| UniProt ID | HXK3_HUMAN | |
|---|---|---|
| UniProt AC | P52790 | |
| Protein Name | Hexokinase-3 | |
| Gene Name | HK3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 923 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MDSIGSSGLRQGEETLSCSEEGLPGPSDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTEQGDFVVLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRRQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGRVCVSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLARCGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLAPECDVSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRLAQLTRV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 67 | Phosphorylation | QALRGQASPAPAVRM HHHCCCCCCCCHHHC | 17.44 | 28450419 | |
| 191 | Phosphorylation | WTKGFRCSGVEGQDV CCCCCCCCCCCCHHH | 41.43 | 24719451 | |
| 298 | Phosphorylation | DHTLDHESLNPGAQR CCCCCHHHCCHHHHH | 29.99 | 24719451 | |
| 408 | Phosphorylation | AALAAVLSCLQHSRE HHHHHHHHHHHHCHH | 13.24 | - | |
| 677 | Methylation | SCGYEDPRCEIGLIV CCCCCCCCCEEEEEE | 42.92 | 115385891 | |
| 728 | Phosphorylation | DGSLAMLSTRFDASV CCCEEEEEECCCCCC | 12.40 | 24719451 | |
| 749 | Ubiquitination | PGKQRFEKMISGMYL CCHHHHHHHHCHHHH | 38.53 | - | |
| 752 | Phosphorylation | QRFEKMISGMYLGEI HHHHHHHCHHHHHHH | 17.63 | - | |
| 755 | Phosphorylation | EKMISGMYLGEIVRH HHHHCHHHHHHHHHH | 18.32 | - | |
| 871 | Phosphorylation | VGVDGTLYKLHPRFS ECCCCCEEECCHHHH | 16.02 | 27762562 | |
| 878 | Phosphorylation | YKLHPRFSSLVAATV EECCHHHHHHHHHHH | 24.84 | 23612710 | |
| 879 | Phosphorylation | KLHPRFSSLVAATVR ECCHHHHHHHHHHHH | 24.93 | 23612710 | |
| 903 | Phosphorylation | FLQSEDGSGKGAALV EEECCCCCCHHHHHH | 50.05 | 28509920 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HXK3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HXK3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HXK3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MITF_HUMAN | MITF | physical | 21988832 | |
| PP2AB_HUMAN | PPP2CB | physical | 21988832 | |
| HKDC1_HUMAN | HKDC1 | physical | 28514442 | |
| HXK2_HUMAN | HK2 | physical | 28514442 | |
| HXK1_HUMAN | HK1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
