EVI5L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EVI5L_HUMAN
• UniProt AC: Q96CN4
• Protein Name: EVI5-like protein
• Gene Name: EVI5L
• Organism: Homo sapiens (Human).
• Sequence Length: 794
• Protein Description: Functions as a GTPase-activating protein (GAP) with a broad specificity..
• Protein Sequence: MASPTLSPDSSSQEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNGSRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKGQVTRAQEAEENYVIKRELAVVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRLRETETLGALREMQDKVLDMEKRNSSLPDENNVAQLQEELKALKVREGQAVASTRELKLQLQELSDTWQAHLARGGRWKESPRKLVVGELQDELMSVRLREAQALAEGRELRQRVVELETQDHIHRNLLNRVEAERAALQEKLQYLAAQNKGLQTQLSESRRKQAEAECKSKEEVMAVRLREADSMAAVAEMRQRIAELEIQREEGRIQGQLNHSDSSQYIRELKDQIEELKAEVRLLKGPPPFEDPLAFDGLSLARHLDEDSLPSSDEELLGVGVGAALQDALYPLSPRDARFFRRLERPAKDSEGSSDSDADELAAPYSQGLDN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASPTLSPDS -----CCCCCCCCCC	19.67	28270605
5	Phosphorylation	---MASPTLSPDSSS ---CCCCCCCCCCCC	37.06	28270605
7	Phosphorylation	-MASPTLSPDSSSQE -CCCCCCCCCCCCCC	29.19	28270605
10	Phosphorylation	SPTLSPDSSSQEALS CCCCCCCCCCCCHHC	34.96	28270605
11	Phosphorylation	PTLSPDSSSQEALSA CCCCCCCCCCCHHCC	43.34	28270605
12	Phosphorylation	TLSPDSSSQEALSAP CCCCCCCCCCHHCCC	35.67	28270605
17	Phosphorylation	SSSQEALSAPTCSPT CCCCCHHCCCCCCCC	38.97	28348404
20	Phosphorylation	QEALSAPTCSPTSDS CCHHCCCCCCCCCCC	25.90	28348404
22	Phosphorylation	ALSAPTCSPTSDSEN HHCCCCCCCCCCCCC	33.42	28348404
24	Phosphorylation	SAPTCSPTSDSENLS CCCCCCCCCCCCCCC	28.95	28348404
25	Phosphorylation	APTCSPTSDSENLSP CCCCCCCCCCCCCCH	42.39	28348404
27	Phosphorylation	TCSPTSDSENLSPDE CCCCCCCCCCCCHHH	28.31	28348404
52	Phosphorylation	NRLLEADSKSMRSMN HHHHHHCHHHHHHCC	33.41	28122231
53	Acetylation	RLLEADSKSMRSMNG HHHHHCHHHHHHCCC	49.14	27452117
54	Phosphorylation	LLEADSKSMRSMNGS HHHHCHHHHHHCCCC	24.31	29978859
65	Phosphorylation	MNGSRRNSGSSLVSS CCCCCCCCCCCCCCC	37.94	28857561
67	Phosphorylation	GSRRNSGSSLVSSSS CCCCCCCCCCCCCCC	21.96	28857561
68	Phosphorylation	SRRNSGSSLVSSSSA CCCCCCCCCCCCCCC	35.99	27080861
71	Phosphorylation	NSGSSLVSSSSASSN CCCCCCCCCCCCCCC	29.78	28857561
72	Phosphorylation	SGSSLVSSSSASSNL CCCCCCCCCCCCCCC	22.34	27080861
73	Phosphorylation	GSSLVSSSSASSNLS CCCCCCCCCCCCCCC	23.55	27080861
74	Phosphorylation	SSLVSSSSASSNLSH CCCCCCCCCCCCCCC	33.83	27080861
76	Phosphorylation	LVSSSSASSNLSHLE CCCCCCCCCCCCCCC	23.00	27080861
77	Phosphorylation	VSSSSASSNLSHLEE CCCCCCCCCCCCCCC	41.32	27080861
226	Phosphorylation	FVRLMQEYRLRELFK HHHHHHHHHHHHHHC	9.69	22817900
244	Phosphorylation	AELGLCIYQFEYMLQ HHHHHHHHHHHHHHH	13.22	22817900
351	Phosphorylation	DKLVLKAYQVKYNPK CHHHHHHHCCCCCHH	16.55	-
355	Phosphorylation	LKAYQVKYNPKKMKR HHHHCCCCCHHHHHH	37.53	-
359	Acetylation	QVKYNPKKMKRLEKE CCCCCHHHHHHHHHH	51.41	18527301
382	Ubiquitination	MEEQIEIKRLRTENR HHHHHHHHHHHHHHH	32.37	-
413	Phosphorylation	AQEAEENYVIKRELA HHHHHHHHHHHHHHH	13.56	29978859
415 (in isoform 2)	Phosphorylation	-	2.16	26270265
424	Phosphorylation	RELAVVRQQCSSAAE HHHHHHHHHHHHHHH	36.70	27642862
435	Ubiquitination	SAAEDLQKAQSTIRQ HHHHHHHHHHHHHHH	56.54	-
472	Phosphorylation	EQSRLRETETLGALR HHHHHHHHHHHHHHH	28.03	-
474	Phosphorylation	SRLRETETLGALREM HHHHHHHHHHHHHHH	37.60	22210691
484	Acetylation	ALREMQDKVLDMEKR HHHHHHHHHHCHHHH	28.01	91321
494	Phosphorylation	DMEKRNSSLPDENNV CHHHHHCCCCCCCCH	47.69	28555341
549	Phosphorylation	RGGRWKESPRKLVVG CCCCCCCCCCEEEHH	26.69	24719451
560	Phosphorylation	LVVGELQDELMSVRL EEHHHHHHHHHHHHH	64.72	24719451
564	Phosphorylation	ELQDELMSVRLREAQ HHHHHHHHHHHHHHH	19.40	29116813
610	Ubiquitination	ERAALQEKLQYLAAQ HHHHHHHHHHHHHHH	28.12	-
626	Phosphorylation	KGLQTQLSESRRKQA CCHHHHHHHHHHHHH	24.57	25159151
637	Phosphorylation	RKQAEAECKSKEEVM HHHHHHHHCCHHHHH	8.54	27251275
683	Phosphorylation	IQGQLNHSDSSQYIR CCCCCCCCCHHHHHH	37.81	30242111
685	Phosphorylation	GQLNHSDSSQYIREL CCCCCCCHHHHHHHH	23.50	30242111
686	Phosphorylation	QLNHSDSSQYIRELK CCCCCCHHHHHHHHH	31.80	30242111
688	Phosphorylation	NHSDSSQYIRELKDQ CCCCHHHHHHHHHHH	12.14	28634120
696	Phosphorylation	IRELKDQIEELKAEV HHHHHHHHHHHHHHH	6.78	27251275
700	Ubiquitination	KDQIEELKAEVRLLK HHHHHHHHHHHHHHC	45.86	19413330
700	Acetylation	KDQIEELKAEVRLLK HHHHHHHHHHHHHHC	45.86	19413330
711	Acetylation	RLLKGPPPFEDPLAF HHHCCCCCCCCCCCC	48.68	19413330
722	Phosphorylation	PLAFDGLSLARHLDE CCCCCHHHHHHHCCC	26.05	23403867
731	Phosphorylation	ARHLDEDSLPSSDEE HHHCCCCCCCCCCHH	39.88	22496350
733	Phosphorylation	HLDEDSLPSSDEELL HCCCCCCCCCCHHHH	35.42	24719451
734	Phosphorylation	LDEDSLPSSDEELLG CCCCCCCCCCHHHHC	56.57	22496350
735	Phosphorylation	DEDSLPSSDEELLGV CCCCCCCCCHHHHCC	47.29	22496350
753	Phosphorylation	AALQDALYPLSPRDA HHHHHHHCCCCHHHH	12.12	30177828
756	Phosphorylation	QDALYPLSPRDARFF HHHHCCCCHHHHHHH	17.24	21552520
773	Phosphorylation	LERPAKDSEGSSDSD CCCCCCCCCCCCCCC	43.05	24144214
776	Phosphorylation	PAKDSEGSSDSDADE CCCCCCCCCCCCHHH	27.24	24144214
777	Phosphorylation	AKDSEGSSDSDADEL CCCCCCCCCCCHHHH	52.57	24144214
779	Phosphorylation	DSEGSSDSDADELAA CCCCCCCCCHHHHHH	36.32	24144214
788	Phosphorylation	ADELAAPYSQGLDN- HHHHHHHHHCCCCC-	14.65	22817900
789	Phosphorylation	DELAAPYSQGLDN-- HHHHHHHHCCCCC--	19.40	24144214

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EVI5L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EVI5L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EVI5L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAB10_HUMAN	RAB10	physical	16923123

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.