GPN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPN2_HUMAN
• UniProt AC: Q9H9Y4
• Protein Name: GPN-loop GTPase 2 {ECO:0000305}
• Gene Name: GPN2 {ECO:0000303|PubMed:20864038, ECO:0000312|HGNC:HGNC:25513}
• Organism: Homo sapiens (Human).
• Sequence Length: 310
• Protein Description: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import..
• Protein Sequence: MAGAAPTTAFGQAVIGPPGSGKTTYCLGMSEFLRALGRRVAVVNLDPANEGLPYECAVDVGELVGLGDVMDALRLGPNGGLLYCMEYLEANLDWLRAKLDPLRGHYFLFDCPGQVELCTHHGALRSIFSQMAQWDLRLTAVHLVDSHYCTDPAKFISVLCTSLATMLHVELPHINLLSKMDLIEHYGKLAFNLDYYTEVLDLSYLLDHLASDPFFRHYRQLNEKLVQLIEDYSLVSFIPLNIQDKESIQRVLQAVDKANGYCFRAQEQRSLEAMMSAAMGADFHFSSTLGIQEKYLAPSNQSVEQEAMQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGAAPTTA ------CCCCCCCCC	19.14	22223895
146	Phosphorylation	TAVHLVDSHYCTDPA HHHHHHCHHCCCCHH	14.63	30576142
186	Phosphorylation	KMDLIEHYGKLAFNL HHHHHHHHHHHHHCC	11.81	30257219
299	Phosphorylation	QEKYLAPSNQSVEQE CCHHCCCCCCCHHHH	41.72	25627689

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RPB2_HUMAN	POLR2B	physical	26186194
GPN1_HUMAN	GPN1	physical	26186194
RPB11_HUMAN	POLR2J	physical	26186194
TBA3C_HUMAN	TUBA3C	physical	26186194
RPAP1_HUMAN	RPAP1	physical	26186194
RPAB5_HUMAN	POLR2L	physical	26186194
RPB11_HUMAN	POLR2J	physical	28514442
RPAP1_HUMAN	RPAP1	physical	28514442
TBA3C_HUMAN	TUBA3C	physical	28514442
RPAB5_HUMAN	POLR2L	physical	28514442
GPN1_HUMAN	GPN1	physical	28514442
RPB2_HUMAN	POLR2B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.