CL16A_HUMAN - dbPTM
CL16A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CL16A_HUMAN
UniProt AC Q2KHT3
Protein Name Protein CLEC16A {ECO:0000305}
Gene Name CLEC16A {ECO:0000312|HGNC:HGNC:29013}
Organism Homo sapiens (Human).
Sequence Length 1053
Subcellular Localization Endosome membrane
Peripheral membrane protein . Lysosome membrane
Peripheral membrane protein . Associates with the endolysosome membrane.
Protein Description Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health..
Protein Sequence MFGRSRSWVGGGHGKTSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVSLDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDDCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSEMYAKTEQDIQRSSAKPSIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPTEDAQEDAEKAKGTEGGSKGIKTSGESEEIEMVIMERSKLSELAASTSVQEQNTTDEEKSAAATCSESTQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPNAAEKTTYNHPLAERLIRIMNNAAQPDGKIRLATLELSCLLLKQQVLMSAGCIMKDVHLACLEGAREESVHLVRHFYKGEDIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSTSTQHLPFRFYDQGRRGSSDPTVQRSVFASVDKVPGFAVAQCINQHSSPSLSSQSPPSASGSPSGSGSTSHCDSGGTSSSSTPSTAQSPADAPMSPELPKPHLPDQLVIVNETEADSKPSKNVARSAAVETASLSPSLVPARQPTISLLCEDTADTLSVESLTLVPPVDPHSLRSLTGMPPLSTPAAACTEPVGEEAACAEPVGTAED
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MFGRSRSWVGGG
---CCCCCCCCCCCC		30.9226657352
7Phosphorylation-MFGRSRSWVGGGHG
-CCCCCCCCCCCCCC		27.6226657352
15UbiquitinationWVGGGHGKTSRNIHS
CCCCCCCCCCCCCCH		37.34-
35MalonylationYLYHVLTKNTTVTEQ
HHHHHHHCCCCCCHH		48.4026320211
53PhosphorylationLLVETIRSITEILIW
HHHHHHHHHHEEEEE		29.97-
144PhosphorylationEIMAYYISFLKTLSL
HHHHHHHHHHHHHHH		14.3824719451
199 (in isoform 2)Ubiquitination-22.51-
356PhosphorylationTEQDIQRSSAKPSIR
HHHHHHHHHCCCCEE		20.4828555341
357UbiquitinationEQDIQRSSAKPSIRC
HHHHHHHHCCCCEEE		42.3629967540
357PhosphorylationEQDIQRSSAKPSIRC
HHHHHHHHCCCCEEE		42.3628555341
359UbiquitinationDIQRSSAKPSIRCFI
HHHHHHCCCCEEEEE		41.0429967540
365 (in isoform 2)Ubiquitination-6.05-
365UbiquitinationAKPSIRCFIKPTETL
CCCCEEEEECCCHHH		6.0529967540
367UbiquitinationPSIRCFIKPTETLER
CCEEEEECCCHHHHH		26.1529967540
371O-linked_GlycosylationCFIKPTETLERSLEM
EEECCCHHHHHHHHH		36.0823301498
380UbiquitinationERSLEMNKHKGKRRV
HHHHHHHCCCCHHCC		45.4424816145
382UbiquitinationSLEMNKHKGKRRVQK
HHHHHCCCCHHCCCC		68.6724816145
404UbiquitinationGEEEDEEKGPTEDAQ
CCHHHHCCCCCHHHH		69.05-
420PhosphorylationDAEKAKGTEGGSKGI
HHHHHHCCCCCCCCC		30.65-
427UbiquitinationTEGGSKGIKTSGESE
CCCCCCCCCCCCCCH		5.1721890473
427 (in isoform 2)Ubiquitination-5.1721890473
429PhosphorylationGGSKGIKTSGESEEI
CCCCCCCCCCCCHHE		39.7930631047
429UbiquitinationGGSKGIKTSGESEEI
CCCCCCCCCCCCHHE		39.7921890473
430PhosphorylationGSKGIKTSGESEEIE
CCCCCCCCCCCHHEE		35.2530631047
433PhosphorylationGIKTSGESEEIEMVI
CCCCCCCCHHEEEEE		44.0228348404
443UbiquitinationIEMVIMERSKLSELA
EEEEEECHHHHHHHH		23.0121890473
445 (in isoform 1)Ubiquitination-63.3521890473
445UbiquitinationMVIMERSKLSELAAS
EEEECHHHHHHHHHC		63.3523000965
452PhosphorylationKLSELAASTSVQEQN
HHHHHHHCCCCCCCC		18.6626074081
453PhosphorylationLSELAASTSVQEQNT
HHHHHHCCCCCCCCC		28.3426074081
454PhosphorylationSELAASTSVQEQNTT
HHHHHCCCCCCCCCC		21.2226074081
460PhosphorylationTSVQEQNTTDEEKSA
CCCCCCCCCHHHHHH		35.0126074081
461PhosphorylationSVQEQNTTDEEKSAA
CCCCCCCCHHHHHHH		49.3026074081
677PhosphorylationFFMLRSLSLQLRGEP
HHHHHHHHHHHCCCC		18.4723403867
796PhosphorylationLQATFIFSDHIRCII
EEEEEECCCHHHHHH		24.3826091039
834PhosphorylationLDLPIQPTTEVLGFG
HCCCCCCCCCEECCC		21.1522210691
835PhosphorylationDLPIQPTTEVLGFGL
CCCCCCCCCEECCCC		30.6827251275
844PhosphorylationVLGFGLGSSTSTQHL
EECCCCCCCCCCCCC		35.1727251275
845PhosphorylationLGFGLGSSTSTQHLP
ECCCCCCCCCCCCCC		25.2833259812
846PhosphorylationGFGLGSSTSTQHLPF
CCCCCCCCCCCCCCE		37.1727251275
847PhosphorylationFGLGSSTSTQHLPFR
CCCCCCCCCCCCCEE		28.1922210691
848PhosphorylationGLGSSTSTQHLPFRF
CCCCCCCCCCCCEEE		21.7922210691
861MethylationRFYDQGRRGSSDPTV
EECCCCCCCCCCCCH		57.05-
863PhosphorylationYDQGRRGSSDPTVQR
CCCCCCCCCCCCHHH		29.7428355574
864PhosphorylationDQGRRGSSDPTVQRS
CCCCCCCCCCCHHHH		50.8925850435
867PhosphorylationRRGSSDPTVQRSVFA
CCCCCCCCHHHHHEE		33.9725850435
971PhosphorylationPSKNVARSAAVETAS
CCHHHHHHHHHHHHC		15.7323403867
976PhosphorylationARSAAVETASLSPSL
HHHHHHHHHCCCCCC		18.2323403867
978PhosphorylationSAAVETASLSPSLVP
HHHHHHHCCCCCCCC		36.4829255136
980PhosphorylationAVETASLSPSLVPAR
HHHHHCCCCCCCCCC		15.2229255136
982PhosphorylationETASLSPSLVPARQP
HHHCCCCCCCCCCCC		38.3329255136
990PhosphorylationLVPARQPTISLLCED
CCCCCCCEEEEEECC		18.1720736484
998PhosphorylationISLLCEDTADTLSVE
EEEEECCCCCCCCEE		12.2528348404
1001PhosphorylationLCEDTADTLSVESLT
EECCCCCCCCEEEEE		20.6128348404
1003PhosphorylationEDTADTLSVESLTLV
CCCCCCCCEEEEEEC		26.4028348404
1006PhosphorylationADTLSVESLTLVPPV
CCCCCEEEEEECCCC		25.2128348404
1008PhosphorylationTLSVESLTLVPPVDP
CCCEEEEEECCCCCH		34.6828348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CL16A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CL16A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CL16A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CL16A_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
222100Diabetes mellitus, insulin-dependent (IDDM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CL16A_HUMAN

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Related Literatures of Post-Translational Modification

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