MSHR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MSHR_HUMAN
• UniProt AC: Q01726
• Protein Name: Melanocyte-stimulating hormone receptor
• Gene Name: MC1R
• Organism: Homo sapiens (Human).
• Sequence Length: 317
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase..
• Protein Sequence: MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	N-linked_Glycosylation	PQLGLAANQTGARCL HHHCCCCCCCCCCCE	34.05	UniProtKB CARBOHYD
62	Phosphorylation	ENALVVATIAKNRNL HCHHHHHHHHHCCCC	15.17	-
154	Phosphorylation	FYALRYHSIVTLPRA HHHHHHCHHCCHHHH	15.15	-
157	Phosphorylation	LRYHSIVTLPRARRA HHHCHHCCHHHHHHH	29.40	19452503
308	Phosphorylation	HSQELRRTLKEVLTC HHHHHHHHHHHHHHC	35.43	22817900
315	S-palmitoylation	TLKEVLTCSW----- HHHHHHHCCC-----	3.30	28869973
316	Phosphorylation	LKEVLTCSW------ HHHHHHCCC------	30.50	17130136
405	Ubiquitination	----------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------		21890473
563	Ubiquitination	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21890473
599	Ubiquitination	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21890473
644	Ubiquitination	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21890473
671	Ubiquitination	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21890473
683	Ubiquitination	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21890473
697	Ubiquitination	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21890473
709	Ubiquitination	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21890473
709	Ubiquitination	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21890473
726	Ubiquitination	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21890473
726	Ubiquitination	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MSHR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MSHR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
62	Phosphorylation	60 (2)	V ⇒ L	rs1805005	Skin colour saturation	25963972
154	Phosphorylation	151;160;155 (3;6;1)	R;I ⇒ C;W;T	rs1805007;rs1805008;rs1110400	Freckles Blond vs. brown hair color Red vs non-red hair color Skin sensitivity to sun Basal cell carcinoma Tanning Hair color Sunburns Non-melanoma skin cancer Perceived skin darkness Cutaneous squamous cell carcinoma Melanoma	17952075 21700618 23548203 25963972 27539887 27424798 28212542
157	Phosphorylation	151;160;155 (6;3;2)	R;I ⇒ C;W;T	rs1805007;rs1805008;rs1110400	Freckles Blond vs. brown hair color Red vs non-red hair color Skin sensitivity to sun Basal cell carcinoma Tanning Hair color Sunburns Non-melanoma skin cancer Perceived skin darkness Cutaneous squamous cell carcinoma Melanoma	17952075 21700618 23548203 25963972 27539887 27424798 28212542

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MGRN1_HUMAN	MGRN1	physical	19737927
MGRN1_HUMAN	MGRN1	physical	21862608
OGFD1_HUMAN	OGFOD1	physical	22863883

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613099: Melanoma, cutaneous malignant 5 (CMM5)
• Kegg Drug
• D00146: Corticotropin (USP/INN); ACTH (TN); Acthar (TN)
• D00284: Cosyntropin (USAN); Tetracosactide (INN); Cortrosyn (TN)
• D02105: Tetracosactide acetate (JAN); Cortrosyn (TN)
• D03593: Corticotropin zinc hydroxide (USP); Corticotropin-Zinc (TN)
• D05827: Seractide acetate (USAN); Seractide acetate hydrate; Acthar gel-syntehtic (TN)
• D06544: Corticotropin, repository (USP); Cortigel (TN)
• D06569: Bremelanotide (USAN/INN); PT-141
• D07417: Alsactide (INN)
• D09801: Giractide acetate (JAN)
• D09937: Giractide (INN)
• DrugBank
• There are no disease associations of PTM sites.