HXK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXK2_HUMAN
• UniProt AC: P52789
• Protein Name: Hexokinase-2
• Gene Name: HK2
• Organism: Homo sapiens (Human).
• Sequence Length: 917
• Subcellular Localization: Mitochondrion outer membrane. Its hydrophobic N-terminal sequence may be involved in membrane binding..
• Protein Sequence: MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MIASHLLA -------CCHHHHHH	5.36	25944712
4	Phosphorylation	----MIASHLLAYFF ----CCHHHHHHHHH	12.07	23401153
9	Phosphorylation	IASHLLAYFFTELNH CHHHHHHHHHHHCCH	10.13	-
13	Ubiquitination	LLAYFFTELNHDQVQ HHHHHHHHCCHHHHH	42.28	32015554
25	Phosphorylation	QVQKVDQYLYHMRLS HHHHHHHHHHHCCCC	12.55	23401153
41	Ubiquitination	ETLLEISKRFRKEME HHHHHHHHHHHHHHH	62.31	21906983
45	Ubiquitination	EISKRFRKEMEKGLG HHHHHHHHHHHHCCC	59.71	22817900
49	Ubiquitination	RFRKEMEKGLGATTH HHHHHHHHCCCCCCC	59.11	29967540
62	Ubiquitination	THPTAAVKMLPTFVR CCCHHHHHCCCEEEE	29.96	20972266
104	Ubiquitination	VTDNGLQKVEMENQI ECCCCCEEEEEECCE	45.25	21906983
112	Phosphorylation	VEMENQIYAIPEDIM EEEECCEEECCHHHH	6.68	28796482
122	Phosphorylation	PEDIMRGSGTQLFDH CHHHHCCCCCHHHHH	28.44	29496963
124	Phosphorylation	DIMRGSGTQLFDHIA HHHCCCCCHHHHHHH	24.64	28450419
147	Ubiquitination	KLQIKDKKLPLGFTF HHCCCCCCCCCCEEE	66.52	-
153	Phosphorylation	KKLPLGFTFSFPCHQ CCCCCCEEEEEECCC	19.30	-
155	Phosphorylation	LPLGFTFSFPCHQTK CCCCEEEEEECCCCC	25.81	28348404
166	Phosphorylation	HQTKLDESFLVSWTK CCCCCCHHHEEEECC	24.44	27499020
173	Ubiquitination	SFLVSWTKGFKSSGV HHEEEECCCCHHCCC	56.97	21906983
176	Ubiquitination	VSWTKGFKSSGVEGR EEECCCCHHCCCCCH	52.99	22817900
238	Phosphorylation	GTGSNACYMEEMRHI ECCCCCCCHHHHCCC	12.73	-
258	Ubiquitination	DEGRMCINMEWGAFG CCCEEEEEEEEEECC	19.86	22817900
262	Ubiquitination	MCINMEWGAFGDDGS EEEEEEEEECCCCCC	9.56	29901268
263	Ubiquitination	CINMEWGAFGDDGSL EEEEEEEECCCCCCH	13.31	22817900
280	Ubiquitination	IRTEFDQEIDMGSLN HHHHCHHCCCCCCCC	42.68	23000965
283	Ubiquitination	EFDQEIDMGSLNPGK HCHHCCCCCCCCCCH	4.89	23000965
284	Ubiquitination	FDQEIDMGSLNPGKQ CHHCCCCCCCCCCHH	25.82	32142685
290	Ubiquitination	MGSLNPGKQLFEKMI CCCCCCCHHHHHHHH	45.12	21906983
291	Ubiquitination	GSLNPGKQLFEKMIS CCCCCCHHHHHHHHH	58.25	22817900
295	Ubiquitination	PGKQLFEKMISGMYM CCHHHHHHHHHCCHH	33.91	22817900
301	Phosphorylation	EKMISGMYMGELVRL HHHHHCCHHHHHHHH	12.90	22817900
305	Ubiquitination	SGMYMGELVRLILVK HCCHHHHHHHHHHHH	1.94	22817900
309	Ubiquitination	MGELVRLILVKMAKE HHHHHHHHHHHHHHH	2.66	32142685
312	Ubiquitination	LVRLILVKMAKEELL HHHHHHHHHHHHHHH	29.69	23000965
314	Ubiquitination	RLILVKMAKEELLFG HHHHHHHHHHHHHHC	15.47	24816145
315	Ubiquitination	LILVKMAKEELLFGG HHHHHHHHHHHHHCC	48.50	23000965
323	Ubiquitination	EELLFGGKLSPELLN HHHHHCCCCCHHHHH	46.28	21906983
325	Phosphorylation	LLFGGKLSPELLNTG HHHCCCCCHHHHHCC	21.58	21406692
331	Phosphorylation	LSPELLNTGRFETKD CCHHHHHCCCCCCCC	29.69	24719451
336	Phosphorylation	LNTGRFETKDISDIE HHCCCCCCCCHHHCC	31.16	21406692
337	Ubiquitination	NTGRFETKDISDIEG HCCCCCCCCHHHCCC	45.96	21906983
340	Phosphorylation	RFETKDISDIEGEKD CCCCCCHHHCCCCCC	42.54	20873877
346	Acetylation	ISDIEGEKDGIRKAR HHHCCCCCCHHHHHH	72.60	27452117
346	Ubiquitination	ISDIEGEKDGIRKAR HHHCCCCCCHHHHHH	72.60	24816145
368	Glutathionylation	LDPTQEDCVATHRIC CCCCHHHHHHHHHHH	1.90	22555962
382	Phosphorylation	CQIVSTRSASLCAAT HHHHCCCCHHHHHHH	23.46	20873877
384	Phosphorylation	IVSTRSASLCAATLA HHCCCCHHHHHHHHH	25.81	20873877
386	Ubiquitination	STRSASLCAATLAAV CCCCHHHHHHHHHHH	1.93	22817900
387	Ubiquitination	TRSASLCAATLAAVL CCCHHHHHHHHHHHH	14.58	22817900
389	Phosphorylation	SASLCAATLAAVLQR CHHHHHHHHHHHHHH	9.82	24719451
401	Ubiquitination	LQRIKENKGEERLRS HHHHHHCCCHHHHHH	69.64	29967540
408	Phosphorylation	KGEERLRSTIGVDGS CCHHHHHHHCCCCCC	29.03	25072903
409	Phosphorylation	GEERLRSTIGVDGSV CHHHHHHHCCCCCCH	18.47	25072903
415	Phosphorylation	STIGVDGSVYKKHPH HHCCCCCCHHHHCHH	20.15	21815630
417	Phosphorylation	IGVDGSVYKKHPHFA CCCCCCHHHHCHHHH	18.93	25072903
418	Acetylation	GVDGSVYKKHPHFAK CCCCCHHHHCHHHHH	42.31	25953088
418	Ubiquitination	GVDGSVYKKHPHFAK CCCCCHHHHCHHHHH	42.31	21906983
419	Ubiquitination	VDGSVYKKHPHFAKR CCCCHHHHCHHHHHH	44.68	22817900
445	Phosphorylation	CDVRFLRSEDGSGKG CCEEEEECCCCCCHH	42.03	20873877
449	Phosphorylation	FLRSEDGSGKGAAMV EEECCCCCCHHHHHH	50.05	20873877
451	Ubiquitination	RSEDGSGKGAAMVTA ECCCCCCHHHHHHHH	47.26	21906983
455	Sulfoxidation	GSGKGAAMVTAVAYR CCCHHHHHHHHHHHH	2.46	30846556
456	Ubiquitination	SGKGAAMVTAVAYRL CCHHHHHHHHHHHHH	2.39	22817900
457	Phosphorylation	GKGAAMVTAVAYRLA CHHHHHHHHHHHHHH	11.43	24719451
460	Ubiquitination	AAMVTAVAYRLADQH HHHHHHHHHHHHHHH	4.93	22817900
461	Phosphorylation	AMVTAVAYRLADQHR HHHHHHHHHHHHHHH	10.28	24927040
469	Ubiquitination	RLADQHRARQKTLEH HHHHHHHHHHHHHHH	19.01	27667366
472	Ubiquitination	DQHRARQKTLEHLQL HHHHHHHHHHHHHCC	49.91	29967540
473	Phosphorylation	QHRARQKTLEHLQLS HHHHHHHHHHHHCCC	29.10	-
488	Ubiquitination	HDQLLEVKRRMKVEM HHHHHHHHHHHHHHH	25.55	21906983
492	Ubiquitination	LEVKRRMKVEMERGL HHHHHHHHHHHHHCC	32.98	22817900
501	Ubiquitination	EMERGLSKETHASAP HHHHCCCCCCCCCCC	72.22	27667366
506	Phosphorylation	LSKETHASAPVKMLP CCCCCCCCCCCCCCC	26.04	-
510	Ubiquitination	THASAPVKMLPTYVC CCCCCCCCCCCEEEE	33.39	29967540
514	Phosphorylation	APVKMLPTYVCATPD CCCCCCCEEEEECCC	25.32	-
515	Phosphorylation	PVKMLPTYVCATPDG CCCCCCEEEEECCCC	7.50	27642862
519	Phosphorylation	LPTYVCATPDGTEKG CCEEEEECCCCCCCC	19.45	27050516
525	Ubiquitination	ATPDGTEKGDFLALD ECCCCCCCCCEEEEE	64.71	-
624	Ubiquitination	LKWTKGFKASGCEGE HHHHCCCHHCCCCCC	50.76	29967540
628	Glutathionylation	KGFKASGCEGEDVVT CCCHHCCCCCCHHHH	5.86	22555962
638	Acetylation	EDVVTLLKEAIHRRE CHHHHHHHHHHHHCC	48.49	27452117
638	Ubiquitination	EDVVTLLKEAIHRRE CHHHHHHHHHHHHCC	48.49	29967540
686	Phosphorylation	GTGSNACYMEEMRNV ECCCCCHHHHHHCCC	12.73	-
706	Ubiquitination	EEGRMCVNMEWGAFG CCCEEEEEECEECCC	20.09	22817900
711	Ubiquitination	CVNMEWGAFGDNGCL EEEECEECCCCCCCC	13.31	22817900
727	Ubiquitination	DFRTEFDVAVDELSL HHHHHCHHHHHHHCC	7.31	22817900
731	Ubiquitination	EFDVAVDELSLNPGK HCHHHHHHHCCCCCH	33.39	23503661
732	Ubiquitination	FDVAVDELSLNPGKQ CHHHHHHHCCCCCHH	6.46	22817900
738	Ubiquitination	ELSLNPGKQRFEKMI HHCCCCCHHHHHHHH	39.29	21906983
743	Ubiquitination	PGKQRFEKMISGMYL CCHHHHHHHHCHHHH	38.53	22817900
746	Phosphorylation	QRFEKMISGMYLGEI HHHHHHHCHHHHHHH	17.63	-
749	Phosphorylation	EKMISGMYLGEIVRN HHHHCHHHHHHHHHH	18.32	-
752	Ubiquitination	ISGMYLGEIVRNILI HCHHHHHHHHHHHHH	35.40	23503661
753	Ubiquitination	SGMYLGEIVRNILID CHHHHHHHHHHHHHH	3.15	23503661
757	Ubiquitination	LGEIVRNILIDFTKR HHHHHHHHHHHHHHC	2.21	32142685
759	Ubiquitination	EIVRNILIDFTKRGL HHHHHHHHHHHHCCE	3.47	22817900
762	Phosphorylation	RNILIDFTKRGLLFR HHHHHHHHHCCEECC	18.98	21406692
763	Ubiquitination	NILIDFTKRGLLFRG HHHHHHHHCCEECCC	44.45	23503661
764	Ubiquitination	ILIDFTKRGLLFRGR HHHHHHHCCEECCCC	37.62	22817900
774	Ubiquitination	LFRGRISERLKTRGI ECCCCHHHHHHHCCC	60.71	23503661
778	O-linked_Glycosylation	RISERLKTRGIFETK CHHHHHHHCCCCHHH	38.43	30379171
784	Ubiquitination	KTRGIFETKFLSQIE HHCCCCHHHHHHHHH	19.15	23503661
785	Ubiquitination	TRGIFETKFLSQIES HCCCCHHHHHHHHHH	36.79	32142685
806	Ubiquitination	QVRAILQHLGLESTC HHHHHHHHCCCCCCC	20.58	23503661
813	Glutathionylation	HLGLESTCDDSIIVK HCCCCCCCCCCCHHH	8.34	22555962
834	Ubiquitination	ARRAAQLCGAGMAAV HHHHHHHHCCCHHHH	2.03	22817900
855	Ubiquitination	NRGLDALKVTVGVDG CCCCCCEEEEECCCC	37.27	22817900
857	Phosphorylation	GLDALKVTVGVDGTL CCCCEEEEECCCCCE	15.23	23403867
863	Phosphorylation	VTVGVDGTLYKLHPH EEECCCCCEEECCHH	23.58	23403867
865	Phosphorylation	VGVDGTLYKLHPHFA ECCCCCEEECCHHHH	16.02	23403867
866	Ubiquitination	GVDGTLYKLHPHFAK CCCCCEEECCHHHHH	43.35	22817900
873	Ubiquitination	KLHPHFAKVMHETVK ECCHHHHHHHHHHHH	38.86	29967540
878	Phosphorylation	FAKVMHETVKDLAPK HHHHHHHHHHHHCCC	20.41	22210691
885	Ubiquitination	TVKDLAPKCDVSFLQ HHHHHCCCCCEEEEE	37.14	29967540
887	Ubiquitination	KDLAPKCDVSFLQSE HHHCCCCCEEEEECC	45.26	22817900
893	Phosphorylation	CDVSFLQSEDGSGKG CCEEEEECCCCCCHH	39.54	28985074
897	Phosphorylation	FLQSEDGSGKGAALI EEECCCCCCHHHHHH	50.05	-
899	Ubiquitination	QSEDGSGKGAALITA ECCCCCCHHHHHHHH	47.26	29967540
905	Phosphorylation	GKGAALITAVACRIR CHHHHHHHHHHHHHH	18.87	-
909	Glutathionylation	ALITAVACRIREAGQ HHHHHHHHHHHHHCC	2.74	22555962

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
473	T	Phosphorylation	Kinase	AKT1	P31749	PSP
473	T	Phosphorylation	Kinase	PIM2	Q9P1W9	PSP
686	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBQL1_HUMAN	UBQLN1	physical	16189514
NUDC3_HUMAN	NUDCD3	physical	22939629
PYGL_HUMAN	PYGL	physical	22863883
MAGAC_HUMAN	MAGEA12	physical	25416956
UBQL1_HUMAN	UBQLN1	physical	25416956
CNBP_HUMAN	CNBP	physical	26344197
SYMC_HUMAN	MARS	physical	26344197
SEP10_HUMAN	SEPT10	physical	26344197
SEPT6_HUMAN	SEPT6	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.