dbPTM

PYGL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PYGL_HUMAN
UniProt AC	P06737
Protein Name	Glycogen phosphorylase, liver form
Gene Name	PYGL
Organism	Homo sapiens (Human).
Sequence Length	847
Subcellular Localization
Protein Description	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties..
Protein Sequence	MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAKPLTDQE ------CCCCCCHHH	23.36	19413330
3	Acetylation	-----MAKPLTDQEK -----CCCCCCHHHH	38.98	26822725
3	Ubiquitination	-----MAKPLTDQEK -----CCCCCCHHHH	38.98	33845483
6	Phosphorylation	--MAKPLTDQEKRRQ --CCCCCCHHHHHHC	44.13	29255136
10	2-Hydroxyisobutyrylation	KPLTDQEKRRQISIR CCCCHHHHHHCCCHH	47.44	-
10	Ubiquitination	KPLTDQEKRRQISIR CCCCHHHHHHCCCHH	47.44	27667366
15	Phosphorylation	QEKRRQISIRGIVGV HHHHHCCCHHHEECC	9.63	26329039
29	2-Hydroxyisobutyrylation	VENVAELKKSFNRHL CCCHHHHHHHHCCCE	37.57	-
29	Acetylation	VENVAELKKSFNRHL CCCHHHHHHHHCCCE	37.57	23954790
29	Malonylation	VENVAELKKSFNRHL CCCHHHHHHHHCCCE	37.57	26320211
29	Ubiquitination	VENVAELKKSFNRHL CCCHHHHHHHHCCCE	37.57	21906983
30	Ubiquitination	ENVAELKKSFNRHLH CCHHHHHHHHCCCEE	73.27	22817900
31	Phosphorylation	NVAELKKSFNRHLHF CHHHHHHHHCCCEEE	26.60	29514088
39	Phosphorylation	FNRHLHFTLVKDRNV HCCCEEEEEECCCCC	21.64	23879269
42	Ubiquitination	HLHFTLVKDRNVATT CEEEEEECCCCCCCH	54.83	21906983
52	Phosphorylation	NVATTRDYYFALAHT CCCCHHHHHHHHHHH	9.37	28152594
53	Phosphorylation	VATTRDYYFALAHTV CCCHHHHHHHHHHHH	6.15	28152594
59	Phosphorylation	YYFALAHTVRDHLVG HHHHHHHHHHHHHHH	16.19	23879269
71	Phosphorylation	LVGRWIRTQQHYYDK HHHHHHHHCCHHHHC	24.36	28331001
75	Phosphorylation	WIRTQQHYYDKCPKR HHHHCCHHHHCCCCE	14.71	21253578
76	Phosphorylation	IRTQQHYYDKCPKRV HHHCCHHHHCCCCEE	13.55	27259358
78	Ubiquitination	TQQHYYDKCPKRVYY HCCHHHHCCCCEEEE	35.99	21963094
81	Ubiquitination	HYYDKCPKRVYYLSL HHHHCCCCEEEEEEE	65.06	22817900
82	Methylation	YYDKCPKRVYYLSLE HHHCCCCEEEEEEEE	13.55	54558411
84	Phosphorylation	DKCPKRVYYLSLEFY HCCCCEEEEEEEEEH	11.61	-
85	Phosphorylation	KCPKRVYYLSLEFYM CCCCEEEEEEEEEHH	6.22	-
87	Phosphorylation	PKRVYYLSLEFYMGR CCEEEEEEEEEHHCC	15.10	-
91	Phosphorylation	YYLSLEFYMGRTLQN EEEEEEEHHCCCHHH	6.84	-
114	Phosphorylation	NACDEAIYQLGLDIE HHHHHHHHHCCCCHH	12.53	-
136	Ubiquitination	DAGLGNGGLGRLAAC HCCCCCCHHHHHHHH	29.02	23000965
158	Ubiquitination	LGLAAYGYGIRYEYG HHHHHHCCCCEEEEE	9.19	21890473
164	Phosphorylation	GYGIRYEYGIFNQKI CCCCEEEEEECCCCC	13.44	29496907
170	Ubiquitination	EYGIFNQKIRDGWQV EEEECCCCCCCCCEE	40.59	21890473
170	Ubiquitination	EYGIFNQKIRDGWQV EEEECCCCCCCCCEE	40.59	23000965
172	Ubiquitination	GIFNQKIRDGWQVEE EECCCCCCCCCEEEE	43.34	21963094
186	Phosphorylation	EADDWLRYGNPWEKS ECCCHHHCCCCCHHC	21.05	22817900
192	Ubiquitination	RYGNPWEKSRPEFML HCCCCCHHCCCCCEE	48.15	21890473
192	Ubiquitination	RYGNPWEKSRPEFML HCCCCCHHCCCCCEE	48.15	21906983
193	Phosphorylation	YGNPWEKSRPEFMLP CCCCCHHCCCCCEEE	41.37	24670416
204	Phosphorylation	FMLPVHFYGKVEHTN CEEEEEEEEEEEECC	10.93	29496907
206	Ubiquitination	LPVHFYGKVEHTNTG EEEEEEEEEEECCCC	32.82	21906983
215	Ubiquitination	EHTNTGTKWIDTQVV EECCCCCCEEEEEEE	43.42	21890473
227	Phosphorylation	QVVLALPYDTPVPGY EEEEEECCCCCCCCC	33.04	-
248	Methylation	TMRLWSARAPNDFNL HHHHCCCCCCCCCCC	45.09	115489739
256	Ubiquitination	APNDFNLRDFNVGDY CCCCCCCCCCCHHHH	47.80	23000965
261	Ubiquitination	NLRDFNVGDYIQAVL CCCCCCHHHHHHHHH	24.10	23000965
263	Phosphorylation	RDFNVGDYIQAVLDR CCCCHHHHHHHHHCH	6.76	27642862
277	Phosphorylation	RNLAENISRVLYPND HHHHHHHHCCCCCCC	28.11	26437602
281	Phosphorylation	ENISRVLYPNDNFFE HHHHCCCCCCCCCCC	9.35	28152594
282	Ubiquitination	NISRVLYPNDNFFEG HHHCCCCCCCCCCCC	37.22	29967540
290	Ubiquitination	NDNFFEGKELRLKQE CCCCCCCCCEECCCE	46.51	23000965
295	Ubiquitination	EGKELRLKQEYFVVA CCCCEECCCEEEHHE	34.35	23000965
298	Phosphorylation	ELRLKQEYFVVAATL CEECCCEEEHHEHHH	10.12	21406692
304	Phosphorylation	EYFVVAATLQDIIRR EEEHHEHHHHHHHHH	18.40	21406692
316	Ubiquitination	IRRFKASKFGSTRGA HHHHHHHHCCCCCCC	59.61	29967540
325	Ubiquitination	GSTRGAGTVFDAFPD CCCCCCCCEECCCCC	19.91	22817900
330	Ubiquitination	AGTVFDAFPDQVAIQ CCCEECCCCCEEEEE	8.04	21890473
337	Ubiquitination	FPDQVAIQLNDTHPA CCCEEEEECCCCCHH	25.19	21963094
359	2-Hydroxyisobutyrylation	RIFVDIEKLPWSKAW HHHCCHHHCCHHHHH	61.25	-
359	Ubiquitination	RIFVDIEKLPWSKAW HHHCCHHHCCHHHHH	61.25	21906983
361	Ubiquitination	FVDIEKLPWSKAWEL HCCHHHCCHHHHHHH	44.34	21890473
363	Phosphorylation	DIEKLPWSKAWELTQ CHHHCCHHHHHHHHH	15.57	27251275
364	Ubiquitination	IEKLPWSKAWELTQK HHHCCHHHHHHHHHH	54.36	21890473
364	Succinylation	IEKLPWSKAWELTQK HHHCCHHHHHHHHHH	54.36	-
364	Succinylation	IEKLPWSKAWELTQK HHHCCHHHHHHHHHH	54.36	21890473
364	Ubiquitination	IEKLPWSKAWELTQK HHHCCHHHHHHHHHH	54.36	22817900
371	Ubiquitination	KAWELTQKTFAYTNH HHHHHHHHHHCCCCC	40.13	21906983
376	Phosphorylation	TQKTFAYTNHTVLPE HHHHHCCCCCCCCHH	19.66	29496907
376	Ubiquitination	TQKTFAYTNHTVLPE HHHHHCCCCCCCCHH	19.66	21963094
387	Ubiquitination	VLPEALERWPVDLVE CCHHHHHHCCHHHHH	43.80	23000965
395	Ubiquitination	WPVDLVEKLLPRHLE CCHHHHHHHHHHHHH	48.09	21890473
395	Ubiquitination	WPVDLVEKLLPRHLE CCHHHHHHHHHHHHH	48.09	22817900
404	Ubiquitination	LPRHLEIIYEINQKH HHHHHHHHHHHCHHH	1.52	22817900
405	Phosphorylation	PRHLEIIYEINQKHL HHHHHHHHHHCHHHH	19.20	28152594
410	Ubiquitination	IIYEINQKHLDRIVA HHHHHCHHHHHHHHH	41.46	21906983
414	Methylation	INQKHLDRIVALFPK HCHHHHHHHHHHCCC	31.47	115489731
421	Ubiquitination	RIVALFPKDVDRLRR HHHHHCCCCHHHHHH	64.15	21890473
421	Acetylation	RIVALFPKDVDRLRR HHHHHCCCCHHHHHH	64.15	23236377
421	Malonylation	RIVALFPKDVDRLRR HHHHHCCCCHHHHHH	64.15	26320211
421	Ubiquitination	RIVALFPKDVDRLRR HHHHHCCCCHHHHHH	64.15	23000965
430	Phosphorylation	VDRLRRMSLIEEEGS HHHHHHHHHHCHHHC	25.12	27273156
431	Ubiquitination	DRLRRMSLIEEEGSK HHHHHHHHHCHHHCC	4.11	22817900
433	Ubiquitination	LRRMSLIEEEGSKRI HHHHHHHCHHHCCCE	56.12	22817900
436	Ubiquitination	MSLIEEEGSKRINMA HHHHCHHHCCCEEEC	41.57	22817900
437	Phosphorylation	SLIEEEGSKRINMAH HHHCHHHCCCEEECC	23.26	28102081
438	Ubiquitination	LIEEEGSKRINMAHL HHCHHHCCCEEECCE	69.06	21906983
445	Ubiquitination	KRINMAHLCIVGSHA CCEEECCEEEECHHH	1.22	22817900
449	Ubiquitination	MAHLCIVGSHAVNGV ECCEEEECHHHHCCC	8.19	27667366
450	Phosphorylation	AHLCIVGSHAVNGVA CCEEEECHHHHCCCH	9.44	-
465	Ubiquitination	KIHSDIVKTKVFKDF HHCHHHHCCCEECCH	42.85	21906983
467	Ubiquitination	HSDIVKTKVFKDFSE CHHHHCCCEECCHHH	39.70	22817900
470	Acetylation	IVKTKVFKDFSELEP HHCCCEECCHHHCCC	61.93	20167786
470	Ubiquitination	IVKTKVFKDFSELEP HHCCCEECCHHHCCC	61.93	21906983
473	Phosphorylation	TKVFKDFSELEPDKF CCEECCHHHCCCHHH	51.94	-
479	Ubiquitination	FSELEPDKFQNKTNG HHHCCCHHHCCCCCC	60.61	21906983
480	Ubiquitination	SELEPDKFQNKTNGI HHCCCHHHCCCCCCC	14.61	23000965
483	Ubiquitination	EPDKFQNKTNGITPR CCHHHCCCCCCCCHH	32.36	21890473
483	Ubiquitination	EPDKFQNKTNGITPR CCHHHCCCCCCCCHH	32.36	21906983
484	Phosphorylation	PDKFQNKTNGITPRR CHHHCCCCCCCCHHH	46.34	26437602
487	Ubiquitination	FQNKTNGITPRRWLL HCCCCCCCCHHHHHH	5.34	21963094
505	Ubiquitination	PGLAELIAEKIGEDY CCHHHHHHHHHCCCH	25.34	23503661
509	Ubiquitination	ELIAEKIGEDYVKDL HHHHHHHCCCHHHCH	32.56	22817900
511	Ubiquitination	IAEKIGEDYVKDLSQ HHHHHCCCHHHCHHH	48.60	22817900
514	Ubiquitination	KIGEDYVKDLSQLTK HHCCCHHHCHHHHHH	46.88	23000965
517	Phosphorylation	EDYVKDLSQLTKLHS CCHHHCHHHHHHHHH	33.02	21712546
521	Ubiquitination	KDLSQLTKLHSFLGD HCHHHHHHHHHHHCC	53.44	21906983
523	Ubiquitination	LSQLTKLHSFLGDDV HHHHHHHHHHHCCHH	20.33	22817900
524	Phosphorylation	SQLTKLHSFLGDDVF HHHHHHHHHHCCHHH	32.38	24275569
535	Ubiquitination	DDVFLRELAKVKQEN CHHHHHHHHHHHHHC	4.52	22817900
539	Ubiquitination	LRELAKVKQENKLKF HHHHHHHHHHCCCCH	51.71	23503661
541	Ubiquitination	ELAKVKQENKLKFSQ HHHHHHHHCCCCHHH	51.09	23503661
543	Ubiquitination	AKVKQENKLKFSQFL HHHHHHCCCCHHHHH	52.91	22817900
545	Ubiquitination	VKQENKLKFSQFLET HHHHCCCCHHHHHCE	44.58	21906983
547	Phosphorylation	QENKLKFSQFLETEY HHCCCCHHHHHCEEE	20.59	21406692
552	Phosphorylation	KFSQFLETEYKVKIN CHHHHHCEEEEEECC	46.92	21406692
554	Phosphorylation	SQFLETEYKVKINPS HHHHCEEEEEECCHH	28.62	21406692
555	Ubiquitination	QFLETEYKVKINPSS HHHCEEEEEECCHHH	30.71	21890473
555	Ubiquitination	QFLETEYKVKINPSS HHHCEEEEEECCHHH	30.71	21906983
557	Ubiquitination	LETEYKVKINPSSMF HCEEEEEECCHHHCC	32.39	21906983
561	Phosphorylation	YKVKINPSSMFDVQV EEEECCHHHCCCEEH	29.91	25072903
562	Phosphorylation	KVKINPSSMFDVQVK EEECCHHHCCCEEHH	25.40	25072903
563	Ubiquitination	VKINPSSMFDVQVKR EECCHHHCCCEEHHH	3.79	27667366
569	Ubiquitination	SMFDVQVKRIHEYKR HCCCEEHHHHHHHHH	28.66	21906983
574	Phosphorylation	QVKRIHEYKRQLLNC EHHHHHHHHHHHHHH	9.41	26437602
575	Acetylation	VKRIHEYKRQLLNCL HHHHHHHHHHHHHHH	30.59	7822987
575	Ubiquitination	VKRIHEYKRQLLNCL HHHHHHHHHHHHHHH	30.59	22817900
586	Phosphorylation	LNCLHVITMYNRIKK HHHHHHHHHHHHHCC	16.71	28509920
588	Phosphorylation	CLHVITMYNRIKKDP HHHHHHHHHHHCCCH	7.82	28509920
597	Ubiquitination	RIKKDPKKLFVPRTV HHCCCHHHCCCCCEE	53.17	27667366
603	Phosphorylation	KKLFVPRTVIIGGKA HHCCCCCEEEECCCC	15.24	29083192
606	Ubiquitination	FVPRTVIIGGKAAPG CCCCEEEECCCCCCC	5.31	22817900
608	Ubiquitination	PRTVIIGGKAAPGYH CCEEEECCCCCCCHH	13.16	22817900
609	Ubiquitination	RTVIIGGKAAPGYHM CEEEECCCCCCCHHH	35.84	21906983
614	Phosphorylation	GGKAAPGYHMAKMII CCCCCCCHHHHHHHH	6.33	26356563
622	Ubiquitination	HMAKMIIKLITSVAD HHHHHHHHHHHHHHH	23.94	22817900
626	Phosphorylation	MIIKLITSVADVVNN HHHHHHHHHHHHHCC	14.33	27251275
639	Phosphorylation	NNDPMVGSKLKVIFL CCCCCCCCEEEEEEE	24.33	28258704
640	Ubiquitination	NDPMVGSKLKVIFLE CCCCCCCEEEEEEEE	46.53	21906983
642	Ubiquitination	PMVGSKLKVIFLENY CCCCCEEEEEEEECC	36.70	22817900
656	Ubiquitination	YRVSLAEKVIPATDL CCHHHHHHEEECCCH	39.60	21906983
661	Phosphorylation	AEKVIPATDLSEQIS HHHEEECCCHHHHHC	31.92	21406692
664	Phosphorylation	VIPATDLSEQISTAG EEECCCHHHHHCCCC	30.20	21406692
668	Phosphorylation	TDLSEQISTAGTEAS CCHHHHHCCCCCCCC	16.34	21406692
669	Phosphorylation	DLSEQISTAGTEASG CHHHHHCCCCCCCCC	30.64	21406692
672	Phosphorylation	EQISTAGTEASGTGN HHHCCCCCCCCCCCC	26.39	21406692
675	Phosphorylation	STAGTEASGTGNMKF CCCCCCCCCCCCCEE	30.56	21406692
677	Phosphorylation	AGTEASGTGNMKFML CCCCCCCCCCCEEEE	23.92	21406692
681	N6-(pyridoxal phosphate)lysine	ASGTGNMKFMLNGAL CCCCCCCEEEECCEE	31.46	-
681	Other	ASGTGNMKFMLNGAL CCCCCCCEEEECCEE	31.46	-
690	Ubiquitination	MLNGALTIGTMDGAN EECCEEEEEECCCCC	4.50	33845483
691	Ubiquitination	LNGALTIGTMDGANV ECCEEEEEECCCCCH	15.11	22817900
696	Ubiquitination	TIGTMDGANVEMAEE EEEECCCCCHHHHHH	16.78	22817900
720	Ubiquitination	GMRIDDVAALDKKGY EEEHHHHHHHCCCCC	14.86	22817900
724	2-Hydroxyisobutyrylation	DDVAALDKKGYEAKE HHHHHHCCCCCCHHH	49.28	-
724	Acetylation	DDVAALDKKGYEAKE HHHHHHCCCCCCHHH	49.28	15618601
724	Ubiquitination	DDVAALDKKGYEAKE HHHHHHCCCCCCHHH	49.28	21906983
725	Ubiquitination	DVAALDKKGYEAKEY HHHHHCCCCCCHHHH	67.41	21906983
726	Ubiquitination	VAALDKKGYEAKEYY HHHHCCCCCCHHHHH	31.11	23503661
727	Phosphorylation	AALDKKGYEAKEYYE HHHCCCCCCHHHHHH	22.92	22817900
730	Ubiquitination	DKKGYEAKEYYEALP CCCCCCHHHHHHHCH	34.02	21906983
732	Phosphorylation	KGYEAKEYYEALPEL CCCCHHHHHHHCHHH	13.10	22817900
733	Phosphorylation	GYEAKEYYEALPELK CCCHHHHHHHCHHHH	8.87	22817900
749	Ubiquitination	VIDQIDNGFFSPKQP EEEECCCCCCCCCCC	22.64	29967540
752	Phosphorylation	QIDNGFFSPKQPDLF ECCCCCCCCCCCCHH	29.00	24719451
753	Ubiquitination	IDNGFFSPKQPDLFK CCCCCCCCCCCCHHH	33.86	29967540
754	Ubiquitination	DNGFFSPKQPDLFKD CCCCCCCCCCCHHHH	73.58	21906983
760	Ubiquitination	PKQPDLFKDIINMLF CCCCCHHHHHHHHHH	56.14	23503661
762	Ubiquitination	QPDLFKDIINMLFYH CCCHHHHHHHHHHHC	2.24	22817900
770	Ubiquitination	INMLFYHDRFKVFAD HHHHHHCHHHEEECC	46.46	23000965
777	Ubiquitination	DRFKVFADYEAYVKC HHHEEECCHHHHHHH	30.27	27667366
778	Phosphorylation	RFKVFADYEAYVKCQ HHEEECCHHHHHHHH	10.07	29496907
781	Phosphorylation	VFADYEAYVKCQDKV EECCHHHHHHHHHHH	6.62	29496907
783	Ubiquitination	ADYEAYVKCQDKVSQ CCHHHHHHHHHHHHH	17.32	29967540
785	Ubiquitination	YEAYVKCQDKVSQLY HHHHHHHHHHHHHHH	48.09	22817900
787	Ubiquitination	AYVKCQDKVSQLYMN HHHHHHHHHHHHHCC	20.22	29967540
796	Ubiquitination	SQLYMNPKAWNTMVL HHHHCCHHHHHHHHH	62.11	22817900
800	Ubiquitination	MNPKAWNTMVLKNIA CCHHHHHHHHHHHHH	9.65	22817900
801	Sulfoxidation	NPKAWNTMVLKNIAA CHHHHHHHHHHHHHH	2.76	30846556
804	Ubiquitination	AWNTMVLKNIAASGK HHHHHHHHHHHHCCC	34.59	21890473
804	Ubiquitination	AWNTMVLKNIAASGK HHHHHHHHHHHHCCC	34.59	23000965
811	Ubiquitination	KNIAASGKFSSDRTI HHHHHCCCCCCCHHH	39.31	21890473
811	Ubiquitination	KNIAASGKFSSDRTI HHHHHCCCCCCCHHH	39.31	27667366
816	Methylation	SGKFSSDRTIKEYAQ CCCCCCCHHHHHHHH	40.05	115489723
819	Ubiquitination	FSSDRTIKEYAQNIW CCCCHHHHHHHHHHC	44.02	21906983
821	Phosphorylation	SDRTIKEYAQNIWNV CCHHHHHHHHHHCCC	14.42	29496907
834	Acetylation	NVEPSDLKISLSNES CCCHHHCEEECCCCC	34.93	68485
834	Ubiquitination	NVEPSDLKISLSNES CCCHHHCEEECCCCC	34.93	22817900
836	Phosphorylation	EPSDLKISLSNESNK CHHHCEEECCCCCCC	24.94	25159151
838	Phosphorylation	SDLKISLSNESNKVN HHCEEECCCCCCCCC	31.59	25159151
843	Ubiquitination	SLSNESNKVNGN--- ECCCCCCCCCCC---	46.48	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
15	S	Phosphorylation	Kinase	PHK-FAMILY	-	GPS
15	S	Phosphorylation	Kinase	PHK	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
15	S	Phosphorylation		10949035
Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PYGL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PYGL_HUMAN	PYGL	physical	10949035
MSHR_HUMAN	MC1R	physical	22863883
OGFD1_HUMAN	OGFOD1	physical	22863883
PSMD9_HUMAN	PSMD9	physical	22863883
GLGB_HUMAN	GBE1	physical	26344197
PFKAL_HUMAN	PFKL	physical	26344197
PFKAP_HUMAN	PFKP	physical	26344197
PGK1_HUMAN	PGK1	physical	26344197
TRAP1_HUMAN	TRAP1	physical	27173435
SND1_HUMAN	SND1	physical	27173435
IF2P_HUMAN	EIF5B	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
232700	Glycogen storage disease 6 (GSD6)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00131	Adenosine monophosphate

Regulatory Network of PYGL_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-75 AND TYR-76, AND MASSSPECTROMETRY.	18083107 [Abstract]

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