| UniProt ID | IFT56_HUMAN | |
|---|---|---|
| UniProt AC | A0AVF1 | |
| Protein Name | Intraflagellar transport protein 56 {ECO:0000250|UniProtKB:Q8BS45} | |
| Gene Name | TTC26 {ECO:0000312|HGNC:HGNC:21882} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 554 | |
| Subcellular Localization | Cell projection, cilium . Localizes at the base to the ciliary transition zone. | |
| Protein Description | Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI3 at the ciliary tip and its dissociation from SUFU.. | |
| Protein Sequence | MMLSRAKPAVGRGVQHTDKRKKKGRKIPKLEELLSKRDFTGAITLLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEAELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDDVQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIPGRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEAFLLIQSEKMKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYSAKAFDVLERLDPNPEYWEGKRGACVGIFQMIIAGREPKETLREVLHLLRSTGNTQVEYMIRIMKKWAKENRVSI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Methylation | RAKPAVGRGVQHTDK CCCCCCCCCCCCCCH | 54560381 | ||
| 36 | Ubiquitination | KLEELLSKRDFTGAI CHHHHHCCCCCCCCE | 21906983 | ||
| 44 (in isoform 3) | Phosphorylation | - | - | ||
| 49 (in isoform 3) | Phosphorylation | - | - | ||
| 49 | Ubiquitination | AITLLEFKRHVGEEE CEEHHHHHHHCCCCC | 21906983 | ||
| 116 | Ubiquitination | QAEAAGFKASKSRLQ HHHHHCCCCCHHHHH | - | ||
| 142 | Phosphorylation | NDEKKLMSFHQNLQD CCHHHHHHHHHHHHH | 26552605 | ||
| 151 | Phosphorylation | HQNLQDVTEDQLSLA HHHHHHCCHHHHHHH | 24043423 | ||
| 156 | Phosphorylation | DVTEDQLSLASIHYM HCCHHHHHHHHHHHH | 24043423 | ||
| 159 | Phosphorylation | EDQLSLASIHYMRSH HHHHHHHHHHHHHHH | 24043423 | ||
| 162 | Phosphorylation | LSLASIHYMRSHYQE HHHHHHHHHHHHHHH | 24043423 | ||
| 167 | Phosphorylation | IHYMRSHYQEAIDIY HHHHHHHHHHHHHHH | 18491316 | ||
| 174 | Phosphorylation | YQEAIDIYKRILLDN HHHHHHHHHHHHCCC | 18491316 | ||
| 175 | Ubiquitination | QEAIDIYKRILLDNR HHHHHHHHHHHCCCH | 21906983 | ||
| 243 | Ubiquitination | RAAEAELKSLMDNAS CHHHHHHHHHHHCCC | 21906983 | ||
| 257 | Ubiquitination | SSSFEFAKELIRHNL CCHHHHHHHHHHCCC | 21906983 | ||
| 309 | Ubiquitination | QEAYNLIKDLEPTTP HHHHHHHHCCCCCCC | - | ||
| 314 | Phosphorylation | LIKDLEPTTPQEYIL HHHCCCCCCCHHHHH | 28674419 | ||
| 315 | Phosphorylation | IKDLEPTTPQEYILK HHCCCCCCCHHHHHH | 28674419 | ||
| 319 | Phosphorylation | EPTTPQEYILKGVVN CCCCCHHHHHHHHHH | 28674419 | ||
| 322 | Ubiquitination | TPQEYILKGVVNAAL CCHHHHHHHHHHHHH | - | ||
| 423 | Ubiquitination | FLLIQSEKMKNDYIY EHHEECHHHCCCEEH | 2190698 | ||
| 428 | Phosphorylation | SEKMKNDYIYLSWLA CHHHCCCEEHHHHHH | 26074081 | ||
| 430 | Phosphorylation | KMKNDYIYLSWLARC HHCCCEEHHHHHHHH | 26074081 | ||
| 432 | Phosphorylation | KNDYIYLSWLARCYI CCCEEHHHHHHHHHH | 26074081 | ||
| 438 | Phosphorylation | LSWLARCYIMNKKPR HHHHHHHHHHCCCCC | 26074081 | ||
| 482 | Ubiquitination | GQFYYSAKAFDVLER CCHHHHHHHHHHHHH | - | ||
| 500 | Ubiquitination | NPEYWEGKRGACVGI CHHHHCCCCCCHHHH | - | ||
| 530 | Phosphorylation | EVLHLLRSTGNTQVE HHHHHHHHCCCCHHH | 23403867 | ||
| 531 | Phosphorylation | VLHLLRSTGNTQVEY HHHHHHHCCCCHHHH | 24719451 | ||
| 534 | Phosphorylation | LLRSTGNTQVEYMIR HHHHCCCCHHHHHHH | 23403867 | ||
| 538 | Phosphorylation | TGNTQVEYMIRIMKK CCCCHHHHHHHHHHH | 23403867 | ||
| 553 | Phosphorylation | WAKENRVSI------ HHHHCCCCC------ | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IFT56_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IFT56_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IFT56_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HXK3_HUMAN | HK3 | physical | 26186194 | |
| ZN579_HUMAN | ZNF579 | physical | 26186194 | |
| UBX10_HUMAN | UBXN10 | physical | 26389662 | |
| TERA_HUMAN | VCP | physical | 26389662 | |
| UFD1_HUMAN | UFD1L | physical | 26389662 | |
| NPL4_HUMAN | NPLOC4 | physical | 26389662 | |
| HXK3_HUMAN | HK3 | physical | 28514442 | |
| IFT46_HUMAN | IFT46 | physical | 27173435 | |
| IFT52_HUMAN | IFT52 | physical | 27173435 | |
| IFT25_HUMAN | HSPB11 | physical | 27173435 | |
| IFT27_HUMAN | IFT27 | physical | 27173435 | |
| IFT74_HUMAN | IFT74 | physical | 27173435 | |
| IFT22_HUMAN | IFT22 | physical | 27173435 | |
| IF172_HUMAN | IFT172 | physical | 27173435 | |
| IFT20_HUMAN | IFT20 | physical | 27173435 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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