| UniProt ID | VWA8_HUMAN | |
|---|---|---|
| UniProt AC | A3KMH1 | |
| Protein Name | von Willebrand factor A domain-containing protein 8 | |
| Gene Name | VWA8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1905 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Exhibits ATPase activity in vitro.. | |
| Protein Sequence | MQSRLLLLGAPGGHGGPASRRMRLLLRQVVQRRPGGDRQRPEVRLLHAGSGADTGDTVNIGDVSYKLKIPKNPELVPQNYISDSLAQSVVQHLRWIMQKDLLGQDVFLIGPPGPLRRSIAMQYLELTKREVEYIALSRDTTETDLKQRREIRAGTAFYIDQCAVRAATEGRTLILEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLRDHTKKELDSWKIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYYLPFKDQLKLLYSIGANVSAEKVSQLLSFATTLCSQESSTLGLPDFPLDSLAAAVQILDSFPMMPIKHAIQWLYPYSILLGHEGKMAVEGVLKRFELQDSGSSLLPKEIVKVEKMMENHVSQASVTIRIADKEVTIKVPAGTRLLSQPCASDRFIQTLSHKQLQAEMMQSHMVKDICLIGGKGCGKTVIAKNFADTLGYNIEPIMLYQDMTARDLLQQRYTLPNGDTAWRSSPLVNAALEGKLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSRLLREDRYMRLKEELQLSDEQLQKRSIFPIHPSFRIIALAEPPVIGSTAHQWLGPEFLTMFFFHYMKPLVKSEEIQVIKEKVPNVPQEALDKLLSFTHKLRETQDPTAQSLAASLSTRQLLRISRRLSQYPNENLHSAVTKACLSRFLPSLARSALEKNLADATIEINTDDNLEPELKDYKCEVTSGTLRIGAVSAPIYNAHEKMKVPDVLFYDNIQHVIVMEDMLKDFLLGEHLLLVGNQGVGKNKIVDRFLHLLNRPREYIQLHRDTTVQTLTLQPSVKDGLIVYEDSPLVKAVKLGHILVVDEADKAPTNVTCILKTLVENGEMILADGRRIVANSANVNGRENVVVIHPDFRMIVLANRPGFPFLGNDFFGTLGDIFSCHAVDNPKPHSELEMLRQYGPNVPEPILQKLVAAFGELRSLADQGIINYPYSTREVVNIVKHLQKFPTEGLSSVVRNVFDFDSYNNDMREILINTLHKYGIPIGAKPTSVQLAKELTLPEQTFMGYWTIGQARSGMQKLLCPVETHHIDIKGPALINIQEYPIERHEERSLNFTEECASWRIPLDEINIICDIATSHENEQNTLYVVTCNPASLYFMNMTGKSGFFVDFFDIFPRTANGVWHPFVTVAPLGSPLKGQVVLHEQQSNVILLLDTTGRALHRLILPSEKFTSKKPFWWNKEEAETYKMCKEFSHKNWLVFYKEKGNSLTVLDVLEGRTHTISLPINLKTVFLVAEDKWLLVESKTNQKYLLTKPAHIESEGSGVCQLYVLKEEPPSTGFGVTQETEFSIPHKISSDQLSSEHLSSAVEQKIASPNRILSDEKNYATIVVGFPDLMSPSEVYSWKRPSSLHKRSGTDTSFYRGKKKRGTPKQSNCVTLLDTNQVVRILPPGEVPLKDIYPKDVTPPQTSGYIEVTDLQSKKLRYIPIPRSESLSPYTTWLSTISDTDALLAEWDKSGVVTVDMGGHIRLWETGLERLQRSLMEWRNMIGQDDRNMQITINRDSGEDVSSPKHGKEDPDNMPHVGGNTWAGGTGGRDTAGLGGKGGPYRLDAGHTVYQVSQAEKDAVPEEVKRAAREMGQRAFQQRLKEIQMSEYDAATYERFSGAVRRQVHSLRIILDNLQAKGKERQWLRHQATGELDDAKIIDGLTGEKAIYKRRGELEPQLGSPQQKPKRLRLVVDVSGSMYRFNRMDGRLERTMEAVCMVMEAFENYEEKFQYDIVGHSGDGYNIGLVPMNKIPKDNKQRLEILKTMHAHSQFCMSGDHTLEGTEHAIKEIVKEEADEYFVIVLSDANLSRYGIHPAKFAQILTRDPQVNAFAIFIGSLGDQATRLQRTLPAGRSFVAMDTKDIPQILQQIFTSTMLSSV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MQSRLLLLGA -----CCCCEEECCC | 28674151 | ||
| 19 | Phosphorylation | GGHGGPASRRMRLLL CCCCCHHHHHHHHHH | 28674151 | ||
| 44 | Ubiquitination | DRQRPEVRLLHAGSG CCCCCEEEEEECCCC | 24816145 | ||
| 118 | Phosphorylation | PPGPLRRSIAMQYLE CCCHHHHHHHHHHHH | 22210691 | ||
| 119 | Ubiquitination | PGPLRRSIAMQYLEL CCHHHHHHHHHHHHH | 24816145 | ||
| 123 | Phosphorylation | RRSIAMQYLELTKRE HHHHHHHHHHHHHHH | 29083192 | ||
| 127 | Phosphorylation | AMQYLELTKREVEYI HHHHHHHHHHHHEEE | 22210691 | ||
| 133 | Phosphorylation | LTKREVEYIALSRDT HHHHHHEEEEECCCC | - | ||
| 137 | Phosphorylation | EVEYIALSRDTTETD HHEEEEECCCCCCCH | 24719451 | ||
| 158 | Phosphorylation | IRAGTAFYIDQCAVR HHCCCEEEEEHHHHH | 29496907 | ||
| 180 | Ubiquitination | LILEGLEKAERNVLP EEEHHHHHHHHCHHH | 24816145 | ||
| 199 | Ubiquitination | LLENREMQLEDGRFL HHHCCCCCCCCCCCC | 24816145 | ||
| 226 | Phosphorylation | HTKKELDSWKIVRVS HCHHHHCCCEEEEEC | 27251275 | ||
| 248 | Phosphorylation | LGLPVPRYSGNPLDP ECCCCCCCCCCCCCC | 18083107 | ||
| 267 | Phosphorylation | RFQARDIYYLPFKDQ HHCCCCEEEEEHHHH | - | ||
| 272 | Succinylation | DIYYLPFKDQLKLLY CEEEEEHHHHHHHHH | 23954790 | ||
| 279 | Phosphorylation | KDQLKLLYSIGANVS HHHHHHHHHCCCCCC | 25690035 | ||
| 280 | Phosphorylation | DQLKLLYSIGANVSA HHHHHHHHCCCCCCH | 25690035 | ||
| 284 | N-linked_Glycosylation | LLYSIGANVSAEKVS HHHHCCCCCCHHHHH | UniProtKB CARBOHYD | ||
| 338 | Ubiquitination | MPIKHAIQWLYPYSI CCHHHHHHHHHHHHH | 24816145 | ||
| 391 | Phosphorylation | ENHVSQASVTIRIAD HHCCCCEEEEEEECC | - | ||
| 393 | Phosphorylation | HVSQASVTIRIADKE CCCCEEEEEEECCCE | 20860994 | ||
| 399 | Acetylation | VTIRIADKEVTIKVP EEEEECCCEEEEEEC | 25953088 | ||
| 399 | Ubiquitination | VTIRIADKEVTIKVP EEEEECCCEEEEEEC | 24816145 | ||
| 402 | Phosphorylation | RIADKEVTIKVPAGT EECCCEEEEEECCCC | 20860994 | ||
| 493 | Ubiquitination | RYTLPNGDTAWRSSP HCCCCCCCCCHHCCH | 24816145 | ||
| 499 | Phosphorylation | GDTAWRSSPLVNAAL CCCCHHCCHHHHHHH | 30576142 | ||
| 554 | Ubiquitination | EDRYMRLKEELQLSD HHHHHHHHHHHCCCH | 24816145 | ||
| 566 | Acetylation | LSDEQLQKRSIFPIH CCHHHHHHCCCCCCC | 30589685 | ||
| 614 | Phosphorylation | YMKPLVKSEEIQVIK HHHHCCCCHHHHHHH | 28258704 | ||
| 670 | Phosphorylation | LRISRRLSQYPNENL HHHHHHHHCCCCCCH | 22210691 | ||
| 672 | Phosphorylation | ISRRLSQYPNENLHS HHHHHHCCCCCCHHH | 22210691 | ||
| 679 | Phosphorylation | YPNENLHSAVTKACL CCCCCHHHHHHHHHH | 30278072 | ||
| 682 | Phosphorylation | ENLHSAVTKACLSRF CCHHHHHHHHHHHHH | 30278072 | ||
| 687 | Phosphorylation | AVTKACLSRFLPSLA HHHHHHHHHHHHHHH | 30278072 | ||
| 741 | Phosphorylation | GAVSAPIYNAHEKMK EEEECCCCCCCCCCC | 20049867 | ||
| 832 | Phosphorylation | GLIVYEDSPLVKAVK CEEEECCCCHHEEEE | 24719451 | ||
| 855 | N-linked_Glycosylation | EADKAPTNVTCILKT CCCCCCCCCEEEEEH | UniProtKB CARBOHYD | ||
| 901 | Ubiquitination | HPDFRMIVLANRPGF CCCCEEEEEECCCCC | 24816145 | ||
| 918 | Ubiquitination | LGNDFFGTLGDIFSC CCCCCCCCHHHHHCC | 24816145 | ||
| 989 | Acetylation | NIVKHLQKFPTEGLS HHHHHHHHCCCCCHH | 25953088 | ||
| 989 | Malonylation | NIVKHLQKFPTEGLS HHHHHHHHCCCCCHH | 32601280 | ||
| 1030 | Malonylation | YGIPIGAKPTSVQLA CCCCCCCCCCHHHHH | 32601280 | ||
| 1085 | Phosphorylation | ALINIQEYPIERHEE EEEEEEEEECCCCCH | 19835603 | ||
| 1096 | N-linked_Glycosylation | RHEERSLNFTEECAS CCCHHCCCCCHHHHH | UniProtKB CARBOHYD | ||
| 1142 | N-linked_Glycosylation | PASLYFMNMTGKSGF HHHEEEEECCCCCCE | UniProtKB CARBOHYD | ||
| 1211 | Acetylation | RLILPSEKFTSKKPF HHHCCCCCCCCCCCC | 25953088 | ||
| 1235 | Phosphorylation | YKMCKEFSHKNWLVF HHHHHHHCCCCEEEE | - | ||
| 1246 | Acetylation | WLVFYKEKGNSLTVL EEEEEECCCCEEEEE | 25953088 | ||
| 1249 | Phosphorylation | FYKEKGNSLTVLDVL EEECCCCEEEEEEEE | - | ||
| 1286 | Acetylation | KWLLVESKTNQKYLL CEEEEECCCCCCEEE | 25953088 | ||
| 1286 | Malonylation | KWLLVESKTNQKYLL CEEEEECCCCCCEEE | 26320211 | ||
| 1309 | Ubiquitination | EGSGVCQLYVLKEEP CCCCEEEEEEEECCC | 24816145 | ||
| 1400 | Phosphorylation | KRSGTDTSFYRGKKK CCCCCCCCCCCCCCC | - | ||
| 1402 | Phosphorylation | SGTDTSFYRGKKKRG CCCCCCCCCCCCCCC | - | ||
| 1440 | Phosphorylation | EVPLKDIYPKDVTPP CCCHHHCCCCCCCCC | 18083107 | ||
| 1549 | Phosphorylation | RDSGEDVSSPKHGKE CCCCCCCCCCCCCCC | 28985074 | ||
| 1584 | Ubiquitination | DTAGLGGKGGPYRLD CCCCCCCCCCCEECC | 29967540 | ||
| 1603 | Ubiquitination | VYQVSQAEKDAVPEE EEEECHHHHCCCHHH | 24816145 | ||
| 1633 | Phosphorylation | RLKEIQMSEYDAATY HHHHHCCCCCCHHHH | 22210691 | ||
| 1640 | Phosphorylation | SEYDAATYERFSGAV CCCCHHHHHHHHHHH | 22210691 | ||
| 1664 | Ubiquitination | ILDNLQAKGKERQWL HHHHHHHCCHHHHHH | 24816145 | ||
| 1683 | Ubiquitination | TGELDDAKIIDGLTG CCCCCCCEEECCCCC | 29967540 | ||
| 1707 | Phosphorylation | ELEPQLGSPQQKPKR CCCCCCCCCCCCCCC | 23401153 | ||
| 1758 | Phosphorylation | NYEEKFQYDIVGHSG CCHHHCCCEEECCCC | - | ||
| 1791 | Phosphorylation | QRLEILKTMHAHSQF HHHHHHHHHHHHCCH | - | ||
| 1833 | N-linked_Glycosylation | VIVLSDANLSRYGIH EEEEECCCHHHCCCC | UniProtKB CARBOHYD | ||
| 1837 | Phosphorylation | SDANLSRYGIHPAKF ECCCHHHCCCCHHHH | 28102081 | ||
| 1843 | Acetylation | RYGIHPAKFAQILTR HCCCCHHHHHHHHHC | 25953088 | ||
| 1843 | Malonylation | RYGIHPAKFAQILTR HCCCCHHHHHHHHHC | 26320211 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VWA8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VWA8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VWA8_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of VWA8_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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