ZN410_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN410_HUMAN
• UniProt AC: Q86VK4
• Protein Name: Zinc finger protein 410
• Gene Name: ZNF410
• Organism: Homo sapiens (Human).
• Sequence Length: 478
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence..
• Protein Sequence: MLSDELESKPELLVQFVQNTSIPLGQGLVESEAKDITCLSLLPVTEASECSRLMLPDDTTNHSNSSKEVPSSAVLRSLRVNVGPDGEETRAQTVQKSPEFLSTSESSSLLQDLQPSDSTSFILLNLTRAGLGSSAEHLVFVQDEAEDSGNDFLSSESTDSSIPWFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQSKDSGPLPQVEKKLKCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAEGCGKSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKNHRRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGSRNVHMRKHHLQLGAAGSQEQEQTAEPLMGSSLLEEASVPSKNLVSMNSQPSLGGESLNLPNTNSILGVDDEVLAEGSPRSLSSVPDVTHHLVTMQSGRQSYEVSVLTAVNPQELLNQGDLTERRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	RLMLPDDTTNHSNSS CEECCCCCCCCCCCC	36.56	-
77	Phosphorylation	PSSAVLRSLRVNVGP CCHHHHHHHEEEECC	19.16	-
189	Ubiquitination	AQLAKNAKTSSNGEN HHHHHHCCCCCCCCC	59.33	-
217	Ubiquitination	GPLPQVEKKLKCTVE CCCCHHHHHEECEEE	65.63	-
220	Ubiquitination	PQVEKKLKCTVEGCD CHHHHHEECEEECCC	36.42	-
254 (in isoform 5)	Ubiquitination	-	39.91	-
258	Ubiquitination	CPAEGCGKSFYVLQR ECCCCCCCCHHHHHH	41.28	-
275 (in isoform 5)	Ubiquitination	-	36.38	-
297	Ubiquitination	FTTAGNLKNHRRIHT EECCCCCCCCCEEEC	55.49	-
304	Phosphorylation	KNHRRIHTGEKPFLC CCCCEEECCCCCEEE	44.67	29214152
334	Phosphorylation	RKHLVVHSGEKPHQC HCEEEEECCCCCEEC	36.72	29214152
370	Phosphorylation	LQLGAAGSQEQEQTA HCCCCCCCHHHHHHC	26.31	28348404
376	Phosphorylation	GSQEQEQTAEPLMGS CCHHHHHHCCCCCCC	32.03	28348404
383 (in isoform 3)	Phosphorylation	-	12.12	27251275
383	Phosphorylation	TAEPLMGSSLLEEAS HCCCCCCCHHHHHCC	12.12	27251275
430	Phosphorylation	DEVLAEGSPRSLSSV HHHHCCCCCCCHHHC	14.51	23403867
433	Phosphorylation	LAEGSPRSLSSVPDV HCCCCCCCHHHCCCE	35.67	26074081
435	Phosphorylation	EGSPRSLSSVPDVTH CCCCCCHHHCCCEEE	30.45	27732954
436	Phosphorylation	GSPRSLSSVPDVTHH CCCCCHHHCCCEEEE	42.85	27732954
441	Phosphorylation	LSSVPDVTHHLVTMQ HHHCCCEEEEEEEEC	15.80	27732954
447	Phosphorylation	VTHHLVTMQSGRQSY EEEEEEEECCCCCEE	2.02	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN410_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN410_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN410_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
CEP70_HUMAN	CEP70	physical	25416956
TSG10_HUMAN	TSGA10	physical	25416956
ZN397_HUMAN	ZNF397	physical	25416956
RAB3I_HUMAN	RAB3IP	physical	25416956
FSD2_HUMAN	FSD2	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.