| UniProt ID | LCA5_HUMAN | |
|---|---|---|
| UniProt AC | Q86VQ0 | |
| Protein Name | Lebercilin | |
| Gene Name | LCA5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 697 | |
| Subcellular Localization | Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, cilium axoneme . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . In non- ciliated cells, localizes to the centrosome and its associat | |
| Protein Description | Might be involved in minus end-directed microtubule transport.. | |
| Protein Sequence | MGERAGSPGTDQERKAGKHHYSYLSDFETPQSSGRSSLVSSSPASVRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPERSPKTYRFSESSERLFNGHHLQDISFSTPKGEGQNSGNVRSPASPNEFAFGSYVPSFAKTSERSNPFSQKSSFLDFQRNSMEKLSKDGVDLITRKEKKANLMEQLFGASGSSTISSKSSDPNSVASSKGDIDPLNFLPGNKGSRDQEHDEDEGFFLSEGRSFNPNRHRLKHADDKPAVKAADSVEDEIEEVALR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MGERAGSPGTDQER -CCCCCCCCCCHHHH | 21.12 | 25849741 | |
| 10 | Phosphorylation | ERAGSPGTDQERKAG CCCCCCCCHHHHHCC | 37.58 | 29514088 | |
| 40 | Phosphorylation | SGRSSLVSSSPASVR CCCCCCCCCCCHHHH | 30.32 | 27732954 | |
| 41 | Phosphorylation | GRSSLVSSSPASVRR CCCCCCCCCCHHHHC | 32.63 | 22199227 | |
| 42 | Phosphorylation | RSSLVSSSPASVRRK CCCCCCCCCHHHHCC | 19.58 | 25849741 | |
| 45 | Phosphorylation | LVSSSPASVRRKNPK CCCCCCHHHHCCCCC | 21.38 | 22617229 | |
| 55 | Phosphorylation | RKNPKRQTSDGQVHH CCCCCCCCCCCCCCC | 32.58 | 27251275 | |
| 56 | Phosphorylation | KNPKRQTSDGQVHHQ CCCCCCCCCCCCCCC | 31.26 | 27251275 | |
| 85 | Phosphorylation | GVRVGFRSQSLNREP CCCEEEECCCCCCCC | 23.12 | 23186163 | |
| 87 | Phosphorylation | RVGFRSQSLNREPLR CEEEECCCCCCCCCC | 28.94 | 23403867 | |
| 106 | Phosphorylation | LVTKRILSARLLKIN HHHHHHHHHHHHHHH | 14.68 | 24719451 | |
| 131 | 2-Hydroxyisobutyrylation | VKLAELLKENKSLKR HHHHHHHHHCHHHHH | 72.38 | - | |
| 210 | Phosphorylation | LQKLKEISEARHLPE HHHHHHHHHHHCCCC | 26.71 | - | |
| 265 | Phosphorylation | LAERKRAYEAHDENK HHHHHHHHHHCCHHH | 20.06 | - | |
| 282 | Phosphorylation | QKEVQRLYHKLKEKE HHHHHHHHHHHHHHH | 10.09 | - | |
| 481 | Phosphorylation | IDRELQDSRNLKYPV HHHHHHHHCCCCCCE | 15.31 | 29514088 | |
| 501 | Phosphorylation | DFESKLHSPERSPKT CHHHHCCCCCCCCCC | 38.60 | 29514088 | |
| 505 | Phosphorylation | KLHSPERSPKTYRFS HCCCCCCCCCCCCCC | 29.14 | 29514088 | |
| 539 | Phosphorylation | PKGEGQNSGNVRSPA CCCCCCCCCCCCCCC | 24.69 | 23090842 | |
| 544 | Phosphorylation | QNSGNVRSPASPNEF CCCCCCCCCCCCCCC | 22.12 | 28857561 | |
| 547 | Phosphorylation | GNVRSPASPNEFAFG CCCCCCCCCCCCCCC | 31.48 | 27966365 | |
| 555 | Phosphorylation | PNEFAFGSYVPSFAK CCCCCCCCCCCCCCC | 19.26 | 23090842 | |
| 556 | Phosphorylation | NEFAFGSYVPSFAKT CCCCCCCCCCCCCCC | 19.43 | 23090842 | |
| 583 | Phosphorylation | FLDFQRNSMEKLSKD HHHHHHHHHHHHHHH | 30.43 | 27251275 | |
| 612 | Phosphorylation | MEQLFGASGSSTISS HHHHHCCCCCCCCCC | 39.32 | 30576142 | |
| 614 | Phosphorylation | QLFGASGSSTISSKS HHHCCCCCCCCCCCC | 23.08 | - | |
| 618 | Phosphorylation | ASGSSTISSKSSDPN CCCCCCCCCCCCCCC | 31.63 | 22468782 | |
| 626 | Phosphorylation | SKSSDPNSVASSKGD CCCCCCCCCCCCCCC | 25.17 | 30576142 | |
| 630 | Phosphorylation | DPNSVASSKGDIDPL CCCCCCCCCCCCCCC | 30.81 | 30576142 | |
| 686 | Phosphorylation | PAVKAADSVEDEIEE CCHHHHHCCHHHHHH | 23.76 | 27966365 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LCA5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LCA5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LCA5_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 604537 | Leber congenital amaurosis 5 (LCA5) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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