MAP7_HUMAN - dbPTM
MAP7_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAP7_HUMAN
UniProt AC Q14244
Protein Name Ensconsin
Gene Name MAP7
Organism Homo sapiens (Human).
Sequence Length 749
Subcellular Localization Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclea
Protein Description Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments..
Protein Sequence MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAELGAGGD
------CCCCCCCCC		22.2619413330
6 (in isoform 4)Phosphorylation-31.2730631047
6 (in isoform 7)Phosphorylation-31.2730631047
12MethylationGAGGDGHRGGDGAVR
CCCCCCCCCCCCCCC		57.21115482563
20PhosphorylationGGDGAVRSETAPDSY
CCCCCCCCCCCCCCC		32.4723312004
22PhosphorylationDGAVRSETAPDSYKV
CCCCCCCCCCCCCCC		44.7428348404
26PhosphorylationRSETAPDSYKVQDKK
CCCCCCCCCCCCCCC		26.2923312004
27PhosphorylationSETAPDSYKVQDKKN
CCCCCCCCCCCCCCC		23.6623312004
36PhosphorylationVQDKKNASSRPASAI
CCCCCCCCCCCCHHH		35.9526330541
37PhosphorylationQDKKNASSRPASAIS
CCCCCCCCCCCHHHC		39.6130576142
41PhosphorylationNASSRPASAISGQNN
CCCCCCCHHHCCCCC		28.9020873877
44PhosphorylationSRPASAISGQNNNHS
CCCCHHHCCCCCCCC		33.7630576142
51PhosphorylationSGQNNNHSGNKPDPP
CCCCCCCCCCCCCCC		46.3020873877
54AcetylationNNNHSGNKPDPPPVL
CCCCCCCCCCCCCCC		55.0826051181
58PhosphorylationSGNKPDPPPVLRVDD
CCCCCCCCCCCCCCH		38.7227251275
66PhosphorylationPVLRVDDRQRLARER
CCCCCCHHHHHHHHH		21.0327251275
73PhosphorylationRQRLARERREEREKQ
HHHHHHHHHHHHHHH		45.8427251275
87 (in isoform 3)Phosphorylation-4.0122210691
89 (in isoform 3)Phosphorylation-2.8525849741
107AcetylationEKHLEERKKRLEEQR
HHHHHHHHHHHHHHH		45.5920167786
146PhosphorylationHEAVVRRTMERSQKP
HHHHHHHHHHHHCCC		16.9028555341
161PhosphorylationKQKHNRWSWGGSLHG
CCCCCCCCCCCCCCC		16.7725159151
161 (in isoform 2)Phosphorylation-16.7720873877
165PhosphorylationNRWSWGGSLHGSPSI
CCCCCCCCCCCCCCC		17.1623401153
165 (in isoform 2)Phosphorylation-17.1620068231
169PhosphorylationWGGSLHGSPSIHSAD
CCCCCCCCCCCCCCC		12.5325159151
169 (in isoform 2)Phosphorylation-12.5320873877
171PhosphorylationGSLHGSPSIHSADPD
CCCCCCCCCCCCCCC		34.3328152594
171 (in isoform 2)Phosphorylation-34.3320068231
174PhosphorylationHGSPSIHSADPDRRS
CCCCCCCCCCCCCCC		32.4728152594
174 (in isoform 2)Phosphorylation-32.4727696853
181PhosphorylationSADPDRRSVSTMNLS
CCCCCCCCCCCCCHH		22.7025159151
183PhosphorylationDPDRRSVSTMNLSKY
CCCCCCCCCCCHHHC		24.1623401153
183 (in isoform 4)Phosphorylation-24.1620873877
184PhosphorylationPDRRSVSTMNLSKYV
CCCCCCCCCCHHHCC		14.1328176443
187PhosphorylationRSVSTMNLSKYVDPV
CCCCCCCHHHCCCHH		3.0327251275
187 (in isoform 4)Phosphorylation-3.0320068231
188PhosphorylationSVSTMNLSKYVDPVI
CCCCCCHHHCCCHHH		19.5528176443
190PhosphorylationSTMNLSKYVDPVISK
CCCCHHHCCCHHHHH		13.5020860994
191PhosphorylationTMNLSKYVDPVISKR
CCCHHHCCCHHHHHH		8.4527251275
191 (in isoform 4)Phosphorylation-8.4520873877
193PhosphorylationNLSKYVDPVISKRLS
CHHHCCCHHHHHHCC		18.4627251275
193 (in isoform 4)Phosphorylation-18.4620068231
196PhosphorylationKYVDPVISKRLSSSS
HCCCHHHHHHCCCCC		16.3828857561
196 (in isoform 4)Phosphorylation-16.3827696853
200PhosphorylationPVISKRLSSSSATLL
HHHHHHCCCCCCHHH		32.0125159151
201PhosphorylationVISKRLSSSSATLLN
HHHHHCCCCCCHHHC		32.6723401153
202PhosphorylationISKRLSSSSATLLNS
HHHHCCCCCCHHHCC		22.1829255136
203PhosphorylationSKRLSSSSATLLNSP
HHHCCCCCCHHHCCH		27.5025159151
205PhosphorylationRLSSSSATLLNSPDR
HCCCCCCHHHCCHHH		33.4523401153
209PhosphorylationSSATLLNSPDRARRL
CCCHHHCCHHHHHHH		28.3119664994
212PhosphorylationTLLNSPDRARRLQLS
HHHCCHHHHHHHCCC		33.1227642862
219PhosphorylationRARRLQLSPWESSVV
HHHHHCCCHHHHHHH		18.2722167270
222PhosphorylationRLQLSPWESSVVNRL
HHCCCHHHHHHHHHH		36.2027251275
223PhosphorylationLQLSPWESSVVNRLL
HCCCHHHHHHHHHHH		25.2722167270
224PhosphorylationQLSPWESSVVNRLLT
CCCHHHHHHHHHHHC		20.6922167270
225PhosphorylationLSPWESSVVNRLLTP
CCHHHHHHHHHHHCC		6.5227251275
227PhosphorylationPWESSVVNRLLTPTH
HHHHHHHHHHHCCCH		27.0827251275
231PhosphorylationSVVNRLLTPTHSFLA
HHHHHHHCCCHHHHH		30.6325159151
233PhosphorylationVNRLLTPTHSFLARS
HHHHHCCCHHHHHCC		25.5625159151
235PhosphorylationRLLTPTHSFLARSKS
HHHCCCHHHHHCCCC		25.1625159151
240PhosphorylationTHSFLARSKSTAALS
CHHHHHCCCCHHHHC		25.9223401153
241PhosphorylationHSFLARSKSTAALSG
HHHHHCCCCHHHHCC		46.3927251275
242PhosphorylationSFLARSKSTAALSGE
HHHHCCCCHHHHCCC		25.2425159151
243PhosphorylationFLARSKSTAALSGEA
HHHCCCCHHHHCCCC		21.4925159151
247PhosphorylationSKSTAALSGEAASCS
CCCHHHHCCCCHHCC		29.8425159151
252PhosphorylationALSGEAASCSPIIMP
HHCCCCHHCCCEEEC		23.3625159151
253PhosphorylationLSGEAASCSPIIMPY
HCCCCHHCCCEEECC		4.8727251275
254PhosphorylationSGEAASCSPIIMPYK
CCCCHHCCCEEECCH		19.3525159151
255PhosphorylationGEAASCSPIIMPYKA
CCCHHCCCEEECCHH		25.1827251275
257PhosphorylationAASCSPIIMPYKAAH
CHHCCCEEECCHHHH		2.3027251275
260PhosphorylationCSPIIMPYKAAHSRN
CCCEEECCHHHHCCC		8.9029116813
264PhosphorylationIMPYKAAHSRNSMDR
EECCHHHHCCCCCCC		31.9527251275
265PhosphorylationMPYKAAHSRNSMDRP
ECCHHHHCCCCCCCC		28.5628102081
268PhosphorylationKAAHSRNSMDRPKLF
HHHHCCCCCCCCCEE		22.4320068231
269PhosphorylationAAHSRNSMDRPKLFV
HHHCCCCCCCCCEEE		6.0627251275
273SumoylationRNSMDRPKLFVTPPE
CCCCCCCCEEECCCC		56.2928112733
274PhosphorylationNSMDRPKLFVTPPEG
CCCCCCCEEECCCCC		4.6527251275
277PhosphorylationDRPKLFVTPPEGSSR
CCCCEEECCCCCCCC		26.2823401153
282PhosphorylationFVTPPEGSSRRRIIH
EECCCCCCCCCEEEE		21.0023401153
283PhosphorylationVTPPEGSSRRRIIHG
ECCCCCCCCCEEEEE		40.4325159151
291PhosphorylationRRRIIHGTASYKKER
CCEEEEECCCCCCHH		9.7725159151
293PhosphorylationRIIHGTASYKKERER
EEEEECCCCCCHHHH		37.0025159151
294PhosphorylationIIHGTASYKKERERE
EEEECCCCCCHHHHC		24.5029396449
295AcetylationIHGTASYKKEREREN
EEECCCCCCHHHHCC		45.7426051181
295SumoylationIHGTASYKKEREREN
EEECCCCCCHHHHCC		45.7428112733
298PhosphorylationTASYKKERERENVLF
CCCCCCHHHHCCEEE		58.0927251275
307PhosphorylationRENVLFLTSGTRRAV
HCCEEEEECCCCCCC		20.1325159151
308PhosphorylationENVLFLTSGTRRAVS
CCEEEEECCCCCCCC		40.0721815630
310PhosphorylationVLFLTSGTRRAVSPS
EEEEECCCCCCCCCC		19.4221815630
312PhosphorylationFLTSGTRRAVSPSNP
EEECCCCCCCCCCCH		38.9027251275
315PhosphorylationSGTRRAVSPSNPKAR
CCCCCCCCCCCHHCC		22.9425159151
317PhosphorylationTRRAVSPSNPKARQP
CCCCCCCCCHHCCCC		59.2524732914
321PhosphorylationVSPSNPKARQPARSR
CCCCCHHCCCCCHHH		19.3227251275
323PhosphorylationPSNPKARQPARSRLW
CCCHHCCCCCHHHCC		40.6427251275
333PhosphorylationRSRLWLPSKSLPHLP
HHHCCCCCCCCCCCC		32.4824719451
335PhosphorylationRLWLPSKSLPHLPGT
HCCCCCCCCCCCCCC		52.0125159151
342PhosphorylationSLPHLPGTPRPTSSL
CCCCCCCCCCCCCCC		17.7425159151
345PhosphorylationHLPGTPRPTSSLPPG
CCCCCCCCCCCCCCC		37.5227251275
346PhosphorylationLPGTPRPTSSLPPGS
CCCCCCCCCCCCCCC		32.0220068231
347PhosphorylationPGTPRPTSSLPPGSV
CCCCCCCCCCCCCCC		32.3421712546
348PhosphorylationGTPRPTSSLPPGSVK
CCCCCCCCCCCCCCC		47.5821712546
353PhosphorylationTSSLPPGSVKAAPAQ
CCCCCCCCCCCCCCC		26.6428857561
365PhosphorylationPAQVRPPSPGNIRPV
CCCCCCCCCCCCCCC		48.3929255136
372PhosphorylationSPGNIRPVKREVKVE
CCCCCCCCCCEEECC		7.0127251275
373SumoylationPGNIRPVKREVKVEP
CCCCCCCCCEEECCC		45.5928112733
377SumoylationRPVKREVKVEPEKKD
CCCCCEEECCCCCCC		35.81-
377SumoylationRPVKREVKVEPEKKD
CCCCCEEECCCCCCC		35.8128112733
395PhosphorylationEPQKVANEPSLKGRA
CCHHHCCCCCCCCCC		26.9127251275
397PhosphorylationQKVANEPSLKGRAPL
HHHCCCCCCCCCCCC		36.2125159151
406SumoylationKGRAPLVKVEEATVE
CCCCCCEEEEECCCC		52.16-
406SumoylationKGRAPLVKVEEATVE
CCCCCCEEEEECCCC		52.1628112733
470PhosphorylationASASVKTSAGTTDPE
CCCEEECCCCCCCHH		20.9824719451
473PhosphorylationSVKTSAGTTDPEEAT
EEECCCCCCCHHHHH		27.9524719451
474PhosphorylationVKTSAGTTDPEEATR
EECCCCCCCHHHHHH		48.9528674419
480PhosphorylationTTDPEEATRLLAEKR
CCCHHHHHHHHHHHH		25.7324719451
634PhosphorylationDIAKGALTGGTEVSA
CCCCCCCCCCCEEEE		32.7924732914
637PhosphorylationKGALTGGTEVSALPC
CCCCCCCCEEEEEEE		34.2624732914
640PhosphorylationLTGGTEVSALPCTTN
CCCCCEEEEEEECCC		20.1824732914
645PhosphorylationEVSALPCTTNAPGNG
EEEEEEECCCCCCCC		22.5824732914
646PhosphorylationVSALPCTTNAPGNGK
EEEEEECCCCCCCCC		35.7824732914
657PhosphorylationGNGKPVGSPHVVTSH
CCCCCCCCCEEEECC		16.4423401153
662PhosphorylationVGSPHVVTSHQSKVT
CCCCEEEECCCCEEE		21.2823401153
663PhosphorylationGSPHVVTSHQSKVTV
CCCEEEECCCCEEEE		14.1224732914
666PhosphorylationHVVTSHQSKVTVEST
EEEECCCCEEEEECC		24.5424732914
672PhosphorylationQSKVTVESTPDLEKQ
CCEEEEECCCCHHHC		40.6916565220
673PhosphorylationSKVTVESTPDLEKQP
CEEEEECCCCHHHCC		13.8125159151
687PhosphorylationPNENGVSVQNENFEE
CCCCCCCCCCCCHHH		7.0527251275
702PhosphorylationIINLPIGSKPSRLDV
HHCCCCCCCCCCCCC		41.9627251275
710PhosphorylationKPSRLDVTNSESPEI
CCCCCCCCCCCCCCC		32.4720068231
712PhosphorylationSRLDVTNSESPEIPL
CCCCCCCCCCCCCCC		30.0420068231
714PhosphorylationLDVTNSESPEIPLNP
CCCCCCCCCCCCCCC		27.8828348404
730PhosphorylationLAFDDEGTLGPLPQV
EEECCCCCCCCCCCC		26.8820068231
742PhosphorylationPQVDGVQTQQTAEVI
CCCCCCCCCCCEECC		21.9020068231
744PhosphorylationVDGVQTQQTAEVI--
CCCCCCCCCEECC--		46.1727251275
745PhosphorylationDGVQTQQTAEVI---
CCCCCCCCEECC---		18.2420068231
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
209SPhosphorylationKinaseCDK1P06493
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAP7_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAP7_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRPV4_HUMANTRPV4physical
14517216
MRE11_HUMANMRE11Aphysical
22863883
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAP7_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-209; SER-219 AND SER-254, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-209; SER-219 AND SER-254, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201; SER-209; SER-219;THR-231; THR-243; SER-254 AND THR-277, AND MASS SPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, AND MASSSPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200; SER-202; SER-209;SER-219 AND THR-277, AND MASS SPECTROMETRY.
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181; SER-200; SER-209AND THR-277, AND MASS SPECTROMETRY.
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219; THR-231 ANDSER-315, AND MASS SPECTROMETRY.
"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; SER-200; SER-209;SER-219; THR-231; THR-277; SER-315; SER-365; SER-672 AND THR-673, ANDMASS SPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209; SER-219; SER-254;THR-277 AND THR-673, AND MASS SPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365, AND MASSSPECTROMETRY.

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