALDSVL
HHHHHHHHHHHHHHC
18.9529396449
906PhosphorylationKATLALDSVLTEEGK
HHHHHHHHHCCCCCE
21.6328555341
909PhosphorylationLALDSVLTEEGKLLV
HHHHHHCCCCCEEEE
29.8129396449
943PhosphorylationSIKENALSSGTLQEE
HHHHHCCCCCCCCCH
25.0623403867
944PhosphorylationIKENALSSGTLQEEQ
HHHHCCCCCCCCCHH
36.3323927012
946PhosphorylationENALSSGTLQEEQRT
HHCCCCCCCCCHHCC
27.5061970499
953PhosphorylationTLQEEQRTPPPGQDT
CCCCHHCCCCCCCCH
39.5823401153
960PhosphorylationTPPPGQDTQQFHEKS
CCCCCCCHHHHHHHC
19.1823403867
967PhosphorylationTQQFHEKSISADCAK
HHHHHHHCCCHHHHH
20.84113314813
981PhosphorylationKDKALQLSNSPGASS
HCHHHHHCCCCCHHH
23.4622167270
983PhosphorylationKALQLSNSPGASSAF
HHHHHCCCCCHHHHH
22.7219664994
987PhosphorylationLSNSPGASSAFLKAE
HCCCCCHHHHHHHHH
28.2823927012
988PhosphorylationSNSPGASSAFLKAET
CCCCCHHHHHHHHHC
23.6223927012
1006PhosphorylationKEVAPQVSLLTQGGA
CCCCCCEEEECCCCC
16.6520068230
1112PhosphorylationRENISHNTQDILIPN
HHCCCCCCCCCCCCH
23.3821712546
1123PhosphorylationLIPNVLLSQEKNAVL
CCCHHHHCCCCCCCC
31.9425159151
1142PhosphorylationALQDKAVTDPQGVGT
ECCCCCCCCCCCCCC
46.9929514088
1149PhosphorylationTDPQGVGTPEMIPLD
CCCCCCCCCCCEECC
17.4225159151
1168PhosphorylationKLEGADHSCTMGDAE
CCCCCCCCCCCCCHH
16.3025159151
1170PhosphorylationEGADHSCTMGDAEEA
CCCCCCCCCCCHHHH
27.4918669648
1197PhosphorylationPVAKELPTDMELSAH
HHHHHCCCCCCCCCC
61.6829214152
1202PhosphorylationLPTDMELSAHDDGAP
CCCCCCCCCCCCCCC
15.3928555341
1221PhosphorylationEVMRAPPSGRERSTP
HHHCCCCCCCCCCCC
49.8024300666
1226PhosphorylationPPSGRERSTPSLPCM
CCCCCCCCCCCCCCE
39.6625159151
1227PhosphorylationPSGRERSTPSLPCMV
CCCCCCCCCCCCCEE
24.1046161299
1229PhosphorylationGRERSTPSLPCMVSA
CCCCCCCCCCCEEEC
45.0625159151
1235PhosphorylationPSLPCMVSAQDAPLP
CCCCCEEECCCCCCC
8.0423312004
1271PhosphorylationKAAGALLTEGEACHM
HHHCCCCCCCCCCCC
42.6830624053
1279PhosphorylationEGEACHMSLSSPELG
CCCCCCCCCCCCCCC
11.0529978859
1281PhosphorylationEACHMSLSSPELGPL
CCCCCCCCCCCCCCC
36.2225159151
1282PhosphorylationACHMSLSSPELGPLT
CCCCCCCCCCCCCCC
27.9025159151
1289PhosphorylationSPELGPLTKGLESAF
CCCCCCCCHHHHHHH
26.6329978859
1294PhosphorylationPLTKGLESAFTEKVS
CCCHHHHHHHHCCCC
33.4528555341
1313PhosphorylationGESLPMGSTPEEATG
CCCCCCCCCHHHHHC
34.2425627689
1314PhosphorylationESLPMGSTPEEATGS
CCCCCCCCHHHHHCC
29.0525627689
1362PhosphorylationDEVDFRASSISEEVA
CCCCCCHHHCCHHHH
24.7726699800
1363PhosphorylationEVDFRASSISEEVAV
CCCCCHHHCCHHHHH
29.2026699800
1365PhosphorylationDFRASSISEEVAVGS
CCCHHHCCHHHHHHH
29.6530087585
1380UbiquitinationIAATLKMKQGPMTQA
HHHHHHCCCCCCCCC
50.98-
1385PhosphorylationKMKQGPMTQAINREN
HCCCCCCCCCCCCCC
20.27961860233
1395PhosphorylationINRENWCTIEPCPDA
CCCCCCEEEEECCCH
21.7128122231
1404PhosphorylationEPCPDAASLLASKQS
EECCCHHHHHHCCCC
26.1527762562
1408PhosphorylationDAASLLASKQSPECE
CHHHHHHCCCCHHHC
31.0623663014
1411PhosphorylationSLLASKQSPECENFL
HHHHCCCCHHHCCCC
26.8029255136
1437PhosphorylationQGVLKRESGSDSDLF
CCCEECCCCCCCCCC
47.8627732954
1439PhosphorylationVLKRESGSDSDLFHS
CEECCCCCCCCCCCC
43.1327732954
1441PhosphorylationKRESGSDSDLFHSPS
ECCCCCCCCCCCCCC
37.6027732954
1446PhosphorylationSDSDLFHSPSDDMDS
CCCCCCCCCCCCCCC
20.8227251275
1448PhosphorylationSDLFHSPSDDMDSII
CCCCCCCCCCCCCCC
49.6227251275
1453PhosphorylationSPSDDMDSIIFPKPE
CCCCCCCCCCCCCCH
15.7927251275
1480PhosphorylationSSTDDTASLDRHSSH
CCCCCCCCCCHHCCC
32.6624275569
1485PhosphorylationTASLDRHSSHGSDVS
CCCCCHHCCCCCCCC
25.5630108239
1486PhosphorylationASLDRHSSHGSDVSL
CCCCHHCCCCCCCCH
26.2420363803
1489PhosphorylationDRHSSHGSDVSLSQI
CHHCCCCCCCCHHHH
29.4327794612
1492PhosphorylationSSHGSDVSLSQILKP
CCCCCCCCHHHHCCC
27.5626055452
1494PhosphorylationHGSDVSLSQILKPNR
CCCCCCHHHHCCCCC
13.9920873877
1507PhosphorylationNRSRDRQSLDGFYSH
CCCCCCCCCCCHHHC
29.3525159151
1512PhosphorylationRQSLDGFYSHGMGAE
CCCCCCHHHCCCCCC
12.8029978859
1513PhosphorylationQSLDGFYSHGMGAEG
CCCCCHHHCCCCCCC
16.0029978859
1523PhosphorylationMGAEGRESESEPADP
CCCCCCCCCCCCCCC
45.0928348404
1525PhosphorylationAEGRESESEPADPGD
CCCCCCCCCCCCCCC
59.1528348404
1540PhosphorylationVEEEEMDSITEVPAN
CCHHHHHCCCCCCCC
30.0526657352
1557PhosphorylationVLRSSMRSLSPFRRH
HHHHHCHHCCCCCCC
25.2622167270
1559PhosphorylationRSSMRSLSPFRRHSW
HHHCHHCCCCCCCCC
24.2022167270
1565PhosphorylationLSPFRRHSWGPGKNA
CCCCCCCCCCCCCCC
31.7330266825
1574 (in isoform 4)Phosphorylation-34.6425056879
1582PhosphorylationDAEMNHRSSMRVLGD
HHHCCHHHHCHHHHH
22.4228857561
1582 (in isoform 2)Phosphorylation-22.4227251275
1582 (in isoform 4)Phosphorylation-22.4225849741
1583PhosphorylationAEMNHRSSMRVLGDV
HHCCHHHHCHHHHHH
15.5724719451
1584 (in isoform 2)Phosphorylation-3.4727251275
1584 (in isoform 4)Phosphorylation-3.4725849741
1588 (in isoform 2)Phosphorylation-23.8627251275
1592 (in isoform 2)Phosphorylation-45.2827251275
1593 (in isoform 2)Phosphorylation-29.7227251275
1597 (in isoform 2)Phosphorylation-25.5227251275
1600PhosphorylationRPPIHRRSFSLEGLT
CCCCCCCCCCCCCCC
21.1030266825
1602PhosphorylationPIHRRSFSLEGLTGG
CCCCCCCCCCCCCCC
27.1019664994
1602 (in isoform 2)Phosphorylation-27.1027251275
1604 (in isoform 2)Phosphorylation-51.4623663014
1606 (in isoform 2)Phosphorylation-2.6919664994
1607PhosphorylationSFSLEGLTGGAGVGN
CCCCCCCCCCCCCCC
44.4130266825
1617PhosphorylationAGVGNKPSSSLEVSS
CCCCCCCCCCCEECC
33.8827732954
1618PhosphorylationGVGNKPSSSLEVSSA
CCCCCCCCCCEECCC
47.6827732954
1619PhosphorylationVGNKPSSSLEVSSAN
CCCCCCCCCEECCCC
32.6528060719
1623PhosphorylationPSSSLEVSSANAEEL
CCCCCEECCCCHHHH
17.8528270605
1624PhosphorylationSSSLEVSSANAEELR
CCCCEECCCCHHHHC
30.6230175587
1635PhosphorylationEELRHPFSGEERVDS
HHHCCCCCCCHHHHH
50.1528176443
1642PhosphorylationSGEERVDSLVSLSEE
CCCHHHHHHHHCCHH
28.0119664994
1645PhosphorylationERVDSLVSLSEEDLE
HHHHHHHHCCHHHHH
31.3219664994
1647PhosphorylationVDSLVSLSEEDLESD
HHHHHHCCHHHHHHH
31.2819664994
1653PhosphorylationLSEEDLESDQREHRM
CCHHHHHHHHHHHHH
46.4723663014
1670MethylationQQICHRSKQQGFNYC
HHHHHHHHHCCCCCC
46.7424129315
1676PhosphorylationSKQQGFNYCTSAISS
HHHCCCCCCHHHCCC
8.5429396449
1678PhosphorylationQQGFNYCTSAISSPL
HCCCCCCHHHCCCCC
15.7222199227
1679PhosphorylationQGFNYCTSAISSPLT
CCCCCCHHHCCCCCC
21.7529396449
1682PhosphorylationNYCTSAISSPLTKSI
CCCHHHCCCCCCCEE
26.1422199227
1683PhosphorylationYCTSAISSPLTKSIS
CCHHHCCCCCCCEEE
20.1625159151
1686PhosphorylationSAISSPLTKSISLMT
HHCCCCCCCEEEEEE
26.5722199227
1688PhosphorylationISSPLTKSISLMTIS
CCCCCCCEEEEEEEC
16.5123684312
1690PhosphorylationSPLTKSISLMTISHP
CCCCCEEEEEEECCC
21.1223684312
1693PhosphorylationTKSISLMTISHPGLD
CCEEEEEEECCCCCC
25.3123684312
1695PhosphorylationSISLMTISHPGLDNS
EEEEEEECCCCCCCC
17.9223312004
1702PhosphorylationSHPGLDNSRPFHSTF
CCCCCCCCCCCCCCC
40.7823312004
1731PhosphorylationNYNFLPHSPSKKDSE
CCCCCCCCCCCCCCC
29.0026074081
1733PhosphorylationNFLPHSPSKKDSEWK
CCCCCCCCCCCCCCC
56.1826074081
1737PhosphorylationHSPSKKDSEWKSGTK
CCCCCCCCCCCCCCC
54.9924144214
1741PhosphorylationKKDSEWKSGTKVSRT
CCCCCCCCCCCCHHH
53.4128152594
1743PhosphorylationDSEWKSGTKVSRTFS
CCCCCCCCCCHHHHH
35.0528152594
1746PhosphorylationWKSGTKVSRTFSYIK
CCCCCCCHHHHHHHH
27.4530814907
1748PhosphorylationSGTKVSRTFSYIKNK
CCCCCHHHHHHHHHH
14.9323403867
1750PhosphorylationTKVSRTFSYIKNKMS
CCCHHHHHHHHHHHC
25.9023927012
1751PhosphorylationKVSRTFSYIKNKMSS
CCHHHHHHHHHHHCC
16.2423927012
1788PhosphorylationDKEKDKKTVNGHTFS
CHHHHHCCCCCCCCC
25.5827762562
1793PhosphorylationKKTVNGHTFSSIPVV
HCCCCCCCCCCCCEE
26.9827762562
1829MalonylationNCSAFVHKGCRESLA
CHHHHHCCCHHHHHH
55.1726320211
1837PhosphorylationGCRESLASCAKVKMK
CHHHHHHHHHCCCCC
21.6525159151
1849PhosphorylationKMKQPKGSLQAHDTS
CCCCCCCCCCCCCCC
24.3523403867
1855PhosphorylationGSLQAHDTSSLPTVI
CCCCCCCCCCCCEEH
15.4523403867
1856PhosphorylationSLQAHDTSSLPTVIM
CCCCCCCCCCCEEHH
35.6225159151
1857PhosphorylationLQAHDTSSLPTVIMR
CCCCCCCCCCEEHHC
40.2225159151
1860PhosphorylationHDTSSLPTVIMRNKP
CCCCCCCEEHHCCCC
28.1423403867
1868PhosphorylationVIMRNKPSQPKERPR
EHHCCCCCCCCCCCC
61.8029083192
1876PhosphorylationQPKERPRSAVLLVDE
CCCCCCCCEEEEEEC
25.9719664994
1884PhosphorylationAVLLVDETATTPIFA
EEEEEECCCCCCEEC
25.4930266825
1886PhosphorylationLLVDETATTPIFANR
EEEECCCCCCEECCC
40.2922199227
1887PhosphorylationLVDETATTPIFANRR
EEECCCCCCEECCCC
16.3623927012
1895PhosphorylationPIFANRRSQQSVSLS
CEECCCCCCCCCCCC
29.3625159151
1898PhosphorylationANRRSQQSVSLSKSV
CCCCCCCCCCCCCCE
13.1626657352
1900PhosphorylationRRSQQSVSLSKSVSI
CCCCCCCCCCCCEEE
31.9721815630
1902PhosphorylationSQQSVSLSKSVSIQN
CCCCCCCCCCEEEEE
18.5129396449
1904PhosphorylationQSVSLSKSVSIQNIT
CCCCCCCCEEEEECC
20.0925159151
1906PhosphorylationVSLSKSVSIQNITGV
CCCCCCEEEEECCCC
26.0823401153
1911PhosphorylationSVSIQNITGVGNDEN
CEEEEECCCCCCCCC
33.1123403867
1920PhosphorylationVGNDENMSNTWKFLS
CCCCCCHHHHHHHHH
42.5623403867
1922PhosphorylationNDENMSNTWKFLSHS
CCCCHHHHHHHHHCC
23.7923403867
1924 (in isoform 4)Phosphorylation-34.1027732954
1925 (in isoform 4)Phosphorylation-6.8022617229
1927PhosphorylationSNTWKFLSHSTDSLN
HHHHHHHHCCHHHHH
20.6526846344
1927 (in isoform 4)Phosphorylation-20.6527732954
1929PhosphorylationTWKFLSHSTDSLNKI
HHHHHHCCHHHHHHH
30.4519664994
1929 (in isoform 4)Phosphorylation-30.4522617229
1930PhosphorylationWKFLSHSTDSLNKIS
HHHHHCCHHHHHHHH
24.9629255136
1932PhosphorylationFLSHSTDSLNKISKV
HHHCCHHHHHHHHHH
33.6519664994
1933 (in isoform 4)Phosphorylation-9.3527732954
1935UbiquitinationHSTDSLNKISKVNES
CCHHHHHHHHHHCCC
54.36-
1937PhosphorylationTDSLNKISKVNESTE
HHHHHHHHHHCCCCC
31.9623927012
1942PhosphorylationKISKVNESTESLTDE
HHHHHCCCCCCCCCC
32.0727422710
1943PhosphorylationISKVNESTESLTDEG
HHHHCCCCCCCCCCC
24.3418669648
1945PhosphorylationKVNESTESLTDEGVG
HHCCCCCCCCCCCCC
36.349584311
1947PhosphorylationNESTESLTDEGVGTD
CCCCCCCCCCCCCCC
41.0818669648
1948 (in isoform 4)Phosphorylation-56.8122115753
1953PhosphorylationLTDEGVGTDMNEGQL
CCCCCCCCCCCCCCE
29.6627422710
1975PhosphorylationSKQLEAESWSRIIDS
CCCCCHHHHHHHHCH
37.0828122231
1977PhosphorylationQLEAESWSRIIDSKF
CCCHHHHHHHHCHHH
23.9228450419
19832-HydroxyisobutyrylationWSRIIDSKFLKQQKK
HHHHHCHHHHHHHHC
51.47-
1983UbiquitinationWSRIIDSKFLKQQKK
HHHHHCHHHHHHHHC
51.47-
2017PhosphorylationVRTLKIMSGVYSQGM
HHHHHHCCCCCCCCH
28.6928270605
2020PhosphorylationLKIMSGVYSQGMMAD
HHHCCCCCCCCHHHH
9.9828270605
2021PhosphorylationKIMSGVYSQGMMADL
HHCCCCCCCCHHHHH
20.1828270605
2070UbiquitinationSLVDKSEKNFLIKRI
HHCCHHHHCHHHHHH
61.15-
2099AcetylationRLKKTYGKFCGQHNQ
HHHHHHHHHCCCCCC
27.3725953088
2107PhosphorylationFCGQHNQSVNYFKDL
HCCCCCCCHHHHHHH
20.0425332170
2112UbiquitinationNQSVNYFKDLYAKDK
CCCHHHHHHHHHCCH
36.14-
2115PhosphorylationVNYFKDLYAKDKRFQ
HHHHHHHHHCCHHHH
23.032035173
2130PhosphorylationAFVKKKMSSSVVRRL
HHHHHHCCHHHHHHH
28.4823403867
2131PhosphorylationFVKKKMSSSVVRRLG
HHHHHCCHHHHHHHC
24.5326657352
2132PhosphorylationVKKKMSSSVVRRLGI
HHHHCCHHHHHHHCC
19.8223403867
2165UbiquitinationQRILQCTKDNEVEQE
HHHHHHCCCCCCCHH
67.21-
2169 (in isoform 2)Ubiquitination-13.27-
2179PhosphorylationEDLAQSLSLVKDVIG
HHHHHHHHHHHHHHH
36.0424719451
2182UbiquitinationAQSLSLVKDVIGAVD
HHHHHHHHHHHHHHH
52.12-
2191UbiquitinationVIGAVDSKVASYEKK
HHHHHHHHHHHHHHC
37.04-
2205PhosphorylationKVRLNEIYTKTDSKS
CEEHHHCEECCCCHH
8.9430459869
2212PhosphorylationYTKTDSKSIMRMKSG
EECCCCHHHHHHHHC
26.1020068231
2218PhosphorylationKSIMRMKSGQMFAKE
HHHHHHHHCCCCCHH
25.5520068231
2237PhosphorylationKKLVRDGSVFLKNAA
CCCCCCCHHHHHCCC
17.6229514088
2241UbiquitinationRDGSVFLKNAAGRLK
CCCHHHHHCCCCCHH
32.83-
2269PhosphorylationLQEKDQKYIFASLDQ
HHHCCCCEEEEECCC
8.8127067055
2273PhosphorylationDQKYIFASLDQKSTV
CCCEEEEECCCCCHH
23.0230576142
2278PhosphorylationFASLDQKSTVISLKK
EEECCCCCHHEEHHH
23.4430873011
2279PhosphorylationASLDQKSTVISLKKL
EECCCCCHHEEHHHH
28.9730873007
2282PhosphorylationDQKSTVISLKKLIVR
CCCCHHEEHHHHHHH
29.7824719451
2331PhosphorylationWIQIIQDTINTLNRD
HHHHHHHHHHHCCCC
10.3528450419
2334PhosphorylationIIQDTINTLNRDEDE
HHHHHHHHCCCCCCC
22.8928450419
2345PhosphorylationDEDEGIPSENEEEKK
CCCCCCCCCCHHHHH
51.6523401153
2356PhosphorylationEEKKMLDTRARELKE
HHHHHHHHHHHHHHH
23.44120161385
2362UbiquitinationDTRARELKEQLHQKD
HHHHHHHHHHHHHHH
38.37-
2368UbiquitinationLKEQLHQKDQKILLL
HHHHHHHHHHHHHHH
51.91-
2371UbiquitinationQLHQKDQKILLLLEE
HHHHHHHHHHHHHHH
45.51-
2390PhosphorylationFRDMAECSTPLPEDC
HHHHHHCCCCCCCCC
25.2723927012
2391PhosphorylationRDMAECSTPLPEDCS
HHHHHCCCCCCCCCC
40.2723927012
2398PhosphorylationTPLPEDCSPTHSPRV
CCCCCCCCCCCCCCE
45.1929255136
2400PhosphorylationLPEDCSPTHSPRVLF
CCCCCCCCCCCCEEE
20.7723401153
2402PhosphorylationEDCSPTHSPRVLFRS
CCCCCCCCCCEEEEC
19.5123401153
2409PhosphorylationSPRVLFRSNTEEALK
CCCEEEECCHHHHHC
40.5526657352
2411PhosphorylationRVLFRSNTEEALKGG
CEEEECCHHHHHCCC
36.1323401153
2436PhosphorylationEILQGLVSGNLGGTL
HHHHHHHHCCCCCCC
27.3225159151
2442PhosphorylationVSGNLGGTLGPTVSS
HHCCCCCCCCCCCCC
27.0925159151
2446PhosphorylationLGGTLGPTVSSPIEQ
CCCCCCCCCCCCCCC
31.0825159151
2448PhosphorylationGTLGPTVSSPIEQDV
CCCCCCCCCCCCCCC
32.6428464451
2449PhosphorylationTLGPTVSSPIEQDVV
CCCCCCCCCCCCCCC
26.0928464451
2460PhosphorylationQDVVGPVSLPRRAET
CCCCCCCCCCCCCCC
35.4711009021
2467PhosphorylationSLPRRAETFGGFDSH
CCCCCCCCCCCCCHH
26.9623401153
2473PhosphorylationETFGGFDSHQMNASK
CCCCCCCHHCCCCCC
17.2323312004
2479PhosphorylationDSHQMNASKGGEKEE
CHHCCCCCCCCCCCC
27.1625159151
2496PhosphorylationDGQDLRRTESDSGLK
CCCCCCCCCCCCCCC
33.1525159151
2498PhosphorylationQDLRRTESDSGLKKG
CCCCCCCCCCCCCCC
36.1425159151
2500PhosphorylationLRRTESDSGLKKGGN
CCCCCCCCCCCCCCC
56.1329978859
2518PhosphorylationVFMLKRNSEQVVQSV
EEEEECCHHHHHHHH
33.1827174698
2524PhosphorylationNSEQVVQSVVHLYEL
CHHHHHHHHHHHHHH
17.9427174698
2529PhosphorylationVQSVVHLYELLSALQ
HHHHHHHHHHHHHHH
6.9427174698
2533PhosphorylationVHLYELLSALQGVVL
HHHHHHHHHHHCCHH
39.2927174698
2544PhosphorylationGVVLQQDSYIEDQKL
CCHHCCCCCCCHHHH
24.5427174698
2545PhosphorylationVVLQQDSYIEDQKLV
CHHCCCCCCCHHHHH
19.3327174698
2559PhosphorylationVLSERALTRSLSRPS
HHCHHHHHHHHCCCH
19.7523828894
2561PhosphorylationSERALTRSLSRPSSL
CHHHHHHHHCCCHHH
26.0122167270
2563PhosphorylationRALTRSLSRPSSLIE
HHHHHHHCCCHHHHH
43.3122167270
2566PhosphorylationTRSLSRPSSLIEQEK
HHHHCCCHHHHHHHH
36.3422167270
2567PhosphorylationRSLSRPSSLIEQEKQ
HHHCCCHHHHHHHHH
35.7322167270
25732-HydroxyisobutyrylationSSLIEQEKQRSLEKQ
HHHHHHHHHHHHHHH
51.19-
2589UbiquitinationQDLANLQKQQAQYLE
HHHHHHHHHHHHHHH
47.76-
2699PhosphorylationTKLMRIPSFFPSPEE
CCCCCCCCCCCCCCC
36.8326055452
2703PhosphorylationRIPSFFPSPEEPPSP
CCCCCCCCCCCCCCC
39.5225159151
2709PhosphorylationPSPEEPPSPSAPSIA
CCCCCCCCCCCCCHH
42.0529255136
2711PhosphorylationPEEPPSPSAPSIAKS
CCCCCCCCCCCHHHC
58.0929255136
2714PhosphorylationPPSPSAPSIAKSGSL
CCCCCCCCHHHCCCC
34.5928176443
2718PhosphorylationSAPSIAKSGSLDSEL
CCCCHHHCCCCCCCC
25.2923401153
2720PhosphorylationPSIAKSGSLDSELSV
CCHHHCCCCCCCCCC
35.7723927012
2723PhosphorylationAKSGSLDSELSVSPK
HHCCCCCCCCCCCCC
45.8125159151
2726PhosphorylationGSLDSELSVSPKRNS
CCCCCCCCCCCCCCC
19.2523401153
2728PhosphorylationLDSELSVSPKRNSIS
CCCCCCCCCCCCCCC
22.7119664994
2733PhosphorylationSVSPKRNSISRTHKD
CCCCCCCCCCCCCCC
26.4430576142
2735PhosphorylationSPKRNSISRTHKDKG
CCCCCCCCCCCCCCC
30.8327486199
2748PhosphorylationKGPFHILSSTSQTNK
CCCEEEEECCCCCCC
30.8528555341
2749PhosphorylationGPFHILSSTSQTNKG
CCEEEEECCCCCCCC
28.7446161287
2750PhosphorylationPFHILSSTSQTNKGP
CEEEEECCCCCCCCC
22.8328555341
2751PhosphorylationFHILSSTSQTNKGPE
EEEEECCCCCCCCCC
36.6328555341
2761PhosphorylationNKGPEGQSQAPASTS
CCCCCCCCCCCCCCC
38.8820068230
2766PhosphorylationGQSQAPASTSASTRL
CCCCCCCCCCHHHHH
23.1025002506
2767PhosphorylationQSQAPASTSASTRLF
CCCCCCCCCHHHHHC
30.3425002506
2768PhosphorylationSQAPASTSASTRLFG
CCCCCCCCHHHHHCC
20.0925002506
2770PhosphorylationAPASTSASTRLFGLT
CCCCCCHHHHHCCCC
17.5220068230
2771PhosphorylationPASTSASTRLFGLTK
CCCCCHHHHHCCCCC
30.9825002506
2791PhosphorylationEKKKKNKTSRSQPGD
HHHHCCCCCCCCCCC
38.4722468782
2792PhosphorylationKKKKNKTSRSQPGDG
HHHCCCCCCCCCCCC
31.3830087585
2794PhosphorylationKKNKTSRSQPGDGPA
HCCCCCCCCCCCCCH
40.2622617229
2802PhosphorylationQPGDGPASEVSAEGE
CCCCCCHHHCCCCCC
41.4881442403
2805PhosphorylationDGPASEVSAEGEEIF
CCCHHHCCCCCCCCC
19.2946161293

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
54TPhosphorylationKinaseCDK1P06493
GPS
1565SPhosphorylationKinasePRKACAP17612
GPS
1565SPhosphorylationKinasePKA-FAMILY-GPS
1565SPhosphorylationKinasePKA_GROUP-PhosphoELM
2733SPhosphorylationKinasePKACAP17612
PSP
2733SPhosphorylationKinasePRKACAP27791
GPS
2733SPhosphorylationKinasePKA-FAMILY-GPS
2733SPhosphorylationKinasePKA_GROUP-PhosphoELM

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AKP13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AKP13_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GNA12_HUMANGNA12physical
14636890
RHOA_HUMANRHOAphysical
11696353
GNAQ_HUMANGNAQphysical
11278452
RXRB_HUMANRXRBphysical
9627117
ESR1_HUMANESR1physical
9627117
PPARA_HUMANPPARAphysical
9627117
THA_HUMANTHRAphysical
9627117
KPCD1_HUMANPRKD1physical
15383279
MLP3A_HUMANMAP1LC3Aphysical
19696020
RHOA_HUMANRHOAphysical
19696020
1433G_HUMANYWHAGphysical
15324660
UBB_HUMANUBBphysical
26186194
METH_HUMANMTRphysical
26186194
KAP2_HUMANPRKAR2Aphysical
15383279
KPCL_HUMANPRKCHphysical
15383279
KPCA_HUMANPRKCAphysical
15383279
KPCL_RATPrkchphysical
15383279
UBB_HUMANUBBphysical
28514442
METH_HUMANMTRphysical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AKP13_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-983; SER-1642; SER-1645;SER-1647; SER-1876; SER-1895 AND SER-2728, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-983; SER-1929; SER-1932;SER-2709 AND SER-2728, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-983; SER-1559; SER-1645;SER-1647; SER-1876; SER-1929; SER-1932; SER-2398; SER-2402; SER-2703;SER-2709 AND SER-2728, AND MASS SPECTROMETRY.
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-983, AND MASSSPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-983 AND SER-2728, ANDMASS SPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1929 AND SER-1932, ANDMASS SPECTROMETRY.

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