SMAP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMAP1_HUMAN
• UniProt AC: Q8IYB5
• Protein Name: Stromal membrane-associated protein 1
• Gene Name: SMAP1
• Organism: Homo sapiens (Human).
• Sequence Length: 467
• Subcellular Localization: Cell membrane; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity)..
• Protein Sequence: MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTAEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYDKNAIAITNISSSDAPLQPLVSSPSLQAAVDKNKLEKEKEKKKEEKKREKEPEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDDLDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFTSQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLSQMNQQMAGMSISSATPTAGFGQPSSTTAGWSGSSSGQTLSTQLWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MATRSCREKAQK ---CCCHHHHHHHHH	17.11	23532336
12	Malonylation	SCREKAQKLNEQHQL HHHHHHHHHHHHHHH	59.13	26320211
23 (in isoform 3)	Ubiquitination	-	48.36	21890473
23 (in isoform 2)	Ubiquitination	-	48.36	21890473
23 (in isoform 1)	Ubiquitination	-	48.36	21890473
23	Acetylation	QHQLILSKLLREEDN HHHHHHHHHHHHHHC	48.36	26051181
23	Ubiquitination	QHQLILSKLLREEDN HHHHHHHHHHHHHHC	48.36	21890473
31	Acetylation	LLREEDNKYCADCEA HHHHHHCCEECCHHC	54.77	26051181
68	Phosphorylation	RNLGVHISRVKSVNL HHCCEEHHHEEECCH	19.02	20873877
72	Phosphorylation	VHISRVKSVNLDQWT EEHHHEEECCHHHCH	17.24	28857561
79	Phosphorylation	SVNLDQWTAEQIQCM ECCHHHCHHHHHHHH	18.06	28857561
140	Phosphorylation	AIAITNISSSDAPLQ EEEEEECCCCCCCCC	26.34	27732954
141	Phosphorylation	IAITNISSSDAPLQP EEEEECCCCCCCCCH	28.57	27732954
142	Phosphorylation	AITNISSSDAPLQPL EEEECCCCCCCCCHH	30.88	27732954
151	Phosphorylation	APLQPLVSSPSLQAA CCCCHHCCCHHHHHH	44.19	30278072
152	Phosphorylation	PLQPLVSSPSLQAAV CCCHHCCCHHHHHHH	15.84	30278072
154	Phosphorylation	QPLVSSPSLQAAVDK CHHCCCHHHHHHHCH	34.75	30278072
192	Acetylation	AKPLTAEKLQKKDQQ CCCCCHHHHHHHHHH	54.47	23236377
195	Ubiquitination	LTAEKLQKKDQQLEP CCHHHHHHHHHHCCC	69.61	-
205	Phosphorylation	QQLEPKKSTSPKKAA HHCCCCCCCCHHHHC	40.00	26055452
206	Phosphorylation	QLEPKKSTSPKKAAE HCCCCCCCCHHHHCC	58.91	30576142
207	Phosphorylation	LEPKKSTSPKKAAEP CCCCCCCCHHHHCCC	41.64	26055452
215	Phosphorylation	PKKAAEPTVDLLGLD HHHHCCCCEEECCCC	20.39	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMAP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMAP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMAP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
HS71L_HUMAN	HSPA1L	physical	26186194
KLH18_HUMAN	KLHL18	physical	26186194
KLH18_HUMAN	KLHL18	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.