OGFD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OGFD1_HUMAN
• UniProt AC: Q8N543
• Protein Name: Prolyl 3-hydroxylase OGFOD1
• Gene Name: OGFOD1
• Organism: Homo sapiens (Human).
• Sequence Length: 542
• Subcellular Localization: Isoform 1: Cytoplasm. Nucleus. Mainly nuclear. A portion relocalizes to cytoplasmic stress granules upon stress.; Isoform 2: Cytoplasm.
• Protein Description: Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation..
• Protein Sequence: MNGKRPAEPGPARVGKKGKKEVMAEFSDAVTEETLKKQVAEAWSRRTPFSHEVIVMDMDPFLHCVIPNFIQSQDFLEGLQKELMNLDFHEKYNDLYKFQQSDDLKKRREPHISTLRKILFEDFRSWLSDISKIDLESTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLVPPWDRSMGGTLDLYSIDEHFQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVLSEEKSRLSISGWFHGPSLTRPPNYFEPPIPRSPHIPQDHEILYDWINPTYLDMDYQVQIQEEFEESSEILLKEFLKPEKFTKVCEALEHGHVEWSSRGPPNKRFYEKAEESKLPEILKECMKLFRSEALFLLLSNFTGLKLHFLAPSEEDEMNDKKEAETTDITEEGTSHSPPEPENNQMAISNNSQQSNEQTDPEPEENETKKESSVPMCQGELRHWKTGHYTLIHDHSKAEFALDLILYCGCEGWEPEYGGFTSYIAKGEDEELLTVNPESNSLALVYRDRETLKFVKHINHRSLEQKKTFPNRTGFWDFSFIYYE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Acetylation	----MNGKRPAEPGP ----CCCCCCCCCCC	50.64	25953088
4	Ubiquitination	----MNGKRPAEPGP ----CCCCCCCCCCC	50.64	-
20	Ubiquitination	RVGKKGKKEVMAEFS CCCCCCCHHHHHHHH	65.30	21890473
23	Sulfoxidation	KKGKKEVMAEFSDAV CCCCHHHHHHHHHHC	2.87	21406390
27	Phosphorylation	KEVMAEFSDAVTEET HHHHHHHHHHCCHHH	19.03	29083192
31	Phosphorylation	AEFSDAVTEETLKKQ HHHHHHCCHHHHHHH	29.80	29083192
34	Phosphorylation	SDAVTEETLKKQVAE HHHCCHHHHHHHHHH	37.33	29083192
36	Ubiquitination	AVTEETLKKQVAEAW HCCHHHHHHHHHHHH	48.88	29967540
37	Ubiquitination	VTEETLKKQVAEAWS CCHHHHHHHHHHHHH	53.79	29967540
42	Ubiquitination	LKKQVAEAWSRRTPF HHHHHHHHHHCCCCC	10.37	22817900
48	Ubiquitination	EAWSRRTPFSHEVIV HHHHCCCCCCCEEEE	27.25	21963094
50	Ubiquitination	WSRRTPFSHEVIVMD HHCCCCCCCEEEEEE	21.68	22817900
51	Ubiquitination	SRRTPFSHEVIVMDM HCCCCCCCEEEEEEC	33.45	22817900
58	Ubiquitination	HEVIVMDMDPFLHCV CEEEEEECCHHHHHH	3.68	29967540
62	Ubiquitination	VMDMDPFLHCVIPNF EEECCHHHHHHCCHH	3.58	21890473
84	Sulfoxidation	EGLQKELMNLDFHEK HHHHHHHHCCCHHHH	4.99	21406390
88	Ubiquitination	KELMNLDFHEKYNDL HHHHCCCHHHHHHHH	10.12	22817900
88 (in isoform 2)	Ubiquitination	-	10.12	21906983
90	Ubiquitination	LMNLDFHEKYNDLYK HHCCCHHHHHHHHHH	58.17	21963094
91	Acetylation	MNLDFHEKYNDLYKF HCCCHHHHHHHHHHH	40.56	25953088
91	Ubiquitination	MNLDFHEKYNDLYKF HCCCHHHHHHHHHHH	40.56	29967540
96	Ubiquitination	HEKYNDLYKFQQSDD HHHHHHHHHHHCCHH	16.78	22817900
97	Sumoylation	EKYNDLYKFQQSDDL HHHHHHHHHHCCHHH	43.95	-
97	Ubiquitination	EKYNDLYKFQQSDDL HHHHHHHHHHCCHHH	43.95	21906983
97 (in isoform 1)	Ubiquitination	-	43.95	21890473
101	Ubiquitination	DLYKFQQSDDLKKRR HHHHHHCCHHHHHHC	23.47	29967540
104	Ubiquitination	KFQQSDDLKKRREPH HHHCCHHHHHHCCCC	9.40	22817900
105	Acetylation	FQQSDDLKKRREPHI HHCCHHHHHHCCCCH	51.75	23749302
105	Ubiquitination	FQQSDDLKKRREPHI HHCCHHHHHHCCCCH	51.75	21906983
105 (in isoform 1)	Ubiquitination	-	51.75	21890473
106	Ubiquitination	QQSDDLKKRREPHIS HCCHHHHHHCCCCHH	65.08	22817900
113	Phosphorylation	KRREPHISTLRKILF HHCCCCHHHHHHHHH	20.53	28152594
114	Phosphorylation	RREPHISTLRKILFE HCCCCHHHHHHHHHH	29.94	28152594
116	Ubiquitination	EPHISTLRKILFEDF CCCHHHHHHHHHHHH	24.85	21890473
117	Ubiquitination	PHISTLRKILFEDFR CCHHHHHHHHHHHHH	47.04	23000965
117 (in isoform 1)	Ubiquitination	-	47.04	21890473
128	Phosphorylation	EDFRSWLSDISKIDL HHHHHHHHCHHCCCH	27.00	-
131	Phosphorylation	RSWLSDISKIDLEST HHHHHCHHCCCHHHC	28.66	-
131	Ubiquitination	RSWLSDISKIDLEST HHHHHCHHCCCHHHC	28.66	22817900
138	Phosphorylation	SKIDLESTIDMSCAK HCCCHHHCCCCHHHC	16.18	28674419
143	Ubiquitination	ESTIDMSCAKYEFTD HHCCCCHHHCCEECC	2.80	29967540
144	Ubiquitination	STIDMSCAKYEFTDA HCCCCHHHCCEECCE	15.34	21963094
145	Ubiquitination	TIDMSCAKYEFTDAL CCCCHHHCCEECCEE	50.03	21963094
149	Phosphorylation	SCAKYEFTDALLCHD HHHCCEECCEEECCC	14.39	24532841
160	Ubiquitination	LCHDDELEGRRIAFI ECCCCCCCCCEEEEE	48.91	29967540
163	Ubiquitination	DDELEGRRIAFILYL CCCCCCCEEEEEEEE	35.13	22817900
166	Ubiquitination	LEGRRIAFILYLVPP CCCCEEEEEEEECCC	3.53	21963094
173	Ubiquitination	FILYLVPPWDRSMGG EEEEECCCCCHHCCC	37.81	22817900
186	Ubiquitination	GGTLDLYSIDEHFQP CCCEEEEEECCCCCH	30.75	22817900
191	Ubiquitination	LYSIDEHFQPKQIVK EEEECCCCCHHHHHH	14.48	21963094
194	Ubiquitination	IDEHFQPKQIVKSLI ECCCCCHHHHHHHHC	41.70	-
196	Ubiquitination	EHFQPKQIVKSLIPS CCCCHHHHHHHHCCC	5.42	33845483
197	Ubiquitination	HFQPKQIVKSLIPSW CCCHHHHHHHHCCCC	2.97	29967540
198	Ubiquitination	FQPKQIVKSLIPSWN CCHHHHHHHHCCCCC	40.97	29967540
203	Ubiquitination	IVKSLIPSWNKLVFF HHHHHCCCCCCEEEE	35.97	29967540
206	Ubiquitination	SLIPSWNKLVFFEVS HHCCCCCCEEEEEEC	39.51	22817900
209	Ubiquitination	PSWNKLVFFEVSPVS CCCCCEEEEEECCCC	6.65	21963094
227	Ubiquitination	VSEVLSEEKSRLSIS HHHHHCHHHHCCCCE	53.61	22817900
228	Ubiquitination	SEVLSEEKSRLSISG HHHHCHHHHCCCCEE	36.50	22817900
228 (in isoform 1)	Ubiquitination	-	36.50	21890473
229	Ubiquitination	EVLSEEKSRLSISGW HHHCHHHHCCCCEEC	41.56	22817900
234	Ubiquitination	EKSRLSISGWFHGPS HHHCCCCEECCCCCC	26.96	21963094
239	Ubiquitination	SISGWFHGPSLTRPP CCEECCCCCCCCCCC	12.20	33845483
245	Ubiquitination	HGPSLTRPPNYFEPP CCCCCCCCCCCCCCC	19.09	29967540
248	Ubiquitination	SLTRPPNYFEPPIPR CCCCCCCCCCCCCCC	18.32	22817900
251	Ubiquitination	RPPNYFEPPIPRSPH CCCCCCCCCCCCCCC	23.40	21963094
257	Ubiquitination	EPPIPRSPHIPQDHE CCCCCCCCCCCCCCC	30.61	-
263	Ubiquitination	SPHIPQDHEILYDWI CCCCCCCCCCCHHCC	20.81	-
265	Ubiquitination	HIPQDHEILYDWINP CCCCCCCCCHHCCCC	3.76	22817900
268	Ubiquitination	QDHEILYDWINPTYL CCCCCCHHCCCCCEE	36.01	21963094
271	Ubiquitination	EILYDWINPTYLDMD CCCHHCCCCCEECCC	20.71	22817900
276	Ubiquitination	WINPTYLDMDYQVQI CCCCCEECCCHHHHH	19.93	21963094
281	Ubiquitination	YLDMDYQVQIQEEFE EECCCHHHHHHHHHH	4.39	33845483
282	Ubiquitination	LDMDYQVQIQEEFEE ECCCHHHHHHHHHHH	19.00	29967540
287	Ubiquitination	QVQIQEEFEESSEIL HHHHHHHHHHHHHHH	14.37	22817900
288	Ubiquitination	VQIQEEFEESSEILL HHHHHHHHHHHHHHH	61.32	-
288	Ubiquitination	VQIQEEFEESSEILL HHHHHHHHHHHHHHH	61.32	21963094
293	Ubiquitination	EFEESSEILLKEFLK HHHHHHHHHHHHHCC	6.20	-
293	Ubiquitination	EFEESSEILLKEFLK HHHHHHHHHHHHHCC	6.20	21963094
298	Ubiquitination	SEILLKEFLKPEKFT HHHHHHHHCCHHHHH	11.54	33845483
299	Ubiquitination	EILLKEFLKPEKFTK HHHHHHHCCHHHHHH	10.70	29967540
300	Ubiquitination	ILLKEFLKPEKFTKV HHHHHHCCHHHHHHH	57.35	29967540
302	Ubiquitination	LKEFLKPEKFTKVCE HHHHCCHHHHHHHHH	60.25	22817900
303	Ubiquitination	KEFLKPEKFTKVCEA HHHCCHHHHHHHHHH	67.85	22817900
305	Ubiquitination	FLKPEKFTKVCEALE HCCHHHHHHHHHHHH	33.37	21963094
306	Ubiquitination	LKPEKFTKVCEALEH CCHHHHHHHHHHHHC	48.28	21963094
324	Ubiquitination	EWSSRGPPNKRFYEK CHHCCCCCCHHHHHH	62.89	29967540
325	Ubiquitination	WSSRGPPNKRFYEKA HHCCCCCCHHHHHHH	51.79	22817900
326	Ubiquitination	SSRGPPNKRFYEKAE HCCCCCCHHHHHHHH	50.05	22817900
330	Ubiquitination	PPNKRFYEKAEESKL CCCHHHHHHHHHCCH	42.98	21963094
331	Ubiquitination	PNKRFYEKAEESKLP CCHHHHHHHHHCCHH	50.12	21963094
335	Ubiquitination	FYEKAEESKLPEILK HHHHHHHCCHHHHHH	30.88	33845483
336	Ubiquitination	YEKAEESKLPEILKE HHHHHHCCHHHHHHH	71.93	33845483
341	Ubiquitination	ESKLPEILKECMKLF HCCHHHHHHHHHHHH	3.49	29967540
346	Ubiquitination	EILKECMKLFRSEAL HHHHHHHHHHHHHHH	57.01	29967540
371	Phosphorylation	KLHFLAPSEEDEMND EEEEECCCCCHHCCC	48.27	20873877
371	Ubiquitination	KLHFLAPSEEDEMND EEEEECCCCCHHCCC	48.27	21963094
371 (in isoform 2)	Ubiquitination	-	48.27	21906983
372	Ubiquitination	LHFLAPSEEDEMNDK EEEECCCCCHHCCCC	69.29	22817900
373	Ubiquitination	HFLAPSEEDEMNDKK EEECCCCCHHCCCCH	64.70	21963094
374	Ubiquitination	FLAPSEEDEMNDKKE EECCCCCHHCCCCHH	57.29	21963094
378	Ubiquitination	SEEDEMNDKKEAETT CCCHHCCCCHHHCCC	63.19	29967540
379	Ubiquitination	EEDEMNDKKEAETTD CCHHCCCCHHHCCCC	47.73	29967540
384	Phosphorylation	NDKKEAETTDITEEG CCCHHHCCCCCCCCC	36.50	29496963
384	Ubiquitination	NDKKEAETTDITEEG CCCHHHCCCCCCCCC	36.50	27667366
385	Ubiquitination	DKKEAETTDITEEGT CCHHHCCCCCCCCCC	19.53	-
385	Phosphorylation	DKKEAETTDITEEGT CCHHHCCCCCCCCCC	19.53	22210691
388	Phosphorylation	EAETTDITEEGTSHS HHCCCCCCCCCCCCC	30.69	30576142
388	Ubiquitination	EAETTDITEEGTSHS HHCCCCCCCCCCCCC	30.69	29967540
389	Ubiquitination	AETTDITEEGTSHSP HCCCCCCCCCCCCCC	55.55	22817900
390	Ubiquitination	ETTDITEEGTSHSPP CCCCCCCCCCCCCCC	60.15	21963094
392	Phosphorylation	TDITEEGTSHSPPEP CCCCCCCCCCCCCCC	26.92	30576142
393	Phosphorylation	DITEEGTSHSPPEPE CCCCCCCCCCCCCCC	32.59	30576142
395	Phosphorylation	TEEGTSHSPPEPENN CCCCCCCCCCCCCCC	41.75	30576142
400	Ubiquitination	SHSPPEPENNQMAIS CCCCCCCCCCCCCCC	68.12	-
405	Ubiquitination	EPENNQMAISNNSQQ CCCCCCCCCCCCCCC	7.72	29967540
413	Phosphorylation	ISNNSQQSNEQTDPE CCCCCCCCCCCCCCC	34.40	28348404
414	Ubiquitination	SNNSQQSNEQTDPEP CCCCCCCCCCCCCCC	40.85	21963094
417	Phosphorylation	SQQSNEQTDPEPEEN CCCCCCCCCCCCCCC	47.55	24461736
417	Ubiquitination	SQQSNEQTDPEPEEN CCCCCCCCCCCCCCC	47.55	21963094
426	Ubiquitination	PEPEENETKKESSVP CCCCCCCCCHHCCCC	60.02	22817900
427	Ubiquitination	EPEENETKKESSVPM CCCCCCCCHHCCCCC	48.65	27667366
428	Sumoylation	PEENETKKESSVPMC CCCCCCCHHCCCCCC	70.96	-
428	Ubiquitination	PEENETKKESSVPMC CCCCCCCHHCCCCCC	70.96	21963094
434	Sulfoxidation	KKESSVPMCQGELRH CHHCCCCCCHHHHCC	2.21	21406390
440	Methylation	PMCQGELRHWKTGHY CCCHHHHCCCCCCCE	29.35	115485997
442	Ubiquitination	CQGELRHWKTGHYTL CHHHHCCCCCCCEEE	8.09	29967540
443	Ubiquitination	QGELRHWKTGHYTLI HHHHCCCCCCCEEEE	38.20	29967540
456	Ubiquitination	LIHDHSKAEFALDLI EECCCCHHHHHHHHH	21.83	21963094
459	Ubiquitination	DHSKAEFALDLILYC CCCHHHHHHHHHHHC	7.53	21963094
468	Ubiquitination	DLILYCGCEGWEPEY HHHHHCCCCCCCCCC	3.79	-
469	Ubiquitination	LILYCGCEGWEPEYG HHHHCCCCCCCCCCC	53.26	27667366
471	Ubiquitination	LYCGCEGWEPEYGGF HHCCCCCCCCCCCCC	8.83	-
473	Ubiquitination	CGCEGWEPEYGGFTS CCCCCCCCCCCCCEE	33.33	21963094
476	Ubiquitination	EGWEPEYGGFTSYIA CCCCCCCCCCEEEEE	24.07	21963094
484	Sumoylation	GFTSYIAKGEDEELL CCEEEEEECCCCCCE	53.96	-
486	Ubiquitination	TSYIAKGEDEELLTV EEEEEECCCCCCEEE	62.64	27667366
510	Ubiquitination	VYRDRETLKFVKHIN EEECHHHHHHHHHCC	3.29	21963094
511	Ubiquitination	YRDRETLKFVKHINH EECHHHHHHHHHCCC	56.37	27667366
511 (in isoform 1)	Ubiquitination	-	56.37	21890473
513	Ubiquitination	DRETLKFVKHINHRS CHHHHHHHHHCCCCC	4.16	21963094
514	Ubiquitination	RETLKFVKHINHRSL HHHHHHHHHCCCCCH	41.73	21963094
523	Ubiquitination	INHRSLEQKKTFPNR CCCCCHHHHCCCCCC	58.81	27667366
524	Ubiquitination	NHRSLEQKKTFPNRT CCCCHHHHCCCCCCC	44.39	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OGFD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OGFD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OGFD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAHH_HUMAN	AHCY	physical	22863883
AL1B1_HUMAN	ALDH1B1	physical	22863883
ASB6_HUMAN	ASB6	physical	22863883
ASNS_HUMAN	ASNS	physical	22863883
PUR9_HUMAN	ATIC	physical	22863883
CPNS1_HUMAN	CAPNS1	physical	22863883
FUMH_HUMAN	FH	physical	22863883
ISOC1_HUMAN	ISOC1	physical	22863883
MCTS1_HUMAN	MCTS1	physical	22863883
STK26_HUMAN	STK26	physical	22863883
MYO1E_HUMAN	MYO1E	physical	22863883
PDIA4_HUMAN	PDIA4	physical	22863883
PCP_HUMAN	PRCP	physical	22863883
PLPHP_HUMAN	PROSC	physical	22863883
PTMA_HUMAN	PTMA	physical	22863883
PYGB_HUMAN	PYGB	physical	22863883
TBCB_HUMAN	TBCB	physical	22863883
TWF2_HUMAN	TWF2	physical	22863883
1433E_HUMAN	YWHAE	physical	22863883

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00126: Vitamin C