AKAP5_HUMAN - dbPTM
AKAP5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AKAP5_HUMAN
UniProt AC P24588
Protein Name A-kinase anchor protein 5
Gene Name AKAP5
Organism Homo sapiens (Human).
Sequence Length 427
Subcellular Localization Membrane
Lipid-anchor . Associates with lipid rafts.
Protein Description May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade..
Protein Sequence METTISEIHVENKDEKRSAEGSPGAERQKEKASMLCFKRRKKAAKALKPKAGSEAADVARKCPQEAGASDQPEPTRGAWASLKRLVTRRKRSESSKQQKPLEGEMQPAINAEDADLSKKKAKSRLKIPCIKFPRGPKRSNHSKIIEDSDCSIKVQEEAEILDIQTQTPLNDQATKAKSTQDLSEGISRKDGDEVCESNVSNSTTSGEKVISVELGLDNGHSAIQTGTLILEEIETIKEKQDVQPQQASPLETSETDHQQPVLSDVPPLPAIPDQQIVEEASNSTLESAPNGKDYESTEIVAEETKPKDTELSQESDFKENGITEEKSKSEESKRMEPIAIIITDTEISEFDVTKSKNVPKQFLISAENEQVGVFANDNGFEDRTSEQYETLLIETASSLVKNAIQLSIEQLVNEMASDDNKINNLLQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationENKDEKRSAEGSPGA
CCHHHHCCCCCCCCH		41.5620363803
22PhosphorylationEKRSAEGSPGAERQK
HHCCCCCCCCHHHHH		16.2120363803
36S-palmitoylationKEKASMLCFKRRKKA
HHHHHHHHHHHHHHH		2.5729196604
53PhosphorylationALKPKAGSEAADVAR
HHCCCCCCHHHHHHH		28.9928857561
69PhosphorylationCPQEAGASDQPEPTR
CCHHHCCCCCCCCCC		35.54101661643
75PhosphorylationASDQPEPTRGAWASL
CCCCCCCCCHHHHHH		39.8222617229
81PhosphorylationPTRGAWASLKRLVTR
CCCHHHHHHHHHHHH		24.5830108239
87PhosphorylationASLKRLVTRRKRSES
HHHHHHHHHHHHCCC		29.37813710401
92PhosphorylationLVTRRKRSESSKQQK
HHHHHHHCCCCCCCC		44.8821712546
95PhosphorylationRRKRSESSKQQKPLE
HHHHCCCCCCCCCCC		30.3618536069
129S-palmitoylationKSRLKIPCIKFPRGP
HHHCCCCEEECCCCC		6.3529196604
148PhosphorylationHSKIIEDSDCSIKVQ
CCCCCCCCCCEEEEE		27.9425849741
151PhosphorylationIIEDSDCSIKVQEEA
CCCCCCCEEEEEHHH		30.3625849741
165PhosphorylationAEILDIQTQTPLNDQ
HEEEEEECCCCCCCH		34.4426074081
167PhosphorylationILDIQTQTPLNDQAT
EEEEECCCCCCCHHH		32.8826074081
174PhosphorylationTPLNDQATKAKSTQD
CCCCCHHHHHCCCHH		26.3826074081
178PhosphorylationDQATKAKSTQDLSEG
CHHHHHCCCHHHHHC		35.8430266825
179PhosphorylationQATKAKSTQDLSEGI
HHHHHCCCHHHHHCC		25.9530266825
183PhosphorylationAKSTQDLSEGISRKD
HCCCHHHHHCCCCCC		41.9120363803
187PhosphorylationQDLSEGISRKDGDEV
HHHHHCCCCCCCCHH		44.1024702127
200PhosphorylationEVCESNVSNSTTSGE
HHHHCCCCCCCCCCC		29.3428985074
202PhosphorylationCESNVSNSTTSGEKV
HHCCCCCCCCCCCEE		26.0928985074
248PhosphorylationDVQPQQASPLETSET
CCCCCCCCCCCCCCC		26.1928985074
263PhosphorylationDHQQPVLSDVPPLPA
CCCCCCCCCCCCCCC		36.4728985074
284PhosphorylationVEEASNSTLESAPNG
HHHHHHCCCCCCCCC		38.5028985074
294PhosphorylationSAPNGKDYESTEIVA
CCCCCCCCCCCCEEE		18.4428674419
296PhosphorylationPNGKDYESTEIVAEE
CCCCCCCCCCEEEEE		25.7223312004
297PhosphorylationNGKDYESTEIVAEET
CCCCCCCCCEEEEEC		20.1423312004
388PhosphorylationEDRTSEQYETLLIET
CCCCHHHHHHHHHHH		13.5621214269
395PhosphorylationYETLLIETASSLVKN
HHHHHHHHHHHHHHH		25.5021214269
398PhosphorylationLLIETASSLVKNAIQ
HHHHHHHHHHHHHHH		34.4221214269
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
87TPhosphorylationKinaseCAMK2AQ9UQM7
PSP
92SPhosphorylationKinaseCAMK2AQ9UQM7
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
36CPalmitoylation

21771783
129CPalmitoylation

21771783
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AKAP5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KAP3_HUMANPRKAR2Bphysical
8509414
PP2BA_HUMANPPP3CAphysical
9765270
DLG4_RATDlg4physical
10939335
NMDE2_RATGrin2bphysical
10939335
DLG1_RATDlg1physical
10939335
GRIA1_RATGria1physical
10939335
KPCA_HUMANPRKCAphysical
9202019
CLK1_HUMANCLK1physical
26496610
HSP72_HUMANHSPA2physical
26496610
HSP7C_HUMANHSPA8physical
26496610
TNPO1_HUMANTNPO1physical
26496610
NUCL_HUMANNCLphysical
26496610
KAPCA_HUMANPRKACAphysical
26496610
KAPCB_HUMANPRKACBphysical
26496610
KAP2_HUMANPRKAR2Aphysical
26496610
SUV91_HUMANSUV39H1physical
26496610
H31_HUMANHIST1H3Aphysical
26496610
CMC1_HUMANSLC25A12physical
26496610
PRP4B_HUMANPRPF4Bphysical
26496610
OTU6B_HUMANOTUD6Bphysical
26496610
LC7L3_HUMANLUC7L3physical
26496610
DERL1_HUMANDERL1physical
26496610
IPO4_HUMANIPO4physical
26496610
RM43_HUMANMRPL43physical
26496610
SMS2_HUMANSGMS2physical
26496610
RSBNL_HUMANRSBN1Lphysical
26496610
RMXL1_HUMANRBMXL1physical
26496610
TRPV1_HUMANTRPV1physical
18701070
TRPV4_HUMANTRPV4physical
18701070
TRPM8_HUMANTRPM8physical
18701070
TRPA1_HUMANTRPA1physical
18701070
TRPV2_HUMANTRPV2physical
18701070
TRPV3_HUMANTRPV3physical
18701070
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AKAP5_HUMAN

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Related Literatures of Post-Translational Modification
Palmitoylation
ReferencePubMed
"Palmitoylation targets AKAP79 protein to lipid rafts and promotes itsregulation of calcium-sensitive adenylyl cyclase type 8.";
Delint-Ramirez I., Willoughby D., Hammond G.V., Ayling L.J.,Cooper D.M.;
J. Biol. Chem. 286:32962-32975(2011).
Cited for: PALMITOYLATION AT CYS-36 AND CYS-129, INTERACTION WITH ADCY8, ANDSUBCELLULAR LOCATION.

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