dbPTM

SMS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SMS2_HUMAN
UniProt AC	Q8NHU3
Protein Name	Phosphatidylcholine:ceramide cholinephosphotransferase 2
Gene Name	SGMS2
Organism	Homo sapiens (Human).
Sequence Length	365
Subcellular Localization	Cell membrane Multi-pass membrane protein. Golgi apparatus membrane Multi-pass membrane protein. Predominantly plasma membrane, some in Golgi apparatus. Some localization in the perinuclear region where it colocalizes with a sialyltransferase.
Protein Description	Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity..
Protein Sequence	MDIIETAKLEEHLENQPSDPTNTYARPAEPVEEENKNGNGKPKSLSSGLRKGTKKYPDYIQIAMPTESRNKFPLEWWKTGIAFIYAVFNLVLTTVMITVVHERVPPKELSPPLPDKFFDYIDRVKWAFSVSEINGIILVGLWITQWLFLRYKSIVGRRFCFIIGTLYLYRCITMYVTTLPVPGMHFQCAPKLNGDSQAKVQRILRLISGGGLSITGSHILCGDFLFSGHTVTLTLTYLFIKEYSPRHFWWYHLICWLLSAAGIICILVAHEHYTIDVIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGEDNEKST

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	EHLENQPSDPTNTYA HHHHCCCCCCCCCCC	46.59	21945579
21	Phosphorylation	ENQPSDPTNTYARPA HCCCCCCCCCCCCCC	45.22	21945579
23	Phosphorylation	QPSDPTNTYARPAEP CCCCCCCCCCCCCCC	22.49	21945579
24	Phosphorylation	PSDPTNTYARPAEPV CCCCCCCCCCCCCCC	11.59	21945579
44	Phosphorylation	NGNGKPKSLSSGLRK CCCCCCCCHHHHHCC	41.85	23927012
46	Phosphorylation	NGKPKSLSSGLRKGT CCCCCCHHHHHCCCC	29.47	23403867
47	Phosphorylation	GKPKSLSSGLRKGTK CCCCCHHHHHCCCCC	47.33	23403867
55	Ubiquitination	GLRKGTKKYPDYIQI HHCCCCCCCCCCEEE	62.95	-
56	Phosphorylation	LRKGTKKYPDYIQIA HCCCCCCCCCCEEEE	11.68	21945579
59	Phosphorylation	GTKKYPDYIQIAMPT CCCCCCCCEEEECCC	7.10	21945579
66	Phosphorylation	YIQIAMPTESRNKFP CEEEECCCCCCCCCC	33.24	21945579
68	Phosphorylation	QIAMPTESRNKFPLE EEECCCCCCCCCCHH	43.56	21945579
71	Ubiquitination	MPTESRNKFPLEWWK CCCCCCCCCCHHHHH	47.45	-
116	Ubiquitination	LSPPLPDKFFDYIDR CCCCCCHHHHHHHHH	46.09	21906983
191	Ubiquitination	MHFQCAPKLNGDSQA CCEEECCCCCCCHHH	35.74	-
331	S-palmitoylation	NVQGSIPCCFSWPLS CCCCCCCEEEECCCC	3.31	19233134
332	S-palmitoylation	VQGSIPCCFSWPLSW CCCCCCEEEECCCCC	2.25	19233134
343	S-palmitoylation	PLSWPPGCFKSSCKK CCCCCCCHHHHHHHH	4.84	19233134
348	S-palmitoylation	PGCFKSSCKKYSRVQ CCHHHHHHHHHHCCC	5.94	19233134
363	Ubiquitination	KIGEDNEKST----- CCCCCCCCCC-----	66.70	21906983
365	Phosphorylation	GEDNEKST------- CCCCCCCC-------	54.41	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SMS2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
331	C	Palmitoylation	19233134
Palmitoylated on Cys-331, Cys-332, Cys-343 and Cys-348; which plays an important role in plasma membrane localization.
332	C	Palmitoylation	19233134
Palmitoylated on Cys-331, Cys-332, Cys-343 and Cys-348; which plays an important role in plasma membrane localization.
343	C	Palmitoylation	19233134
Palmitoylated on Cys-331, Cys-332, Cys-343 and Cys-348; which plays an important role in plasma membrane localization.
348	C	Palmitoylation	19233134
Palmitoylated on Cys-331, Cys-332, Cys-343 and Cys-348; which plays an important role in plasma membrane localization.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SMS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SMS2_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SMS2_HUMAN

Related Literatures of Post-Translational Modification

Palmitoylation
Reference	PubMed
"Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail,which is involved in its localization in plasma membranes."; Tani M., Kuge O.; Biochem. Biophys. Res. Commun. 381:328-332(2009). Cited for: SUBCELLULAR LOCATION, PALMITOYLATION AT CYS-331; CYS-332; CYS-343 ANDCYS-348, AND MUTAGENESIS OF 331-CYS-CYS-332; CYS-343 AND CYS-348.	19233134 [Abstract]

show

show

show

show