| UniProt ID | ASB6_HUMAN | |
|---|---|---|
| UniProt AC | Q9NWX5 | |
| Protein Name | Ankyrin repeat and SOCS box protein 6 | |
| Gene Name | ASB6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 421 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.. | |
| Protein Sequence | MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQALHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDDI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Phosphorylation | FRRIIFEYQPLVDAI CHHHHHHHHHHHHHH | 12.51 | 24043423 | |
| 24 | Phosphorylation | LVDAILGSLGIQDPE HHHHHHHHCCCCCHH | 21.70 | 24043423 | |
| 35 | Phosphorylation | QDPERQESLDRPSYV CCHHHHHHCCCCHHH | 27.51 | 22210691 | |
| 59 | Ubiquitination | LTELLERKAHSPFYQ HHHHHHHHCCCHHHH | 40.87 | 22053931 | |
| 75 | Ubiquitination | GVSNALLKMAELGLT HHHHHHHHHHHHCCH | 36.59 | - | |
| 172 | Ubiquitination | NAADKHGKTALLHAL CHHHHCCHHHHHHHH | 30.28 | - | |
| 204 | Ubiquitination | LEGGADVKATTKDGD ECCCCCEEEECCCCC | 40.33 | - | |
| 206 | Phosphorylation | GGADVKATTKDGDTV CCCCEEEECCCCCCC | 28.76 | - | |
| 269 | Phosphorylation | LTHICLKSFKLHFPL HHHHHHHHHHHCHHH | 18.05 | 24719451 | |
| 337 | Phosphorylation | LDLMVTNSQKLQLPE HHHHCCCCCCCCCCC | 21.23 | - | |
| 397 | Ubiquitination | WPVDVKVKALPLPDR CCCCEEEEEEECCCH | 38.19 | - | |
| 416 | Phosphorylation | LLSEHSGSVEDDI-- HHHCCCCCCCCCC-- | 25.91 | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ASB6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ASB6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ASB6_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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