MAP9_HUMAN - dbPTM
MAP9_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAP9_HUMAN
UniProt AC Q49MG5
Protein Name Microtubule-associated protein 9
Gene Name MAP9
Organism Homo sapiens (Human).
Sequence Length 647
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle . Localizes to microtubules in interphase, associates with the mitotic spindle during mitosis, localizes to the central body during cytokinesis.
Protein Description Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules..
Protein Sequence MSDEVFSTTLAYTKSPKVTKRTTFQDELIRAITARSARQRSSEYSDDFDSDEIVSLGDFSDTSADENSVNKKMNDFHISDDEEKNPSKLLFLKTNKSNGNITKDEPVCAIKNEEEMAPDGCEDIVVKSFSESQNKDEEFEKDKIKMKPKPRILSIKSTSSAENNSLDTDDHFKPSPRPRSMLKKKSHMEEKDGLEDKETALSEELELHSAPSSLPTPNGIQLEAEKKAFSENLDPEDSCLTSLASSSLKQILGDSFSPGSEGNASGKDPNEEITENHNSLKSDENKENSFSADHVTTAVEKSKESQVTADDLEEEKAKAELIMDDDRTVDPLLSKSQSILISTSATASSKKTIEDRNIKNKKSTNNRASSASARLMTSEFLKKSSSKRRTPSTTTSSHYLGTLKVLDQKPSQKQSIEPDRADNIRAAVYQEWLEKKNVYLHEMHRIKRIESENLRIQNEQKKAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAARKGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEEETVAEKKKDNLTAVEKWNEKKEAFFKQKEKEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKRHSFLESEALPPWSPPSRTVFAKVF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSDEVFSTT
------CCCCCHHCE		42.3419413330
2Phosphorylation------MSDEVFSTT
------CCCCCHHCE		42.3423663014
7Phosphorylation-MSDEVFSTTLAYTK
-CCCCCHHCEECCCC		26.1723663014
8PhosphorylationMSDEVFSTTLAYTKS
CCCCCHHCEECCCCC		17.8619690332
9PhosphorylationSDEVFSTTLAYTKSP
CCCCHHCEECCCCCC		14.2723663014
12PhosphorylationVFSTTLAYTKSPKVT
CHHCEECCCCCCCCC		20.1523663014
13PhosphorylationFSTTLAYTKSPKVTK
HHCEECCCCCCCCCC		21.3123663014
15PhosphorylationTTLAYTKSPKVTKRT
CEECCCCCCCCCCCC		23.3523663014
19PhosphorylationYTKSPKVTKRTTFQD
CCCCCCCCCCCCCHH		22.4226074081
22PhosphorylationSPKVTKRTTFQDELI
CCCCCCCCCCHHHHH		33.2526074081
41PhosphorylationARSARQRSSEYSDDF
HHHHHHHCCCCCCCC		21.13-
79 (in isoform 2)Phosphorylation-30.3621406692
79PhosphorylationKMNDFHISDDEEKNP
HHCCCCCCCCCCCCH		30.3630266825
87PhosphorylationDDEEKNPSKLLFLKT
CCCCCCHHHEEEEEE		45.3823927012
128PhosphorylationCEDIVVKSFSESQNK
CCEEEEECCCHHCCC		23.54-
130PhosphorylationDIVVKSFSESQNKDE
EEEEECCCHHCCCCH		43.35-
132PhosphorylationVVKSFSESQNKDEEF
EEECCCHHCCCCHHH		37.5417525332
154PhosphorylationKPKPRILSIKSTSSA
CCCCCEEEEECCCCC		26.1224719451
157PhosphorylationPRILSIKSTSSAENN
CCEEEEECCCCCCCC		31.6729978859
158PhosphorylationRILSIKSTSSAENNS
CEEEEECCCCCCCCC		23.0029978859
159PhosphorylationILSIKSTSSAENNSL
EEEEECCCCCCCCCC		34.3429978859
160PhosphorylationLSIKSTSSAENNSLD
EEEECCCCCCCCCCC		39.4229978859
165PhosphorylationTSSAENNSLDTDDHF
CCCCCCCCCCCCCCC		38.9229978859
175PhosphorylationTDDHFKPSPRPRSML
CCCCCCCCCCCHHHH		33.8527251275
180PhosphorylationKPSPRPRSMLKKKSH
CCCCCCHHHHHHHHC		31.0227251275
209PhosphorylationSEELELHSAPSSLPT
HHHHHHHCCCCCCCC		55.2725921289
212PhosphorylationLELHSAPSSLPTPNG
HHHHCCCCCCCCCCC		44.2025921289
238PhosphorylationENLDPEDSCLTSLAS
CCCCHHHHHHHHHHH		14.9028348404
241PhosphorylationDPEDSCLTSLASSSL
CHHHHHHHHHHHHHH		26.4828348404
242PhosphorylationPEDSCLTSLASSSLK
HHHHHHHHHHHHHHH		14.6928348404
245PhosphorylationSCLTSLASSSLKQIL
HHHHHHHHHHHHHHH		26.2528348404
246PhosphorylationCLTSLASSSLKQILG
HHHHHHHHHHHHHHC		33.8028348404
247PhosphorylationLTSLASSSLKQILGD
HHHHHHHHHHHHHCC		36.7728348404
255PhosphorylationLKQILGDSFSPGSEG
HHHHHCCCCCCCCCC		26.3129978859
257PhosphorylationQILGDSFSPGSEGNA
HHHCCCCCCCCCCCC		32.1029978859
260PhosphorylationGDSFSPGSEGNASGK
CCCCCCCCCCCCCCC		45.7929978859
265PhosphorylationPGSEGNASGKDPNEE
CCCCCCCCCCCCCHH		50.8329978859
279PhosphorylationEITENHNSLKSDENK
HHHCCHHCCCCCCCC		29.6225627689
282PhosphorylationENHNSLKSDENKENS
CCHHCCCCCCCCCCC		56.2922617229
289PhosphorylationSDENKENSFSADHVT
CCCCCCCCCCHHHHH		22.9725849741
291PhosphorylationENKENSFSADHVTTA
CCCCCCCCHHHHHHH		32.3830377224
296PhosphorylationSFSADHVTTAVEKSK
CCCHHHHHHHHHHHH		12.9629449344
305PhosphorylationAVEKSKESQVTADDL
HHHHHHHHCCCHHHH		33.4225159151
336PhosphorylationVDPLLSKSQSILIST
CCHHHCCCCEEEEEC		26.2827251275
338PhosphorylationPLLSKSQSILISTSA
HHHCCCCEEEEECCC		26.8428348404
343PhosphorylationSQSILISTSATASSK
CCEEEEECCCCCCCC		18.52-
349PhosphorylationSTSATASSKKTIEDR
ECCCCCCCCCCHHHH		35.39-
363PhosphorylationRNIKNKKSTNNRASS
HCCCCCCCCCCCHHH		37.6726074081
364PhosphorylationNIKNKKSTNNRASSA
CCCCCCCCCCCHHHH		45.4526074081
369PhosphorylationKSTNNRASSASARLM
CCCCCCHHHHHHHHH		24.1726074081
370PhosphorylationSTNNRASSASARLMT
CCCCCHHHHHHHHHH		25.8426074081
372PhosphorylationNNRASSASARLMTSE
CCCHHHHHHHHHHHH		18.8326074081
377PhosphorylationSASARLMTSEFLKKS
HHHHHHHHHHHHHHC		29.6926074081
378PhosphorylationASARLMTSEFLKKSS
HHHHHHHHHHHHHCC		16.6426074081
385PhosphorylationSEFLKKSSSKRRTPS
HHHHHHCCCCCCCCC		49.08-
390PhosphorylationKSSSKRRTPSTTTSS
HCCCCCCCCCCCCCH		26.1429978859
392PhosphorylationSSKRRTPSTTTSSHY
CCCCCCCCCCCCHHH		37.4629978859
393PhosphorylationSKRRTPSTTTSSHYL
CCCCCCCCCCCHHHH		34.9829978859
394PhosphorylationKRRTPSTTTSSHYLG
CCCCCCCCCCHHHHH		29.0829978859
395PhosphorylationRRTPSTTTSSHYLGT
CCCCCCCCCHHHHHE		28.4629449344
396PhosphorylationRTPSTTTSSHYLGTL
CCCCCCCCHHHHHEE		17.0229978859
397PhosphorylationTPSTTTSSHYLGTLK
CCCCCCCHHHHHEEE		17.6629978859
399PhosphorylationSTTTSSHYLGTLKVL
CCCCCHHHHHEEEEC		14.5829978859
402PhosphorylationTSSHYLGTLKVLDQK
CCHHHHHEEEECCCC		22.3229978859
429PhosphorylationDNIRAAVYQEWLEKK
HHHHHHHHHHHHHHC		8.9327642862
451PhosphorylationHRIKRIESENLRIQN
HHHHHHHHHCHHCCH		29.4328857561
496AcetylationAKKRLEEKNKKKTEE
HHHHHHHHHHHHHHH		65.7720167786
603PhosphorylationDKQAINEYEKWLENK
HHHHHHHHHHHHHCH		20.51-
625PhosphorylationRKQKKRHSFLESEAL
HHHHHHHCHHHCCCC		35.2429514088
629PhosphorylationKRHSFLESEALPPWS
HHHCHHHCCCCCCCC		30.2529514088
636PhosphorylationSEALPPWSPPSRTVF
CCCCCCCCCCCCCEE		32.4827251275
639PhosphorylationLPPWSPPSRTVFAKV
CCCCCCCCCCEEEEC		43.9229449344
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
289SPhosphorylationKinasePLK1P53350
PSP
305SPhosphorylationKinaseAURKAO14965
GPS
625SPhosphorylationKinaseAURKAO14965
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAP9_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAP9_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
P53_HUMANTP53physical
22672907
EP300_HUMANEP300physical
22672907
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAP9_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-257, AND MASSSPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-12, AND MASSSPECTROMETRY.

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