| UniProt ID | MYZAP_HUMAN | |
|---|---|---|
| UniProt AC | P0CAP1 | |
| Protein Name | Myocardial zonula adherens protein | |
| Gene Name | MYZAP | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 466 | |
| Subcellular Localization |
Cytoplasm, cytoskeleton . Cell membrane Peripheral membrane protein Cytoplasmic side . Cytoplasm, myofibril, sarcomere, I band . Cytoplasm, myofibril, sarcomere, Z line . Cell junction . Detected predominantly at the intercalated disk in cardiomy |
|
| Protein Description | Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).. | |
| Protein Sequence | MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MLRSTSTVTLL ----CCCCCCEEEEE | 23.81 | 27251275 | |
| 5 | Phosphorylation | ---MLRSTSTVTLLS ---CCCCCCEEEEEC | 23.22 | 30576142 | |
| 5 (in isoform 11) | Phosphorylation | - | 23.22 | 27251275 | |
| 6 | Phosphorylation | --MLRSTSTVTLLSG --CCCCCCEEEEECC | 23.33 | 25002506 | |
| 7 | Phosphorylation | -MLRSTSTVTLLSGG -CCCCCCEEEEECCC | 20.00 | 30576142 | |
| 9 | Phosphorylation | LRSTSTVTLLSGGAA CCCCCEEEEECCCCC | 23.28 | 22210691 | |
| 12 | Phosphorylation | TSTVTLLSGGAARTP CCEEEEECCCCCCCC | 37.99 | 27251275 | |
| 18 | Phosphorylation | LSGGAARTPGAPSRR ECCCCCCCCCCCCCC | 22.73 | 25002506 | |
| 23 | Phosphorylation | ARTPGAPSRRANVCR CCCCCCCCCCCCEEE | 33.59 | 30576142 | |
| 39 | Phosphorylation | RLTVPPESPVPEQCE EEECCCCCCCCHHHH | 36.65 | 27499020 | |
| 59 | Ubiquitination | KEQLLDLSNGEPTRK HHHHHHCCCCCCCCC | 42.32 | 29967540 | |
| 64 | Phosphorylation | DLSNGEPTRKLPQGV HCCCCCCCCCCCCCC | 35.81 | 21888424 | |
| 71 | Ubiquitination | TRKLPQGVVYGVVRR CCCCCCCCEEEEEEC | 2.23 | 29967540 | |
| 72 | Phosphorylation | RKLPQGVVYGVVRRS CCCCCCCEEEEEECC | 4.38 | 32142685 | |
| 83 | Ubiquitination | VRRSDQNQQKEMVVY EECCCCCCCEEEEEE | 50.52 | 24816145 | |
| 110 | Phosphorylation | YIKDVRATLEKVRKR HHHHHHHHHHHHHHH | 25.53 | 24719451 | |
| 125 | Ubiquitination | MYGDYDEMRQKIRQL HHCCHHHHHHHHHHH | 5.13 | 33845483 | |
| 169 | Ubiquitination | AMNSALASDSIGLQK HHHHHHHHCCCCCCC | 32.51 | 29967540 | |
| 189 | Ubiquitination | TLENSNIKDQIRNLQ HCCCCCHHHHHHHHH | 48.07 | 29967540 | |
| 208 | Phosphorylation | ASMDKLREKQRQLEV HHHHHHHHHHHHHHH | 65.07 | 33259812 | |
| 216 | Ubiquitination | KQRQLEVAQVENQLL HHHHHHHHHHHHHHH | 9.79 | 29967540 | |
| 229 | Phosphorylation | LLKMKVESSQEANAE HHHHHHCCCHHHCHH | 40.07 | 29978859 | |
| 230 | Phosphorylation | LKMKVESSQEANAEV HHHHHCCCHHHCHHH | 20.66 | 29978859 | |
| 242 | Phosphorylation | AEVMREMTKKLYSQY HHHHHHHHHHHHHHH | 21.92 | 29978859 | |
| 273 | Phosphorylation | ALLEETNSFLKAIEE HHHHHHHHHHHHHHH | 39.10 | 24719451 | |
| 282 | Ubiquitination | LKAIEEANKKMQAAE HHHHHHHHHHHHHHH | 48.00 | 33845483 | |
| 291 | Phosphorylation | KMQAAEISLEEKDQR HHHHHHCCHHHHHHH | 22.64 | 29116813 | |
| 326 | Ubiquitination | QLLEHETEMSGELTD HHHHHHHHHCCCCCC | 28.50 | 29967540 | |
| 328 | Phosphorylation | LEHETEMSGELTDSD HHHHHHHCCCCCCCH | 23.92 | 25332170 | |
| 339 | Phosphorylation | TDSDKERYQQLEEAS CCCHHHHHHHHHHHH | 11.16 | 20736484 | |
| 346 | Phosphorylation | YQQLEEASASLRERI HHHHHHHHHHHHHHH | 22.98 | 24905233 | |
| 348 | Phosphorylation | QLEEASASLRERIRH HHHHHHHHHHHHHHH | 26.01 | 24905233 | |
| 352 (in isoform 9) | Phosphorylation | - | 25.47 | 29116813 | |
| 354 (in isoform 9) | Phosphorylation | - | 30.45 | 29116813 | |
| 364 (in isoform 9) | Phosphorylation | - | 53.59 | 29116813 | |
| 365 | Phosphorylation | DMVHCQQKKVKQMVE HHHHHCHHHHHHHHH | 33.39 | 33259812 | |
| 376 | Phosphorylation | QMVEEIESLKKKLQQ HHHHHHHHHHHHHHH | 51.67 | 28509920 | |
| 383 (in isoform 4) | Phosphorylation | - | 45.99 | 29116813 | |
| 385 (in isoform 4) | Phosphorylation | - | 36.84 | 29116813 | |
| 411 | Phosphorylation | ELQSRLDYLTETQAK HHHHHHHHHHHHHHC | 21.81 | 25262027 | |
| 413 | Phosphorylation | QSRLDYLTETQAKTE HHHHHHHHHHHHCCC | 30.66 | 25262027 | |
| 415 | Phosphorylation | RLDYLTETQAKTEVE HHHHHHHHHHCCCEE | 28.70 | 25262027 | |
| 419 | Phosphorylation | LTETQAKTEVETREI HHHHHHCCCEECCCC | 48.56 | 25262027 | |
| 423 | Phosphorylation | QAKTEVETREIGVGC HHCCCEECCCCCCCC | 38.48 | 25262027 | |
| 451 | Phosphorylation | VMPSRNYTPYTRVLE ECCCCCCCCCCHHHH | 17.23 | 22210691 | |
| 452 (in isoform 11) | Phosphorylation | - | 20.38 | 27251275 | |
| 453 | Phosphorylation | PSRNYTPYTRVLELT CCCCCCCCCHHHHHH | 10.20 | 22210691 | |
| 454 | Phosphorylation | SRNYTPYTRVLELTM CCCCCCCCHHHHHHH | 18.59 | 22210691 | |
| 464 | Ubiquitination | LELTMKKTLT----- HHHHHHHCCC----- | 30.06 | 33845483 | |
| 464 | Phosphorylation | LELTMKKTLT----- HHHHHHHCCC----- | 30.06 | - | |
| 466 | Phosphorylation | LTMKKTLT------- HHHHHCCC------- | 41.62 | - | |
| 468 | Ubiquitination | MKKTLT--------- HHHCCC--------- | 29967540 | ||
| 469 | Phosphorylation | KKTLT---------- HHCCC---------- | 32142685 | ||
| 480 | Ubiquitination | --------------------- --------------------- | 24816145 | ||
| 508 | Ubiquitination | ------------------------------------------------- ------------------------------------------------- | 29967540 | ||
| 546 | Phosphorylation | --------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------- | 19651622 | ||
| 546 (in isoform 11) | Phosphorylation | - | 27251275 | ||
| 547 | Phosphorylation | ---------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------- | 19651622 | ||
| 547 (in isoform 11) | Phosphorylation | - | 27251275 | ||
| 613 | Ubiquitination | ---------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------- | 29967540 | ||
| 679 | Ubiquitination | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | 33845483 | ||
| 723 | Ubiquitination | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ | 29967540 | ||
| 762 | Phosphorylation | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | 33259812 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MYZAP_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MYZAP_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MYZAP_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| There are no disease associations of PTM sites. | ||||||
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| There are no disease associations of PTM sites. | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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