WDR89_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR89_HUMAN
• UniProt AC: Q96FK6
• Protein Name: WD repeat-containing protein 89
• Gene Name: WDR89
• Organism: Homo sapiens (Human).
• Sequence Length: 387
• Protein Sequence: MEKIEEQFANLHIVKCSLGTKEPTYLLGIDTSKTVQAGKENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDTLHVIGGTNKGRIHLMNCSMSGLTHVTSLQGGHAATVRSFCWNVQDDSLLTGGEDAQLLLWKPGAIEKTFTKKESMKIASSVHQRVRVHSNDSYKRRKKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Ubiquitination	FANLHIVKCSLGTKE HHCCEEEECCCCCCC	19.94	-
17	Phosphorylation	NLHIVKCSLGTKEPT CCEEEECCCCCCCCE	24.90	26074081
20	Phosphorylation	IVKCSLGTKEPTYLL EEECCCCCCCCEEEE	37.21	26074081
21	Acetylation	VKCSLGTKEPTYLLG EECCCCCCCCEEEEE	60.95	26051181
21	Ubiquitination	VKCSLGTKEPTYLLG EECCCCCCCCEEEEE	60.95	-
24	Phosphorylation	SLGTKEPTYLLGIDT CCCCCCCEEEEEEEC	28.08	26074081
25	Phosphorylation	LGTKEPTYLLGIDTS CCCCCCEEEEEEECC	15.62	26074081
31	Phosphorylation	TYLLGIDTSKTVQAG EEEEEEECCCCCCCC	30.15	26074081
32	Phosphorylation	YLLGIDTSKTVQAGK EEEEEECCCCCCCCC	23.68	26074081
33	Ubiquitination	LLGIDTSKTVQAGKE EEEEECCCCCCCCCC	55.60	-
34	Phosphorylation	LGIDTSKTVQAGKEN EEEECCCCCCCCCCC	20.02	26074081
39	Acetylation	SKTVQAGKENLVAVL CCCCCCCCCCEEEEE	46.58	26051181
67	Phosphorylation	LNVLREFSGYPGLLN HHHHHHHCCCCCHHC	32.44	22817900
69	Phosphorylation	VLREFSGYPGLLNGV HHHHHCCCCCHHCCE	7.91	22817900
95	Acetylation	ACTDGTVKCWDARVA HCCCCCCCEECCHHH	29.46	26051181
95	Ubiquitination	ACTDGTVKCWDARVA HCCCCCCCEECCHHH	29.46	-
105	Ubiquitination	DARVAREKPVQLFKG CCHHHCCCCEEEECC	44.96	-
156	Phosphorylation	RMNSQNLSTTKDSLG CCCCCCCCCCHHHCC	41.39	22817900
157	Phosphorylation	MNSQNLSTTKDSLGA CCCCCCCCCHHHCCC	40.82	-
158	Phosphorylation	NSQNLSTTKDSLGAY CCCCCCCCHHHCCCC	29.49	-
159	Ubiquitination	SQNLSTTKDSLGAYS CCCCCCCHHHCCCCC	45.46	21906983
161	Phosphorylation	NLSTTKDSLGAYSET CCCCCHHHCCCCCCC	30.20	18452278
166	Phosphorylation	KDSLGAYSETHSDDV HHHCCCCCCCCCCCC	35.17	18452278
256	Phosphorylation	LDTDEPVTRLNIQDV CCCCCCCEECCHHHH	39.91	-
270	Ubiquitination	VREVVNMKEDALDYL HHHHHCCCHHHHHHH	47.43	21906983
285	Ubiquitination	IGGLYHEKTDTLHVI HHHCCCCCCCEEEEE	38.09	-
297	Ubiquitination	HVIGGTNKGRIHLMN EEECCCCCCCEEEEE	49.78	-
356	Phosphorylation	KPGAIEKTFTKKESM CCCCEEEEECHHHHH	24.60	-
358	Phosphorylation	GAIEKTFTKKESMKI CCEEEEECHHHHHHH	46.57	-
362	Phosphorylation	KTFTKKESMKIASSV EEECHHHHHHHHHHH	33.97	-
364	Methylation	FTKKESMKIASSVHQ ECHHHHHHHHHHHHH	44.38	115978601
377	Phosphorylation	HQRVRVHSNDSYKRR HHHHCCCCCCHHHHH	39.20	28258704
380	Phosphorylation	VRVHSNDSYKRRKKQ HCCCCCCHHHHHCCC	36.48	27282143
381	Phosphorylation	RVHSNDSYKRRKKQ- CCCCCCHHHHHCCC-	16.04	28258704

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR89_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR89_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR89_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67 AND TYR-69, AND MASSSPECTROMETRY.
PubMed: 18187866