GL1AD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GL1AD_HUMAN
• UniProt AC: Q6EEV4
• Protein Name: DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5
• Gene Name: POLR2M
• Organism: Homo sapiens (Human).
• Sequence Length: 148
• Protein Sequence: MATPARAPESPPSADPALVAGPAEEAECPPPRQPQPAQNVLAAPRLRAPSSRGLGAAEFGGAAGNVEAPGETFAQRVSWGPAESPPGSFSSSSLGAPLPSRTLFPSLEGDFDSVTFASVLRASGRRACCGRAVPLPGQKIHLQIARQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATPARAPES -----CCCCCCCCCC	19.04	26074081
3 (in isoform 2)	Phosphorylation	-	19.04	26074081
10	Phosphorylation	TPARAPESPPSADPA CCCCCCCCCCCCCCC	40.84	23401153
10 (in isoform 2)	Phosphorylation	-	40.84	23401153
13	Phosphorylation	RAPESPPSADPALVA CCCCCCCCCCCCCEE	49.00	25159151
13 (in isoform 2)	Phosphorylation	-	49.00	25159151
45	Methylation	QNVLAAPRLRAPSSR CCCCCCCCCCCCCCC	31.89	80702223
50	Phosphorylation	APRLRAPSSRGLGAA CCCCCCCCCCCCCCH	31.51	30576142
50 (in isoform 2)	Phosphorylation	-	31.51	30576142
51	Phosphorylation	PRLRAPSSRGLGAAE CCCCCCCCCCCCCHH	29.34	26699800
51 (in isoform 2)	Phosphorylation	-	29.34	26699800
93	Phosphorylation	PGSFSSSSLGAPLPS CCCCCCCCCCCCCCC	32.54	30576142
100	Phosphorylation	SLGAPLPSRTLFPSL CCCCCCCCCCCCCCC	45.65	30576142
113	Phosphorylation	SLEGDFDSVTFASVL CCCCCCCHHHHHHHH	24.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GL1AD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GL1AD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GL1AD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HIG1B_HUMAN	HIGD1B	physical	16169070
AHSP_HUMAN	AHSP	physical	16169070
WDR89_HUMAN	WDR89	physical	16169070
ANKH1_HUMAN	ANKHD1	physical	16169070
MYO3A_HUMAN	MYO3A	physical	16169070
MYO9A_HUMAN	MYO9A	physical	16169070
QCR8_HUMAN	UQCRQ	physical	16169070
SCMH1_HUMAN	SCMH1	physical	16169070
ZN410_HUMAN	ZNF410	physical	16169070
APOD_HUMAN	APOD	physical	16169070
DGKZ_HUMAN	DGKZ	physical	16169070
CE126_HUMAN	KIAA1377	physical	16169070
RBM4B_HUMAN	RBM4B	physical	16169070
PRS7_HUMAN	PSMC2	physical	16169070
RL7A_HUMAN	RPL7A	physical	16169070
RPB7_HUMAN	POLR2G	physical	26186194
RPAP1_HUMAN	RPAP1	physical	26186194
RPAP2_HUMAN	RPAP2	physical	26186194
UBP47_HUMAN	USP47	physical	26186194
RPB1_HUMAN	POLR2A	physical	26186194
RPB4_HUMAN	POLR2D	physical	26186194
RPR1A_HUMAN	RPRD1A	physical	26186194
DCAM_HUMAN	AMD1	physical	26186194
RECQ5_HUMAN	RECQL5	physical	26186194
RPB2_HUMAN	POLR2B	physical	26186194
SHIP2_HUMAN	INPPL1	physical	26186194
COA1_HUMAN	COA1	physical	26186194
SPT6H_HUMAN	SUPT6H	physical	26186194
GPN1_HUMAN	GPN1	physical	26186194
RPB11_HUMAN	POLR2J	physical	26186194
UBR2_HUMAN	UBR2	physical	26186194
RPB9_HUMAN	POLR2I	physical	26186194
RPAB1_HUMAN	POLR2E	physical	26186194
RPB3_HUMAN	POLR2C	physical	26186194
BIN1_HUMAN	BIN1	physical	26186194
SSNA1_HUMAN	SSNA1	physical	26186194
KLH26_HUMAN	KLHL26	physical	26186194
FRIL_HUMAN	FTL	physical	26186194
FABD_HUMAN	MCAT	physical	26186194
RPAB5_HUMAN	POLR2L	physical	26186194
GPN2_HUMAN	GPN2	physical	26186194
RPAB2_HUMAN	POLR2F	physical	26186194
RPB7_HUMAN	POLR2G	physical	28514442
RECQ5_HUMAN	RECQL5	physical	28514442
BIN1_HUMAN	BIN1	physical	28514442
RPR1A_HUMAN	RPRD1A	physical	28514442
RPAP2_HUMAN	RPAP2	physical	28514442
GPN2_HUMAN	GPN2	physical	28514442
COA1_HUMAN	COA1	physical	28514442
SPT6H_HUMAN	SUPT6H	physical	28514442
UBP47_HUMAN	USP47	physical	28514442
RPB1_HUMAN	POLR2A	physical	28514442
RPB9_HUMAN	POLR2I	physical	28514442
RPB11_HUMAN	POLR2J	physical	28514442
RPAP1_HUMAN	RPAP1	physical	28514442
GPN1_HUMAN	GPN1	physical	28514442
DCAM_HUMAN	AMD1	physical	28514442
RPB3_HUMAN	POLR2C	physical	28514442
RPAB5_HUMAN	POLR2L	physical	28514442
RPB2_HUMAN	POLR2B	physical	28514442
SHIP2_HUMAN	INPPL1	physical	28514442
KLH26_HUMAN	KLHL26	physical	28514442
SSNA1_HUMAN	SSNA1	physical	28514442
RPAB2_HUMAN	POLR2F	physical	28514442
FRIL_HUMAN	FTL	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.