DGKZ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DGKZ_HUMAN
• UniProt AC: Q13574
• Protein Name: Diacylglycerol kinase zeta
• Gene Name: DGKZ
• Organism: Homo sapiens (Human).
• Sequence Length: 1117
• Subcellular Localization: Cytoplasm . Nucleus . Cell membrane .
• Protein Description: Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity..
• Protein Sequence: METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7 (in isoform 2)	Phosphorylation	-	28.30	22210691
7 (in isoform 4)	Phosphorylation	-	28.30	22210691
7 (in isoform 5)	Phosphorylation	-	28.30	22210691
7 (in isoform 6)	Phosphorylation	-	28.30	22210691
24	Phosphorylation	GEGQQRPSSVGLPTG CCCCCCCCCCCCCCC	39.58	28857561
25	Phosphorylation	EGQQRPSSVGLPTGK CCCCCCCCCCCCCCC	23.92	28857561
30	Phosphorylation	PSSVGLPTGKARRRS CCCCCCCCCCCCCCC	57.25	28857561
37	Phosphorylation	TGKARRRSPAGQASS CCCCCCCCCCHHHCH	19.79	28857561
43	Phosphorylation	RSPAGQASSSLAQRR CCCCHHHCHHHHHHH	16.75	-
45	Phosphorylation	PAGQASSSLAQRRRS CCHHHCHHHHHHHHH	25.81	-
49 (in isoform 3)	Phosphorylation	-	30.30	-
52	Phosphorylation	SLAQRRRSSAQLQGC HHHHHHHHHHHHHHH	28.37	28450419
53	Phosphorylation	LAQRRRSSAQLQGCL HHHHHHHHHHHHHHH	20.44	28450419
62	Phosphorylation	QLQGCLLSCGVRAQG HHHHHHHHHCCCCCC	8.90	-
75	Phosphorylation	QGSSRRRSSTVPPSC CCCCCCCCCCCCCCC	28.66	24247654
76	Phosphorylation	GSSRRRSSTVPPSCN CCCCCCCCCCCCCCC	31.45	27251275
77	Phosphorylation	SSRRRSSTVPPSCNP CCCCCCCCCCCCCCC	37.97	24247654
153	Ubiquitination	PRGAQPLLPLPRYLR CCCCCCCCCHHHHHH	5.36	24816145
163	Phosphorylation	PRYLRRASSHLLPAD HHHHHHHHHCCCCHH	19.24	28450419
164	Phosphorylation	RYLRRASSHLLPADA HHHHHHHHCCCCHHH	19.71	28450419
173	Phosphorylation	LLPADAVYDHALWGL CCCHHHHHHHHHHHH	12.06	28450419
183	Phosphorylation	ALWGLHGYYRRLSQR HHHHHHHHHHHHHCC	5.31	-
188	Phosphorylation	HGYYRRLSQRRPSGQ HHHHHHHHCCCCCCC	21.60	24719451
193	Phosphorylation	RLSQRRPSGQHPGPG HHHCCCCCCCCCCCC	49.64	29978859
205	Phosphorylation	GPGGRRASGTTAGTM CCCCCCCCCCCCCCC	34.56	28348404
207	Phosphorylation	GGRRASGTTAGTMLP CCCCCCCCCCCCCCC	15.81	28450419
208	Phosphorylation	GRRASGTTAGTMLPT CCCCCCCCCCCCCCC	26.98	26074081
211	Phosphorylation	ASGTTAGTMLPTRVR CCCCCCCCCCCCCCC	17.05	26074081
212	Sulfoxidation	SGTTAGTMLPTRVRP CCCCCCCCCCCCCCC	4.06	21406390
215	Phosphorylation	TAGTMLPTRVRPLSR CCCCCCCCCCCCCHH	37.52	-
231	Ubiquitination	RQVALRRKAAGPQAW HHHHHHHHHHCHHHH	35.83	-
249	Phosphorylation	LAKAITKSGLQHLAP HHHHHHHHCHHHCCC	35.77	23312004
250	Ubiquitination	AKAITKSGLQHLAPP HHHHHHHCHHHCCCC	30.80	24816145
255	Ubiquitination	KSGLQHLAPPPPTPG HHCHHHCCCCCCCCC	16.66	24816145
260	Phosphorylation	HLAPPPPTPGAPCSE HCCCCCCCCCCCCCH	39.88	26552605
266	Phosphorylation	PTPGAPCSESERQIR CCCCCCCCHHHHHHH	43.00	26552605
268	Phosphorylation	PGAPCSESERQIRST CCCCCCHHHHHHHHC	23.06	23312004
272	Ubiquitination	CSESERQIRSTVDWS CCHHHHHHHHCCCHH	4.74	24816145
273	Ubiquitination	SESERQIRSTVDWSE CHHHHHHHHCCCHHH	20.24	24816145
277	Ubiquitination	RQIRSTVDWSESATY HHHHHCCCHHHHCCC	43.18	24816145
278	Ubiquitination	QIRSTVDWSESATYG HHHHCCCHHHHCCCC	10.32	24816145
281	Ubiquitination	STVDWSESATYGEHI HCCCHHHHCCCCCEE	22.01	29967540
289	Ubiquitination	ATYGEHIWFETNVSG CCCCCEEEEEECCCC	6.22	24816145
290	Ubiquitination	TYGEHIWFETNVSGD CCCCEEEEEECCCCC	9.08	24816145
303	Ubiquitination	GDFCYVGEQYCVARM CCCEECCHHHHHHHH	28.47	29967540
304	Ubiquitination	DFCYVGEQYCVARML CCEECCHHHHHHHHH	30.88	29967540
308	Ubiquitination	VGEQYCVARMLKSVS CCHHHHHHHHHHHCC	6.39	29967540
312	Acetylation	YCVARMLKSVSRRKC HHHHHHHHHCCCCCC	39.20	30588129
320	Ubiquitination	SVSRRKCAACKIVVH HCCCCCCCCCEEEEE	20.94	29967540
323	Acetylation	RRKCAACKIVVHTPC CCCCCCCEEEEECHH	33.53	25953088
336	Ubiquitination	PCIEQLEKINFRCKP HHHHHHHHCCCCCCC	52.09	-
344	Phosphorylation	INFRCKPSFRESGSR CCCCCCCCCCCCCCC	23.56	21712546
348	Phosphorylation	CKPSFRESGSRNVRE CCCCCCCCCCCCCCC	37.50	23186163
348	Ubiquitination	CKPSFRESGSRNVRE CCCCCCCCCCCCCCC	37.50	30230243
350	Phosphorylation	PSFRESGSRNVREPT CCCCCCCCCCCCCCC	29.93	29214152
370	Ubiquitination	WVHRRRQDGKCRHCG HHCCCCCCCCCCCCC	57.62	30230243
371	Ubiquitination	VHRRRQDGKCRHCGK HCCCCCCCCCCCCCC	23.71	30230243
375	Ubiquitination	RQDGKCRHCGKGFQQ CCCCCCCCCCCCHHH	33.87	30230243
387	Ubiquitination	FQQKFTFHSKEIVAI HHHEEEECCCCEEEE	34.60	30230243
443	Phosphorylation	RARRPQNTLKASKKK HCCCCCCCCHHCHHH	25.12	-
447	Phosphorylation	PQNTLKASKKKKRAS CCCCCHHCHHHHHHH	43.34	26437602
451	Ubiquitination	LKASKKKKRASFKRK CHHCHHHHHHHHCCH	63.17	30230243
454	Phosphorylation	SKKKKRASFKRKSSK CHHHHHHHHCCHHCC	35.02	24719451
461	Ubiquitination	SFKRKSSKKGPEEGR HHCCHHCCCCCCCCC	69.69	24816145
462	Ubiquitination	FKRKSSKKGPEEGRW HCCHHCCCCCCCCCC	80.01	24816145
473	Ubiquitination	EGRWRPFIIRPTPSP CCCCCCEEECCCCCC	2.64	30230243
474	Ubiquitination	GRWRPFIIRPTPSPL CCCCCEEECCCCCCC	4.40	30230243
478	Ubiquitination	PFIIRPTPSPLMKPL CEEECCCCCCCCCCE	36.31	30230243
490	Ubiquitination	KPLLVFVNPKSGGNQ CCEEEEECCCCCCHH	27.15	30230243
492	Ubiquitination	LLVFVNPKSGGNQGA EEEEECCCCCCHHHH	57.43	29967540
497	Ubiquitination	NPKSGGNQGAKIIQS CCCCCCHHHHHHHHH	57.40	24816145
508	Phosphorylation	IIQSFLWYLNPRQVF HHHHHHHHCCHHHCC	9.96	-
519	Ubiquitination	RQVFDLSQGGPKEAL HHCCCCCCCCHHHHH	69.06	24816145
520	Ubiquitination	QVFDLSQGGPKEALE HCCCCCCCCHHHHHH	51.50	24816145
529	Phosphorylation	PKEALEMYRKVHNLR HHHHHHHHHHHCCCE	9.63	-
559	Ubiquitination	TLDQLRLKPPPPVAI HHHHHCCCCCCCEEE	49.39	30230243
583	Ubiquitination	ARTLNWGGGYTDEPV HHHCCCCCCCCCCCH	19.97	30230243
605	Ubiquitination	EEGNVVQLDRWDLHA CCCCEEEEECCCCCC	3.05	30230243
606	Ubiquitination	EGNVVQLDRWDLHAE CCCEEEEECCCCCCC	32.31	30230243
610	Ubiquitination	VQLDRWDLHAEPNPE EEEECCCCCCCCCCC	3.07	30230243
622	Ubiquitination	NPEAGPEDRDEGATD CCCCCCCCCCCCCCC	67.47	30230243
662	Ubiquitination	SREANPEKFNSRFRN HHCCCHHHHHHHHHH	51.61	30230243
673	Phosphorylation	RFRNKMFYAGTAFSD HHHHCCCCCCCHHHH	10.71	-
680	Ubiquitination	YAGTAFSDFLMGSSK CCCCHHHHHHHCCCH	33.96	24816145
685	Phosphorylation	FSDFLMGSSKDLAKH HHHHHHCCCHHHHHH	21.90	26657352
686	Phosphorylation	SDFLMGSSKDLAKHI HHHHHCCCHHHHHHH	25.18	22817900
691	Ubiquitination	GSSKDLAKHIRVVCD CCCHHHHHHHHHEEC	47.03	-
700	Sulfoxidation	IRVVCDGMDLTPKIQ HHHEECCCCCCHHHH	2.14	21406390
705	Phosphorylation	DGMDLTPKIQDLKPQ CCCCCCHHHHHCCCC	48.00	23186163
710	Ubiquitination	TPKIQDLKPQCVVFL CHHHHHCCCCEEEEE	41.13	-
771	Phosphorylation	GGHGERLTQCREVVL CCCCHHHCCCCEEEE	31.66	-
777	Ubiquitination	LTQCREVVLTTSKAI HCCCCEEEEECCCCC	3.17	24816145
779	Phosphorylation	QCREVVLTTSKAIPV CCCEEEEECCCCCCE	19.88	-
781	Phosphorylation	REVVLTTSKAIPVQV CEEEEECCCCCCEEE	18.17	23186163
782	Ubiquitination	EVVLTTSKAIPVQVD EEEEECCCCCCEEEC	48.52	24816145
794	Ubiquitination	QVDGEPCKLAASRIR EECCEECHHHHHHHH	52.45	30230243
799	Ubiquitination	PCKLAASRIRIALRN ECHHHHHHHHHHHHC	19.92	24816145
800	Ubiquitination	CKLAASRIRIALRNQ CHHHHHHHHHHHHCH	3.28	24816145
804	Ubiquitination	ASRIRIALRNQATMV HHHHHHHHHCHHHHH	5.00	24816145
805	Ubiquitination	SRIRIALRNQATMVQ HHHHHHHHCHHHHHH	24.96	24816145
814	Ubiquitination	QATMVQKAKRRSAAP HHHHHHHHHHHCCCC	8.09	29967540
816	Ubiquitination	TMVQKAKRRSAAPLH HHHHHHHHHCCCCCC	42.52	24816145
817	Ubiquitination	MVQKAKRRSAAPLHS HHHHHHHHCCCCCCC	29.91	24816145
818	Phosphorylation	VQKAKRRSAAPLHSD HHHHHHHCCCCCCCC	32.58	28450419
824	Phosphorylation	RSAAPLHSDQQPVPE HCCCCCCCCCCCCCH	44.81	28450419
836	Ubiquitination	VPEQLRIQVSRVSMH CCHHHEEEEEEECHH	22.24	29967540
837	Ubiquitination	PEQLRIQVSRVSMHD CHHHEEEEEEECHHH	3.52	29967540
841	Phosphorylation	RIQVSRVSMHDYEAL EEEEEEECHHHHHHH	14.86	27642862
841	Ubiquitination	RIQVSRVSMHDYEAL EEEEEEECHHHHHHH	14.86	29967540
845	Phosphorylation	SRVSMHDYEALHYDK EEECHHHHHHHCCCH	6.60	28796482
850	Phosphorylation	HDYEALHYDKEQLKE HHHHHHCCCHHHHHH	29.56	28796482
853	Ubiquitination	EALHYDKEQLKEASV HHHCCCHHHHHHCCC	59.24	29967540
878	Ubiquitination	SDLELCRAHIERLQQ CHHHHHHHHHHHHHC	13.65	29967540
893	Ubiquitination	EPDGAGAKSPTCQKL CCCCCCCCCCCCCCC	56.93	-
894	Phosphorylation	PDGAGAKSPTCQKLS CCCCCCCCCCCCCCC	25.55	25159151
896	Phosphorylation	GAGAKSPTCQKLSPK CCCCCCCCCCCCCCC	34.36	25394399
900	Ubiquitination	KSPTCQKLSPKWCFL CCCCCCCCCCCEEEE	4.34	29967540
901	Phosphorylation	SPTCQKLSPKWCFLD CCCCCCCCCCEEEEE	31.31	25159151
901	Ubiquitination	SPTCQKLSPKWCFLD CCCCCCCCCCEEEEE	31.31	29967540
905	Ubiquitination	QKLSPKWCFLDATTA CCCCCCEEEEECCCH	2.79	29967540
906	Ubiquitination	KLSPKWCFLDATTAS CCCCCEEEEECCCHH	7.22	29967540
917	Ubiquitination	TTASRFYRIDRAQEH CCHHHCCCHHHHHHH	22.94	29967540
947	Phosphorylation	DPELLGASARPDLPT CHHHHCCCCCCCCCC	24.02	26074081
954	Phosphorylation	SARPDLPTPTSPLPT CCCCCCCCCCCCCCC	46.63	25850435
956	Phosphorylation	RPDLPTPTSPLPTSP CCCCCCCCCCCCCCC	45.51	25850435
957	Phosphorylation	PDLPTPTSPLPTSPC CCCCCCCCCCCCCCC	26.16	25850435
961	Phosphorylation	TPTSPLPTSPCSPTP CCCCCCCCCCCCCCC	53.64	25850435
962	Phosphorylation	PTSPLPTSPCSPTPR CCCCCCCCCCCCCCC	23.21	25850435
965	Phosphorylation	PLPTSPCSPTPRSLQ CCCCCCCCCCCCCCC	34.88	25850435
967	Phosphorylation	PTSPCSPTPRSLQGD CCCCCCCCCCCCCCC	18.29	26074081
970	Phosphorylation	PCSPTPRSLQGDAAP CCCCCCCCCCCCCCC	26.67	22115753
988	Ubiquitination	EELIEAAKRNDFCKL HHHHHHHHHCCCHHH	59.80	24816145
989	Ubiquitination	ELIEAAKRNDFCKLQ HHHHHHHHCCCHHHH	43.13	24816145
1012	Phosphorylation	LMHRDEQSRTLLHHA CCCCCHHHHHHHHHH	25.78	-
1014	Phosphorylation	HRDEQSRTLLHHAVS CCCHHHHHHHHHHHH	38.63	27080861
1021	Phosphorylation	TLLHHAVSTGSKDVV HHHHHHHHCCCHHHH	28.03	27080861
1022	Phosphorylation	LLHHAVSTGSKDVVR HHHHHHHCCCHHHHH	38.59	27080861
1024	Phosphorylation	HHAVSTGSKDVVRYL HHHHHCCCHHHHHHH	26.27	22617229
1024	Ubiquitination	HHAVSTGSKDVVRYL HHHHHCCCHHHHHHH	26.27	24816145
1025	Ubiquitination	HAVSTGSKDVVRYLL HHHHCCCHHHHHHHH	56.75	29967540
1046	Ubiquitination	ILDAVEENGETCLHQ HHHHHHHHHCCHHHH	39.84	24816145
1047	Ubiquitination	LDAVEENGETCLHQA HHHHHHHHCCHHHHH	34.57	24816145
1061	Phosphorylation	AAALGQRTICHYIVE HHHHCCCHHHHHHHH	21.77	27251275
1065	Phosphorylation	GQRTICHYIVEAGAS CCCHHHHHHHHHHHH	11.40	27642862
1072	Phosphorylation	YIVEAGASLMKTDQQ HHHHHHHHHHHHCCC	28.25	29449344
1076	Phosphorylation	AGASLMKTDQQGDTP HHHHHHHHCCCCCCH	25.69	22210691
1082	Phosphorylation	KTDQQGDTPRQRAEK HHCCCCCCHHHHHHH	27.48	29449344
1089	Ubiquitination	TPRQRAEKAQDTELA CHHHHHHHHHHHHHH	50.81	29967540
1105	Phosphorylation	YLENRQHYQMIQRED HHHHHHHHHHEEHHH	7.46	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DGKZ_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DGKZ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DGKZ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PK3CA_HUMAN	PIK3CA	physical	12890670
PLCG1_HUMAN	PLCG1	physical	12890670
SNTA1_HUMAN	SNTA1	physical	11352924
SNTB1_HUMAN	SNTB1	physical	11352924
SNTB2_HUMAN	SNTB2	physical	11352924
RASH_HUMAN	HRAS	physical	11257115
GRP1_HUMAN	RASGRP1	physical	11257115
VHL_HUMAN	VHL	physical	17350623
PAR6A_HUMAN	PARD6A	physical	17350623
RB_HUMAN	RB1	physical	16286473
RBL1_HUMAN	RBL1	physical	16286473
RBL2_HUMAN	RBL2	physical	16286473
P53_HUMAN	TP53	physical	23606744

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-686, AND MASSSPECTROMETRY.
PubMed: 17081983