| UniProt ID | GPC3_HUMAN | |
|---|---|---|
| UniProt AC | P51654 | |
| Protein Name | Glypican-3 | |
| Gene Name | GPC3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 580 | |
| Subcellular Localization |
Cell membrane Lipid-anchor, GPI-anchor Extracellular side. Secreted glypican-3: Secreted, extracellular space. |
|
| Protein Description | Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.. | |
| Protein Sequence | MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQQATPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFFLVH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MAGTVRTACLV ----CCCHHHHHHHH | 9.40 | 26853621 | |
| 25 | Pyrrolidone_carboxylic_acid | LDFPGQAQPPPPPPD CCCCCCCCCCCCCCC | 43.05 | 29345911 | |
| 50 | Ubiquitination | QRLQPGLKWVPETPV HHHCCCCCCCCCCCC | 52.65 | 21906983 | |
| 124 | N-linked_Glycosylation | IVVRHAKNYTNAMFK HHHHHHHHHHHHHHH | 50.04 | 29345911 | |
| 241 | N-linked_Glycosylation | NLGIEVINTTDHLKF HHCCEEEECCCCCHH | 41.94 | 29345911 | |
| 242 | Phosphorylation | LGIEVINTTDHLKFS HCCEEEECCCCCHHC | 23.60 | 27174698 | |
| 243 | Phosphorylation | GIEVINTTDHLKFSK CCEEEECCCCCHHCH | 19.55 | 27174698 | |
| 299 | Phosphorylation | IDKYWREYILSLEEL HHHHHHHHHHCHHHH | 9.89 | - | |
| 311 | Phosphorylation | EELVNGMYRIYDMEN HHHHCCCHHHHCHHH | 8.68 | - | |
| 342 (in isoform 3) | Phosphorylation | - | 25.94 | - | |
| 343 (in isoform 3) | Phosphorylation | - | 27.18 | - | |
| 344 (in isoform 3) | Phosphorylation | - | 23.61 | - | |
| 346 (in isoform 3) | Phosphorylation | - | 18.13 | - | |
| 352 | Phosphorylation | IGKLCAHSQQRQYRS HHHHHHHHHHHHHHH | 14.96 | 10814714 | |
| 359 | O-linked_Glycosylation | SQQRQYRSAYYPEDL HHHHHHHHCCCCHHH | 18.71 | 55833519 | |
| 388 | Ubiquitination | EETLSSRRRELIQKL HHHHHHHHHHHHHHH | 38.07 | 21890473 | |
| 418 | N-linked_Glycosylation | SHSPVAENDTLCWNG CCCCCCCCCCCCCCH | 37.52 | 29345911 | |
| 442 | Ubiquitination | KAARNGMKNQFNLHE HHHHCCCCCCCCHHH | 49.33 | 21890473 | |
| 465 | Ubiquitination | VVSQIIDKLKHINQL HHHHHHHHHHHHHHH | 49.37 | - | |
| 465 | Ubiquitination | VVSQIIDKLKHINQL HHHHHHHHHHHHHHH | 49.37 | 21890473 | |
| 465 | Ubiquitination | VVSQIIDKLKHINQL HHHHHHHHHHHHHHH | 49.37 | 21890473 | |
| 495 | O-linked_Glycosylation | LDEEGFESGDCGDDE CCCCCCCCCCCCCCC | 37.36 | - | |
| 509 | O-linked_Glycosylation | EDECIGGSGDGMIKV CCCCCCCCCCCCHHH | 28.62 | - | |
| 554 | GPI-anchor | NEISTFHNLGNVHSP CCCCCCCCCCCCCCH | 45.51 | - | |
| 571 | Phosphorylation | LLTSMAISVVCFFFL HHHHHHHHHHHHHHH | 10.04 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 352 | S | Phosphorylation | Kinase | FAM20C | Q8IXL6 | Uniprot |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GPC3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GPC3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FGF2_HUMAN | FGF2 | physical | 12478660 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00048 | Hepatocellular carcinoma | |||||
| H00493 | Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker ty | |||||
| H01215 | Simpson-Golabi-Behmel syndrome (SGBS) | |||||
| OMIM Disease | ||||||
| 312870 | Simpson-Golabi-Behmel syndrome 1 (SGBS1) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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