| UniProt ID | WRP73_HUMAN | |
|---|---|---|
| UniProt AC | Q9P2S5 | |
| Protein Name | WD repeat-containing protein WRAP73 | |
| Gene Name | WRAP73 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 460 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Not | |
| Protein Description | The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. [PubMed: 26545777 Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles] | |
| Protein Sequence | MNFSEVFKLSSLLCKFSPDGKYLASCVQYRLVVRDVNTLQILQLYTCLDQIQHIEWSADSLFILCAMYKRGLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILNTTEFHLRITVWSLCTKSVSYIKYPKACLQGITFTRDGRYMALAERRDCKDYVSIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAVWDTCLEYKILLYSLDGRLLSTYSAYEWSLGIKSVAWSPSSQFLAVGSYDGKVRILNHVTWKMITEFGHPAAINDPKIVVYKEAEKSPQLGLGCLSFPPPRAGAGPLPSSESKYEIASVPVSLQTLKPVTDRANPKIGIGMLAFSPDSYFLATRNDNIPNAVWVWDIQKLRLFAVLEQLSPVRAFQWDPQQPRLAICTGGSRLYLWSPAGCMSVQVPGEGDFAVLSLCWHLSGDSMALLSKDHFCLCFLETEAVVGTACRQLGGHT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Ubiquitination | KLSSLLCKFSPDGKY HHHHHHHHCCCCCCH | 49.17 | - | |
| 21 | Ubiquitination | CKFSPDGKYLASCVQ HHCCCCCCHHHHHEE | 44.46 | - | |
| 117 | Phosphorylation | TEFHLRITVWSLCTK CCEEHHHHHHHHHCC | 14.97 | 22817900 | |
| 120 | Phosphorylation | HLRITVWSLCTKSVS EHHHHHHHHHCCCCH | 14.83 | 22817900 | |
| 123 | Phosphorylation | ITVWSLCTKSVSYIK HHHHHHHCCCCHHCC | 31.48 | 22817900 | |
| 125 | Phosphorylation | VWSLCTKSVSYIKYP HHHHHCCCCHHCCCC | 9.72 | 17322306 | |
| 128 | Phosphorylation | LCTKSVSYIKYPKAC HHCCCCHHCCCCHHH | 10.16 | - | |
| 130 | Ubiquitination | TKSVSYIKYPKACLQ CCCCHHCCCCHHHHC | 47.47 | - | |
| 131 | Phosphorylation | KSVSYIKYPKACLQG CCCHHCCCCHHHHCC | 10.62 | 17322306 | |
| 133 | Ubiquitination | VSYIKYPKACLQGIT CHHCCCCHHHHCCCE | 48.95 | - | |
| 135 | Carbamidation | YIKYPKACLQGITFT HCCCCHHHHCCCEEE | 3.49 | 17322306 | |
| 140 | Phosphorylation | KACLQGITFTRDGRY HHHHCCCEEECCCCE | 26.27 | 17322306 | |
| 159 | Phosphorylation | ERRDCKDYVSIFVCS ECCCCCCCEEEEEEC | 5.00 | - | |
| 161 | Phosphorylation | RDCKDYVSIFVCSDW CCCCCCEEEEEECCH | 12.22 | - | |
| 228 | Phosphorylation | EWSLGIKSVAWSPSS CHHCCCEEEEECCCC | 18.36 | - | |
| 246 (in isoform 1) | Ubiquitination | - | 25.99 | 21906983 | |
| 246 | Ubiquitination | AVGSYDGKVRILNHV EEECCCCCEEEECCE | 25.99 | 21906983 | |
| 271 | Ubiquitination | PAAINDPKIVVYKEA CCCCCCCEEEEEEEC | 51.50 | - | |
| 276 | Ubiquitination | DPKIVVYKEAEKSPQ CCEEEEEEECCCCCC | 38.55 | 21906983 | |
| 276 (in isoform 1) | Ubiquitination | - | 38.55 | 21906983 | |
| 280 | Ubiquitination | VVYKEAEKSPQLGLG EEEEECCCCCCCCCC | 74.59 | - | |
| 281 | Phosphorylation | VYKEAEKSPQLGLGC EEEECCCCCCCCCCC | 14.91 | 27050516 | |
| 307 (in isoform 1) | Ubiquitination | - | 42.74 | 21906983 | |
| 307 | Ubiquitination | PLPSSESKYEIASVP CCCCCCCCEEEEECC | 42.74 | 21890473 | |
| 319 | Phosphorylation | SVPVSLQTLKPVTDR ECCEEECCCCCCCCC | 41.88 | - | |
| 321 | Ubiquitination | PVSLQTLKPVTDRAN CEEECCCCCCCCCCC | 40.61 | 21906983 | |
| 321 (in isoform 1) | Ubiquitination | - | 40.61 | 21906983 | |
| 324 | Phosphorylation | LQTLKPVTDRANPKI ECCCCCCCCCCCCCC | 28.44 | - | |
| 330 | Ubiquitination | VTDRANPKIGIGMLA CCCCCCCCCEEEEEE | 54.06 | 21890473 | |
| 339 | Phosphorylation | GIGMLAFSPDSYFLA EEEEEEECCCCEEEE | 23.38 | - | |
| 363 | Ubiquitination | VWVWDIQKLRLFAVL EEEEEHHHHHHHHHH | 35.59 | 2190698 | |
| 363 (in isoform 1) | Ubiquitination | - | 35.59 | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WRP73_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WRP73_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WRP73_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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