TRPV2_HUMAN - dbPTM
TRPV2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRPV2_HUMAN
UniProt AC Q9Y5S1
Protein Name Transient receptor potential cation channel subfamily V member 2
Gene Name TRPV2
Organism Homo sapiens (Human).
Sequence Length 764
Subcellular Localization Cell membrane
Multi-pass membrane protein. Cytoplasm. Melanosome . Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV..
Protein Description Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH..
Protein Sequence MTSPSSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQGEDRKFAPQIRVNLNYRKGTGASQPDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHCKSPHRHRMVVLEPLNKLLQAKWDLLIPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAEVGNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPTLCEDPSGAGVPRTLENPVLASPPKEDEDGASEENYVPVQLLQSN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTSPSSSPV
------CCCCCCCCE		49.7129255136
3Phosphorylation-----MTSPSSSPVF
-----CCCCCCCCEE		22.8329255136
5Phosphorylation---MTSPSSSPVFRL
---CCCCCCCCEEEE		43.1229255136
6Phosphorylation--MTSPSSSPVFRLE
--CCCCCCCCEEEEE		41.8829255136
7Phosphorylation-MTSPSSSPVFRLET
-CCCCCCCCEEEEEE		29.4429255136
14PhosphorylationSPVFRLETLDGGQED
CCEEEEEECCCCCCC		34.4429083192
23PhosphorylationDGGQEDGSEADRGKL
CCCCCCCCHHHCCCC		41.7730108239
49UbiquitinationQFQGEDRKFAPQIRV
HHCCCCCCCCCEEEE		59.19-
60PhosphorylationQIRVNLNYRKGTGAS
EEEEECCCCCCCCCC		19.50-
67PhosphorylationYRKGTGASQPDPNRF
CCCCCCCCCCCCCCC		43.5222985185
84PhosphorylationDRLFNAVSRGVPEDL
HHHHHHHHCCCCHHH		22.40-
100UbiquitinationGLPEYLSKTSKYLTD
CCHHHHHHHCCCCCC		54.9829967540
103UbiquitinationEYLSKTSKYLTDSEY
HHHHHHCCCCCCCCC		49.89-
104PhosphorylationYLSKTSKYLTDSEYT
HHHHHCCCCCCCCCC		18.0127642862
110PhosphorylationKYLTDSEYTEGSTGK
CCCCCCCCCCCCCCC		17.6527642862
114PhosphorylationDSEYTEGSTGKTCLM
CCCCCCCCCCCHHHH		27.9630576142
115PhosphorylationSEYTEGSTGKTCLMK
CCCCCCCCCCHHHHH		54.2630576142
117UbiquitinationYTEGSTGKTCLMKAV
CCCCCCCCHHHHHHH		35.83-
173UbiquitinationALHIAIEKRSLQCVK
HHHHHHHHCCHHHHH		40.9729967540
200UbiquitinationACGRFFQKGQGTCFY
CCHHHCCCCCCEEEE		48.31-
231UbiquitinationVVSYLLENPHQPASL
HHHHHHCCCCCCCCC		39.0522817900
234UbiquitinationYLLENPHQPASLQAT
HHHCCCCCCCCCEEE		36.1922817900
299UbiquitinationLQDLTPLKLAAKEGK
CCCCCHHHHHHHHCC		36.9622817900
303UbiquitinationTPLKLAAKEGKIEIF
CHHHHHHHHCCHHHH		62.4822817900
327UbiquitinationGLSHLSRKFTEWCYG
CCHHHHHHHHHHHHC		53.9421906983
378UbiquitinationVVLEPLNKLLQAKWD
EEEHHHHHHHHHHHH		59.2521890473
383UbiquitinationLNKLLQAKWDLLIPK
HHHHHHHHHHHHHHH		28.4222817900
401PhosphorylationNFLCNLIYMFIFTAV
HHHHHHHHHHHHHHH		6.80-
406PhosphorylationLIYMFIFTAVAYHQP
HHHHHHHHHHHHCCC		18.53-
430PhosphorylationLKAEVGNSMLLTGHI
CCCHHCCHHHHHHHH		12.6024043423
434PhosphorylationVGNSMLLTGHILILL
HCCHHHHHHHHHHHH		23.8124043423
445PhosphorylationLILLGGIYLLVGQLW
HHHHHHHHHHHHHHH		9.3924043423
453PhosphorylationLLVGQLWYFWRRHVF
HHHHHHHHHHHHHHH		11.2324043423
523PhosphorylationGFQHTGIYSVMIQKV
CCCCCCHHHHHHHHH		9.1422817900
524PhosphorylationFQHTGIYSVMIQKVI
CCCCCHHHHHHHHHH		11.8622817900
526SulfoxidationHTGIYSVMIQKVILR
CCCHHHHHHHHHHHH		1.9031719194
567PhosphorylationAWRPEAPTGPNATES
HHCCCCCCCCCCCCC		72.7722210691
570N-linked_GlycosylationPEAPTGPNATESVQP
CCCCCCCCCCCCCCC		61.92UniProtKB CARBOHYD
572PhosphorylationAPTGPNATESVQPME
CCCCCCCCCCCCCCC		35.1222210691
574PhosphorylationTGPNATESVQPMEGQ
CCCCCCCCCCCCCCC		23.0022210691
590PhosphorylationDEGNGAQYRGILEAS
CCCCCHHHHHHHHHH		15.4022210691
607SulfoxidationLFKFTIGMGELAFQE
HHHHCCCCCHHHHHH		3.1331719194
660UbiquitinationATDSWSIWKLQKAIS
HHCHHHHHHHHHHHH		6.9822817900
661UbiquitinationTDSWSIWKLQKAISV
HCHHHHHHHHHHHHH		39.0922817900
663UbiquitinationSWSIWKLQKAISVLE
HHHHHHHHHHHHHHC		29.4322817900
664AcetylationWSIWKLQKAISVLEM
HHHHHHHHHHHHHCC		59.1112655291
664UbiquitinationWSIWKLQKAISVLEM
HHHHHHHHHHHHHCC		59.1122817900
733PhosphorylationSGAGVPRTLENPVLA
CCCCCCCCCCCCCCC		32.1426074081
741PhosphorylationLENPVLASPPKEDED
CCCCCCCCCCCCCCC		37.2628796482
751PhosphorylationKEDEDGASEENYVPV
CCCCCCCCCCCCCCH		51.4723898821
755PhosphorylationDGASEENYVPVQLLQ
CCCCCCCCCCHHHHC		14.9226657352
763PhosphorylationVPVQLLQSN------
CCHHHHCCC------		44.4726074081
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TRPV2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRPV2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRPV2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TRPV2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRPV2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-523 AND SER-524, ANDMASS SPECTROMETRY.

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