TRPV4_HUMAN - dbPTM
TRPV4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRPV4_HUMAN
UniProt AC Q9HBA0
Protein Name Transient receptor potential cation channel subfamily V member 4
Gene Name TRPV4
Organism Homo sapiens (Human).
Sequence Length 871
Subcellular Localization Apical cell membrane
Multi-pass membrane protein . Cell junction, adherens junction . Cell projection, cilium . Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum.
Isoform 1: Cell membrane .
Isoform 5: Cell membra
Protein Description Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. [PubMed: 18826956]
Protein Sequence MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDNKRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDEVVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
91PhosphorylationDLLESTLYESSVVPG
HHHHHHHHHCCCCCC		17.5422817900
106PhosphorylationPKKAPMDSLFDYGTY
CCCCCCCHHCCCCCC		25.3725850435
110PhosphorylationPMDSLFDYGTYRHHS
CCCHHCCCCCCCCCC		12.2027259358
112PhosphorylationDSLFDYGTYRHHSSD
CHHCCCCCCCCCCCC		15.9125850435
113PhosphorylationSLFDYGTYRHHSSDN
HHCCCCCCCCCCCCC		12.0022817900
134PhosphorylationIIEKQPQSPKAPAPQ
HHHHCCCCCCCCCCC		34.7424719451
162PhosphorylationFDIVSRGSTADLDGL
EEHHHCCCCCCCCCH		21.2222817900
175PhosphorylationGLLPFLLTHKKRLTD
CHHHHHHHCHHCCCC		33.5222817900
189PhosphorylationDEEFREPSTGKTCLP
CHHHCCCCCCCCCHH		45.0722817900
203PhosphorylationPKALLNLSNGRNDTI
HHHHHHCCCCCCCCC		35.8422210691
253PhosphorylationIERRCKHYVELLVAQ
HHHHCHHHHHHHHHC		4.9012538589
293UbiquitinationELPLSLAACTNQPHI
EEECCHHHHCCCCHH		13.1323000965
297UbiquitinationSLAACTNQPHIVNYL
CHHHHCCCCHHHHHH		16.8823000965
306UbiquitinationHIVNYLTENPHKKAD
HHHHHHCCCCCCHHH		67.1923000965
310UbiquitinationYLTENPHKKADMRRQ
HHCCCCCCHHHHCCC		51.4123000965
319PhosphorylationADMRRQDSRGNTVLH
HHHCCCCCCCCHHHH		33.48-
335PhosphorylationLVAIADNTRENTKFV
HHHHHCCCCCCCHHH		39.6524719451
340UbiquitinationDNTRENTKFVTKMYD
CCCCCCCHHHHHHHH		49.7923000965
344UbiquitinationENTKFVTKMYDLLLL
CCCHHHHHHHHHHHH		30.1123000965
346PhosphorylationTKFVTKMYDLLLLKC
CHHHHHHHHHHHHHH		12.6625690035
348UbiquitinationFVTKMYDLLLLKCAR
HHHHHHHHHHHHHHH		1.6823000965
391UbiquitinationGIFQHIIRREVTDED
EEHHHHHHCCCCCHH		28.2723000965
395UbiquitinationHIIRREVTDEDTRHL
HHHHCCCCCHHHHHH		28.9923000965
411PhosphorylationRKFKDWAYGPVYSSL
HHHHHHHCCCHHCCH		20.0812538589
470PhosphorylationWRKFGAVSFYINVVS
HHHHCHHHHHHHHHH		16.29-
505PhosphorylationPPYPYRTTVDYLRLA
CCCCCCCHHHHHHHH		11.4616964243
508PhosphorylationPYRTTVDYLRLAGEV
CCCCHHHHHHHHHHH		6.8716964243
739PhosphorylationIWKLQWATTILDIER
CEEEEEEHHHHHHHH		16.0626126808
740PhosphorylationWKLQWATTILDIERS
EEEEEEHHHHHHHHH		16.2826126808
805PhosphorylationDPGKNETYQYYGFSH
CCCCCCEEEECEECC		6.58-
813PhosphorylationQYYGFSHTVGRLRRD
EECEECCCHHHCCHH		24.37-
823PhosphorylationRLRRDRWSSVVPRVV
HCCHHCHHHCCCCEE		17.72-
824PhosphorylationLRRDRWSSVVPRVVE
CCHHCHHHCCCCEEE		21.8520043876
836PhosphorylationVVELNKNSNPDEVVV
EEECCCCCCCCCEEE		51.8829255136
860PhosphorylationCDGHQQGYPRKWRTD
CCCCCCCCCCCCCCC		8.7723663014
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
162SPhosphorylationKinasePRKCDQ05655
GPS
175TPhosphorylationKinasePRKCDQ05655
GPS
189SPhosphorylationKinasePRKCDQ05655
GPS
253YPhosphorylationKinaseLYNP07948
PhosphoELM
824SPhosphorylationKinasePRKACAP17612
GPS
824SPhosphorylationKinaseSGK1Q9WVC6
PSP
-KUbiquitinationE3 ubiquitin ligaseITCHQ96J02
PMID:17110928
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRPV4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRPV4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MAP7_HUMANMAP7physical
14517216
SRC_HUMANSRCphysical
12538589
LYN_HUMANLYNphysical
12538589
YES_HUMANYES1physical
12538589
LCK_HUMANLCKphysical
12538589
HCK_HUMANHCKphysical
12538589
FYN_HUMANFYNphysical
12538589
OS9_HUMANOS9physical
17932042
KRIT1_HUMANKRIT1physical
12724311
AKAP5_HUMANAKAP5physical
18701070
Drug and Disease Associations
Kegg Disease
H00455 Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II
H00522 TRPV4-related skeletal dysplasias, including: Autosomal dominant brachyolmia; Spondylometaphyseal dy
H00524 TRPV4-related peripheral neuropathies, including: Congenital distal spinal muscular atrophy (CDSMA);
H00856 Distal hereditary motor neuropathies (dHMN)
OMIM Disease
113500Brachyolmia 3 (BCYM3)
184252Spondylometaphyseal dysplasia Kozlowski type (SMDK)
156530Metatropic dysplasia (MTD)
600175Distal spinal muscular atrophy, congenital non-progressive (DSMAC)
606071Charcot-Marie-Tooth disease 2C (CMT2C)
181405Scapuloperoneal spinal muscular atrophy (SPSMA)
184095Spondyloepiphyseal dysplasia Maroteaux type (SEDM)
168400Parastremmatic dwarfism (PSTD)
606835Digital arthropathy-brachydactyly, familial (FDAB)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRPV4_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Identification of a Protein Kinase C-dependent phosphorylation siteinvolved in sensitization of TRPV4 channel.";
Peng H., Lewandrowski U., Muller B., Sickmann A., Walz G.,Wegierski T.;
Biochem. Biophys. Res. Commun. 391:1721-1725(2010).
Cited for: PHOSPHORYLATION AT SER-824, MASS SPECTROMETRY, AND MUTAGENESIS OFSER-824.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory